One Day MD | Evidence-Based Wellness

Quick Summary The search for a scientifically proven "anti-aging drug" has never been more exciting. Three therapies dominate the longevity conversation in 2026: Rapamycin — the strongest experimental lifespan extender and mTOR inhibitor. Metformin — the widely used diabetes drug with decades of safety data and potential healthy-aging benefits. GLP-1 receptor agonists (Ozempic®, Wegovy®, Mounjaro®, Zepbound®) — originally developed for diabetes and obesity, now being investigated for their effects on aging, inflammation, cardiovascular disease, dementia, and cancer. Each works through different biological pathways and offers unique strengths. Bottom Line If the goal is maximizing lifespan in laboratory animals , rapamycin remains the clear leader. If the goal is improving metabolic health in humans , GLP-1 receptor agonists currently have the strongest clinical evidence. Metformin occupies the middle ground with an excellent safety profile and pro...

What is Metformin? Metformin is an oral anti-diabetic drug in the biguanide class for the treatment of type 2 diabetes mellitus, in particular, in overweight and obese people and those with normal kidney function.  It is only available by prescription and is subject to regulation by healthcare professionals. Metformin has several benefits in patients with type 2 diabetes mellitus, including decreased hyperinsulinemia, weight reduction, augmented fibrinolysis, improved lipid profiles and enhanced endothelial function. ( R ) Best Natural Alternatives to Metformin Some people might like using natural supplements or adjuncts in addition to their diabetic treatments. It's important to consult with a healthcare professional before making any changes to your diabetes treatment plan, including incorporating natural remedies. Here are some natural alternatives that may be considered: Berberine Berberine is a compound found in various plants, including the roots, rhizomes, and stem bark...

Mercola.com - Earlier this year, I reported that carcinogenic N-nitrosodimethylamine (NDMA) had been found in certain blood pressure, heartburn and diabetes medications. As of February 2020, drugs recalled due to contamination with this poison included: (1) Valsartan, losartan and irbesartan (high blood pressure medications) Zantac (2) and Axid (heartburn medications) Metformin (diabetes medication) In the case of valsartan, the three companies whose drugs were recalled in 2018 had all purchased the active ingredient from a Chinese company called Zhejiang Huahai Pharmaceutical Co. It’s one of China’s largest manufacturers of generics.3 Since 2018, the recall has been expanded dozens of times to also include losartan and irbesartan, made by more than 10 different companies with distribution in some 30 countries.4 As reported5 by Bloomberg in December 2019, the U.S. Food and Drug Administration checks less than 1% of imported drugs for impurities (or potency for that matter). Clearly, th...