GLP-1 Advisor | One Day MD

Semaglutide, tirzepatide, retatrutide, CagriSema, orforglipron and next-generation obesity medicines Research snapshot: 3 November 2026 · Curated Phase 3, pivotal and landmark human studies · Last editorial review: 3 November 2026 This tracker follows major clinical studies of GLP-1 receptor agonists and related incretin-based medicines across obesity, type 2 diabetes, cardiovascular disease, kidney disease, metabolic dysfunction-associated steatohepatitis (MASH), obstructive sleep apnea and other obesity-related complications. It is designed as a research navigation tool: each entry links to its ClinicalTrials.gov record and, where available, a peer-reviewed paper, regulatory source or clearly identified sponsor announcement. The tracker distinguishes completed trials from posted results and distinguishes peer-reviewed evidence from sponsor-reported topline findings. How to use this tracker: Search by medicine, trial acronym, NCT number or condition. Use the dropdowns...

By Dr. Frank Yap, MD  |  Published: September 28, 2026  |  Last updated: October 2026  |  Reference: U.S. FDA labeling  |  Purpose: evidence and safety education, not individual medical advice Quick Answer In the U.S. in 2026, adult weight-management GLP-1 options include Wegovy (weekly injection), Wegovy HD 7.2 mg (weekly, only after 2.4 mg is tolerated for 4+ weeks), the Wegovy pill (daily), Zepbound (tirzepatide, weekly) and Foundayo (orforglipron, daily pill). The only direct head-to-head trial, SURMOUNT-5, found -20.2% weight loss with tirzepatide vs -13.7% with semaglutide at 72 weeks, but pills and injections should not be ranked across different trials. Pick by goal (weight, heart risk, sleep apnea, liver), route, tolerability and cost, protect muscle with protein and resistance training, and plan for long-term maintenance because weight re...