One Day MD | Evidence-Based Wellness

Corticosteroids such as prednisone, prednisolone, methylprednisolone and dexamethasone remain among the most effective anti-inflammatory medicines in modern medicine. They can rapidly suppress dangerous inflammation and can be lifesaving. But prolonged or repeated exposure can produce substantial metabolic, skeletal, cardiovascular, infectious and endocrine complications. The modern goal is therefore not simply “avoid steroids,” but use the lowest effective exposure for the shortest clinically appropriate period while treating the underlying disease and transitioning to steroid-sparing therapy whenever possible. Evidence review: Updated August 2026   |   Format: Peer-review-style clinical evidence review   |   Scope: Autoimmune and inflammatory disease Abstract Glucocorticoids are potent anti-inflammatory and immunosuppressive agents used across rheumatology, gastroenterology, dermatology, pulmonology, neurology and many other specialties. The...

Testosterone is one of the most important hormones in male health. It influences sexual function, muscle mass, bone health, red-blood-cell production, body composition and aspects of mood and energy. Testosterone levels also tend to decline as men age, creating growing interest in testosterone testing, testosterone replacement therapy (TRT), men's health optimization and longevity. Interest in testosterone treatment is also increasing again. New 2026 data from Epic Research show that testosterone prescribing rates in the United States have begun rising again after nearly a decade of decline. The trend is important because it suggests a renewed clinical and consumer focus on testosterone, men's health and hormonal aging—but a rise in prescribing does not itself prove that testosterone therapy is appropriate for every man. The central question remains: Does a man have clinically meaningful testosterone deficiency, what is causing it, and is testosterone replacement lik...

Updated: August 2026 | Article type: Evidence review | Original publication: 2022; substantially revised and rebuilt in 2026 Clinical focus: Alzheimer’s disease prevention, dementia risk reduction, multidomain lifestyle intervention, p-tau217 blood biomarkers, metabolic health, GLP-1 receptor agonists, SGLT2 inhibitors, and dietary supplements. Abstract Background: Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder in which age, genetics, vascular disease, metabolic dysfunction, hearing loss, physical inactivity, depression, social isolation and other modifiable factors contribute to risk. The prevention landscape has changed substantially since this article was first published in 2022. Objective: To update the evidence concerning practical strategies for reducing dementia risk, with particular attention to multidomain lifestyle interventions, nutritional adequacy, dietary supplements, blood-based biomarkers and emerging metabolic therapies. Metho...

Bruce Willis... The man who once ruled Hollywood now lives with 24/7 care, unable to speak and unable to recall he was ever a legend. Money, fame, and status... all gone in the fog of dementia. And if that doesn’t shake you to your core, you might wanna pay attention more to yourself. ( source ) Can natural supplements effectively treat or prevent dementia ? Some studies suggest that B vitamins, omega-3 fatty acids, vitamin D3 and magnesium may have modest benefits, but it's important to consult a doctor before starting any supplement regimen. Let's dive into the evidence. In This Article: B Vitamins Vitamin D3 Omega-3 fatty acids Magnesium and Molecular Hydrogen Soy Isoflavones Ginseng Melatonin Ginko Biloba Green Tea (EGCG) Quercetin Coconut Oil Lutein (carotenoids) Selenium Zinc Turmeric (Curcumin) Citicoline Combined Metabolic Activators (NR, NAC, L-Carnitine and L-Serine) Centrum Silver Multivitamin Creatine Mushrooms (Ergothioneine, Lion's Mane and Reishi) Choline Pre...