One Day MD | Evidence-Based Wellness

When you get your annual physical, your Primary Care Physician (PCP) reviews your lab work through a narrow lens: the absence of acute disease. If your markers fall just one point inside the standard population reference range, you are given a clean bill of health. But standard reference ranges reflect an increasingly sick, metabolically dysfunctional average population. Longevity medicine shifts the paradigm from "normal" to optimal, tracking upstream biomarkers to maximize healthspan decades before chronic pathology manifests. 1. Advanced Metabolic and Insulin Dynamics Standard blood panels assess metabolic health using Fasting Blood Glucose and Hemoglobin A1c (HbA1c). The critical flaw? HbA1c is a trailing indicator. Your pancreas can compensate for underlying insulin resistance for over a decade by pumping out massive amounts of insulin to force glucose into cells, keeping your A1c looking perfectly stable while metabolic damage accelerates silently. ...

A standard lipid panel measures Low-Density Lipoprotein Cholesterol (LDL-C). However, measuring the total mass of cholesterol inside those particles frequently miscalculates actual cardiovascular event risk. To accurately assess and mitigate cardiovascular disease, modern longevity medicine tracks particle concentration, genetic risk variants, and the molecular factors that drive endothelial plaque stabilization. 1. Defining the Core Biomarkers and Their Deficiencies Apolipoprotein B (ApoB) Apolipoprotein B is the mandatory structural protein found on the surface of every single potentially plaque-forming lipoprotein particle, including Low-Density Lipoproteins (LDL), Very-Low-Density Lipoproteins (VLDL), and Intermediate-Density Lipoproteins (IDL). Because there is exactly one ApoB molecule per particle, measuring ApoB gives an absolute count of the total number of atherogenic particles in circulation. The Inadequacy of LDL-C: In ...

Vegetable oils have become one of the most controversial topics in nutrition. While mainstream health authorities generally consider many seed oils safe when consumed in moderation, some researchers argue that excessive intake of linoleic acid (LA)—the primary omega-6 fat found in soybean, corn, sunflower, safflower, and canola oils—may contribute to oxidative stress, inflammation, and increased sensitivity to sun damage. A recent article by Dr. Joseph Mercola has reignited interest in the question: Can vegetable oils accumulate in your skin, and if so, how can you reduce them? In this article, we review the science behind linoleic acid storage, skin health, ultraviolet (UV) damage, and the emerging research on pentadecanoic acid (C15:0). Do Vegetable Oils Really Accumulate in Your Body? Yes. The primary omega-6 fat found in many vegetable oils, linoleic acid (LA) , is incorporated into cell membranes and stored in body fat after consumption.   Unlike carbohydrates, which...

A comprehensive, peer-reviewed synthesis of preclinical and clinical evidence for H₂ therapy across 20 disease categories — 2026 Update Published: June 2026 Last Reviewed: June 2026   2026 Update References: 160+ citations Category: Integrative Medicine | Antioxidant Therapy Reading Time: ~18 min Peer-Reviewed Format Abstract Molecular hydrogen (H₂) has emerged over the past two decades as a uniquely versatile therapeutic agent, distinguished by its ability to selectively scavenge cytotoxic reactive oxygen species (ROS) while crossing all biological barriers, including the blood-brain barrier. Since the landmark 2007 Nature Medicine publication, more than 5,000 papers and over 100 registered clinical trials have examined H₂ across conditions spanning neurodegeneration, cancer, cardiovascular disease, metabolic syndrome, inflammatory disorders, and respiratory illness. This updated review synth...

Choosing the best multivitamin can be overwhelming. With hundreds of products on the market, consumers are faced with varying ingredient quality, dosages, certifications, and health claims. While a balanced diet remains the foundation of good health, multivitamins can help fill nutritional gaps, especially among older adults, busy professionals, vegetarians, vegans, and individuals with increased nutrient requirements.   In this guide, we review the best multivitamin brands in the United States for 2026 based on ingredient quality, manufacturing standards, scientific evidence, third-party testing, and overall value. How We Selected the Best Multivitamin Brands We evaluated multivitamin brands using the following criteria: Third-party testing and quality certifications Bioavailable vitamin and mineral forms Good Manufacturing Practice (GMP) compliance Transparency of ingredients and labeling Clinical reputation and consumer reviews Value for money The highest-rated prod...