GLP-1 Advisor | One Day MD

OneDayMD Research Team • Updated October 2026 A practical guide to metabolic dysfunction-associated steatotic liver disease: how to recognize fatty liver, estimate fibrosis risk with FIB-4, decide when FibroScan or specialist assessment is needed, and understand what actually works in 2026. The key idea: fatty liver is not simply a problem of “too much fat in the liver.” The clinically important question is whether there is inflammation and, especially, significant liver fibrosis . That changes the level of risk and the treatment conversation. OneDayMD bottom line: For most adults with suspected MASLD, the practical pathway is identify metabolic risk → calculate FIB-4 → use a second non-invasive test when indicated → stage fibrosis → treat weight, glucose, lipids and cardiovascular risk → consider MASH-targeted medication when significant fibrosis is present . Supplements remain secondary because guideline-level evidence is not strong enough to recom...

Updated October 3, 2026 GLP-1 therapy has moved far beyond the simple phrase “weight-loss drugs.” Semaglutide, tirzepatide and newer oral and multi-receptor therapies are reshaping obesity, diabetes and cardiometabolic care. But a useful GLP-1 guide needs two columns: what these medicines can do, and what they can cost if treatment is poorly matched, escalated too quickly, or accompanied by inadequate nutrition and physical activity. This GLP-1 manual brings the major evidence together in one place: the drug family, approved 2026 therapies, emerging candidates, expected weight loss, cardiovascular and kidney outcomes, liver and sleep-apnea data, adverse effects, contraindications, oral contraceptive issues, peri-procedural considerations, muscle and bone preservation, monitoring and what happens when treatment is stopped. The central idea: GLP-1 therapy should not be judged by the scale alone. The clinically meaningful goal is better health w...