One Day MD | Evidence-Based Wellness

By Dr. Frank Yap, MD · Medically reviewed by the One Day MD Editorial Team | Last updated 17 September 2026 Quick Answer The landmark medical papers that changed medicine are not the most-cited articles. They are the publications that forced a new mechanism, a new tool, or a new standard of proof. Harvey (1628) closed the circulation. Jenner (1798) invented vaccination. Bigelow (1846) made painless surgery public. Lister (1867) made that surgery survivable. Banting (1922) turned type 1 diabetes from a death sentence into a treatable disease. Fleming (1929) opened antibiotics. The 1948 MRC streptomycin trial created the modern randomized controlled trial. Doll and Hill (1950) made smoking a medical cause. Watson and Crick (1953) gave medicine a molecule. Marshall and Warren (1984) turned ulcers into an infection. 4S (1994) proved statins save lives. The 2002 Women’s Health Initiative stopped a global prescribing habit overnight. This guide is written for patients who want the...

A comprehensive, peer-reviewed synthesis of preclinical and clinical evidence for H₂ therapy across 20 disease categories — 2026 Update Published: June 2026 Last Reviewed: June 2026   2026 Update References: 160+ citations Category: Integrative Medicine | Antioxidant Therapy Reading Time: ~18 min Peer-Reviewed Format Abstract Molecular hydrogen (H₂) has emerged over the past two decades as a uniquely versatile therapeutic agent, distinguished by its ability to selectively scavenge cytotoxic reactive oxygen species (ROS) while crossing all biological barriers, including the blood-brain barrier. Since the landmark 2007 Nature Medicine publication, more than 5,000 papers and over 100 registered clinical trials have examined H₂ across conditions spanning neurodegeneration, cancer, cardiovascular disease, metabolic syndrome, inflammatory disorders, and respiratory illness. This updated review synth...

Testosterone is one of the most important hormones in male health. It influences sexual function, muscle mass, bone health, red-blood-cell production, body composition and aspects of mood and energy. Testosterone levels also tend to decline as men age, creating growing interest in testosterone testing, testosterone replacement therapy (TRT), men's health optimization and longevity. Interest in testosterone treatment is also increasing again. New 2026 data from Epic Research show that testosterone prescribing rates in the United States have begun rising again after nearly a decade of decline. The trend is important because it suggests a renewed clinical and consumer focus on testosterone, men's health and hormonal aging—but a rise in prescribing does not itself prove that testosterone therapy is appropriate for every man. The central question remains: Does a man have clinically meaningful testosterone deficiency, what is causing it, and is testosterone replacement lik...