GLP-1 Advisor | One Day MD

GLP-1 Advisor SERIES Evidence Update By Dr. Frank Yap , MD · Published September 29, 2026 · Updated October 2026   Quick Answer: Do GLP-1 drugs cause nutrient deficiencies? GLP-1 drugs such as semaglutide and tirzepatide are not known to drain vitamins directly. Nutrient risk rises mainly because appetite suppression, nausea, vomiting and rapid weight loss reduce intake of protein, vitamin D, iron, calcium and B vitamins. The best-supported approach is food first, protein plus resistance training, risk-based blood tests and targeted rather than blanket supplementation. Persistent vomiting, confusion or unsteady walking needs urgent medical care. Core principle The goal of GLP-1 nutrition is high-quality weight loss , not maximum appetite suppression: protect protein, muscle, bone, hydration and physical fu...