One Day MD | Evidence-Based Wellness

By Dr. Frank Yap, MD | Medically reviewed by the One Day MD Editorial Team | Originally published January 26, 2026 | Fully updated September 2026 for the new 2026 ACC/AHA dyslipidemia guideline Quick Answer Saturated fat's relationship to heart disease is more nuanced than decades of "avoid it" messaging suggested — large meta-analyses of cohort studies have found no consistent independent link between total saturated fat intake and cardiovascular mortality, but randomized trials show that replacing it with polyunsaturated fat (not refined carbohydrates) does lower cardiovascular events. Industrial trans fat remains unambiguously harmful, with no safe level of intake. The newly released 2026 ACC/AHA dyslipidemia guideline (published in Circulation , March 2026) restored specific numeric LDL-C targets (roughly <100 / <70 / <55 mg/dL depending on your risk category), added universal one-time Lp(a) screening, and — notably — downgraded routine LDL particle...

Can you get some of the benefits of Mounjaro naturally? There is increasing interest in foods, dietary strategies and supplements that may reduce appetite, improve insulin sensitivity, increase satiety and support fat loss without using a prescription GLP-1/GIP medication. The important distinction is that there is no proven natural supplement that is equivalent to Mounjaro (tirzepatide) . Tirzepatide is a pharmacological dual GIP and GLP-1 receptor agonist. It produces substantially larger average weight loss than any individual food, supplement or lifestyle technique currently supported by human evidence. That does not make natural strategies irrelevant. For people who do not want medication, cannot tolerate it, or simply want to improve metabolic health alongside medical treatment, a more useful question is: Which natural interventions have the best evidence for reducing hunger, improving metabolic health, supporting fat loss and preserving muscle? This article re...

Clinical Quick-Reference Card Protocol Definition: A 5-day, plant-based, low-protein, low-carbohydrate, high-unsaturated-fat dietary regimen engineered to trigger the metabolic and cellular cellular renewal pathways of water fasting without starvation. Standard Caloric Allocation: Day 1: ~1,100 kcal (~11% protein, 46% fat, 43% complex carbs). Days 2–5: ~725–750 kcal (~9% protein, 44% fat, 47% complex carbs). Primary Molecular Triggers: Downregulation of mTOR, IGF-1, and PKA pathways; activation of AMPK, Sirtuins (SIRT1/SIRT3), and autophagy; elevation of circulating beta-hydroxybutyrate (βHB). Landmark Human Findings (Nature Comms, 2024): 3 consecutive monthly cycles resulted in a median biological age reduction of 2.5 years , alongside significant decreases in hepatic fat, fasting insulin, and blood pressure, independent of total weight loss. Medical Oversight Requirement: Mandatory physician clearance for individuals taking ...