One Day MD | Evidence-Based Wellness

Updated September 25, 2026 Popular GLP-1-based medicines are now at the center of a growing legal and medical debate over a rare form of sudden vision loss called nonarteritic anterior ischemic optic neuropathy (NAION) . Patients in the United States have filed lawsuits against the manufacturers of widely used medicines including Ozempic, Wegovy, Mounjaro and Zepbound , alleging that the drugs caused NAION and that patients were not adequately warned about the potential risk. Those lawsuits are allegations at the moment—not findings that the medications caused the injuries. The scientific evidence is still evolving and is not completely consistent. Importantly, the regulatory evidence is stronger for semaglutide , the active ingredient in Ozempic, Wegovy and Rybelsus, than for the entire GLP-1 drug class. Patient safety message: Sudden or rapidly worsening vision loss is not a symptom to monitor at home. Anyone experiencing sudden vision loss while taking a GLP-1-based medi...

By Dr. Frank Yap, MD | Medically reviewed by One Day MD Review Team | Last updated: August 2026 Quick Answer Most content ranking for "injectable peptides for anti-aging" actually describes topical cosmetic peptides (Matrixyl, Argireline, copper peptide serums) that are never injected at all. True injectable anti-aging peptides fall into distinct categories: skin-quality "boosters" used in medical aesthetics (injectable GHK-Cu, growth-factor mesotherapy), growth-hormone secretagogues (sermorelin, tesamorelin, CJC-1295, ipamorelin), regenerative peptides (BPC-157, TB-500), and cellular/metabolic peptides (MOTS-c, epitalon). Evidence quality varies enormously — from large randomized trials (tesamorelin, GLP-1 drugs) down to animal-only data (BPC-157, most "longevity" peptides). As of August 2026, several popular peptides (BPC-157, KPV, TB-500, MOTS-c, Semax, epitalon) were recommended by an FDA advisory panel for legal compounding but are not yet...

By Dr. Frank Yap, MD  |  Originally published April 2026  |  Fully updated August 26, 2026 for the FDA's July 2026 compounding committee vote Quick Answer As of August 2026, GLP-1 receptor agonists (semaglutide, tirzepatide) remain the only peptides in this guide with full FDA approval. On July 23–24, 2026, an FDA advisory committee (PCAC) recommended adding BPC-157, KPV, TB-500, MOTS-c, Semax, and Epitalon to the list of substances compounding pharmacies may use — but that vote is non-binding, and none of the six is lawful to compound yet; formal rulemaking is expected to take 12–24 months. Separately, AOD-9604 failed its pivotal human obesity trial back in 2007. The best human evidence among the non-GLP-1 peptides here belongs to topical GHK-Cu (skin) and Selank (anxiety); the weakest belongs to BPC-157 and TB-500 (mostly animal data). Any protocol should run through a licensed physician — not a gray-market vendor. Medical & regu...