One Day MD | Evidence-Based Wellness

Chronic joint pain affects almost one-quarter of people worldwide. Common joints affected include the knees, hands, elbows, shoulders, back and elsewhere. In most cases, this is caused by the most common type of arthritis, osteoarthritis. Treatments being used range from health supplements, hyaluronic acid, platelet rich plasma (PRP), stem cell therapy, to surgical methods such as minimal invasive method to joint replacement surgery (total knee replacement, total hip replacement). Pain relievers such as acetaminophen (Tylenol or Panadol) or non-steroidal anti-inflammatory drugs, such as ibuprofen (Advil or Nurofen), are usually the first choice for joint pain relief. Of late, there are also dozens of supplements that claim to treat joint pain, but which ones actually work? Here’s a look at the best options and what the existing research says about them. 1. Glucosamine and Chondroitin Glucosamine  Glucosamine is a natural component of cartilage, a substance that prevents b...

Drugs like Ozempic (semaglutide for diabetes), Wegovy (higher-dose semaglutide for weight loss), Mounjaro (tirzepatide for diabetes), and Zepbound (tirzepatide for weight loss) mimic the gut hormone GLP-1, promoting fullness, slowing digestion, and enhancing insulin sensitivity. In 2025, these therapies have solidified their role not just in obesity management but also in cardiovascular and kidney protection, with the World Health Organization issuing global guidelines endorsing their use for obesity as a chronic disease. Credit: GoodRx Health Key Benefits in 2025 GLP-1 agonists continue to outperform expectations: Significant Weight Loss : Clinical trials show 15-21% average body weight reduction over 68-72 weeks (e.g., Wegovy ~15%, Zepbound ~21%). Dual agonists like tirzepatide (Mounjaro/Zepbound) often edge out single GLP-1 agents like semaglutide. Blood Sugar Control : Superior glycemic management for type 2 diabetes, reducing HbA1c by up to 2.4%. Cardiovascular Protection : Ro...