One Day MD | Evidence-Based Wellness

A Malaysian mesenchymal stem cell review study, "Characteristics and clinical applications of Wharton’s jelly-derived mesenchymal stromal cells" was led by Dr LL Liau from Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, 56000 Kuala Lumpur, Malaysia (Curr Res Transl Med. 2020).  According to the study's conclusion: WJ-MSCs (Wharton Jelly Mesenchymal Stem Cells) have many advantages compared to MSCs (mesenchymal stem cells) from adult tissues. The discrepancies in the WJ-MSC characteristics reported in the above studies might have arisen from differences in cell isolation site and technique and cell culture procedure. Even though WJ-MSCs are safe and efficacious for treating certain diseases, most of the clinical studies/trials reported thus far do not provide sufficient evidence to support its routine use in the clinic. What are Mesenchymal Stem Cells? There are mainly two types of naturally occurring stem cells found in a human body, Hem...

Clinical studies using mesenchymal stem cells (MSCs) yield positive outcome in treating global pandemic, Covid-19. Critically ill patients showed reduction in lung inflammation and significant improvement in their respiratory system with the administration of mesenchymal stem cells. What are Mesenchymal Stem Cells? There are mainly two types of naturally occuring stem cells found in a human body, Hematopoietic Stem Cells and Mesenchymal Stem Cells (MSCs). Hematopoietic stem cells are found in cord blood, bone marrow and peripheral blood. MSCs are found in Wharton's jelly (refer to image below), bone marrow, fat tissue and tooth pulp. There was 178 registered clinical trials and 98 publications about cell therapy that employ Umbilical Cord derived Mesenchymal Stem Cells (UC-MSC), for the years 2007–2017 ( Regenerative Medicine, 2019 ). Sources of Mesenchymal Stem Cells Umbilical Cord The umbilical cord itself is a rich source of stem cells, where its Wharton’...