One Day MD | Evidence-Based Wellness

In the world of hepatology and metabolic health, we are witnessing a massive paradigm shift. What we historically referred to as NAFLD (Non-Alcoholic Fatty Liver Disease) and NASH (Non-Alcoholic Steatohepatitis) have officially entered a new era of nomenclature and clinical management. This isn't just a minor tweak in vocabulary. The transition from NAFLD to MASLD and NASH to MASH represents a fundamental evolution in how we view, diagnose, and treat liver disease. The 2023 Breakthrough: Why the Name Changed In June 2023, an international consensus led by major global liver societies (including AASLD, EASL, and ALEH) announced a landmark nomenclature change. For decades, the terms "fatty" and "non-alcoholic" had faced growing criticism. This historic change aimed to solve two major clinical issues: Reducing Patient Stigma: The word "fatty" can carry unintended social stigma, making patient communication unnecessarily...

In today’s highly industrialized world, the global population is exposed to toxic substances. From pesticides to additives found in food, your body is facing an assault on all fronts. To make matters worse, heavy metals, which come from practically anywhere, are undermining your health. These naturally occurring elements impede important cellular functions, making optimal liver health — as well as familiarizing yourself with other natural detox methods — even more important. The Liver — The First Line of Defense Against Toxins What does the liver have to do with removing heavy metals? As it turns out, it metabolizes heavy metals, which are transported into your intestines via bile. From there, toxins are excreted. 1 • The primary filtration system —  According to Columbia Surgery, “All the blood leaving the stomach and intestines passes through the liver, which removes toxins, byproducts and other harmful substances.” 2 ...

The liver is the largest and one of the most important organs in your body. Every one of your body systems depends on the liver: Best known for processing food, it also plays a role in maintaining your overall energy level and boosting your immune system. Your liver also helps transport essential nutrients, flushes out harmful toxins, and keeps your cholesterol and blood sugar in check. However, stress, pollution, and unhealthy habits take a toll on liver health over time. In today's fast-paced world, it's not always possible to consume a well-balanced diet that will provide you with all of the essential nutrients your liver needs to function optimally. What is Fatty Liver? Fatty liver is when excess fat (lipid) becomes deposited in the liver. Over time the excess fat can lead to inflammation, liver cell damage, and even permanent liver scarring. Fatty liver is also associated with a doubling in risk of developing type 2 diabetes, irrespective of obesity and other risk factors....

Researchers identified the 17 most potentially liver-toxic drugs in a June 24 study published in JAMA Internal Medicine. The study authors said they ranked the drugs according to the rates of severe liver injury, though they could not determine if the 17 drugs caused the acute injury in every event. According to their findings , 11 of the 17 drugs identified may have wrongly received a lower hepatotoxicity (potential to harm the liver) rank according to the current ranking system. To establish drugs’ potential for liver toxicity, researchers have used case reports of liver toxicity listed on the National Institutes of Health LiverTox website. Case reports are detailed reports on an individual patient; they often describe a novel or unusual patient case. Doctors write case reports when encountering a unique or novel patient presentation in their clinics. Some doctors write case reports, and others do not. This “undoubtedly leads to underreporting,” senior autho...