Two districts under ‘haze emergency’ - Nation | The Star Online

Two districts under ‘haze emergency’ - Nation | The Star Online

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SELECT, STEP, SURPASS, SURMOUNT & FLOW: What the Landmark Semaglutide and Tirzepatide Trials Actually Prove (2026)

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By Dr. Frank Yap, MD  |  Medically reviewed by One Day MD Review Team  |  Last updated: August 2026 Quick Answer SELECT showed that semaglutide 2.4 mg cuts major cardiovascular events by 20% in people with overweight/obesity and existing heart disease who do not have diabetes. The STEP program (STEP 1–5, STEP 8, and the newer STEP UP trials) established semaglutide's weight-loss profile, with losses ranging from roughly 10% to over 20% of body weight depending on dose, population, and duration. The SURPASS program showed that tirzepatide — a dual GIP/GLP-1 agonist — produces larger HbA1c and weight reductions than semaglutide in type 2 diabetes, and the newly published SURPASS-CVOT (December 2025) confirmed tirzepatide is at least as cardioprotective as dulaglutide. FLOW showed semaglutide cuts major kidney disease events by 24% in people with type 2 diabetes and chronic kidney disease, which led the FDA to approve a dedicated kidney-protection indic...
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How Many Years Can a Healthy Lifestyle Add to Your Life? The Evidence on Diet, Exercise, Supplements & Anti-Aging Drugs (2026)

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Short answer: A healthy lifestyle may add years to life—and potentially a decade or more in some populations—but there is no scientifically valid number that applies to everyone. The strongest evidence suggests that the biggest gains come from a combination of not smoking, regular physical activity, a high-quality diet, maintaining a healthy body weight, and controlling major cardiovascular and metabolic risk factors . One influential U.S. analysis estimated that people who followed five low-risk lifestyle factors at age 50 had a projected life expectancy about 14 years longer for women and 12 years longer for men than people following none of those factors. However, this was a prospective observational analysis combined with life-table modelling—not a randomized trial proving that each person will live exactly 12–14 years longer. That distinction matters. It is tempting to interpret longevity studies as if they were a prescription for an extra number of years: exercise gi...
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NAC vs NAD vs NR vs NMN vs Niacin: What Are the Differences?

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By the One Day MD Editorial Team  |  Originally published September 2020  |  Last updated and medically fact-checked: July 26, 2026 NAD, NAD+, NADH, NR, NMN, niacin, niacinamide, and NAC — these overlapping names cause constant confusion, and understandably so. Some are simply different names for the same molecule. Others are metabolic precursors that your body converts, step by step, into NAD+. One of them, NAC, isn't related to NAD+ metabolism at all. This guide breaks down what each compound actually does, how the human evidence stacks up as of 2026, and where the real safety trade-offs lie — including the January 2026 head-to-head human trial that finally pitted NR against NMN directly, and the FDA's 2025 reversal on NMN's legal status. Quick Answer NAD+ is the coenzyme your cells actually need for energy production and DNA repair, and it can't be taken as an oral supplement because it's too large a molecule to survive digestion intact. NR, NMN,...
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Ivermectin for Parkinson’s and Dementia: Analyzing the Neuroprotective Molecular Evidence and Clinical Case Reports (2026)

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Scientific Review & Regulatory Audit by the Clinical Editorial Team The therapeutic paradigm for progressive neurodegenerative disorders like Parkinson’s disease (PD) and various forms of dementia faces a critical bottleneck. Standard pharmacology, primarily anchored by levodopa (L-DOPA) for Parkinson’s and acetylcholinesterase inhibitors for dementia, remains strictly symptomatic. These options frequently suffer from diminishing efficacy and significant side-effect profiles like L-DOPA-induced dyskinesia over long-term use. Consequently, the pharmaceutical community has focused heavily on drug repurposing—identifying established, safety-vetted compounds capable of crossing pathways to modify disease progression. An unexpected frontline candidate emerging in this space is ivermectin. Traditionally classified as a broad-spectrum antiparasitic agent, a surge of preclinical studies between 2020 and 2024 has unveiled its complex, multi-targeted pharmacodynamics within the mam...
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Testosterone, Men's Health & Healthy Aging: Low T, Testosterone Replacement and the Science of Anti-Aging

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Testosterone is one of the most important hormones in male health. It influences sexual function, muscle mass, bone health, red-blood-cell production, body composition and aspects of mood and energy. Testosterone levels also tend to decline as men age, creating growing interest in testosterone testing, testosterone replacement therapy (TRT), men's health optimization and longevity. Interest in testosterone treatment is also increasing again. New 2026 data from Epic Research show that testosterone prescribing rates in the United States have begun rising again after nearly a decade of decline. The trend is important because it suggests a renewed clinical and consumer focus on testosterone, men's health and hormonal aging—but a rise in prescribing does not itself prove that testosterone therapy is appropriate for every man. The central question remains: Does a man have clinically meaningful testosterone deficiency, what is causing it, and is testosterone replacement lik...
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10 Best Vitamin & Longevity Supplement Brands on Amazon (2026 Doctor-Reviewed Guide)

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Medical & Science Review: Updated by the One Day MD Editorial Team | Evidence Level: High (Clinical trials, cGMP Standards, Advanced Liposomal Tech, & Third-Party Lab Testing). Navigating dietary supplements on Amazon requires cutting through marketing hype to find medical-grade purity and verified cellular absorption. While generic store brands often rely on synthetic, low-yield compounds (like cyanocobalamin or inorganic oxide minerals), leading functional medicine, liposomal delivery, and longevity science brands prioritize bioavailable forms that bypass GI degradation. In this guide, we review the 10 best US supplement and vitamin brands on Amazon —evaluating practitioner-grade multivitamins, nano-liposomal nutrient technology, and targeted longevity molecules. 🔬 Beyond Standard Multivitamins: The 3 Pillars of Superior Supplementation When selecting clinical-grade supplements on Amazon, pay close attention to three key performa...
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Procyanidin C1 (PCC1): Senolytic Effects, Anti-Aging Research & 2026 Evidence

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OneDayMD • Longevity • Senotherapeutics Procyanidin C1 (PCC1) is a grape-seed-derived polyphenol that has attracted major interest in longevity research because of its reported senolytic and senomorphic effects . Laboratory and animal studies suggest that PCC1 can alter senescent-cell behavior and, under certain experimental conditions, selectively eliminate senescent cells. 2026 Evidence Update: The landmark 2021 PCC1 study published in Nature Metabolism has received an Editorial Expression of Concern . The journal reported concerns involving one figure and the availability of underlying raw data. This does not establish that PCC1 is ineffective, but it means that some of the original findings — particularly lifespan-related claims — should be interpreted cautiously pending independent confirmation. Bottom line: PCC1 is a promising experimental senotherapeutic compound, ...
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Preventive Medicine & Longevity Science (2026)

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An evidence-based guide to reducing chronic disease risk, extending healthspan, and understanding what truly works — beyond hype, supplements, and shortcuts. This page serves as the central hub for OneDayMD’s coverage of preventive medicine, cancer prevention, cardiometabolic health, and longevity science, grounded in epidemiology, clinical trials, and systems biology. What This Hub Covers (Quick Overview) This hub explains: What preventive medicine actually means in modern clinical science The difference between lifespan and healthspan Which interventions reduce disease risk with high-quality evidence Where longevity science is promising — and where it becomes speculation How lifestyle, medications, and emerging tools interact over decades It is designed for readers who want risk reduction, not biohacking fantasy . Executive Summary Preventive medicine focuses on reducing the probability of disease before it occurs , rather than treating pathology after it is established. Longevity ...
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Reprogramming Life at the Cellular Level: Epigenetics, Detoxification, Gut Health, Nutrition and Next-Generation Therapies for Optimal Health and Longevity (2026)

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Can we influence how our cells age? For decades, aging was largely viewed as an unavoidable accumulation of damage. Today, longevity science is developing a more sophisticated picture. Researchers are investigating aging as a dynamic biological process involving epigenetic changes, mitochondrial dysfunction, cellular senescence, impaired autophagy, chronic inflammation, altered nutrient sensing, loss of protein quality control, stem-cell exhaustion and changes in the gut microbiome . This has opened an extraordinary possibility: rather than simply treating diseases after they appear, medicine may increasingly learn how to preserve, repair and potentially rejuvenate some of the biological systems that deteriorate with age. That does not mean humans can currently "reset" their biological age or reverse aging at will. Much of the most exciting research remains experimental. But the direction of science is clear: aging is increasingly being studied at the level of cells...
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Corticosteroids and Autoimmune Disease: The Real Risks, Benefits and Path Toward Steroid-Sparing Treatment

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Corticosteroids such as prednisone, prednisolone, methylprednisolone and dexamethasone remain among the most effective anti-inflammatory medicines in modern medicine. They can rapidly suppress dangerous inflammation and can be lifesaving. But prolonged or repeated exposure can produce substantial metabolic, skeletal, cardiovascular, infectious and endocrine complications. The modern goal is therefore not simply “avoid steroids,” but use the lowest effective exposure for the shortest clinically appropriate period while treating the underlying disease and transitioning to steroid-sparing therapy whenever possible. Evidence review: Updated August 2026   |   Format: Peer-review-style clinical evidence review   |   Scope: Autoimmune and inflammatory disease Abstract Glucocorticoids are potent anti-inflammatory and immunosuppressive agents used across rheumatology, gastroenterology, dermatology, pulmonology, neurology and many other specialties. The...
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