The Elixir

Abstract Longevity is influenced by a combination of genetic, behavioral, and environmental factors. This review synthesizes evidence on modifiable determinants of lifespan, emphasizing metabolic health, physical fitness, sleep, psychosocial factors, and behavioral interventions. Epidemiologic and interventional studies indicate that preserving muscle mass, maintaining cardiorespiratory fitness, optimizing metabolic markers, and sustaining social connectedness confer substantial reductions in all-cause mortality. Practical strategies, including resistance training, moderate-intensity aerobic activity, caloric moderation, sleep hygiene, and stress management, are highlighted as high-impact, evidence-supported interventions to extend healthspan. Keywords: longevity, insulin resistance, metabolic health, muscle mass, cardiorespiratory fitness, sleep,  stress management, healthspan 1. Introduction Human longevity is determined by complex interactions between genetics and lifestyle. Wh...

An evidence-based guide to reducing chronic disease risk, extending healthspan, and understanding what truly works — beyond hype, supplements, and shortcuts. This page serves as the central hub for OneDayMD’s coverage of preventive medicine, cancer prevention, cardiometabolic health, and longevity science, grounded in epidemiology, clinical trials, and systems biology. What This Hub Covers (Quick Overview) This hub explains: What preventive medicine actually means in modern clinical science The difference between lifespan and healthspan Which interventions reduce disease risk with high-quality evidence Where longevity science is promising — and where it becomes speculation How lifestyle, medications, and emerging tools interact over decades It is designed for readers who want risk reduction, not biohacking fantasy . Executive Summary Preventive medicine focuses on reducing the probability of disease before it occurs , rather than treating pathology after it is established. Longevity ...

Quercetin with Bromelain for Weight Loss Some people believe that consuming quercetin, whether in foods or as a natural supplement, can help promote weight loss. However, there have been mixed reviews and conclusions on the effects of quercetin for weight loss and its effect on the expression of certain genes.  These inconsistent findings from the studies maybe are due to the difference in the range of fitness of the subjects, differences in research design, different methods in the preparation of quercetin extract, etc. In order to assist you in doing your own research, let's dive into some relevant studies and reviews. Matthew Solan , author of Doctor’s Detox Diet reports that quercetin can mimic the effect of calorie restriction. However, it shows to have a greater effect on weight loss when combined with other fat-fighting phytochemicals such as  resveratrol  and  genistein . Another interesting side effect of quercetin, as reported by  MuscularDevelopment.c...

Executive Summary Long COVID (post‑acute sequelae of SARS‑CoV‑2 infection, PASC) affects millions worldwide and remains one of the most complex post‑viral syndromes in modern medicine. While early narratives focused on a single culprit — persistent spike protein — current evidence suggests long COVID is multifactorial , involving immune dysregulation, metabolic dysfunction, microvascular injury, and in some cases residual viral antigens. Among emerging therapeutic strategies, nicotinamide riboside (NR) — a NAD+ precursor — has gained attention due to promising clinical trial signals targeting fatigue, sleep, and metabolic recovery. This article merges and updates insights from spike‑protein hypotheses and NR/NAD+ research, separating established evidence from speculation, and presenting a balanced, science‑grounded view for 2026. What Is Long COVID? Long COVID refers to persistent or new symptoms lasting three months or longer after acute SARS‑CoV‑2 infection, not explained by altern...

Berberine is a compound found in various plants, including goldenseal, barberry, oregon grape, tree turmeric, and the roots, rhizomes, and stem bark of the Berberis family of plants. It has been used in traditional medicine for thousands of years to treat various health conditions. Berberine supplements have been studied for their potential health benefits, and here are some of them: Regulating blood sugar levels: A study in people in type 2 diabetes indicates that berberine is a potent oral hypoglycemic agent with beneficial effects on lipid metabolism. Another study in patients with metabolic syndrome is also suggesr that combined application of berberine can effectively regulate blood glucose and blood lipid of patients, alleviate insulin resistance and reduce the level of inflammatory response in the body. Reducing cholesterol levels: Berberine has been shown to lower LDL c...