One Day MD | Evidence-Based Wellness

OneDayMD • Longevity • Senotherapeutics Procyanidin C1 (PCC1) is a grape-seed-derived polyphenol that has attracted major interest in longevity research because of its reported senolytic and senomorphic effects . Laboratory and animal studies suggest that PCC1 can alter senescent-cell behavior and, under certain experimental conditions, selectively eliminate senescent cells. 2026 Evidence Update: The landmark 2021 PCC1 study published in Nature Metabolism has received an Editorial Expression of Concern . The journal reported concerns involving one figure and the availability of underlying raw data. This does not establish that PCC1 is ineffective, but it means that some of the original findings — particularly lifespan-related claims — should be interpreted cautiously pending independent confirmation. Bottom line: PCC1 is a promising experimental senotherapeutic compound, ...

Can diet, lifestyle and anti aging supplements reverse your age? This comprehensive guide examines the latest, scientifically-backed anti-aging supplements and methods, drawing on over 1,000 references and studies. By exploring both the biological hallmarks of aging and the most promising interventions, this article aims to provide readers with practical, evidence-based insights into how to support healthy aging and potentially extend lifespan. However, search engine results for "anti-aging" are largely dominated by skin care products and beauty guides. In reality, anti-aging science goes far beyond skin deep.  In This Article: Chapter 1: Methodology Chapter 2: What is Aging? Chapter 3: Biological Age vs Chronological Age Chapter 4: Causes of Aging and Hallmarks of Aging Chapter 5: What is Cell Senescence? Chapter 6: What is Epigenetics? Chapter 7:  Diet and Lifestyle for Anti Aging Avoid Sugar and Ultra-processed Foods Mediterranean Diet and Vegetables Avoid Smoking and Alc...