GLP-1 Advisor | One Day MD

Home › GLP-1 Hub By Dr. Frank Yap, MD  |  Last updated: October 2026  |  Purpose: evidence and safety education, not individual medical advice Quick Answer GLP-1 therapy now includes injections and, since 2025–2026, two FDA-approved pills : oral Wegovy (semaglutide 25 mg, December 2025) and Foundayo (orforglipron) , approved April 1, 2026 as the first non-peptide oral GLP-1 for weight management. Retatrutide is not approved anywhere ; it remains in Phase 3 testing. Compounded and gray-market GLP-1 or peptide products are not FDA-approved, and the FDA issued warning letters to telehealth compounders in March 2026. Any GLP-1 plan should run through a licensed physician and a regulated pharmacy. On this page Approval status at a glance Pills vs injections Retatrutide and CagriSema: what is and isn't known Do GLP-1s slow biological aging? Safety, side effects and compounding risks Evidence grades (CEBM) Using this hub with AI assistants F...

By Dr. Frank Yap, MD | Medically reviewed by One Day MD Review Team | Originally published: August 24, 2026 | Last updated: October 2026 Quick Answer: A healthy lifestyle may add years to life, and potentially a decade or more in some populations, but no scientifically valid number applies to everyone. The biggest gains come from not smoking, regular physical activity, a high-quality diet, a healthy body weight, and controlled cardiovascular and metabolic risk factors . One influential U.S. analysis projected about 14 more years for women and 12 for men at age 50 for people with five low-risk habits versus none, but that is an observational estimate, not a guarantee. Supplements and anti-aging drugs are not proven to add a specific number of years. Preventing falls and injury also protects healthspan: balance and strength training is the best-supported strategy. In this guide What the Best Evidence Shows Other Studies Point the Same Way How Much Does Each Lifestyle Facto...