One Day MD | Evidence-Based Wellness

What's the difference between NAD+ and NMN? We will cover the essentials and explain about each of these nutrients below.   NAD NAD is derived from Nicotinamide Riboside (NR) and other NAD precursors. NR is one of the 3 main forms of Niacin (vitamin B3). NAD+ is a substrate for a number of important enzymes, including poly(ADP-ribose) polymerase (PARP) and sirtuin 1 (SIRT1), which is known as a classic longevity protein. NAD+ is also essential in metabolic processes such as creating ATP in your mitochondria. It accepts and donates electrons and is used in oxidation-reduction reactions in the mitochondrial electron transport chain. The levels of NAD in our body determine the speed of aging process. In younger cells and tissues, the levels of NAD are higher. As a result, younger people tend to have better physical activity, cognitive function and potential for cell repair and regeneration. As we grow, the levels of NAD in our body start to decline. This is reflected in the form of sl...

What Is NAD+ (and Why It Matters More Than You Think) NAD+ (nicotinamide adenine dinucleotide) is an essential coenzyme present in every living cell. It plays a central role in: Cellular energy production (ATP generation) DNA repair and genomic stability Mitochondrial function Activation of sirtuins , proteins linked to metabolic health and longevity Redox balance and oxidative stress control Without adequate NAD+, cells struggle to produce energy, repair DNA damage, and maintain metabolic balance — processes that are foundational to healthy aging. Importantly, NAD+ levels decline with age, and this decline has been observed across multiple tissues, including muscle, brain, liver, and immune cells. Why NAD+ Declines With Age Several mechanisms drive age-related NAD+ depletion: Increased DNA damage requiring NAD-dependent repair enzymes (PARPs) Chronic inflammation and oxidative stress Reduced efficiency of NAD+ recycling pathways Higher metabolic demand without adequate precursor ava...

Abstract Longevity is influenced by a combination of genetic, behavioral, and environmental factors. This review synthesizes evidence on modifiable determinants of lifespan, emphasizing metabolic health, physical fitness, sleep, psychosocial factors, and behavioral interventions. Epidemiologic and interventional studies indicate that preserving muscle mass, maintaining cardiorespiratory fitness, optimizing metabolic markers, and sustaining social connectedness confer substantial reductions in all-cause mortality. Practical strategies, including resistance training, moderate-intensity aerobic activity, caloric moderation, sleep hygiene, and stress management, are highlighted as high-impact, evidence-supported interventions to extend healthspan. Keywords: longevity, insulin resistance, metabolic health, muscle mass, cardiorespiratory fitness, sleep,  stress management, healthspan 1. Introduction Human longevity is determined by complex interactions between genetics and lifestyle. Wh...

Introduction The wellness and longevity world is buzzing with supplements like NAC, NR, NMN, NAD⁺, and Niacin. They often get grouped together, but each works differently in the body. Understanding these differences helps you choose what supports your energy, metabolism, and cellular health — safely and effectively. This guide explains each compound, the latest scientific evidence, and practical tips for supplementation in 2026. 1. NAD⁺ — The Master Coenzyme What it is: NAD⁺ (nicotinamide adenine dinucleotide) is a coenzyme present in every cell, essential for: Energy production (ATP) DNA repair Activating sirtuins and other longevity enzymes Regulating metabolism and cellular stress Key points: NAD⁺ levels naturally decline with age. Oral NAD⁺ supplements are poorly absorbed; precursors like NR or NMN are more effective. Clinical studies suggest boosting NAD⁺ may support metabolism and repair, but anti-aging effects in humans remain unproven. 2. NAC (N-Acetyl Cysteine) Function: Precu...

If you are looking for the top 10 supplement brands in the world , you've come to the right place. When it comes to selecting the best supplements, label is the most significant aspect. If you’re thinking about taking a supplement, always read the label and compare information and ingredients. Some supplements, even the most costly ones, may contain fillers in addition to the active substance. How do we know if our supplement brand is good? – Third-party testing (for instance, NSF International, Consumer Lab, and the United States Pharmacopeia) (USP). We looked for brands that have been tested by an independent lab to guarantee they were free of contaminants such as heavy metals or microbes. – Certifications. In addition to being certified, third-party testing, such as non-GMO verification, is required. – Ingredients. We chose manufacturers that emphasise the use of high-quality ingredients and easily absorbed vitamin and mineral forms. Best to avoid or limit the use of artific...