One Day MD | Evidence-Based Wellness

Updated: August 2026 | Article type: Evidence review | Original publication: 2022; substantially revised and rebuilt in 2026 Clinical focus: Alzheimer’s disease prevention, dementia risk reduction, multidomain lifestyle intervention, p-tau217 blood biomarkers, metabolic health, GLP-1 receptor agonists, SGLT2 inhibitors, and dietary supplements. Abstract Background: Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder in which age, genetics, vascular disease, metabolic dysfunction, hearing loss, physical inactivity, depression, social isolation and other modifiable factors contribute to risk. The prevention landscape has changed substantially since this article was first published in 2022. Objective: To update the evidence concerning practical strategies for reducing dementia risk, with particular attention to multidomain lifestyle interventions, nutritional adequacy, dietary supplements, blood-based biomarkers and emerging metabolic therapies. Metho...

Bruce Willis... The man who once ruled Hollywood now lives with 24/7 care, unable to speak and unable to recall he was ever a legend. Money, fame, and status... all gone in the fog of dementia. And if that doesn’t shake you to your core, you might wanna pay attention more to yourself. ( source ) Can natural supplements effectively treat or prevent dementia ? Some studies suggest that B vitamins, omega-3 fatty acids, vitamin D3 and magnesium may have modest benefits, but it's important to consult a doctor before starting any supplement regimen. Let's dive into the evidence. In This Article: B Vitamins Vitamin D3 Omega-3 fatty acids Magnesium and Molecular Hydrogen Soy Isoflavones Ginseng Melatonin Ginko Biloba Green Tea (EGCG) Quercetin Coconut Oil Lutein (carotenoids) Selenium Zinc Turmeric (Curcumin) Citicoline Combined Metabolic Activators (NR, NAC, L-Carnitine and L-Serine) Centrum Silver Multivitamin Creatine Mushrooms (Ergothioneine, Lion's Mane and Reishi) Choline Pre...