One Day MD | Evidence-Based Wellness

Updated Review • Critical Appraisal of RCTs, Observational Confounding, & Saturated vs. Polyunsaturated Fat 💡 Executive Summary & Key Takeaways Surrogate Endpoints vs. Hard Outcomes: Seed oils (rich in linoleic acid) lower LDL cholesterol compared to butter. However, lowering LDL via dietary substitution has not reliably translated into reductions in total mortality or cardiovascular events in randomized trials. Re-analyzed RCT Data: Historically buried data from the Minnesota Coronary Experiment and the Sydney Vegetable Oil Heart Study showed that replacing saturated fats with seed oils lowered cholesterol, but failed to reduce heart disease deaths—and in some subgroups, mortality actually increased. Observational Confounding: Large observational studies favoring seed oils suffer heavily from "healthy user bias," where seed oil consumers also exercise more, smoke less, and eat higher quality diets overa...

OneDayMD Editorial Team · Reviewed & updated August 2026 · ~18 min read Quick Answer Ray Peat (1936–2022) was an American biologist whose "bioenergetic" or "pro-metabolic" theory framed nearly every health outcome — mood, fertility, sleep, immunity, aging — as downstream of how efficiently the body's cells convert fuel and oxygen into usable energy. His framework centers on thyroid function, progesterone, dietary sugar and glycogen, and avoidance of polyunsaturated fats (PUFAs), while treating adrenaline and cortisol as a costly emergency backup system rather than a healthy baseline. Parts of the framework overlap with established physiology; central claims — high sugar intake as broadly protective, routine aspirin use, and blanket PUFA avoidance — lack clinical trial support and in several places run counter to current mainstream nutrition and cardiology guidance. It's best treated as an interesting theoretical lens, not a substitute for indi...

A comprehensive analysis merging clinical trials on high-dose fermented soy enzyme therapy, statin head-to-head comparisons, and plaque regression mechanisms. Atherosclerosis remains the leading cause of cardiovascular events worldwide. While statins focus primarily on lowering low-density lipoprotein (LDL) cholesterol, groundbreaking clinical research reveals that nattokinase —a fibrinolytic enzyme derived from traditional Japanese nattō —acts directly on the structural matrix of established arterial plaque. Credit: Oasis Medical Institute 1. The Head-to-Head Clinical Trial (Ren et al., 2017) In a 26-week randomized controlled study, 82 patients with carotid atherosclerosis received either Nattokinase (6,000 FU/day) or Simvastatin (20 mg/day). Key outcomes included: Carotid Plaque Reduction: Nattokinase achieved a 36.6% reduction in plaque area vs. 11.5% in the statin group. HDL Elevation: Nattokinase significantly increased benefici...

An evidence-based guide to reducing chronic disease risk, extending healthspan, and understanding what truly works — beyond hype, supplements, and shortcuts. This page serves as the central hub for OneDayMD’s coverage of preventive medicine, cancer prevention, cardiometabolic health, and longevity science, grounded in epidemiology, clinical trials, and systems biology. What This Hub Covers (Quick Overview) This hub explains: What preventive medicine actually means in modern clinical science The difference between lifespan and healthspan Which interventions reduce disease risk with high-quality evidence Where longevity science is promising — and where it becomes speculation How lifestyle, medications, and emerging tools interact over decades It is designed for readers who want risk reduction, not biohacking fantasy . Executive Summary Preventive medicine focuses on reducing the probability of disease before it occurs , rather than treating pathology after it is established. Longevity ...

Bruce Willis... The man who once ruled Hollywood now lives with 24/7 care, unable to speak and unable to recall he was ever a legend. Money, fame, and status... all gone in the fog of dementia. And if that doesn’t shake you to your core, you might wanna pay attention more to yourself. ( source ) Can natural supplements effectively treat or prevent dementia ? Some studies suggest that B vitamins, omega-3 fatty acids, vitamin D3 and magnesium may have modest benefits, but it's important to consult a doctor before starting any supplement regimen. Let's dive into the evidence. In This Article: B Vitamins Vitamin D3 Omega-3 fatty acids Magnesium and Molecular Hydrogen Soy Isoflavones Ginseng Melatonin Ginko Biloba Green Tea (EGCG) Quercetin Coconut Oil Lutein (carotenoids) Selenium Zinc Turmeric (Curcumin) Citicoline Combined Metabolic Activators (NR, NAC, L-Carnitine and L-Serine) Centrum Silver Multivitamin Creatine Mushrooms (Ergothioneine, Lion's Mane and Reishi) Choline Pre...