One Day MD | Evidence-Based Wellness

What Is CoQ10? Coenzyme Q10 (CoQ10, ubiquinone/ubiquinol) is a naturally occurring antioxidant involved in mitochondrial energy production. It plays a central role in ATP generation and cellular redox balance. CoQ10 levels tend to decline with: Aging Chronic inflammation Statin use Chemotherapy-related oxidative stress Advanced cancer-associated cachexia and mitochondrial dysfunction Interest in CoQ10 and cancer largely comes from: Its role in mitochondrial metabolism Antioxidant and anti-inflammatory effects Potential cardioprotective effects during chemotherapy Anecdotal and integrative oncology reports Proposed Anti-Cancer Mechanisms 1. Mitochondrial Support Cancer metabolism is increasingly recognized as involving mitochondrial dysfunction alongside glycolysis (“Warburg effect”). CoQ10 may: Improve mitochondrial electron transport Reduce oxidative damage Support normal-cell energy metabolism Potentially improve resilience during treatment This aligns with the broader field of metab...

Coenzyme Q10 (CoQ10) is the third-most consumed supplement, yet many people don’t realize how clinically effective it really is. Several new studies show that taking CoQ10 supplements may help address several chronic health conditions, including atrial fibrillation (a-fib), nonalcoholic fatty liver disease (NAFLD), insulin resistance, heart failure, cancer and migraines, to name a few. Ubiquinol — the reduced, electron-rich form of CoQ10 that your body produces naturally — plays an important role in the electron transport chain of your mitochondria, where it facilitates the conversion of energy substrates and oxygen into the biological energy (adenosine triphosphate or ATP) needed by your cells for life, repair and regeneration. It’s a fat-soluble antioxidant, meaning it works in the fat portions of your body, such as your cell membranes, where it mops up potentially harmful byproducts of metabolism known as reactive oxygen species (ROS). As such, ubiquinol and CoQ10 supplements help ...

Why insulin resistance, visceral fat, and metabolic dysfunction quietly drive most modern illnesses — and what actually improves outcomes. This article is a core cluster within the Preventive Medicine & Longevity pillar on OneDayMD. It explains why metabolic health sits upstream of cancer, cardiovascular disease, dementia, kidney failure, and accelerated aging. Executive Overview Over the past 50 years, the global disease burden has shifted from infectious illness to chronic, lifestyle-associated disease . Despite appearing unrelated, most of these conditions share common biological roots: Insulin resistance Visceral adiposity Chronic low-grade inflammation Mitochondrial dysfunction Endothelial damage This article explains why metabolic dysfunction is not just a risk factor, but a unifying driver of modern disease — and why improving metabolic health consistently reduces mortality across populations. What Is Metabolic Health? Metabolic health refers to the body’s ability to: Mainta...

Executive Summary Sleep is not a passive state — it is a biological repair system that influences metabolism, immune function, brain health, and lifespan. Large‑scale population data now show that chronic short sleep is independently associated with shorter life expectancy, rivaling smoking and obesity as a longevity risk factor. This article integrates epidemiological data, mechanistic biology, and clinical implications into a single evidence‑based framework. Why Sleep Is a Longevity Pillar Sleep regulates: Hormonal balance (insulin, cortisol, growth hormone) Immune surveillance and inflammation Brain waste clearance (glymphatic system) Cellular repair and mitochondrial function When sleep is consistently insufficient or fragmented, these systems deteriorate in parallel — accelerating biological aging. Population‑Level Evidence: Sleep and Life Expectancy County‑Level Data Across the United States A major epidemiological analysis published in Sleep Advances  (2025) examined sleep ...

Can simple lifestyle habits improve sleep more effectively than supplements, gadgets, and “sleep hacks”? A recent 31-day sleep challenge involving nearly 39,000 participants suggests the answer may be yes. Instead of relying on melatonin gummies, expensive biohacking devices, or prescription sleep aids, participants focused on four foundational habits: Morning sunlight exposure Time-restricted eating Moderate aerobic exercise Breathwork and stress reduction The results point toward a growing realization in sleep medicine: sleep quality is heavily influenced by circadian rhythm alignment and lifestyle consistency. In this article, we break down: What the 31-day challenge found The science behind circadian rhythm optimization Which interventions have the strongest evidence The limitations of wearable-based sleep studies How to improve sleep naturally using evidence-based strategies What Was the 31-Day Sleep Challenge? The challenge, highlighted by The Epoch Times (1) , involved approxima...

Food is supposed to make us healthy. It is supposed to provide the building blocks needed to build and repair the body, supply the energy to do so, and help us remain free of chronic disease. Yet by almost every measure, the modern diet is failing us. Roughly 90% of a typical supermarket is filled with what author Michael Pollan famously called "food-like substances." No matter which chronic disease you examine — obesity, diabetes, heart disease, metabolic syndrome — rates have risen from rare or virtually unknown to epidemic proportions. Over just a 20-year span, with no meaningful increase in caloric intake and only a moderate rise in exercise, obesity rates in the United States climbed from 30% to 42%. Something in our environment has changed, and the evidence increasingly points to what we are being told to eat.   What Are Seed Oils? Seed oils are industrial oils extracted almost exclusively from seeds and beans — products that would...