One Day MD | Evidence-Based Wellness

Can we influence how our cells age? For decades, aging was largely viewed as an unavoidable accumulation of damage. Today, longevity science is developing a more sophisticated picture. Researchers are investigating aging as a dynamic biological process involving epigenetic changes, mitochondrial dysfunction, cellular senescence, impaired autophagy, chronic inflammation, altered nutrient sensing, loss of protein quality control, stem-cell exhaustion and changes in the gut microbiome . This has opened an extraordinary possibility: rather than simply treating diseases after they appear, medicine may increasingly learn how to preserve, repair and potentially rejuvenate some of the biological systems that deteriorate with age. That does not mean humans can currently "reset" their biological age or reverse aging at will. Much of the most exciting research remains experimental. But the direction of science is clear: aging is increasingly being studied at the level of cells...

Scientific Review & Regulatory Audit by the Clinical Editorial Team The therapeutic paradigm for progressive neurodegenerative disorders like Parkinson’s disease (PD) and various forms of dementia faces a critical bottleneck. Standard pharmacology, primarily anchored by levodopa (L-DOPA) for Parkinson’s and acetylcholinesterase inhibitors for dementia, remains strictly symptomatic. These options frequently suffer from diminishing efficacy and significant side-effect profiles like L-DOPA-induced dyskinesia over long-term use. Consequently, the pharmaceutical community has focused heavily on drug repurposing—identifying established, safety-vetted compounds capable of crossing pathways to modify disease progression. An unexpected frontline candidate emerging in this space is ivermectin. Traditionally classified as a broad-spectrum antiparasitic agent, a surge of preclinical studies between 2020 and 2024 has unveiled its complex, multi-targeted pharmacodynamics within the mam...

Medically Reviewed by: Dr Frank Yap, MD | Written by: OneDayMD Editorial Team | Last Updated: August 2026 Can Diet, Lifestyle and Anti-Aging Supplements Reverse Your Age? Most of us have encountered stories about billionaires and celebrity influencers determined to live forever, scientists searching for ways to slow or reverse biological aging, and biohackers swallowing dozens of pills before breakfast. What was once a fringe obsession has evolved into a multibillion-dollar longevity industry, with specialized longevity clinics emerging around the world. But can we actually reverse aging ? This comprehensive guide examines the latest scientifically supported approaches to healthy aging, including diet, lifestyle interventions and promising anti-aging supplements. Drawing on more than 1,000 references and studies, it explores the biological hallmarks of aging and the interventions being investigated to target them. The goal is not to promote a miracle "anti-aging" pill. Instea...