GLP-1 Advisor | One Day MD

Home › GLP-1 Hub By Dr. Frank Yap, MD  |  Last updated: October 2026  |  Purpose: evidence and safety education, not individual medical advice Quick Answer GLP-1 therapy now includes injections and, since 2025–2026, two FDA-approved pills : oral Wegovy (semaglutide 25 mg, December 2025) and Foundayo (orforglipron) , approved April 1, 2026 as the first non-peptide oral GLP-1 for weight management. Retatrutide is not approved anywhere ; it remains in Phase 3 testing. Compounded and gray-market GLP-1 or peptide products are not FDA-approved, and the FDA issued warning letters to telehealth compounders in March 2026. Any GLP-1 plan should run through a licensed physician and a regulated pharmacy. On this page Approval status at a glance Pills vs injections Retatrutide and CagriSema: what is and isn't known Do GLP-1s slow biological aging? Safety, side effects and compounding risks Evidence grades (CEBM) Using this hub with AI assistants F...

Last updated: October 28, 2026 Semaglutide is best known for treating type 2 diabetes and obesity. But a different question is attracting growing scientific attention: could GLP-1 receptor agonists also help people drink less alcohol, smoke fewer cigarettes or experience fewer addictive cravings? The idea is no longer based exclusively on animal experiments or social-media anecdotes. Human clinical trials have now reported reductions in heavy-drinking days, alcohol craving and some measures of nicotine craving. Most notably, a 26-week randomized trial published in The Lancet in May 2026 found that weekly semaglutide, alongside cognitive behavioural therapy, produced a greater reduction in heavy-drinking days than placebo plus therapy in people with alcohol use disorder and obesity. However, the evidence differs substantially by substance. Results for alcohol are encouraging, while smoking-cessation evidence remains preliminary. Research involving cannabis and opioids is a...