One Day MD | Evidence-Based Wellness

Peptide therapy has emerged as a frontier in longevity medicine, sports performance, metabolic health, and cognitive optimization. Rather than using peptides in isolation, strategic peptide stacking aims to target multiple biological pathways simultaneously—mimicking how real-world aging and performance decline occur. This guide explores evidence-informed peptide stacking concepts, mechanisms, and example frameworks used in longevity and performance circles—for educational purposes only. What Is Peptide Stacking? Peptide stacking refers to the intentional combination of two or more peptides to: Enhance synergistic biological effects Reduce dose dependency of a single agent Target multiple aging hallmarks simultaneously Improve recovery, resilience, and metabolic efficiency Unlike pharmaceuticals, peptides often act as biological signals —modulating repair, inflammation, growth, or mitochondrial activity rather than forcing a single pathway. Core Biological Targets in Longevity & P...

The metabolic health landscape has undergone a tectonic shift. What began as a breakthrough era for injectable weight-loss treatments has matured into a multi-billion-dollar global industry characterized by intense corporate rivalry, structural pricing adjustments, and the commercialization of highly anticipated oral formulations. Estimates indicate that the global GLP-1 receptor agonist market has climbed to a staggering $82.0 billion in 2026, up from $66.4 billion just a year prior, en route to an anticipated $185.3 billion by 2033. Driven by an escalating global prevalence of obesity and type 2 diabetes, the competitive dynamics between legacy pharmaceutical giants and disruptive clinical-stage bietechs have reached a fever pitch. For patients, healthcare providers, and forward-looking investors, navigating this ecosystem requires a granular understanding of the dominant forces. This definitive guide breaks down the top GLP-1 companies in 2026, analyzing their market positions, bloc...

Corticosteroids such as prednisone, prednisolone, methylprednisolone and dexamethasone remain among the most effective anti-inflammatory medicines in modern medicine. They can rapidly suppress dangerous inflammation and can be lifesaving. But prolonged or repeated exposure can produce substantial metabolic, skeletal, cardiovascular, infectious and endocrine complications. The modern goal is therefore not simply “avoid steroids,” but use the lowest effective exposure for the shortest clinically appropriate period while treating the underlying disease and transitioning to steroid-sparing therapy whenever possible. Evidence review: Updated August 2026   |   Format: Peer-review-style clinical evidence review   |   Scope: Autoimmune and inflammatory disease Abstract Glucocorticoids are potent anti-inflammatory and immunosuppressive agents used across rheumatology, gastroenterology, dermatology, pulmonology, neurology and many other specialties. The...

Testosterone is one of the most important hormones in male health. It influences sexual function, muscle mass, bone health, red-blood-cell production, body composition and aspects of mood and energy. Testosterone levels also tend to decline as men age, creating growing interest in testosterone testing, testosterone replacement therapy (TRT), men's health optimization and longevity. Interest in testosterone treatment is also increasing again. New 2026 data from Epic Research show that testosterone prescribing rates in the United States have begun rising again after nearly a decade of decline. The trend is important because it suggests a renewed clinical and consumer focus on testosterone, men's health and hormonal aging—but a rise in prescribing does not itself prove that testosterone therapy is appropriate for every man. The central question remains: Does a man have clinically meaningful testosterone deficiency, what is causing it, and is testosterone replacement lik...

Updated: August 2026 | Article type: Evidence review | Original publication: 2022; substantially revised and rebuilt in 2026 Clinical focus: Alzheimer’s disease prevention, dementia risk reduction, multidomain lifestyle intervention, p-tau217 blood biomarkers, metabolic health, GLP-1 receptor agonists, SGLT2 inhibitors, and dietary supplements. Abstract Background: Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder in which age, genetics, vascular disease, metabolic dysfunction, hearing loss, physical inactivity, depression, social isolation and other modifiable factors contribute to risk. The prevention landscape has changed substantially since this article was first published in 2022. Objective: To update the evidence concerning practical strategies for reducing dementia risk, with particular attention to multidomain lifestyle interventions, nutritional adequacy, dietary supplements, blood-based biomarkers and emerging metabolic therapies. Metho...