One Day MD | Evidence-Based Wellness

By Editorial Team , medically reviewed by Dr Frank Yap, MD | Last updated: August 2026 | Originally published: June 2024 Related: Bryan Johnson's Blueprint Longevity Mix Review Quick Answer Bryan Johnson's protocol has been substantially simplified since the 40+ item pill list he published in 2024. His January 2026 update replaces most of the granular, individually-dosed compounds (NAC, red yeast rice, DHEA, genistein, standalone taurine, and others) with combined formulations — Essential Capsules, Advanced Antioxidants, and a merged Ashwagandha & Rhodiola product — alongside NR or NMN, omega-3, and Proferrin. His daily creatine dose has increased to 7.5 g total. The bigger change is on the prescription side: he has added three cardiometabolic drugs not previously disclosed — the SGLT2 inhibitor Jardiance (empagliflozin) , the PCSK9 inhibitor Repatha (evolocumab) , and the ARB candesartan — and switched metformin from continuous daily dosing to a s...

Editor's Update — August 2026 This article has been substantially updated to reflect developments in human follistatin gene-therapy research, emerging clinical trials, and the evolving science of biological-aging biomarkers. The key conclusion remains cautious: follistatin gene therapy is biologically interesting and increasingly studied, but there is still no clinical evidence that it extends human lifespan. Can gene therapy actually slow human aging? Bryan Johnson's experiment with follistatin gene therapy became one of the most visible examples of extreme longevity biohacking. Johnson reported improvements in muscle mass, body composition and selected biological-aging measurements after receiving an experimental gene therapy designed to increase follistatin. But an important distinction has been blurred in the longevity debate: Changing a biomarker of aging is not the same thing as demonstrating longer human life. That distinction is central to understanding both ...