One Day MD | Evidence-Based Wellness

Are you taking enough of vitamin C? From the dozens of different brands and products, which one should you choose? Vitamin C is an essential nutrient which cannot be produced by humans ( Nutrients  2017).  Because your body doesn't produce or store it, you need daily vitamin C for continued health. Vitamin C may be one of the most well-known immune nutrients that protect against immune deficiencies and which supports the prevention and recovery from the common cold and upper-respiratory issues, and also protects your cardiovascular system, eyes, skin, and other parts of your body.   SOMMAI/ Shutterstock   Vitamin C is a particularly unique nutrient because it also functions as an antioxidant that protects your cells against potential damage ( Source ).  Vitamin C can be found in a variety of whole, plant-based foods like citrus ...

A comprehensive analysis merging clinical trials on high-dose fermented soy enzyme therapy, statin head-to-head comparisons, and plaque regression mechanisms. Atherosclerosis remains the leading cause of cardiovascular events worldwide. While statins focus primarily on lowering low-density lipoprotein (LDL) cholesterol, groundbreaking clinical research reveals that nattokinase —a fibrinolytic enzyme derived from traditional Japanese nattō —acts directly on the structural matrix of established arterial plaque. Credit: Oasis Medical Institute 1. The Head-to-Head Clinical Trial (Ren et al., 2017) In a 26-week randomized controlled study, 82 patients with carotid atherosclerosis received either Nattokinase (6,000 FU/day) or Simvastatin (20 mg/day). Key outcomes included: Carotid Plaque Reduction: Nattokinase achieved a 36.6% reduction in plaque area vs. 11.5% in the statin group. HDL Elevation: Nattokinase significantly increased benefici...

By Dr. Frank Yap, MD | Medically reviewed by the One Day MD Editorial Team | Originally published January 26, 2026 | Fully updated September 2026 for the new 2026 ACC/AHA dyslipidemia guideline Quick Answer Saturated fat's relationship to heart disease is more nuanced than decades of "avoid it" messaging suggested — large meta-analyses of cohort studies have found no consistent independent link between total saturated fat intake and cardiovascular mortality, but randomized trials show that replacing it with polyunsaturated fat (not refined carbohydrates) does lower cardiovascular events. Industrial trans fat remains unambiguously harmful, with no safe level of intake. The newly released 2026 ACC/AHA dyslipidemia guideline (published in Circulation , March 2026) restored specific numeric LDL-C targets (roughly <100 / <70 / <55 mg/dL depending on your risk category), added universal one-time Lp(a) screening, and — notably — downgraded routine LDL particle...