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Are GLP-1s the first longevity drugs? - Nature 2025

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This Nature Biotechnology article (1) discusses presentations from the Aging Research and Drug Discovery meeting in Copenhagen, where experts from Novo Nordisk and Eli Lilly proposed that GLP-1 receptor agonists (GLP-1s), commonly used for obesity and type 2 diabetes, could emerge as the first true longevity drugs. These medications have demonstrated strong efficacy in reducing comorbidities like heart disease, stroke, heart failure, kidney disease, liver disease, osteoarthritis, and sleep apnea, especially in high-risk individuals with metabolic conditions. Key Background Aging involves a systemic decline due to accumulated damage outweighing repair processes, with 14 identified hallmarks (e.g., genetic instability, epigenetic changes, mitochondrial dysfunction). Longevity drugs aim to target these pathways to prevent multiple age-related diseases and extend healthspan (healthy lifespan) rather than just lifespan. Past candidates like sirtuin activators, senolytics, metformin, and rap...

Top 10 Nutritional Supplement Brands In The World 2025

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If you are looking for the top 10 supplement brands in the world , you've come to the right place. When it comes to selecting the best supplements, label is the most significant aspect. If you’re thinking about taking a supplement, always read the label and compare information and ingredients. Some supplements, even the most costly ones, may contain fillers in addition to the active substance. How do we know if our supplement brand is good? – Third-party testing (for instance, NSF International, Consumer Lab, and the United States Pharmacopeia) (USP). We looked for brands that have been tested by an independent lab to guarantee they were free of contaminants such as heavy metals or microbes. – Certifications. In addition to being certified, third-party testing, such as non-GMO verification, is required. – Ingredients. We chose manufacturers that emphasise the use of high-quality ingredients and easily absorbed vitamin and mineral forms. Best to avoid or limit the use of artific...

Tiger Milk Mushroom Supplement: What You Need to Know (2025)

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In recent years, Tiger Milk Mushroom, also known as Lignosus rhinocerus has gained popularity as a dietary supplement due to its purported medicinal properties. This medicinal mushroom native to tropical forests in Southeast Asia and has been traditionally used in various traditional medicine systems for its potential health benefits. Tiger Milk Mushroom Benefits Here are some potential benefits and information about Tiger Milk Mushroom supplements: Respiratory Health: Tiger Milk Mushroom is believed to improve respiratory health. A study demonstrated that supplementation of TMM significantly (p < 0.05) suppressed the level of IL-1β, IL-8, MDA, as well as respiratory symptoms. In additional to that, TMM also significantly (p < 0.05) induced the level of IgA, total antioxidant capacity, as well as pulmonary function Immune Support: Tiger Milk Mushroom is believed to have immunomodulatory properties, meaning it may help regulate and enhance the immune system's function. ...