One Day MD | Evidence-Based Wellness

An evidence-based guide to reducing chronic disease risk, extending healthspan, and understanding what truly works — beyond hype, supplements, and shortcuts. This page serves as the central hub for OneDayMD’s coverage of preventive medicine, cancer prevention, cardiometabolic health, and longevity science, grounded in epidemiology, clinical trials, and systems biology. What This Hub Covers (Quick Overview) This hub explains: What preventive medicine actually means in modern clinical science The difference between lifespan and healthspan Which interventions reduce disease risk with high-quality evidence Where longevity science is promising — and where it becomes speculation How lifestyle, medications, and emerging tools interact over decades It is designed for readers who want risk reduction, not biohacking fantasy . Executive Summary Preventive medicine focuses on reducing the probability of disease before it occurs , rather than treating pathology after it is established. Longevity ...

Executive Summary Sleep is not a passive state — it is a biological repair system that influences metabolism, immune function, brain health, and lifespan. Large‑scale population data now show that chronic short sleep is independently associated with shorter life expectancy, rivaling smoking and obesity as a longevity risk factor. This article integrates epidemiological data, mechanistic biology, and clinical implications into a single evidence‑based framework. Why Sleep Is a Longevity Pillar Sleep regulates: Hormonal balance (insulin, cortisol, growth hormone) Immune surveillance and inflammation Brain waste clearance (glymphatic system) Cellular repair and mitochondrial function When sleep is consistently insufficient or fragmented, these systems deteriorate in parallel — accelerating biological aging. Population‑Level Evidence: Sleep and Life Expectancy County‑Level Data Across the United States A major epidemiological analysis published in Sleep Advances  (2025) examined sleep ...

Aging shortens our lives through lifestyle and biological damage — but new longevity research suggests aging may be slowed and partially reversed. Here’s what science says. Can Aging Be Reversed — Or Are We Shortening Our Lives Without Realizing It? Modern science suggests that aging is not just the passage of time — it is a biological process driven by cumulative damage . Poor diet, sedentary behavior, chronic stress, sleep deprivation, and metabolic dysfunction all accelerate this damage, shortening both lifespan and healthspan. But there’s a shift underway. Researchers now believe aging may be modifiable , with growing evidence that targeted lifestyle changes and emerging medical interventions can slow aging — and potentially reverse certain biological markers of age . How We Shorten Our Lives (Often Without Knowing It) Many of the most powerful accelerators of aging are deeply embedded in modern life: 1. Chronic Inflammation Low-grade, long-term inflammation damages tissues, accele...

Abstract Longevity is influenced by a combination of genetic, behavioral, and environmental factors. This review synthesizes evidence on modifiable determinants of lifespan, emphasizing metabolic health, physical fitness, sleep, psychosocial factors, and behavioral interventions. Epidemiologic and interventional studies indicate that preserving muscle mass, maintaining cardiorespiratory fitness, optimizing metabolic markers, and sustaining social connectedness confer substantial reductions in all-cause mortality. Practical strategies, including resistance training, moderate-intensity aerobic activity, caloric moderation, sleep hygiene, and stress management, are highlighted as high-impact, evidence-supported interventions to extend healthspan. Keywords: longevity, insulin resistance, metabolic health, muscle mass, cardiorespiratory fitness, sleep,  stress management, healthspan 1. Introduction Human longevity is determined by complex interactions between genetics and lifestyle. Wh...

On September 29, 2025, the U.S. Food and Drug Administration (FDA) reversed its previous stance and confirmed that nicotinamide mononucleotide (NMN) can be legally sold as a dietary supplement in the United States . This decision follows a period of regulatory uncertainty and effectively restores NMN's legal status as a supplement. NMN is one of the most popular supplements in the anti aging community. NMN stands for nicotinamide mononucleotide and is a precursor to NAD+, or nicotinamide adenine dinucleotide. NMN is the direct precursor of the essential molecule nicotinamide adenine dinucleotide (NAD+) and is considered a key component to increase NAD+ levels in cells. NAD+ is a critical molecule found in every cell of your body, but levels of NAD+ naturally fall with age, making it — and NMN, as a result — crucial. As per MRFR analysis , the Nicotinamide Adenine Dinucleotide Market Size was estimated at 3.51(USD Billion) in 2024. The Nicotinamide Adenine Dinucleotid...