10 Best NMN Supplements (2025 Review)
NMN stands for nicotinamide mononucleotide and is a precursor to NAD+, or nicotinamide adenine dinucleotide. NMN is the direct precursor of the essential molecule nicotinamide adenine dinucleotide (NAD+) and is considered a key component to increase NAD+ levels in cells. NAD+ is a critical molecule found in every cell of your body, but levels of NAD+ naturally fall with age, making it — and NMN, as a result — crucial.
NMN is one of the most popular supplements in the anti aging community. The global Nicotinamide Mononucleotide (NMN) market was valued at US$ 98.5 million in 2019 and it is expected to reach US$ 296.5 million (R) by the end of 2026, growing at a CAGR (Compound Annual Growth Rate) of 7.3% during 2021-2026.The NAD story took off toward the end of 2013 with a high-profile paper by Harvard's David Sinclair and colleagues. Sinclair, recall, achieved fame in the mid-2000s for research on yeast and mice that suggested the red wine ingredient resveratrol mimics anti-aging effects of calorie restriction. This time his lab made headlines by reporting that the mitochondria in muscles of elderly mice were restored to a youthful state after just a week of injections with NMN (nicotinamide mononucleotide), a molecule that naturally occurs in cells and, like NR, boosts levels of NAD.
What Does NMN Supplement Do?
This has precipitated dozens of studies since that are focused on investigating NMN supplementation to treat cardiovascular disease, diabetes, obesity, life extension, cancer, Alzheimer’s disease, Parkinson’s disease, and many more.
Best NMN Supplements
1. Nutricost Niacinamide (Best Affordable NMN Alternative)

- Niacinamide is a popular form of Vitamin B3, but without the often uncomfortable feeling known as "Niacin Flush". Vitamin B3 is most often found in meats like tuna and beef. However, in order to get a similar amount of Vitamin B3, you would have to eat large amounts of tuna and beef or other sources containing Vitamin B3.
- Technically, Niacinamide is not the same molecule as NMN but they are both NAD precursors and are categorised under Vitamin B3 (Niacin) supplements by Amazon.com. Since, Niacinamide is the #2 best seller under this category, we have decided to feature them as part of the best 10 list.
- 240 Capsules of Niacinamide Per bottle / 1 Capsule per serving
- 500mg of Vitamin B3 (Niacinamide) Per Capsule
- No "Niacin Flush"
- Non-GMO, Gluten Free, Soy Free, and Made in a GMP Compliant, FDA Registered Facility
2. TRU Niagen NAD+ Booster Supplement (NMN Alternative)
- 30 count / Serving Size: 1 Capsule once a day - Servings Per Container: 30
- 90 count / Serving Size: 1 Capsule once a day - Servings Per Container: 90 (recommended option)
- 120 count / Serving Size: 1 Capsule once a day - Servings Per Container: 120
- 90 count / Serving Size: 1 Capsule once a day (Pack of 2)
- Technically, Nicotinamide Riboside is not the same molecule as NMN but they are both NAD precursors and are categorised under Vitamin B3 (Niacin) supplements by Amazon.com.
- ChromaDex markets TruNiagen, which is based on its branded Niagen ingredient, which is a form of nicotinamide riboside (NR), the form of nicotinamide that actively crosses into the cell to participate in the NAD+ pathway (R).
- Reduces the cellular effects of aging by elevating NAD+, a key coenzyme your body uses for healthy cellular metabolism.
- Nicotinamide Riboside for Energy, Metabolism, Vitality, Muscle Health, Healthy Aging, Cellular Repair
- Unlike NMN, the key ingredient Niagen was successfully notified two times as an NDI (New Dietary Ingredient) and reviewed as GRAS (Generally Recognized As Safe) under the United States notification programs.
- Tru Niagen® Is Supported by Peer-Reviewed Clinical Research. The patented cellular nutrient increases NAD+ by 40-50% after two weeks. 25+ published, peer-reviewed clinical studies support Niagen, with more than 40 registered, ongoing trials on CLINICALTRIALS.GOV.
- Niagen® and NAD+ research has been made possible through the CERP™ (ChromaDex External Research Program) with180 peer-reviewed published studies on Niagen® and other ingredients and 30 ongoing clinical trials registered on clinicaltrials.gov.
- There are many cheaper alternative sources to buy NMN today, but are you getting what you paid for? If the price for NMN is too good to be true, it probably is not NMN.
Established in 1999, ChromaDex is a pioneer in NAD+ research and applies that knowledge to their flagship product, Tru Niagen®. The latter is a clinically proven NAD+ booster that features NIAGEN®.
ChromaDex prioritizes scientific research highlighting Nobel Prize winners, multiple human clinical studies, and published studies to support Tru Niagen® 's efficacy. Their NR product is also backed by a strong safety record, having received GRAS status from the FDA and approval from several regulatory bodies worldwide.
3. Thorne Research ResveraCel (Best Nicotinamide Riboside with Resveratrol and Quercetin Phytosome)
4. Liposomal Nicotinamide Riboside, Resveratrol & Quercetin Phytosome by Reus Research
- INCREASE NAD BY 63%: Fight aging with Liposomal Nicotinamide Riboside - the direct sub to NMN supplements. It helps your body absorb and utilize NAD precursor more efficiently, producing wonderfeel results.
- MADE & TESTED IN THE USA: Our NR supplement is made and third-party tested in the USA to ensure its purity and effectiveness. Certificate available upon request. Get back to feeling your best with NAD+ supplement booster.
- INCREASE ABSORPTION BY 71%: maximize bioavailability with our Liposomal Nicotinamide Riboside encapsulation technology. Unleash the full potential of this supplement and experience 50% more effectiveness compared to other delivery methods.
- FEEL YOUTHFUL AGAIN: With daily dose of our Liposomal Nicotinamide Riboside capsules, you'll get a unique blend that supports healthy aging, energy production, focus and longevity.
5. ELYSIUM Basis NAD Supplement - Nicotinamide Riboside (NR) Supplement 250mg with Pterostilbene
Technically, Nicotinamide Riboside is not the same molecule as NMN but they are both NAD precursors and are categorised under Vitamin B3 (Niacin) supplements by Amazon.com.
About this item
- Want healthy aging? We’re the experts. Leonard Guarente, Elysium Health co-founder, has been studying aging for three decades. Our flagship product, Basis, is formulated to raise NAD+ by 40%, combat aging at the deepest level—your cells, and has sold over 3.5 million bottles. TIME magazine has called Basis “the supplements experts take.” All our products contain rigorously studied ingredients, and we partner with major research institutions like Oxford and Yale.
- Why should you take NAD? At a recent conference, 80% of doctors were taking an NAD+ supplement. What do they know that we don’t? In scientific research, NAD+ levels correlate with health status—it helps protect your DNA from stressors, boost cellular energy, and support healthy muscle function, and we have less of it as we age. Luckily, there’s a way to safely and sustainably raise your NAD+: Basis has been proven to increase levels by 40% in a double-blind, placebo-controlled clinical trial.
- Basis contains two powerful components: Proprietary nicotinamide riboside (NR-E), the raw material your body uses to make NAD+, and pterostilbene (PT), a plant polyphenol that protects against stress. From day 1, these ingredients support cellular energy, mitochondrial function, and protect cells from everyday stressors.
- Be sure of what’s in your supplement: We set the industry standard. We publicly publish the quality and purity results of third-party testing on every lot of Basis so you know exactly what you’re putting in your body. Our supplements are NSF Certified for Sport. We partner with major institutions like Oxford and Yale, and our company decisions are guided by the expertise of our Scientific Advisory Board, which includes internationally recognized experts and 8 Nobel laureates.
- Need more proof that Basis is the science-backed choice, and the superior NAD+ product on the market? TIME magazine called Basis “the supplement experts take,” W Magazine has said “This is the supplement sitting on the nightstands of every cerebral beauty junkie,” and Good Housekeeping has awarded us their Innovation Emblem to recognize trailblazing initiatives in health and wellness. We’ve been featured in many other publications and are the choice for doctors, athletes, and celebrities alike.
6. Age Defying Longevity (Latest NMN Alternative - New)
The Wellness Company's science-backed Longevity formula maintains youthful cellular function, helping you feel your best no matter the year you were born.
Target the root causes of aging with Liposomal Glutathione – the “master antioxidant," Nicotinamide Riboside (NR)*, and Resveratrol. This age-defying combination helps your cells clean up “dirty” DNA to increase energy production and reduce inflammation.
*Technically, Nicotinamide Riboside is not the same molecule as NMN but they are both NAD precursors and are categorised under Vitamin B3 (Niacin) supplements by Amazon.com.
The Wellness Company combine these powerful ingredients with probiotics superior absorption. Feel like a younger version of yourself, everyday.
LONGEVITY FORMULA CONTAINS:
- NR (Nicotinamide Riboside) - The best booster of your body’s natural production of NAD+, the key coenzyme required for hundreds of vital cellular processes.
- Liposomal Glutathione - Optimizes the body for healthy detoxification, supports tissue repair, and protects your cells from free radical.
- Resveratrol - A potent polyphenol that combats aging by activating sirtuin proteins to promote heart, cognitive and cellular health.
- Betaine HCl - Promotes healthy digestion
- Probiotics BL21, LRa05 and LC86 - Help your digestive system work more efficiently, supporting muscle, immune and cognitive health.
The Wellness Company's science-backed Longevity formula maintains youthful cellular function, helping you feel your best no matter the year you were born.
Target the root causes of aging with Liposomal Glutathione – the “master antioxidant," Nicotinamide Riboside (NR)*, and Resveratrol. This age-defying combination helps your cells clean up “dirty” DNA to increase energy production and reduce inflammation.
The Wellness Company combine these powerful ingredients with probiotics superior absorption. Feel like a younger version of yourself, everyday.
Where to buy the Longevity Formula: Available on The Wellness Company's website. Here is the link: The Longevity Formula
Note: To get 10% OFF, please use this coupon code: ONEDAYMD
7. Wonderfeel Youngr NMN
This is not your average NAD supplement. Wonderfeel® Youngr™ NMN provides a unique solution to aging; this NAD-boosting, patented formula has been developed by Harvard Med-trained entrepreneur and inventor Professor Andrew Salzman MD, who has worked in biomedical drug discovery for more than three decades.
With a dose backed by a human clinical trial based on cutting-edge science, Youngr aims to change the way you age. One of the most comprehensive NMN clinical trial to date on human subjects, with 80 participants ranging between the ages of 40 and 65, and an eye to determining dosing efficacy. The study is now peer-reviewed. The study confirmed that NMN effectively raises NAD levels in the blood, and health scores for participants taking NMN improved significantly over the course of the trial. In addition to substantiating the role of NMN in human health, the study also highlights the importance of dosing for efficacy.
Youngr™ NMN is a patented solution to aging. Formulated with emergent antioxidants and sirtuin activation, it uses a multi-targeted approach to defend and slow down biological aging at the cellular level.Ingredients
60 Capsules per Bottle. Each capsule contains:- 450 mg Nicotinamide Mononucleotide
- 2 mg Ergothioneine
- 50 mg Trans Resveratrol
- 40 mg Olea25® (25% hydroxytyrosol)
- 10 mcg Vitamin D3 (Cholecalciferol)
Does not contain soy, gluten, dairy or fish. Non-GMO, vegan friendly, does not contain preservatives. Rice hull powder added for stabilization. Capsule shells are made from vegetable cellulose and are 100% vegan.
To increase the absorption of some ingredients in the capsule, the manufacturer advises taking it with healthy, fat-rich food.
Company review
Wonderfeel is a longevity company based in San Francisco. The company leverages bioscience to develop science-backed products aimed at optimizing healthspan and promoting a longer lifespan.
The team of scientists is led by Dr. Andrew Salzman, a renowned physician and inventor with extensive experience in drug discovery and development. Wonderfeel goes beyond product efficacy by prioritizing sustainability. They use refillable glass bottles for their NMN and recyclable packaging for subsequent orders, minimizing their environmental footprint.
- 450 mg Nicotinamide Mononucleotide
- 2 mg Ergothioneine
- 50 mg Trans Resveratrol
- 40 mg Olea25® (25% hydroxytyrosol)
- 10 mcg Vitamin D3 (Cholecalciferol)
Wonderfeel is a longevity company based in San Francisco. The company leverages bioscience to develop science-backed products aimed at optimizing healthspan and promoting a longer lifespan.
The team of scientists is led by Dr. Andrew Salzman, a renowned physician and inventor with extensive experience in drug discovery and development. Wonderfeel goes beyond product efficacy by prioritizing sustainability. They use refillable glass bottles for their NMN and recyclable packaging for subsequent orders, minimizing their environmental footprint.
8. Codeage Liposomal NMN + Resveratrol + Quercetin + TMG Supplement

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About this item
- Liposomal delivery matrix: NAD precursor blend offering NMN nicotinamide mononucleotide + resveratrol, betaine (TMG), riboflavin, vitamin B12, and quercetin all-in-one through a liposomal phospholipid complex.
- NAD Supplement Precursor & Betaine: This NAD precursor athletic fitness formulation delivers 85 mg of betaine anhydrous in each serving. Also called trimethyglycine (TMG), betaine usually consists of an amino acid derived from plants and sugar beets. NAD has been researched for its role on stem cells, telomere, and cellular energy. The combination of trimethylglycine and NMN ensures you get the energy increase from NAD while the improved distribution with TMG.
- Riboflavin & Vitamin B12 with Quercetin: Codeage Liposomal NMN formula also combines two of the vitamin B complex essential vitamins as well as quercetin. This formula provides Vitamin B2 as riboflavin-5-phosphate and vitamin B12 as methylcobalamine. These essential vitamins to support the metabolism have been blended with quercetin dihydrate from Japanese sophora flowers.
- Manufactured in the USA: Codeage NMN & resveratrol vitality blend is non-GMO and manufactured in the USA in a cGMP certified facility. This liposomal nicotinamide with riboflavin supplement doesn't contain any fillers, hormones, or artificial ingredients. Third-party tested.
- Liposomal delivery matrix: NAD precursor blend offering NMN nicotinamide mononucleotide + resveratrol, betaine, riboflavin, vitamin B12, and quercetin all-in-one through a liposomal phospholipid complex.
- Suggested use: Take 3 capsules daily with 8 ounces of water or your favorite beverage. May be taken with or without food.
- iHerb Best Seller Product Rank: #2 in Nicotinamide Mononucleotide (NMN) category;
#2 in NAD+ category. - Over 800 customer reviews, most of them 5-stars on iHerb.com.
Important safety note: Resveratrol is not suitable for people undergoing blood-thinning medication.
Related evidence: Published in Pharmacology Research and Perspectives (2022), Jiang and colleagues from Macau University of Science and Technology in China demonstrated that combining NMN with resveratrol increases NAD+ levels in heart and skeletal muscle of mice significantly more than NMN alone.
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- Liposomal delivery matrix: NAD precursor blend offering NMN nicotinamide mononucleotide + resveratrol, betaine (TMG), riboflavin, vitamin B12, and quercetin all-in-one through a liposomal phospholipid complex.
- NAD Supplement Precursor & Betaine: This NAD precursor athletic fitness formulation delivers 85 mg of betaine anhydrous in each serving. Also called trimethyglycine (TMG), betaine usually consists of an amino acid derived from plants and sugar beets. NAD has been researched for its role on stem cells, telomere, and cellular energy. The combination of trimethylglycine and NMN ensures you get the energy increase from NAD while the improved distribution with TMG.
- Riboflavin & Vitamin B12 with Quercetin: Codeage Liposomal NMN formula also combines two of the vitamin B complex essential vitamins as well as quercetin. This formula provides Vitamin B2 as riboflavin-5-phosphate and vitamin B12 as methylcobalamine. These essential vitamins to support the metabolism have been blended with quercetin dihydrate from Japanese sophora flowers.
- Manufactured in the USA: Codeage NMN & resveratrol vitality blend is non-GMO and manufactured in the USA in a cGMP certified facility. This liposomal nicotinamide with riboflavin supplement doesn't contain any fillers, hormones, or artificial ingredients. Third-party tested.
- Liposomal delivery matrix: NAD precursor blend offering NMN nicotinamide mononucleotide + resveratrol, betaine, riboflavin, vitamin B12, and quercetin all-in-one through a liposomal phospholipid complex.
- Suggested use: Take 3 capsules daily with 8 ounces of water or your favorite beverage. May be taken with or without food.
- iHerb Best Seller Product Rank: #2 in Nicotinamide Mononucleotide (NMN) category;
#2 in NAD+ category. - Over 800 customer reviews, most of them 5-stars on iHerb.com.
9. NAD + PQQ + Methylene Blue: RECHARGE
The ultimate brain hack. RECHARGE is the first-ever combination of Methylene Blue, NAD+, and PQQ for enhanced cognitive function and ultimate mitochondrial health.
From sharper thinking to stronger cells, Methylene Blue enhances how your brain and body perform by enhancing mental clarity and focus, supporting blood flow, and increasing ATP production.
While methylene blue is safe, there are some contraindications. One is G6PD deficiency*, which is also a contraindication for high-dose ascorbic acid treatments, which could be deadly.
*Note: Always check G6PD first to avoid hemolysis. G6PD deficiency is when the body is missing or doesn't have enough of an enzyme called G6PD (glucose-6-phosphate dehydrogenase).
Where to Buy Methylene Blue + NAD + PQQ (RECHARGE): Here is the link: Methylene Blue + NAD + PQQ
10. Nuchido TIME+ Nicotinamide, EGCG, Vitamin C, Alpha Lipoic Acid, Zinc
In this trial, they measured levels of NAMPT. This is the key enzyme which powers NAD+ production and recycling (the Salvage Pathway) in youthful cells.
Unfortunately, levels of this enzyme decline as we get older and this is one of the main causes of NAD+ decline.
Nuchido TIME+ is the only product clinically proven to restore NAMPT and fix the root causes of NAD+ decline.
Precursor supplements such as NR or NMN fail to fix the Salvage Pathway and therefore, fail to address the root causes of NAD+ decline.
This is why precursor supplements can cause further cellular dysfunction such as methyl donor depletion and inadvertently driving inflammation.
Note: To get 20% discount on your first purchase, please use this coupon code: ONEDAYMD20
Chromadex NR Supplement Test Report: 87% of NR Supplements Fail Tests (2025)
Chromadex NMN Supplement Test Report: 64% of NMN Supplements Fail Tests (2021)
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Credit: ChromaDex |
- In February 2025, Chromadex uncovered 87% of NR products do not meet their label claim: NAD-Boosting NR Supplements: 87% of NR Supplements Fail Tests (2025)
- In February 2022, another third-party investigation uncovered tens of thousands of fake supplements sold on Amazon. Many of these included NMN.
David Sinclair Supplements List
Keep in mind that to date, Dr. David Sinclair has made a point to not promote or endorse any supplement products. We compiled this list from interviews and books in which Professor David Sinclair mentions supplements he takes.We don’t know if he still takes these supplements, or whether he takes additional supplements that are not included on this list.
For example, in his book Lifespan, he mentions on page 304 that he takes NMN and resveratrol every morning, often mixed in his yogurt.
- Nicotinamide Mononucleotide (NMN), 1g per day, in the morning
- Quercetin and fisetin, 500 mg each, once per day, in the morning
- Resveratrol, 1g per day, in the morning
- Vitamin D3 and K2
- Spermidine, 1 mg per day, in the morning
- Metformin (prescription drug) 1 gram per day: 500 mg in the morning and 500 mg in the evening
- Statin (prescription drug) – taken since his early 20s due to family history of cardiovascular disease
- Low-dose aspirin – 83 mg per day
- Alpha lipoic Acid
- Coenzyme Q10
Best NMN Supplements FAQs
NR vs NMN Molecule
Stability and storage of NMN and NR
What Foods Contain NMN?
NMN Supplement dosage?
Nicotinamide mononucleotide supplement side effects
Research in humans has shown that doses of up to 1,200 mg daily are safe to consume.
Nicotinamide Riboside Supplement and Cancer
NMN is just one of the promising ingredients. For more details on other anti aging supplements, check out "Best Anti Aging Supplements - Evidence Based".
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