10 Best NMN Supplements (2023 Review)
NMN stands for nicotinamide mononucleotide and is a precursor to NAD+, or nicotinamide adenine dinucleotide. NMN is the direct precursor of the essential molecule nicotinamide adenine dinucleotide (NAD+) and is considered a key component to increase NAD+ levels in cells. NAD+ is a critical molecule found in every cell of your body, but levels of NAD+ naturally fall with age, making it — and NMN, as a result — crucial.
NMN is one of the most popular supplements in the anti aging community. The global Nicotinamide Mononucleotide (NMN) market was valued at US$ 98.5 million in 2019 and it is expected to reach US$ 296.5 million (R) by the end of 2026, growing at a CAGR (Compound Annual Growth Rate) of 7.3% during 2021-2026.The NAD story took off toward the end of 2013 with a high-profile paper by Harvard's David Sinclair and colleagues. Sinclair, recall, achieved fame in the mid-2000s for research on yeast and mice that suggested the red wine ingredient resveratrol mimics anti-aging effects of calorie restriction. This time his lab made headlines by reporting that the mitochondria in muscles of elderly mice were restored to a youthful state after just a week of injections with NMN (nicotinamide mononucleotide), a molecule that naturally occurs in cells and, like NR, boosts levels of NAD.
Update and Alert: Starting March 13th, 2023, Amazon stated it would require further documentation from all nicotinamide mononucleotide (NMN) suppliers if they wanted to continue selling their product on the site. They must show proof that they have been approved by the U.S. Food and Drug Administration (FDA) for over-the-counter sales. If you regularly take NMN supplements, it may be a good idea to consider stocking up on an extra one or two bottles.
However, NMN is like a large bed that movers are trying to get through a
door: It doesn’t enter the cell easily. One way for NMN to enter the cell is
for it to chemically transform into another molecule (called nicotinamide
riboside, or NR) before it can enter the cell. NR has earned a name for
itself as a highly efficient precursor to NAD+ and can enter the cell as is.
NMN, meanwhile, sometimes becomes NR before entering the cell, where it
chemically transforms back to NMN and then ultimately becomes NAD+.
We've learned that NR leads to NAD+ and that it also has its own pathway
that bypasses various steps other NAD+ precursors have to take. In early
2019, though, new research revealed NMN might only have to become NR for
certain cell types, as NMN can enter cells in the small intestine of mice.
It’s unclear whether or how this will translate to humans.
To reduce the confusion, do note that NR, nicotinamide mononucleotide (NMN),
Niacin (NA) and Niacinamide (NAM) are all NAD precursors, meaning all these
precursors will be transformed into NAD. That said, each precursor has it's
own different pathway that will lead to NAD.
Related: Best NMN supplement David Sinclair
What Does NMN Supplement Do?
In
numerous studies (2020), supplementation with NMN has increased NAD+ biosynthesis,
suppressed age-related adipose tissue inflammation, enhanced insulin
secretion and insulin action, improved mitochondrial function, improved
neuronal function in the brain, and more. NMN is also one of the supplements that targets various hallmarks of aging.
Here, we look at the science
behind NMN, its stability, possible pharmacokinetics, transport, function,
and ability to induce biosynthesis of NAD+. Supplementing NMN may be an
effective nutraceutical anti-aging intervention, with beneficial effects
on a wide array of physiological functions.
This has precipitated dozens of studies since that are focused on investigating NMN supplementation to treat cardiovascular disease, diabetes, obesity, life extension, cancer, Alzheimer’s disease, Parkinson’s disease, and many more.
A
2022 study on human subjects
concluded that Oral Administration of Nicotinamide Mononucleotide (NMN)
Is Safe and Efficiently Increases Blood Nicotinamide Adenine Dinucleotide
(NAD) Levels.
Best NMN Supplements 2023
Although there are many NMN supplement customer reviews on many online
sites, we have sifted and curated some of the helpful ones below. Not all NMN supplements are created equal. Check
out below our 10 best NMN supplements league.
1. TRU Niagen NAD+ Booster Supplement (NMN Alternative)
TRU Niagen NAD+ Supplement comes in 3 sizes:
- 30 count / Serving Size: 1 Capsule once a day - Servings Per Container: 30
- 90 count / Serving Size: 1 Capsule once a day - Servings Per Container: 90
- 120 count / Serving Size: 1 Capsule once a day - Servings Per Container: 120
Tru Niagen Reviews: Over 14,000 global ratings, most of them 5 stars on Amazon.com.
Amazon Best Sellers: #1 in Vitamin B3 (Niacin) Supplements.
- Technically, Nicotinamide Riboside is not the same molecule as NMN
but they are both NAD precursors and are categorised under Vitamin
B3 (Niacin) supplements by Amazon.com. Since, TruNiagen is the #1
best seller, we have decided to feature them as part of the best 10
list.
- ChromaDex markets TruNiagen, which is based on its branded Niagen
ingredient, which is a form of nicotinamide riboside (NR), the form
of nicotinamide that actively crosses into the cell to participate
in the NAD+ pathway (R).
- Reduces the cellular effects of aging by elevating NAD+, a key
coenzyme your body uses for healthy cellular metabolism.
- Nicotinamide Riboside for Energy, Metabolism, Vitality, Muscle
Health, Healthy Aging, Cellular Repair
- There are many cheaper alternative sources to buy NMN today, but are
you getting what you paid for? If the price for NMN is too good to be
true, it probably is not NMN.
Tru Niagen Review
While this is not a scientific review I have been taking Niagen in
one form or another non stop for several years. I have been gradually
increasing my doses with what I can only describe as a profound
effect. Without a doubt I feel younger than 46. I also think I look
younger than most people my age. I certainly don't feel my age and
have a ton of energy every single day. I also try to eat plenty of
vegetables with lots of non meat proteins along with limited meat
consumption. I am not a health nut but basically try to stay away
excess sugars and processed foods whenever I can. I also do a hard
bike ride once or twice a week. I think this also helps the entire
aging process some.
2. Nutricost Niacinamide (NMN Alternative)
Amazon Best Sellers: #2 in Vitamin B3 (Niacin) Supplements.
Ratings: 4.6 out of 5 - more than 13,000 global ratings
Do not confused with Nutricost Niacin. Niacin is the form that may cause 'Niacin Flush'. Niacinamide
is the 'non-flush' form.
- Technically, Niacinamide is not the same molecule as NMN but
they are both NAD precursors and are categorised under Vitamin B3
(Niacin) supplements by Amazon.com.
- Niacinamide is a popular form of Vitamin B3, but without the often
uncomfortable feeling known as "Niacin Flush". Vitamin B3 is most
often found in meats like tuna and beef. However, in order to get a
similar amount of Vitamin B3, you would have to eat large amounts of
tuna and beef or other sources containing Vitamin B3.
- Technically, Niacinamide is not the same molecule as NMN but they
are both NAD precursors and are categorised under Vitamin B3
(Niacin) supplements by Amazon.com. Since, Niacinamide is the #2
best seller under this category, we have decided to feature them as
part of the best 10 list.
- 240 Capsules of Niacinamide Per bottle / 1 Capsule per serving
- 500mg of Vitamin B3 (Niacinamide) Per Capsule
- No "Niacin Flush"
- Non-GMO, Gluten Free, Soy Free, and Made in a GMP Compliant, FDA
Registered Facility
Nutricost Niacinamide Review
After a recent news article about this being a favorite supplement
in Australia for sun damage protection, I asked my dermatologist
about it. She said it might help prevent me getting as many
'barnacles' as she calls them. You know, those nasty, old-age,
sun-damage, crunchy brown or white patches all over your body. (I
have many). I'm still on my first bottle but after about two weeks
the most amazing thing happened. I happened to scratch an area near
one of my barnacles and it just flaked off in my hand. Since then,
many more have succumbed. Not all; just some. But I'm happy. Even
one less of those ugly bumps is an improvement.
Niacinamide Review
Dr. Conlon has concluded, and Dr Mercola thoroughly agree with her,
that the best single NAD+ precursor is niacinamide (also known as
nicotinamide), not niacin, NR or NMN. It is now beyond obvious to me
why no one is promoting niacinamide. This is because it costs less
than one cent a day and as a result there is simply no money to be
made in promoting it. Ideally you buy niacinamide powder and use 1 to 1/2 of 1/64th of a teaspoon three times a day
(25-50 mg). - Mercola.com.
3. Thorne Research ResveraCel (Best Nicotinamide Riboside with Resveratrol and Quercetin Phytosome)
Amazon Best Sellers: #4 in Resveratrol Nutritional Supplements.
Ratings: 4.6 out of 5 - more than 600 global ratings
- Each capsule contains Nicotinamide Riboside
(NR) ingredient, in addition to Resveratrol, Quercetin Phytosome, and Betaine.
- The ingredients in this product are complexed with Time-Sorb, a
time-release matrix.
- Supports healthy aging and helps regulate metabolism.
- Resveratrol and quercetin increase the activity of sirtuins.
- Betaine provides important methylation factors.
- Flavors, colors, preservatives, and sweeteners derived from natural
sources.
- No gluten, Genetically Modified Organisms (known as GMOs), artificial
preservatives, stearates, wheat, rye, barley, eggs, or nuts. This
product does not contain dairy, soy, corn, yeast, sugar, or magnesium
stearate.
- No unnecessary binders, coatings, disintegrants, fillers, or
lubricants (including magnesium stearate) that could impair absorption.
- Adheres to the FDA’s current Good Manufacturing Practices (cGMPs) and
has the highest number of NSF Certified for Sport products which tests
for more than 200 banned substances for elite athletic competitions.
Review - My husband and I are in our 60s and have been taking these capsules for
a few weeks. We both started with 2 capsules daily and experienced an
increase in energy and in focus. We also both had trouble remaining
asleep at night and had strange dreams. We have decreased our
consumption of the capsules to one per day and have had a resolution to
the sleep problems. We both continue to enjoy an increase in energy and
in focus. We have reordered this Thorne product and are very satisfied
with the results. It would be best to start with one capsule per day and
work up from there until you find your own correct dosage.
Important safety note: Resveratrol is not suitable for
people undergoing blood-thinning medication.
4. Liposomal Nicotinamide Riboside, Resveratrol & Quercetin Phytosome by Reus Research
Ratings: 4.7 out of 5 - more than 70 global ratings
About this item
- INCREASE NAD BY 63%: Fight aging with Liposomal Nicotinamide Riboside - the direct sub to NMN supplements. It helps your body absorb and utilize NAD precursor more efficiently, producing wonderfeel results.
- MADE & TESTED IN THE USA: Our NR supplement is made and third-party tested in the USA to ensure its purity and effectiveness. Certificate available upon request. Get back to feeling your best with NAD+ supplement booster.
- INCREASE ABSORPTION BY 71%: maximize bioavailability with our Liposomal Nicotinamide Riboside encapsulation technology. Unleash the full potential of this supplement and experience 50% more effectiveness compared to other delivery methods.
- FEEL YOUTHFUL AGAIN: With daily dose of our Liposomal Nicotinamide Riboside capsules, you'll get a unique blend that supports healthy aging, energy production, focus and longevity.
Important safety note: Resveratrol is not suitable for people undergoing blood-thinning medication.
5. ELYSIUM Basis NAD Supplement - Nicotinamide Riboside (NR) Supplement 250mg with Pterostilbene
Technically, Nicotinamide Riboside is not the same molecule as NMN but they are both NAD precursors and are categorised under Vitamin B3 (Niacin) supplements by Amazon.com.
Elysium Health is a startup cofounded by Sinclair's former mentor, MIT biologist Leonard Guarente. Elysium is taking no chances when it comes to scientific credibility. Its website lists a dream team of advising scientists, including five Nobel laureates and other big names such as the Mayo Clinic's Jim Kirkland, a leader in geroscience, and biotech pioneer Lee Hood.
Compared to other usual sources of NR, the price of Basis is relatively higher. However, those other products lack pterostilbene, and ELYSIUM is a trusted brand.
Ratings: 4.2 out of 5 - more than 70 global ratings
About this item
About this item
ProHealth Longevity NMN Pro Review:
- Not all NMN supplements are created equal! Many
supplements come with just NMN, which by itself is less
effective to produce higher levels of NAD which the body needs
to prevent cellular degeneration as we age. Peak Performance
combines NMN with Resveratrol. Resveratrol works synergistically
with NMN as it acts as an accelerator to produce better results
in DNA repair.
- Published in Pharmacology Research and Perspectives (2022),
Jiang and colleagues from Macau University of Science and
Technology in China demonstrated that combining NMN with resveratrol increases NAD+ levels in
heart and skeletal muscle of mice significantly more than NMN
alone.
Editor's Note: In February 2022, another third-party investigation
uncovered
tens of thousands of fake supplements sold on Amazon. Many of these included NMN.
We don’t know if he still takes these supplements, or whether he takes additional supplements that are not included on this list.
For example, in his book Lifespan, he mentions on page 304 that he takes NMN and resveratrol every morning, often mixed in his yogurt.
As research grows, it is likely to become clearer that NMN and NR
may have differing benefits depending on the part of the body and
their use. Where NMN transporters are found, they could make one
more preferable over the other. NMN has also been found to improve
insulin activity and production which could help to accelerate
metabolisms and make the body more glucose tolerant.
NMN (Nicotinamide MonoNucleotide) is a molecule found in various foods
such as broccoli, cabbage, avocado, mushrooms, meat, and shrimp.
However, obtaining sufficient amounts through diet alone can be
challenging.
About this item
- Want healthy aging? We’re the experts. Leonard Guarente, Elysium Health co-founder, has been studying aging for three decades. Our flagship product, Basis, is formulated to raise NAD+ by 40%, combat aging at the deepest level—your cells, and has sold over 3.5 million bottles. TIME magazine has called Basis “the supplements experts take.” All our products contain rigorously studied ingredients, and we partner with major research institutions like Oxford and Yale.
- Why should you take NAD? At a recent conference, 80% of doctors were taking an NAD+ supplement. What do they know that we don’t? In scientific research, NAD+ levels correlate with health status—it helps protect your DNA from stressors, boost cellular energy, and support healthy muscle function, and we have less of it as we age. Luckily, there’s a way to safely and sustainably raise your NAD+: Basis has been proven to increase levels by 40% in a double-blind, placebo-controlled clinical trial.
- Basis contains two powerful components: Proprietary nicotinamide riboside (NR-E), the raw material your body uses to make NAD+, and pterostilbene (PT), a plant polyphenol that protects against stress. From day 1, these ingredients support cellular energy, mitochondrial function, and protect cells from everyday stressors.
- Be sure of what’s in your supplement: We set the industry standard. We publicly publish the quality and purity results of third-party testing on every lot of Basis so you know exactly what you’re putting in your body. Our supplements are NSF Certified for Sport. We partner with major institutions like Oxford and Yale, and our company decisions are guided by the expertise of our Scientific Advisory Board, which includes internationally recognized experts and 8 Nobel laureates.
- Need more proof that Basis is the science-backed choice, and the superior NAD+ product on the market? TIME magazine called Basis “the supplement experts take,” W Magazine has said “This is the supplement sitting on the nightstands of every cerebral beauty junkie,” and Good Housekeeping has awarded us their Innovation Emblem to recognize trailblazing initiatives in health and wellness. We’ve been featured in many other publications and are the choice for doctors, athletes, and celebrities alike.
6. Codeage Liposomal NMN + Resveratrol + Quercetin + TMG Supplement
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| Click to Enlarge |
- Liposomal delivery matrix: NAD precursor blend offering NMN nicotinamide mononucleotide + resveratrol, betaine (TMG), riboflavin, vitamin B12, and quercetin all-in-one through a liposomal phospholipid complex.
- NAD Supplement Precursor & Betaine: This NAD precursor athletic fitness formulation delivers 85 mg of betaine anhydrous in each serving. Also called trimethyglycine (TMG), betaine usually consists of an amino acid derived from plants and sugar beets. NAD has been researched for its role on stem cells, telomere, and cellular energy. The combination of trimethylglycine and NMN ensures you get the energy increase from NAD while the improved distribution with TMG.
- Riboflavin & Vitamin B12 with Quercetin: Codeage Liposomal NMN formula also combines two of the vitamin B complex essential vitamins as well as quercetin. This formula provides Vitamin B2 as riboflavin-5-phosphate and vitamin B12 as methylcobalamine. These essential vitamins to support the metabolism have been blended with quercetin dihydrate from Japanese sophora flowers.
- Manufactured in the USA: Codeage NMN & resveratrol vitality blend is non-GMO and manufactured in the USA in a cGMP certified facility. This liposomal nicotinamide with riboflavin supplement doesn't contain any fillers, hormones, or artificial ingredients. Third-party tested.
- Liposomal delivery matrix: NAD precursor blend offering NMN nicotinamide mononucleotide + resveratrol, betaine, riboflavin, vitamin B12, and quercetin all-in-one through a liposomal phospholipid complex.
- Suggested use: Take 3 capsules daily with 8 ounces of water or your favorite beverage. May be taken with or without food.
- iHerb Best Seller Product Rank: #2 in Nicotinamide Mononucleotide (NMN) category;
#2 in NAD+ category. - Over 800 customer reviews, most of them 5-stars on iHerb.com.
Important safety note: Resveratrol is not suitable for people undergoing blood-thinning medication.
Related evidence: Published in Pharmacology Research and Perspectives (2022), Jiang and colleagues from Macau University of Science and Technology in China demonstrated that combining NMN with resveratrol increases NAD+ levels in heart and skeletal muscle of mice significantly more than NMN alone.
- Pure NMN Pro 100 Grams Bulk Powder.
- NMN Pro 300
- NMN Pro 1000
- Prohealth Longevity NMN Pro Complete (NMN, Trans-Resveratrol and TMG)
"Uthever’s research team is led by U.S. doctors from the pharmaceutical giant GlaxoSmithKline. This NMN is tested both in-house by Uthever and then batch-tested again by ProHealth to verify authenticity and purity.
Painstaking attention to quality and purity has led to findings that ProHealth NMN remains intact and stable for up to two years. Pro 300 gets rave reviews, often beating popular products like Genex. Pay attention to price, however, as I’ve seen it fluctuate by nearly $50. I’ve also noticed that there isn’t a GMP-certified logo on the bottle itself. If you want a shelf-stable NMN that lasts, ProHealth Pro 300 is a top choice." - outliyr.com
Painstaking attention to quality and purity has led to findings that ProHealth NMN remains intact and stable for up to two years. Pro 300 gets rave reviews, often beating popular products like Genex. Pay attention to price, however, as I’ve seen it fluctuate by nearly $50. I’ve also noticed that there isn’t a GMP-certified logo on the bottle itself. If you want a shelf-stable NMN that lasts, ProHealth Pro 300 is a top choice." - outliyr.com
- One of the few NMN products from the ChromaDex NMN Supplement Test Report (refer below) that passed the test (contained at least 88% of the NMN label claim).
- ProHealth Uthever NMN is CLINICALLY PROVEN TO BOOST NAD+ LEVELS IN HUMANS. In a peer reviewed, double blind placebo controlled clinical study NAD+ decline was reversed by an average of 12 years. That's 38% more NAD+ in 60 days. Higher NAD+ levels are associated with more energy, feeling younger, less genetic damage, heart health, and SIRTUIN activation- longevity genes that are key for living better longer. Also, study participants’ quality-of-life test scores improved by 6.5%.
- ProHealth is the most trusted longevity supplement brand on the market, celebrating 34 YEARS with a BBB A+ RATING. Other brands may be cheaper, but do you trust that they actually contain any NMN?
- PUREST, HIGHEST QUALITY, PHARMACEUTICAL GRADE NMN IN THE WORLD. Every batch is 3rd party tested in a US lab to be at least 99.5% pure, and independent lab tests prove that our NMN products contain at least the number of grams of NMN per serving listed on the label. All 3rd party lab Certificates of Analysis are publicly posted. Our NMN is always manufactured in a FDA registered, GMP certified facility in the USA.
- ProHealth Uthever NMN is proven safe for human consumption in a clinical study. And our unique NMN capsules dissolve after passing unharmed through the stomach so the potency is preserved when it is delivered to the section of the intestine with the highest absorption rates- maximizing bioavailability.
- SHELF STABLE FOR TWO YEARS, and at OVER 200 DEGREES. Lab tests prove that ProHealth's Uthever NMN can be safely stored at ambient room temperature for up to two years with no loss in quality or potency. No refrigeration required.
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| UTHEVER's CO-BRANDING PARTNERS |
8. Wonderfeel NMN
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This is not your average NAD supplement. Wonderfeel® Youngr™ NMN provides a unique solution to aging; this NAD-boosting, patented formula has been developed by Harvard Med-trained entrepreneur and inventor Professor Andrew Salzman MD, who has worked in biomedical drug discovery for more than three decades.
With a dose backed by a human clinical trial based on cutting-edge science, Youngr aims to change the way you age. One of the most comprehensive NMN clinical trial to date on human subjects, with 80 participants ranging between the ages of 40 and 65, and an eye to determining dosing efficacy. The study is now peer-reviewed. The study confirmed that NMN effectively raises NAD levels in the blood, and health scores for participants taking NMN improved significantly over the course of the trial. In addition to substantiating the role of NMN in human health, the study also highlights the importance of dosing for efficacy.
Youngr™ NMN is a patented solution to aging. Formulated with emergent antioxidants and sirtuin activation, it uses a multi-targeted approach to defend and slow down biological aging at the cellular level.
Ingredients
60 Capsules per Bottle. Each capsule contains:
- 450 mg Nicotinamide Mononucleotide
- 2 mg Ergothioneine
- 50 mg Trans Resveratrol
- 40 mg Olea25® (25% hydroxytyrosol)
- 10 mcg Vitamin D3 (Cholecalciferol)
9. Life Extension NAD+ Cell Regenerator and Resveratrol Elite
- NAD+ Cell Regenerator™ and Resveratrol Elite™ is Life Extension's Best in Class formula for energy support. It combines 300 mg of NIAGEN® nicotinamide riboside with an ultra-bioavailable trans-resveratrol (as well as bioavailability-enhanced forms of the phytonutrients quercetin and fisetin) to fight general fatigue and promote longevity with every dose.
- NIAGEN® nicotinamide riboside increases your levels of NAD+, an enzyme critical to healthy cellular energy production. Resveratrol promotes a variety of health and longevity mechanisms; quercetin supports heart and immune health; and fisetin encourages your body to clear senescent cells. This formula combines highly bioavailable forms of all four of these nutrients, creating an unrivaled supplement for energy, vitality and defense against cellular aging.
- iHerb Best Seller Product Rank: #1 in Fisetin category; #2 in Nicotinamide Riboside category.
- Over 1,000 customer reviews, most of them 5-stars on iHerb.com.
10. Peak Performance NMN + Resveratrol
Update: Not available on Amazon
- Anti Aging = NMN + Resveratrol! Our cells use NAD+ to produce
energy and to activate proteins that repair damaged DNA.
Scientists believe that the decline of NAD+ as we age results in
many health-related problems. To sustain healthy levels of NAD+
we can supplement this with its precursor, nicotinamide
mononucleotide (NMN) . When combined with Resveratrol this
supplement becomes even more powerful. Great for cellular + DNA
repair, muscle endurance and strength, vascular health and blood
flow.
- What's in your supplement? - Many supplements on the market
use standard formulas that may contain cheap fillers and
sometimes questionable ingredients. All of our ingredients are
carefully chosen and 3rd party tested for purity.
- Vegan & Allergy Free - Free Of Soy, Milk, Egg, Shellfish,
Corn, Wheat & Peanuts. Contains NO Gluten or Preservatives.
Manufactured Under The Highest Quality GMP Regulations and USA
Standards.
Related: Benefits of NMN and Resveratrol
Chromadex NMN Supplement Test Report: 64% of NMN Supplements Fail Tests
ChromaDex NMN Report (Oct 2021): Supplement manufacturer ChromaDex alleges that
testing has revealed that more than half of NMN anti aging
supplements being sold on Amazon contained almost none of the
bioactive molecule.
ChromaDex markets TruNiagen, which is based on its branded Niagen
ingredient, which is a form of nicotinamide riboside (NR), the
form of nicotinamide that actively crosses into the cell to
participate in the NAD+ pathway. Boosting this pathway, and thus
maintaining cellular function at a lively, youthful level, has
become a prominent theme in recent anti aging research.
|
| Credit: ChromaDex |
* The same distributor (SerumLab S&C International LLC) was
listed on the product packaging from 10 of the 22 product
brands.
Some researchers have argued that a transporter exists for NMN
too, which is something that ChromaDex disputes. It claims that NMN must first be converted into NR in the blood
before it can be used by the cells.
In the several years since the NMN transporter discovery was
asserted, the NAD+ anti aging field has become crowded with NMN
based supplements all seeking a piece of the pie created by
ChromaDex and its competitor and one time customer Elysium. (The
two companies have been locked in various patent infringement and
breach of contract suits for several years.)
Last fall, ChromaDex obtained 22 samples of NMN products being
sold on Amazon. Of these, 14 claimed to contain 500 mg of NMN. A
further two products claimed 300 mg on the label; five claimed 250
mg and one product claimed 125 mg.
Only one of the 500 mg products came close to meeting label claim.
It had 456 mg of NMN. All of the other 13 products in the 500 mg
group either came in at below reporting limit (BRL, defined as
less than 1% of the stated amount) or, in the case of 3 products,
no NMN was detected at all.
Almost all of the rest of the products performed better, having at
least 88% of the label claim. A lone 250 mg product was identified
as BRL.
In summary, ChromaDex said that 64% of the products tested
contained less than 1% of the stated amount of the active
ingredient, which should give consumers pause, the company said.
"While this is a limited snapshot of the vast NMN finished
product landscape, it does provide a glimpse into the high
variability of product quality that is available... According to
this study, the majority of the products one might purchase
online contain such a small amount of NMN that there would be no
clinical benefits achieved from the dose. Another concern with
these adulterated products is that the actual contents are not
known and could pose a risk to the user," the company said in a statement.
David Sinclair Supplements List
Keep in mind that to date, Dr. David Sinclair has made a point to not promote or endorse any supplement products. We compiled this list from interviews and books in which Professor David Sinclair mentions supplements he takes.We don’t know if he still takes these supplements, or whether he takes additional supplements that are not included on this list.
For example, in his book Lifespan, he mentions on page 304 that he takes NMN and resveratrol every morning, often mixed in his yogurt.
Here is the summary list:
- Nicotinamide Mononucleotide (NMN), 1g per day, in the morning
- Quercetin and fisetin, 500 mg each, once per day, in the morning
- Resveratrol, 1g per day, in the morning
- Vitamin D3 and K2
- Spermidine, 1 mg per day, in the morning
- Metformin (prescription drug) 1 gram per day: 500 mg in the morning and 500 mg in the evening
- Statin (prescription drug) – taken since his early 20s due to family history of cardiovascular disease
- Low-dose aspirin – 83 mg per day
- Alpha lipoic Acid
- Coenzyme Q10
NR vs NMN Molecule
Pitting
NR vs NMN
against each other is, for now, somewhat of a moot point because the
two molecules have never been studied side by side in humans. The
biggest, and most obvious, difference between NMN and NR is size.
NMN is simply larger than NR, meaning it often needs to be broken
down to fit into the cell. NR (Nicotinamide Riboside), when compared
to other NAD+ precursors (like nicotinic acid or nicotinamide)
reigns supreme in efficiency.
But give NMN a new door, one it can fit through, and it’s a whole
new game. This is where cellular transporters come into play.
Transporters are proteins that are doors on the cell; they allow
molecules to enter the cell without needing to chemically
transform.
Research from Shin-ichiro Imai, M.D., Ph.D., a professor of
developmental biology at Washington University in St. Louis,
identified a transporter that allows NMN to get into the cell
without converting to NR. The catch? The transporter is only on
cells located in the gut of mice and only works in the presence of
sodium ions. NR, however, has been shown to enter cells in the
liver, muscle, and brain tissue of mouse models. To date there is
not yet evidence that these mouse studies can be extrapolated to
humans. But again, the two have never been matched up against each
other in a way that can truly identify one as superior to the
other.
Stability and storage of NMN and NR
A stability analysis demonstrates NR is stable (does not undergo degradation) for up to six hours at room temperature and seven days at two to eight degrees Celsius. Regarding stability of NMN and NR, David Sinclair, PhD, A.O. of Harvard University says, “Make sure your NR and NMN is kept in the cold. If it’s just on the shelf and it’s not in a stabilized form, then it will degrade to nicotinamide, which is something you don’t want to take high doses of because we’ve shown in my lab many years ago that nicotinamide will inhibit the sirtuins, and PARP as well, and interfere with DNA repair.”What Foods Contain NMN?
Studies suggest that daily dosages of NMN range from 50mg to 250mg,
and a 150-pound (68kg) person would require approximately 560mg per
day. Unfortunately, obtaining these amounts solely through diet would
be impractical. For example, you would need to consume about 100
pounds of edamame, 1,800 pounds of broccoli, or unrealistic amounts of
cucumber, cabbage, avocado, tomato, mushrooms, raw beef, or shrimp to
achieve the required intake. Therefore, taking NMN supplements may be
a more practical approach to ensure adequate daily intake.
NMN Supplement dosage and side effects?
NMN is an ideal supplement to increase cellular levels of NAD because it’s well-tolerated, and both human and animal studies have observed it had minimal side effects.A clinical study (GeroScience 2022) suggests that NMN supplementation can indeed elevate NAD+ levels and increase walking distance in healthy participants, and has narrowed in on 600 milligrams a day being the optimal dose.
Research in humans has shown that doses of up to 1,200 mg daily are safe to consume.
NMN is just one of the promising ingredients. For more details on other anti aging supplements, check out "10 Best Anti Aging Supplements 2023 - Evidence Based".
Research in humans has shown that doses of up to 1,200 mg daily are safe to consume.
NMN is just one of the promising ingredients. For more details on other anti aging supplements, check out "10 Best Anti Aging Supplements 2023 - Evidence Based".
This article is part of the Anti Aging series.
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