10 Best NMN Supplements (2022 Review)

NMN stands for nicotinamide mononucleotide, a molecule naturally occurring in all life forms. NMN is the direct precursor of the essential molecule nicotinamide adenine dinucleotide (NAD+) and is considered a key component to increase NAD+ levels in cells.

NMN is a precursor to NAD+, or nicotinamide adenine dinucleotide, meaning it becomes NAD+ through a series of chemical transformations. NAD+ is a critical found in every cell of your body, but levels of NAD+ naturally fall with age, making it — and NMN, as a result — crucial.

However, NMN is like a large bed that movers are trying to get through a door: It doesn’t enter the cell easily. One way for NMN to enter the cell is for it to chemically transform into another molecule (called nicotinamide riboside, or NR) before it can enter the cell. NR has earned a name for itself as a highly efficient precursor to NAD+ and can enter the cell as is. NMN, meanwhile, sometimes becomes NR before entering the cell, where it chemically transforms back to NMN and then ultimately becomes NAD+.

We've learned that NR leads to NAD+ and that it also has its own pathway that bypasses various steps other NAD+ precursors have to take. In early 2019, though, new research revealed NMN might only have to become NR for certain cell types, as NMN can enter cells in the small intestine of mice. It’s unclear whether or how this will translate to humans, if at all, but it’s teed up NMN as the newer kid on the block, making many wonder: How does it stack up against NR?


What Does NMN Supplement Do?

In numerous studies (2020), supplementation with NMN has increased NAD+ biosynthesis, suppressed age-related adipose tissue inflammation, enhanced insulin secretion and insulin action, improved mitochondrial function, improved neuronal function in the brain, and more. Here, we look at the science behind NMN, its stability, possible pharmacokinetics, transport, function, and ability to induce biosynthesis of NAD+. Supplementing NMN may be an effective nutraceutical anti-aging intervention, with beneficial effects on a wide array of physiological functions.

Can NMN truly reverse aging? In a 2013 Harvard study, the Harvard scientists observed that “NMN was able to mitigate most age-related declines in mice,” and that “treatment of old mice with NMN reversed all of these biochemical aspects of aging.” The study concluded that “enhancing NAD+ biosynthesis by using NAD+ intermediates, such as NMN and NR (Nicotinamide Riboside), is expected to ameliorate age-associated physiological decline”.

This has precipitated dozens of studies since that are focused on investigating NMN supplementation to treat cardiovascular disease, diabetes, obesity, life extension, cancer, Alzheimer’s disease, Parkinson’s disease, and many more.

A 2022 study on human subjects concluded that Oral Administration of Nicotinamide Mononucleotide Is Safe and Efficiently Increases Blood Nicotinamide Adenine Dinucleotide Levels.


Best NMN Supplements 2022

1. TRU Niagen NAD+ Booster Supplement More Efficient Than NMN



TRU Niagen NAD+ Supplement comes in 3 sizes:

Amazon Best Sellers: #1 in Vitamin B3 (Niacin) Supplements.

- ChromaDex markets TruNiagen, which is based on its branded Niagen ingredient, which is a form of nicotinamide riboside (NR), the form of nicotinamide that actively crosses into the cell to participate in the NAD+ pathway. 
- Reduces the cellular effects of aging by elevating NAD+, a key coenzyme your body uses for healthy cellular metabolism.
- Nicotinamide Riboside for Energy, Metabolism, Vitality, Muscle Health, Healthy Aging, Cellular Repair 
- Unlike NMN, the key ingredient Niagen was successfully notified two times as an NDI (New Dietary Ingredient) and reviewed as GRAS (Generally Recognized As Safe) under the United States notification programs.
- There are many cheaper alternative sources to buy NMN today, but are you getting what you paid for? If the price for NMN is too good to be true, it probably is not NMN.
 
Everyday Renewal
Tru Niagen takes repair down to the foundation of our health, your cells. Every day, our cells are exposed to environmental toxins, hazardous compounds, and pathogens. These environmental factors and pathogens attempt to attack our DNA. Tru Niagen helps counteract this damage by activating tiny repair enzymes called sirtuins.

Fight Daily Stressors
Things like poor diet, alcohol consumption, lack of sleep, sun-exposure, and lack of exercise can be taxing on the body. These stressors affect us on the cellular level, putting our cells into overdrive in order to repair the damage. Tru Niagen helps combat these metabolic stressors.

Fitness Support
Tru Niagen helps fuel your workout and helps you recover after. It gives you fuel by supercharging your cells—focusing on continuous energy, not jolts of energy. After your workout is over, Tru Niagen helps you recover from intense exercise by boosting NAD+, a key coenzyme needed for cellular repair.

Lasting Energy
Tru Niagen promotes natural energy production deep in your cells. There are no stimulants like caffeine added. Tru Niagen helps provide every day sustaining energy through your body's natural energy-generating mechanisms.

While this is not a scientific review I have been taking Niagen in one form or another non stop for several years. I have been gradually increasing my doses with what I can only describe as a profound effect. Without a doubt I feel younger than 46. I also think I look younger than most people my age. I certainly don't feel my age and have a ton of energy every single day. I also try to eat plenty of vegetables with lots of non meat proteins along with limited meat consumption. I am not a health nut but basically try to stay away excess sugars and processed foods whenever I can. I also do a hard bike ride once or twice a week. I think this also helps the entire aging process some.

2. Double Wood NMN Supplement


- Most generic NMN supplements degrade in less than two months and need to be kept refrigerated due to its short shelf life. Double Wood NMN is fully stabilized and do not need refrigeration. Their process of stabilization ensures that the NMN does not deactivate before it reaches your cells.
- Made in the USA
- GMO-Free 

I've been using resveratrol (Jeuness) for 3.5 years, resveratrol was discovered by Dr David Sinclair (Harvard Medical School) discovered in 1992. No longer get cold. However, I'm still get tired due to aging, I believe. And getting worse lately when I've been working hard. So I started looking and noticed Dr Sinclair's book titled Lifespan: Why We Age—and Why We Don't Have To. From which I learned NMN. Then I ordered 1 bottle of NMN (Underwood). I take 4 capsules per day. Label says you can take 2-8 pills. The first week I felt less tired, but wasn't so sure it is due to NMN or something else. The second week, I started running instead of walking, so even I'm shocked! I haven't felt so hungary and energetic for the past decade! So it has to be NMN that worked!!
While I continue using resveratrol at the same time, I feel NMN makes you feel much more energetic. Can't comment longevity yet, but possible, even with NMN.

Ratings: 4.6 out of 5 - more than 1,200 global ratings

Amazon Best Sellers: #17 in Vitamin B3 (Niacin) Supplements.

Question: Nmn needs to be refrigerated and kept out of the light. true? typically how old is the product at shippment? thanks
Answer: NMN only needs to be refrigerated when mixed into a solution. I assume you heard Dr. Sinclair mention this and he was referring to his NMN / Walter solution he would give to mice. He was not talking about stabilized NMN powder. We have performed third party tests on this product 6-12 months after production showing it is stabilized and there is no break down in the molecule.

3. Nutricost Niacinamide



Amazon Best Sellers: #2 in Vitamin B3 (Niacin) Supplements.

Niacinamide is a popular form of Vitamin B3, but without the often uncomfortable feeling known as "Niacin Flush". Vitamin B3 is most often found in meats like tuna and beef. However, in order to get a similar amount of Vitamin B3, you would have to eat large amounts of tuna and beef or other sources containing Vitamin B3.

Do not get confused with Nutricost Niacin. This is the form that may cause 'Niacin Flush'. Niacinamide is the 'non-flush' form.

- 240 Capsules of Niacinamide Per bottle / 1 Capsule per serving
- 500mg of Vitamin B3 (Niacinamide) Per Capsule
- No "Niacin Flush"
- Non-GMO, Gluten Free, Soy Free, and Made in a GMP Compliant, FDA Registered Facility

After a recent news article about this being a favorite supplement in Australia for sun damage protection, I asked my dermatologist about it. She said it might help prevent me getting as many 'barnacles' as she calls them. You know, those nasty, old-age, sun-damage, crunchy brown or white patches all over your body. (I have many). I'm still on my first bottle but after about two weeks the most amazing thing happened. I happened to scratch an area near one of my barnacles and it just flaked off in my hand. Since then, many more have succumbed. Not all; just some. But I'm happy. Even one less of those ugly bumps is an improvement.

Ratings: 4.6 out of 5 - more than 9,000 global ratings

4. ProHealth Longevity NMN Pro 500


Buy on Amazon (capsules)

Also available as Pure NMN Pro 100 Grams Bulk Powder.

- One of the few NMN products from the ChromaDex NMN Supplement Test Report (Oct 2021) that passed the test (contained at least 88% of the NMN label claim).
- ProHealth Uthever NMN is CLINICALLY PROVEN TO BOOST NAD+ LEVELS IN HUMANS. In a peer reviewed, double blind placebo controlled clinical study NAD+ decline was reversed by an average of 12 years. That's 38% more NAD+ in 60 days. Higher NAD+ levels are associated with more energy, feeling younger, less genetic damage, heart health, and SIRTUIN activation- longevity genes that are key for living better longer. Also, study participants’ quality-of-life test scores improved by 6.5%.
- ProHealth is the most trusted longevity supplement brand on the market, celebrating 34 YEARS with a BBB A+ RATING. Other brands may be cheaper, but do you trust that they actual contain any NMN?
- PUREST, HIGHEST QUALITY, PHARMACEUTICAL GRADE NMN IN THE WORLD. Every batch is 3rd party tested in a US lab to be at least 99.5% pure, and independent lab tests prove that our NMN products contain at least the number of grams of NMN per serving listed on the label. All 3rd party lab Certificates of Analysis are publicly posted. Our NMN is always manufactured in a FDA registered, GMP certified facility in the USA.
- ProHealth Uthever NMN is proven safe for human consumption in a clinical study. And our unique NMN capsules dissolve after passing unharmed through the stomach so the potency is preserved when it is delivered to the section of the intestine with the highest absorption rates- maximizing bioavailability.
- SHELF STABLE FOR TWO YEARS, and at OVER 200 DEGREES. Lab tests prove that ProHealth's Uthever NMN can be safely stored at ambient room temperature for up to two years with no loss in quality or potency. No refrigeration required.

Amazon Reviews: 4.5 out of 5 - more than 200 global ratings
Amazon Best Sellers: #24 in Vitamin B3 (Niacin) Supplements

UTHEVER's CO-BRANDING PARTNERS

5. Toniiq NMN Powder


- One of the few NMN products from the ChromaDex NMN Supplement Test Report (Oct 2021) that passed the test (contained at least 88% of the NMN label claim).
- Boost NAD+ Levels - Nicotinamide Mononucleotide Powder Supplement.
- Highly Purified Form of NMN Powder 
- Our NMN powder contains an unprecedented purity level of 99+% (other NMN supplements and NAD supplement products won't disclose their purity levels).
- Fully Stabilized - NMN typically needs to be kept cold (fridge or freezer) because of its short shelf life. Our NMN formula comes in a completely shelf-stable non-refrigerated form and is packaged and sold in black sealed bottles that block light, moisture, and oxygen to ensure maintained and maximum potency.
- Toniiq products are produced in a GMP-certified and NSF-approved state-of-the-art manufacturing facility right here in the USA.
- We test each batch both ourselves and through a third-party independent laboratory to ensure our ingredients contain the correct standardized level of purity and active ingredients. We also test each batch for any possible additives, contaminants, and impurities to ensure the highest level of quality.

I have been using Toniiq NMN along with Resveratrol for about 7 and a half months now. I started taking these for longevity purposes after reading about them in Lifespan. Unexpectedly, I started to see my male pattern baldness reversing about 4 months in; I was not expecting this. Based on the regrowth process speed, it appears I'll reverse 8 years of hair loss in less than a year! My barber is totally floored that hair follicles can come back to life. I can only assume the cells in the rest of my body are rejuvenating as well.

I had been taking the NMN in pill form, but the powder seems to be a much better value. It has a slight tart flavor which I actually enjoy. I've only been using this new form for a short time, but I expect to continue to see the same results.

Amazon Ratings: 4.5 out of 5 - more than 300 global ratings
Amazon Best Sellers: #11 in Vitamin B3 (Niacin) Supplements.

6. Peak Performance NMN supplement + Resveratrol

peak performance nmn resveratrol


Not all NMN supplements are created equal! Many supplements come with just NMN, which by itself is less effective to produce higher levels of NAD which the body needs to prevent cellular degeneration as we age. Peak Performance combines NMN with Resveratrol. Resveratrol works synergistically with NMN as it acts as an accelerator to produce better results in DNA repair.
- Published in Pharmacology Research and Perspectives, Jiang and colleagues from Macau University of Science and Technology in China demonstrated that combining NMN with resveratrol increases NAD+ levels in heart and skeletal muscle of mice significantly more than NMN alone.
- Anti Aging = NMN + Resveratrol! Our cells use NAD+ to produce energy and to activate proteins that repair damaged DNA. Scientists believe that the decline of NAD+ as we age results in many health-related problems. To sustain healthy levels of NAD+ we can supplement this with its precursor, nicotinamide mononucleotide (NMN) . When combined with Resveratrol this supplement becomes even more powerful. Great for cellular + DNA repair, muscle endurance and strength, vascular health and blood flow.
- What's in your supplement? - Many supplements on the market use standard formulas that may contain cheap fillers and sometimes questionable ingredients. All of our ingredients are carefully chosen and 3rd party tested for purity.
- Vegan & Allergy Free - Free Of Soy, Milk, Egg, Shellfish, Corn, Wheat & Peanuts. Contains NO Gluten or Preservatives. Manufactured Under The Highest Quality GMP Regulations and USA Standards.
- Over 400,000 Happy Customers + 1-for-1 Donation To Vitamins Angels. Peak Performance is celebrating over 400,000 happy customers and we are also very proud of our 1-for-1 donation match program. For every unit you purchase, through our partnership with the nonprofit Vitamin Angels, we will supply a child at risk of malnutrition with vitamins for 1 year! To date, we've supplied over 1 Million children with life changing Vitamins- So thank you for helping us continue this great cause!

7. Codeage Liposomal NMN + Resveratrol + Quercetin Supplement


About this item

  • Liposomal Phospholipid Complex: Phospholipids sourced from non-GMO sunflower oil and containing phosphatidylcholine also feature protective liposomes, which are offered through a liposomal delivery matrix.
  • NMN Stabilized Form + Resveratrol: Codeage NMN nicotinamide mononucleotide performance supplement comes in powder-filled capsules for both women and men. This nicotinamide mononucleotide stable blend has been paired with trans-resveratrol, a polyphenol extracted from the root of Japanese knotweed, also know as Polygonum cuspidatum.
  • NAD Supplement Precursor & Betaine: This NAD precursor athletic fitness formulation delivers 85 mg of betaine anhydrous in each serving. Also called trimethyglycine (TMG), betaine usually consists of an amino acid derived from plants and sugar beets. NAD has been researched for its role on stem cells, telomere, and cellular energy.
  • Riboflavin & Vitamin B12 with Quercetin: Codeage Liposomal NMN formula also combines two of the vitamin B complex essential vitamins as well as quercetin. This formula provides Vitamin B2 as riboflavin-5-phosphate and vitamin B12 as methylcobalamine. These essential vitamins to support the metabolism have been blended with quercetin dihydrate from Japanese sophora flowers.
  • Manufactured in the USA: Codeage NMN & resveratrol vitality blend is non-GMO and manufactured in the USA in a cGMP certified facility. This liposomal nicotinamide with riboflavin supplement doesn't contain any fillers, hormones, or artificial ingredients. Third-party tested.

8. Tru Niagen Immune Support Supplement (Nicotinamide Riboside with Vitamin D, C, Zinc and Curcumin)


ChromaDex Corp. (NASDAQ:CDXC) announced the company’s latest product innovation with the U.S. launch of Tru Niagen® Immune in April 2022, a first-of-its-kind combination of ChromaDex’s proprietary NAD-boosting ingredient Niagen® (patented nicotinamide riboside or NR), high-quality and proven immune-boosting nutrients (vitamins C, D, and zinc) for the optimal maintenance of aging cells, and Theracurmin® (a superior form of curcumin). NAD+ is important to the healthy function of immune cells and is depleted by up to 80% when the body is under immune stress. Born from consumer insights, this new innovation was created to fulfill a customer need for an immune product. Tru Niagen Immune is now available online in the United States.

Ratings: 4.4 out of 5 - more than 30 reviews

9. aSquared Nutrition Nicotinamide with Resveratrol


aSquared Nutrition's maximum strength Nicotinamide supplement is enhanced with Resveratrol to promote cellular health & repair, normal NAD levels, longevity and anti-aging. Our unique formula helps your cells metabolize & synthesize nutrients more effectively to boost energy. 

- 120 capsules per bottle
- 500mg of Nicotinamide per Capsule / 100mg of Resveratrol powder per Capsule
- Contains 500mg of Non-Flush vitamin B3 per vegetable capsule, and is enhanced with 100mg of Resveratrol powder (7% potency yield) to promote cellular health & repair, normal NAD levels, longevity and anti-aging. 
- Made in USA
- All Natural, Non-GMO, and Vegetarian
- Third Party Tested for Quality & Purity
- Supplement Pills to Support NAD, Anti Aging Skin Cell Health & Energy
- Complex contains powerful antioxidants and anti-inflammatory properties to combat poor aging. 
Resveratrol is not suitable for people undergoing blood-thinning medication

Nicotinamide + Resveratrol Formula Benefits

- Promotes Cellular Health & Repair 
- Supports DNA Health & Wellness 
- Supports Longevity & Anti-Aging 
- Helps Boost Energy Levels 
- Supports Upregulation of Sirtuin Pathway 
- Supports Normal NAD / NAD+ Levels 
- Powerful Antioxidant Properties 
- Helps Boost Skin & Immune Health 
- Contains Anti-Inflammatory Properties 
- Helps Brain Health & Cognition 

This product is probably about as close as you can get to the niagen supplements, like Thorne ResveraCel, without actually containing niagen or using the patented process. Nicotinamide is a form of niacin easily processed by the body. And it contains bonus resveratrol. I've only been taking these two weeks, but I've found these supplements give me some mental boost/clarity and physical energy. My skin seems more elastic. I have less appetite (my usual tendency is to over eat) and sleep better. I've lost a couple of pounds. One side effect I get is upset stomach, but the seller/manufacturer claims this will go away with time. Overall, while these supplements are no "miracle cure," I think they are providing some benefit, and I will continue to take them. I'll reevaluate once I've made it through the first bottle.

TWO MONTH UPDATE: I still feel that I am benefiting from this product. Stomach upset has diminished. I have less joint pain. I have more energy and mental clarity. Better sleep. Skin feels younger. No additional weight loss.

Amazon Ratings: 4.5 out of 5 - more than 1,800 global ratings
Amazon Best Sellers: #8 in Resveratrol Nutritional Supplements.

10. Purely Beneficial NMN 500 mg


- 100% PURE & Powerful Ingredients to Promote Healthy Brain Function, Healthy Aging & much more…
- 500MG PHARMACEUTICAL GRADE NMN (Nicotinamide Mononucleotide). Manufactured in USA in a cGMP Facility
- PROMOTES HEALTH AND LONGEVITY -- Nicotinamide mononucleotide (NMN) is a derivative of the B-vitamin niacin that is known to promote health and longevity by serving as a precursor to NAD+. NAD+ is required for our longevity genes to work
- NO Additives, NO Fillers, NO Animal Products, NO Gluten, NO Artificial Ingredients, NO Harmful Preservatives, NO Inferior Ingredients, NON-GMO.

Chromadex NMN Supplement Test Report: 64% of NMN Supplements Fail Tests

ChromaDex NMN Report (Oct 2021): Supplement manufacturer ChromaDex alleges that testing has revealed that more than half of NMN anti aging supplements being sold on Amazon contained almost none of the bioactive molecule.

ChromaDex markets TruNiagen, which is based on its branded Niagen ingredient, which is a form of nicotinamide riboside (NR), the form of nicotinamide that actively crosses into the cell to participate in the NAD+ pathway. Boosting this pathway, and thus maintaining cellular function at a lively, youthful level, has become a prominent theme in recent anti aging research.

Credit: ChromaDex

* The same distributor (SerumLab S&C International LLC) was listed on the product packaging from 10 of the 22 product brands.

Some researchers have argued that a transporter exists for NMN too, which is something that ChromaDex disputes. It claims that NMN must first be converted into NR in the blood before it can be used by the cells.

In the several years since the NMN transporter discovery was asserted, the NAD+ anti aging field has become crowded with NMN based supplements all seeking a piece of the pie created by ChromaDex and its competitor and one time customer Elysium. (The two companies have been locked in various patent infringement and breach of contract suits for several years.)

Last fall, ChromaDex obtained 22 samples of NMN products being sold on Amazon. Of these, 14 claimed to contain 500 mg of NMN. A further two products claimed 300 mg on the label; five claimed 250 mg and one product claimed 125 mg.

Only one of the 500 mg products came close to meeting label claim. It had 456 mg of NMN. All of the other 13 products in the 500 mg group either came in at below reporting limit (BRL, defined as less than 1% of the stated amount) or, in the case of 3 products, no NMN was detected at all.

Almost all of the rest of the products performed better, having at least 88% of the label claim. A lone 250 mg product was identified as BRL.

In summary, ChromaDex said that 64% of the products tested contained less than 1% of the stated amount of the active ingredient, which should give consumers pause, the company said.

"While this is a limited snapshot of the vast NMN finished product landscape, it does provide a glimpse into the high variability of product quality that is available... According to this study, the majority of the products one might purchase online contain such a small amount of NMN that there would be no clinical benefits achieved from the dose. Another concern with these adulterated products is that the actual contents are not known and could pose a risk to the user," the company said in a statement.

David Sinclair Supplements List

Keep in mind that to date, Dr. David Sinclair has made a point to not promote or endorse any supplement products. We compiled this list from interviews and books in which Professor David Sinclair mentions supplements he takes.

We don’t know if he still takes these supplements, or whether he takes additional supplements that are not included on this list.

For example, in his book Lifespan, he mentions on page 304 that he takes NMN and resveratrol every morning, often mixed in his yogurt.

Here is the summary list:

1. Nicotinamide Mononucleotide (NMN), 1g per day, in the morning
2. Resveratrol, 1g per day, in the morning
3. Metformin (prescription drug) 1 gram per day: 500 mg in the morning and 500 mg in the evening
4. Vitamin D3
5. Vitamin K2
6. Statin (prescription drug) – taken since his early 20s due to family history of cardiovascular disease
7. Low-dose aspirin – 83 mg per day
8. Alpha lipoic Acid
9. Coenzyme Q10
10. Spermidine, 1 mg per day, in the morning
11. Quercetin and fisetin, 500 mg each, once per day, in the morning


NR vs NMN Molecule

Pitting NR and NMN against each other is, for now, somewhat of a moot point because the two molecules have never been studied side by side in humans. The biggest, and most obvious, difference between NMN and NR is size. NMN is simply larger than NR, meaning it often needs to be broken down to fit into the cell. NR (Nicotinamide Riboside), when compared to other NAD+ precursors (like nicotinic acid or nicotinamide) reigns supreme in efficiency.

But give NMN a new door, one it can fit through, and it’s a whole new game. This is where cellular transporters come into play. Transporters are proteins that are doors on the cell; they allow molecules to enter the cell without needing to chemically transform.

Research from Shin-ichiro Imai, M.D., Ph.D., a professor of developmental biology at Washington University in St. Louis, identified a transporter that allows NMN to get into the cell without converting to NR. The catch? The transporter is only on cells located in the gut of mice and only works in the presence of sodium ions. NR, however, has been shown to enter cells in the liver, muscle, and brain tissue of mouse models. To date there is not yet evidence that these mouse studies can be extrapolated to humans. But again, the two have never been matched up against each other in a way that can truly identify one as superior to the other.

As research grows, it is likely to become clearer that NMN and NR may have differing benefits depending on the part of the body and their use. Where NMN transporters are found, they could make one more preferable over the other. NMN has also been found to improve insulin activity and production which could help to accelerate metabolisms and make the body more glucose tolerant.

What Foods Contain NMN?

NMN is available in vegetables (broccoli and cabbage), avocado, mushrooms, meat, and shrimp but trying to obtain sufficient through diet alone would be problematic. Studies dosages have been about 50mg - 250mg and suggested that a 150 pound (68kg) human would require about 560mg per day. The difficulty is that you would have to eat about 100 pounds of edamame, 1,800 pounds of broccoli, or similarly impossible amounts of cucumber, cabbage, avocado, tomato, mushrooms, raw beef, or shrimp.

 

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