10 Best NAD+ Supplements 2025
It’s the energetic currency keeping your body functioning at its peak. NAD deficiency dramatically speeds up how fast you age.
What is NAD+ and What is its Function?

- Converting food to energy
- Repairing DNA
- Creating androgen hormones
- Building muscles
- Recovery
- Activating a group of seven essential longevity proteins called sirtuins
Nicotinamide adenine dinucleotide (NAD) is a coenzyme found in all living cells. It exists in two forms: an oxidized form and a reduced form, which are NAD+ and NADH (H for hydrogen).
It is central to energy metabolism and maintaining proper cell function. It plays a crucial role for our mitochondria function, which turn food and oxygen into energy for our body to use. NAD+ also supports the function of sirtuins. Sirtuins are proteins that help protect cells from age-related decline, regulate biological pathways and turn certain genes on and off. However, NAD+ levels decline with age which drive the aging process.
If you have suboptimal NAD levels, you’ll age faster and have difficultly performing at your peak.Most NAD Supplements Are Fake or Dangerous?
Third-party reports across brands and ingredients have found outright fraud: some products contain absolutely zero of the stated ingredient but rather another unrelated compound instead.Since it’s new, supplement manufacturers and commercial sources have only begun appearing in the last few years. Suppliers cannot match the demand spike. The market and online stores have become littered with fake (and expensive) NAD boosters.
Best NAD Supplements
- Tru Niagen NAD Supplement
- Nutricost Niacinamide
- ProHealth Longevity NMN Pro 500
- Codeage Liposomal NMN + Resveratrol + Quercetin + TMG Supplement
- Life Extension NAD+ Cell Regenerator and Resveratrol Elite
- Nuchido TIME+ Nicotinamide, EGCG, Vitamin C, Alpha Lipoic Acid, Zinc
- Wonderfeel® Youngr™ NMN
- Thorne Research ResveraCel
- aSquared Nutrition Nicotinamide with Resveratrol
- Peak Performance NMN supplement + Resveratrol
1. TRU Niagen NAD+ Booster Supplement
- 30 count / Serving Size: 1 Capsule once a day - Servings Per Container: 30
- 90 count / Serving Size: 1 Capsule once a day - Servings Per Container: 90
- 120 count / Serving Size: 1 Capsule once a day - Servings Per Container: 120
- A clinical trial published in Scientific Reports in 2019 (Read More)
- A study published Nature Communications in 2018 (Read More)
- A study published in Cell Reports in 2019 (Read More)
- A study published in the American Journal of Clinical Nutrition in 2018 (Read More)
- A study published in the American Journal of Clinical Nutrition in 2020 (Read More)
2. Nutricost Niacinamide (NMN Alternative)

3. Thorne Research ResveraCel (Best Nicotinamide Riboside with Resveratrol and Quercetin Phytosome)

4. Liposomal Nicotinamide Riboside, Resveratrol & Quercetin Phytosome by Reus Research
- INCREASE NAD BY 63%: Fight aging with Liposomal Nicotinamide Riboside - the direct sub to NMN supplements. It helps your body absorb and utilize NAD precursor more efficiently, producing wonderfeel results.
- MADE & TESTED IN THE USA: Our NR supplement is made and third-party tested in the USA to ensure its purity and effectiveness. Certificate available upon request. Get back to feeling your best with NAD+ supplement booster.
- INCREASE ABSORPTION BY 71%: maximize bioavailability with our Liposomal Nicotinamide Riboside encapsulation technology. Unleash the full potential of this supplement and experience 50% more effectiveness compared to other delivery methods.
- FEEL YOUTHFUL AGAIN: With daily dose of our Liposomal Nicotinamide Riboside capsules, you'll get a unique blend that supports healthy aging, energy production, focus and longevity.
5. ELYSIUM Basis NAD Supplement - Nicotinamide Riboside (NR) Supplement 250mg with Pterostilbene
Technically, Nicotinamide Riboside is not the same molecule as NMN but they are both NAD precursors and are categorised under Vitamin B3 (Niacin) supplements by Amazon.com.
About this item
- Want healthy aging? We’re the experts. Leonard Guarente, Elysium Health co-founder, has been studying aging for three decades. Our flagship product, Basis, is formulated to raise NAD+ by 40%, combat aging at the deepest level—your cells, and has sold over 3.5 million bottles. TIME magazine has called Basis “the supplements experts take.” All our products contain rigorously studied ingredients, and we partner with major research institutions like Oxford and Yale.
- Why should you take NAD? At a recent conference, 80% of doctors were taking an NAD+ supplement. What do they know that we don’t? In scientific research, NAD+ levels correlate with health status—it helps protect your DNA from stressors, boost cellular energy, and support healthy muscle function, and we have less of it as we age. Luckily, there’s a way to safely and sustainably raise your NAD+: Basis has been proven to increase levels by 40% in a double-blind, placebo-controlled clinical trial.
- Basis contains two powerful components: Proprietary nicotinamide riboside (NR-E), the raw material your body uses to make NAD+, and pterostilbene (PT), a plant polyphenol that protects against stress. From day 1, these ingredients support cellular energy, mitochondrial function, and protect cells from everyday stressors.
- Be sure of what’s in your supplement: We set the industry standard. We publicly publish the quality and purity results of third-party testing on every lot of Basis so you know exactly what you’re putting in your body. Our supplements are NSF Certified for Sport. We partner with major institutions like Oxford and Yale, and our company decisions are guided by the expertise of our Scientific Advisory Board, which includes internationally recognized experts and 8 Nobel laureates.
- Need more proof that Basis is the science-backed choice, and the superior NAD+ product on the market? TIME magazine called Basis “the supplement experts take,” W Magazine has said “This is the supplement sitting on the nightstands of every cerebral beauty junkie,” and Good Housekeeping has awarded us their Innovation Emblem to recognize trailblazing initiatives in health and wellness. We’ve been featured in many other publications and are the choice for doctors, athletes, and celebrities alike.
6. Codeage Liposomal NMN + Resveratrol + Quercetin + TMG Supplement
Click to Enlarge |
- Liposomal delivery matrix: NAD precursor blend offering NMN nicotinamide mononucleotide + resveratrol, betaine (TMG), riboflavin, vitamin B12, and quercetin all-in-one through a liposomal phospholipid complex.
- NAD Supplement Precursor & Betaine: This NAD precursor athletic fitness formulation delivers 85 mg of betaine anhydrous in each serving. Also called trimethyglycine (TMG), betaine usually consists of an amino acid derived from plants and sugar beets. NAD has been researched for its role on stem cells, telomere, and cellular energy. The combination of trimethylglycine and NMN ensures you get the energy increase from NAD while the improved distribution with TMG.
- Riboflavin & Vitamin B12 with Quercetin: Codeage Liposomal NMN formula also combines two of the vitamin B complex essential vitamins as well as quercetin. This formula provides Vitamin B2 as riboflavin-5-phosphate and vitamin B12 as methylcobalamine. These essential vitamins to support the metabolism have been blended with quercetin dihydrate from Japanese sophora flowers.
- Manufactured in the USA: Codeage NMN & resveratrol vitality blend is non-GMO and manufactured in the USA in a cGMP certified facility. This liposomal nicotinamide with riboflavin supplement doesn't contain any fillers, hormones, or artificial ingredients. Third-party tested.
- Liposomal delivery matrix: NAD precursor blend offering NMN nicotinamide mononucleotide + resveratrol, betaine, riboflavin, vitamin B12, and quercetin all-in-one through a liposomal phospholipid complex.
- Suggested use: Take 3 capsules daily with 8 ounces of water or your favorite beverage. May be taken with or without food.
- iHerb Best Seller Product Rank: #2 in Nicotinamide Mononucleotide (NMN) category;
#2 in NAD+ category. - Over 800 customer reviews, most of them 5-stars on iHerb.com.
- Pure NMN Pro 100 Grams Bulk Powder.
- NMN Pro 300
- NMN Pro 1000
- Prohealth Longevity NMN Pro Complete (NMN, Trans-Resveratrol and TMG)
Painstaking attention to quality and purity has led to findings that ProHealth NMN remains intact and stable for up to two years. Pro 300 gets rave reviews, often beating popular products like Genex. Pay attention to price, however, as I’ve seen it fluctuate by nearly $50. I’ve also noticed that there isn’t a GMP-certified logo on the bottle itself. If you want a shelf-stable NMN that lasts, ProHealth Pro 300 is a top choice." - outliyr.com
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UTHEVER's CO-BRANDING PARTNERS |
8. Life Extension NAD+ Cell Regenerator and Resveratrol Elite
- NAD+ Cell Regenerator™ and Resveratrol Elite™ is Life Extension's Best in Class formula for energy support. It combines 300 mg of NIAGEN® nicotinamide riboside with an ultra-bioavailable trans-resveratrol (as well as bioavailability-enhanced forms of the phytonutrients quercetin and fisetin) to fight general fatigue and promote longevity with every dose.
- NIAGEN® nicotinamide riboside increases your levels of NAD+, an enzyme critical to healthy cellular energy production. Resveratrol promotes a variety of health and longevity mechanisms; quercetin supports heart and immune health; and fisetin encourages your body to clear senescent cells. This formula combines highly bioavailable forms of all four of these nutrients, creating an unrivaled supplement for energy, vitality and defense against cellular aging.
- iHerb Best Seller Product Rank: #1 in Fisetin category; #2 in Nicotinamide Riboside category.
- Over 1,000 customer reviews, most of them 5-stars on iHerb.com.
9. Wonderfeel NMN
With a dose backed by a human clinical trial based on cutting-edge science, Youngr aims to change the way you age.
- 450 mg Nicotinamide Mononucleotide
- 2 mg Ergothioneine
- 50 mg Trans Resveratrol
- 40 mg Olea25® (25% hydroxytyrosol)
- 10 mcg Vitamin D3 (Cholecalciferol)
10. Peak Performance NMN + Resveratrol
64% of NMN Supplements Fail Tests
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Credit: ChromaDex
* The same distributor (SerumLab S&C International LLC)
was listed on the product packaging from 10 of the 22
product brands.
Recently researchers have argued that a transporter exists for NMN
too, which is something that ChromaDex disputes. It claims that NMN must first be converted into NR in the
blood before it can be used by the cells.
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Cost Comparison of various NAD supplements
- Cost per bottle: $58
- Dosage: 500mg
- Cost per gram: $2
- Delivery Method: Capsule
- Cost per bottle: $59.95
- Dosage: 500mg
- Cost per gram: $4.00
- Delivery Method: Capsule
- Cost per bottle: $49.99
- Dosage: 500mg
- Cost per gram: $3.33
- Delivery Method: Capsule
- Cost per bottle: $47
- Dosage: 300mg
- Cost per gram: $5
- Delivery Method: Capsule
NAD+ vs NADH
The key question is what ratio of NAD+ does your body need compared to NADH. While the optimal NAD to NADH ratio remains elusive, research suggests that a generally higher NAD to NADH ratio is favorable.
When it comes to a plain NAD label, it’s not wrong to be identified as a NAD booster. Generating more NAD+ will naturally generate more NADH. However, the specificity of NAD+ is more indicative of what your cells are truly building when using NAD+ boosting supplements.
Read more at NAD+ and NADH: What's the Difference?
How can I increase my NAD+ naturally?
- Exercise- Reduce sun exposure
- Spend more time in warm places, like hot tubs or saunas
- Consume more food with Vitamin B like avocados, steam fish or milk
- Consume fermented food and drinks which contain NAD+ like sauerkraut and kombucha
- Intermittent fasting : Popular fasting plans often include 16- to 24-hour fasting periods twice a week, followed by healthy meals. This eating pattern triggers body shock, which can boost your natural supply of NAD+.- Ketosis Diets : a low-carb, high-protein, healthy fats food plan.
Do NAD+ Supplements Work?
The answer may not be so simple. NAD+ is a ubiquitous and fundamental molecule, involved in many biological pathways and cellular operations. Its ingestion could lead to a mix of positive and negative outcomes, the balance of which might depend on context. NAD+ precursors, consumed orally, may be taken up by some tissues more than others. And different cell types are known to employ distinct metabolic programs, which could lead to tissue-specific responses to NAD+.
Concerns and Cautions: Be aware that some of these NAD supplements provide amounts of vitamin B-3 above the established daily upper tolerable intake level. There is also a theoretical safety concern that compounds that raise NAD+ levels like, nicotinamide riboside, as well as NAD, NADH, and possibly NMN, may promote the growth of existing cancers.
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