10 Best NAD+ Supplements to Buy in 2024

Nicotinamide adenine dinucleotide (NAD) is a coenzyme found in all living cells. Most cells in your body use NAD as a coenzyme in the production of energy from glucose. NAD exists in two forms: an oxidized form and a reduced form, which are NAD+ and NADH (H for hydrogen).

best nad supplement on the market

Nicotinamide Adenine Dinucleotide Market size is anticipated to exceed USD 1.4 billion by 2030, as per research report announced by Global Market Insights Inc. NAD market size was recorded at over USD 488 million in 2021. Driven by changing lifestyle choices, the industry is expected to grow at around 13% CAGR (compound annual growth rate) from 2022 to 2030.

Anti-aging and longevity researcher David Sinclair brought nicotinamide adenine dinucleotide (NAD) into the limelight. Here’s what you might not know though: scientists discovered NAD in the early 20th century. Why is it making a comeback?

It’s the energetic currency keeping your body functioning at its peak. NAD deficiency dramatically speeds up how fast you age.

Recent years have seen a surge of interest in supplements designed to boost levels of nicotinamide adenine dinucleotide (NAD). Research suggests NAD+ can help your body to repair DNA, boost immune systems and slow the aging process, but people also take supplements for short term gains such as increased energy levels. 

When choosing between the various options available, much will depend on your current health condition and what you’re hoping to get from it. To help you out, we’ve had a look at what’s going on the market to offer a varying selection in the hope that one of them will hit the sweet spot for you.

NMN stands for nicotinamide mononucleotide, a molecule naturally occurring in all life forms. NMN is the direct precursor of the essential molecule nicotinamide adenine dinucleotide (NAD+) and is considered a key component to increase NAD+ levels in cells.

What is NAD+ and What is its Function?


Over 500 different enzymes rely on NAD and without it, you'd die in 30-seconds.

Nicotinamide riboside is a form of vitamin B3 (also called niacin or nicotinic acid). Unlike the other forms, research shows that NR increases levels of NAD+, a key central metabolism regulator. Core functions of NAD include:
  • Converting food to energy
  • Repairing DNA
  • Creating androgen hormones
  • Building muscles
  • Recovery
  • Activating a group of seven essential longevity proteins called sirtuins

Nicotinamide adenine dinucleotide (NAD) is a coenzyme found in all living cells. It exists in two forms: an oxidized form and a reduced form, which are NAD+ and NADH (H for hydrogen).

It is central to energy metabolism and maintaining proper cell function. It plays a crucial role for our mitochondria function, which turn food and oxygen into energy for our body to use. NAD+ also supports the function of sirtuins. Sirtuins are proteins that help protect cells from age-related decline, regulate biological pathways and turn certain genes on and off. However, NAD+ levels decline with age which drive the aging process.

If you have suboptimal NAD levels, you’ll age faster and have difficultly performing at your peak.

Most NAD Supplements Are Fake or Dangerous?

Third-party reports across brands and ingredients have found outright fraud: some products contain absolutely zero of the stated ingredient but rather another unrelated compound instead.

Since it’s new, supplement manufacturers and commercial sources have only begun appearing in the last few years. Suppliers cannot match the demand spike. The market and online stores have become littered with fake (and expensive) NAD boosters.

Best NAD Supplements

After our review and research process, here is a recommended list of the best 10 NAD+ supplements league for you to compare in 2023:
  1. Tru Niagen NAD Supplement
  2. Nutricost Niacinamide
  3. ProHealth Longevity NMN Pro 500
  4. Codeage Liposomal NMN + Resveratrol + Quercetin + TMG Supplement
  5. Life Extension NAD+ Cell Regenerator and Resveratrol Elite
  6. Nuchido TIME+ Nicotinamide, EGCG, Vitamin C, Alpha Lipoic Acid, Zinc
  7. Wonderfeel® Youngr™ NMN
  8. Thorne Research ResveraCel
  9. aSquared Nutrition Nicotinamide with Resveratrol
  10. Peak Performance NMN supplement + Resveratrol
Although there are many NAD+ supplement customer reviews on many online sites, we have curated some of the helpful ones below.

1. TRU Niagen NAD+ Booster Supplement



This is one of the most popular supplements on the market. It contains nicotinamide riboside (NR) which is thought to be one of the fastest and most efficient NAD+ precursors available. It comes FDA approved with doses of 300mg of NR and makes all the usual claims associated with NAD+ of promoting cellular repair, accelerating metabolism and cellular energy production in order to improve your overall health and well-being. Taken over a period of time, therefore, it should have a positive impact on your health and may protect you against the onset of long-term disease. What makes it so popular, if online reviews are anything to go by, is that it can have a more immediate effect by boosting your energy levels. 

TRU Niagen NAD+ Supplements come in 3 sizes:

Amazon Best Sellers: #2 in Vitamin B3 (Niacin) Supplements.

- ChromaDex markets TruNiagen, which is based on its branded Niagen ingredient, which is a form of nicotinamide riboside (NR), the form of nicotinamide that actively crosses into the cell to participate in the NAD+ pathway. 
- Reduces the cellular effects of aging by elevating NAD+, a key coenzyme your body uses for healthy cellular metabolism.
- Nicotinamide Riboside for Energy, Metabolism, Vitality, Muscle Health, Healthy Aging, Cellular Repair 
- Unlike NMN, ChromaDex key ingredient Niagen was successfully notified two times as an NDI (New Dietary Ingredient) and reviewed as GRAS (Generally Recognized As Safe) under the United States notification programs.

Everyday Renewal
Tru Niagen takes repair down to the foundation of our health, your cells. Every day, our cells are exposed to environmental toxins, hazardous compounds, and pathogens. These environmental factors and pathogens attempt to attack our DNA. Tru Niagen helps counteract this damage by activating tiny repair enzymes called sirtuins.

Fight Daily Stressors
Things like poor diet, alcohol consumption, lack of sleep, sun-exposure, and lack of exercise can be taxing on the body. These stressors affect us on the cellular level, putting our cells into overdrive in order to repair the damage. Tru Niagen helps combat these metabolic stressors.

Fitness Support
Tru Niagen helps fuel your workout and helps you recover after. It gives you fuel by supercharging your cells—focusing on continuous energy, not jolts of energy. After your workout is over, Tru Niagen helps you recover from intense exercise by boosting NAD+, a key coenzyme needed for cellular repair.

Lasting Energy
Tru Niagen promotes natural energy production deep in your cells. There are no stimulants like caffeine added. Tru Niagen helps provide every day sustaining energy through your body's natural energy-generating mechanisms.

"While this is not a scientific review I have been taking Niagen in one form or another non stop for several years. I have been gradually increasing my doses with what I can only describe as a profound effect. Without a doubt I feel younger than 46. I also think I look younger than most people my age. I certainly don't feel my age and have a ton of energy every single day. I also try to eat plenty of vegetables with lots of non meat proteins along with limited meat consumption. I am not a health nut but basically try to stay away excess sugars and processed foods whenever I can. I also do a hard bike ride once or twice a week. I think this also helps the entire aging process some." - Amazon

Over 75% of registered ongoing or completed nicotinamide riboside trials use Niagen®. Here are five of their studies, just to name a few.
  1. A clinical trial published in Scientific Reports in 2019 (Read More)
  2. A study published Nature Communications in 2018 (Read More)
  3. A study published in Cell Reports in 2019 (Read More)
  4. A study published in the American Journal of Clinical Nutrition in 2018 (Read More)
  5. A study published in the American Journal of Clinical Nutrition in 2020 (Read More)

2. Nutricost Niacinamide (NMN Alternative)



Amazon Best Sellers: #1 in Vitamin B3 (Niacin) Supplements.

Ratings: 4.6 out of 5 - more than 13,000 global ratings

Do not confused with Nutricost Niacin. Niacin is the form that may cause 'Niacin Flush'. Niacinamide is the 'non-flush' form.

- Technically, Niacinamide is not the same molecule as NMN but they are both NAD precursors and are categorised under Vitamin B3 (Niacin) supplements by Amazon.com.
- Niacinamide is a popular form of Vitamin B3, but without the often uncomfortable feeling known as "Niacin Flush". Vitamin B3 is most often found in meats like tuna and beef. However, in order to get a similar amount of Vitamin B3, you would have to eat large amounts of tuna and beef or other sources containing Vitamin B3.
- Technically, Niacinamide is not the same molecule as NMN but they are both NAD precursors and are categorised under Vitamin B3 (Niacin) supplements by Amazon.com. Since, Niacinamide is the #2 best seller under this category, we have decided to feature them as part of the best 10 list.
- 240 Capsules of Niacinamide Per bottle / 1 Capsule per serving
- 500mg of Vitamin B3 (Niacinamide) Per Capsule
- No "Niacin Flush"
- Non-GMO, Gluten Free, Soy Free, and Made in a GMP Compliant, FDA Registered Facility

Nutricost Niacinamide Review
After a recent news article about this being a favorite supplement in Australia for sun damage protection, I asked my dermatologist about it. She said it might help prevent me getting as many 'barnacles' as she calls them. You know, those nasty, old-age, sun-damage, crunchy brown or white patches all over your body. (I have many). I'm still on my first bottle but after about two weeks the most amazing thing happened. I happened to scratch an area near one of my barnacles and it just flaked off in my hand. Since then, many more have succumbed. Not all; just some. But I'm happy. Even one less of those ugly bumps is an improvement.

Niacinamide Review
Dr. Conlon has concluded, and Dr Mercola thoroughly agree with her, that the best single NAD+ precursor is niacinamide (also known as nicotinamide), not niacin, NR or NMN. It is now beyond obvious to me why no one is promoting niacinamide. This is because it costs less than one cent a day and as a result there is simply no money to be made in promoting it. Ideally you buy niacinamide powder and use 1 to 1/2 of 1/64th of a teaspoon three times a day (25-50 mg). - Mercola.com.

3. Thorne Research ResveraCel (Best Nicotinamide Riboside with Resveratrol and Quercetin Phytosome)


Amazon Best Sellers: #4 in Resveratrol Nutritional Supplements.

Ratings: 4.6 out of 5 - more than 600 global ratings

Trusted by 12 U.S. National teams and many professional sports teams, Thorne research provides safe, effective products free of contamination. If you can’t (or don’t want to) risk accidentally consuming banned substances, Thorne’s got you covered.

- Each capsule contains Nicotinamide Riboside (NR) ingredient, in addition to Resveratrol, Quercetin Phytosome, and Betaine. 
- The ingredients in this product are complexed with Time-Sorb, a time-release matrix.
- Supports healthy aging and helps regulate metabolism.
- Resveratrol and quercetin increase the activity of sirtuins.
- Betaine provides important methylation factors.
- Flavors, colors, preservatives, and sweeteners derived from natural sources. 
- No gluten, Genetically Modified Organisms (known as GMOs), artificial preservatives, stearates, wheat, rye, barley, eggs, or nuts. This product does not contain dairy, soy, corn, yeast, sugar, or magnesium stearate.
- No unnecessary binders, coatings, disintegrants, fillers, or lubricants (including magnesium stearate) that could impair absorption.
- Adheres to the FDA’s current Good Manufacturing Practices (cGMPs) and has the highest number of NSF Certified for Sport products which tests for more than 200 banned substances for elite athletic competitions.

Review - My husband and I are in our 60s and have been taking these capsules for a few weeks. We both started with 2 capsules daily and experienced an increase in energy and in focus. We also both had trouble remaining asleep at night and had strange dreams. We have decreased our consumption of the capsules to one per day and have had a resolution to the sleep problems. We both continue to enjoy an increase in energy and in focus. We have reordered this Thorne product and are very satisfied with the results. It would be best to start with one capsule per day and work up from there until you find your own correct dosage.

Important safety note: Resveratrol is not suitable for people undergoing blood-thinning medication.

4. Liposomal Nicotinamide Riboside, Resveratrol & Quercetin Phytosome by Reus Research


Ratings: 4.7 out of 5 - more than 70 global ratings 

About this item
  • INCREASE NAD BY 63%: Fight aging with Liposomal Nicotinamide Riboside - the direct sub to NMN supplements. It helps your body absorb and utilize NAD precursor more efficiently, producing wonderfeel results.
  • MADE & TESTED IN THE USA: Our NR supplement is made and third-party tested in the USA to ensure its purity and effectiveness. Certificate available upon request. Get back to feeling your best with NAD+ supplement booster.
  • INCREASE ABSORPTION BY 71%: maximize bioavailability with our Liposomal Nicotinamide Riboside encapsulation technology. Unleash the full potential of this supplement and experience 50% more effectiveness compared to other delivery methods.
  • FEEL YOUTHFUL AGAIN: With daily dose of our Liposomal Nicotinamide Riboside capsules, you'll get a unique blend that supports healthy aging, energy production, focus and longevity.
Important safety note: Resveratrol is not suitable for people undergoing blood-thinning medication.

5. ELYSIUM Basis NAD Supplement - Nicotinamide Riboside (NR) Supplement 250mg with Pterostilbene




Technically, Nicotinamide Riboside is not the same molecule as NMN but they are both NAD precursors and are categorised under Vitamin B3 (Niacin) supplements by Amazon.com. 

Elysium Health is a startup cofounded by Sinclair's former mentor, MIT biologist Leonard Guarente. Elysium is taking no chances when it comes to scientific credibility. Its website lists a dream team of advising scientists, including five Nobel laureates and other big names such as the Mayo Clinic's Jim Kirkland, a leader in geroscience, and biotech pioneer Lee Hood.

Compared to other usual sources of NR, the price of Basis is relatively higher. However, those other products lack pterostilbene, and ELYSIUM is a trusted brand.

Ratings: 4.2 out of 5 - more than 70 global ratings 

About this item
  • Want healthy aging? We’re the experts. Leonard Guarente, Elysium Health co-founder, has been studying aging for three decades. Our flagship product, Basis, is formulated to raise NAD+ by 40%, combat aging at the deepest level—your cells, and has sold over 3.5 million bottles. TIME magazine has called Basis “the supplements experts take.” All our products contain rigorously studied ingredients, and we partner with major research institutions like Oxford and Yale.
  • Why should you take NAD? At a recent conference, 80% of doctors were taking an NAD+ supplement. What do they know that we don’t? In scientific research, NAD+ levels correlate with health status—it helps protect your DNA from stressors, boost cellular energy, and support healthy muscle function, and we have less of it as we age. Luckily, there’s a way to safely and sustainably raise your NAD+: Basis has been proven to increase levels by 40% in a double-blind, placebo-controlled clinical trial.
  • Basis contains two powerful components: Proprietary nicotinamide riboside (NR-E), the raw material your body uses to make NAD+, and pterostilbene (PT), a plant polyphenol that protects against stress. From day 1, these ingredients support cellular energy, mitochondrial function, and protect cells from everyday stressors.
  • Be sure of what’s in your supplement: We set the industry standard. We publicly publish the quality and purity results of third-party testing on every lot of Basis so you know exactly what you’re putting in your body. Our supplements are NSF Certified for Sport. We partner with major institutions like Oxford and Yale, and our company decisions are guided by the expertise of our Scientific Advisory Board, which includes internationally recognized experts and 8 Nobel laureates.
  • Need more proof that Basis is the science-backed choice, and the superior NAD+ product on the market? TIME magazine called Basis “the supplement experts take,” W Magazine has said “This is the supplement sitting on the nightstands of every cerebral beauty junkie,” and Good Housekeeping has awarded us their Innovation Emblem to recognize trailblazing initiatives in health and wellness. We’ve been featured in many other publications and are the choice for doctors, athletes, and celebrities alike.

6. Codeage Liposomal NMN + Resveratrol + Quercetin + TMG Supplement


Buy on iHerb (over 800 reviews)

Click to Enlarge

About this item
  • Liposomal delivery matrix: NAD precursor blend offering NMN nicotinamide mononucleotide + resveratrol, betaine (TMG), riboflavin, vitamin B12, and quercetin all-in-one through a liposomal phospholipid complex.
  • NAD Supplement Precursor & Betaine: This NAD precursor athletic fitness formulation delivers 85 mg of betaine anhydrous in each serving. Also called trimethyglycine (TMG), betaine usually consists of an amino acid derived from plants and sugar beets. NAD has been researched for its role on stem cells, telomere, and cellular energy. The combination of trimethylglycine and NMN ensures you get the energy increase from NAD while the improved distribution with TMG. 
  • Riboflavin & Vitamin B12 with Quercetin: Codeage Liposomal NMN formula also combines two of the vitamin B complex essential vitamins as well as quercetin. This formula provides Vitamin B2 as riboflavin-5-phosphate and vitamin B12 as methylcobalamine. These essential vitamins to support the metabolism have been blended with quercetin dihydrate from Japanese sophora flowers.
  • Manufactured in the USA: Codeage NMN & resveratrol vitality blend is non-GMO and manufactured in the USA in a cGMP certified facility. This liposomal nicotinamide with riboflavin supplement doesn't contain any fillers, hormones, or artificial ingredients. Third-party tested.
  • Liposomal delivery matrix: NAD precursor blend offering NMN nicotinamide mononucleotide + resveratrol, betaine, riboflavin, vitamin B12, and quercetin all-in-one through a liposomal phospholipid complex.
  • Suggested use: Take 3 capsules daily with 8 ounces of water or your favorite beverage. May be taken with or without food.
  • iHerb Best Seller Product Rank: #2 in Nicotinamide Mononucleotide (NMN) category;
    #2 in NAD+ category.
  • Over 800 customer reviews, most of them 5-stars on iHerb.com.
Important safety note: Resveratrol is not suitable for people undergoing blood-thinning medication.

Related evidence: Published in Pharmacology Research and Perspectives (2022), Jiang and colleagues from Macau University of Science and Technology in China demonstrated that combining NMN with resveratrol increases NAD+ levels in heart and skeletal muscle of mice significantly more than NMN alone.

7. ProHealth Longevity NMN Pro 500


Buy on iHerb (capsules)

Also available as: 
ProHealth Longevity NMN Pro Review:
"Uthever’s research team is led by U.S. doctors from the pharmaceutical giant GlaxoSmithKline. This NMN is tested both in-house by Uthever and then batch-tested again by ProHealth to verify authenticity and purity.
Painstaking attention to quality and purity has led to findings that ProHealth NMN remains intact and stable for up to two years. Pro 300 gets rave reviews, often beating popular products like Genex. Pay attention to price, however, as I’ve seen it fluctuate by nearly $50. I’ve also noticed that there isn’t a GMP-certified logo on the bottle itself. If you want a shelf-stable NMN that lasts, ProHealth Pro 300 is a top choice." - 
outliyr.com

- One of the few NMN products from the ChromaDex NMN Supplement Test Report (refer below) that passed the test (contained at least 88% of the NMN label claim).
- ProHealth Uthever NMN is CLINICALLY PROVEN TO BOOST NAD+ LEVELS IN HUMANS. In a peer reviewed, double blind placebo controlled clinical study NAD+ decline was reversed by an average of 12 years. That's 38% more NAD+ in 60 days. Higher NAD+ levels are associated with more energy, feeling younger, less genetic damage, heart health, and SIRTUIN activation- longevity genes that are key for living better longer. Also, study participants’ quality-of-life test scores improved by 6.5%.
- ProHealth is the most trusted longevity supplement brand on the market, celebrating 34 YEARS with a BBB A+ RATING. Other brands may be cheaper, but do you trust that they actually contain any NMN?
- PUREST, HIGHEST QUALITY, PHARMACEUTICAL GRADE NMN IN THE WORLD. Every batch is 3rd party tested in a US lab to be at least 99.5% pure, and independent lab tests prove that our NMN products contain at least the number of grams of NMN per serving listed on the label. All 3rd party lab Certificates of Analysis are publicly posted. Our NMN is always manufactured in a FDA registered, GMP certified facility in the USA.
- ProHealth Uthever NMN is proven safe for human consumption in a clinical study. And our unique NMN capsules dissolve after passing unharmed through the stomach so the potency is preserved when it is delivered to the section of the intestine with the highest absorption rates- maximizing bioavailability.
- SHELF STABLE FOR TWO YEARS, and at OVER 200 DEGREES. Lab tests prove that ProHealth's Uthever NMN can be safely stored at ambient room temperature for up to two years with no loss in quality or potency. No refrigeration required.

UTHEVER's CO-BRANDING PARTNERS
 

8. Life Extension NAD+ Cell Regenerator and Resveratrol Elite

  • NAD+ Cell Regenerator™ and Resveratrol Elite™ is Life Extension's Best in Class formula for energy support. It combines 300 mg of NIAGEN® nicotinamide riboside with an ultra-bioavailable trans-resveratrol (as well as bioavailability-enhanced forms of the phytonutrients quercetin and fisetin) to fight general fatigue and promote longevity with every dose.
  • NIAGEN® nicotinamide riboside increases your levels of NAD+, an enzyme critical to healthy cellular energy production. Resveratrol promotes a variety of health and longevity mechanisms; quercetin supports heart and immune health; and fisetin encourages your body to clear senescent cells. This formula combines highly bioavailable forms of all four of these nutrients, creating an unrivaled supplement for energy, vitality and defense against cellular aging.
  • iHerb Best Seller Product Rank: #1 in Fisetin category; #2 in Nicotinamide Riboside category.
  • Over 1,000 customer reviews, most of them 5-stars on iHerb.com.

9. Wonderfeel NMN

This is not your average NAD supplement. Wonderfeel® Youngr™ NMN provides a unique solution to aging; this NAD-boosting, patented formula has been developed by Harvard Med-trained entrepreneur and inventor Professor Andrew Salzman MD, who has worked in biomedical drug discovery for more than three decades.

With a dose backed by a human clinical trial based on cutting-edge science, Youngr aims to change the way you age.

Youngr™ NMN is a patented solution to aging. Formulated with emergent antioxidants and sirtuin activation, it uses a multi-targeted approach to defend and slow down biological aging at the cellular level.

It’s an investment in your cells that pays off across your entire body by increasing energy levels, restoring skin elasticity, while optimizing organ health, and cognition. You can enjoy faster recovery from rigorous activity or even from late nights by improved sleep quality.

Ingredients

60 Capsules per Bottle. Each capsule contains:
  • 450 mg Nicotinamide Mononucleotide
  • 2 mg Ergothioneine
  • 50 mg Trans Resveratrol
  • 40 mg Olea25® (25% hydroxytyrosol)
  • 10 mcg Vitamin D3 (Cholecalciferol)
Does not contain soy, gluten, dairy or fish. Non-GMO, vegan friendly, does not contain preservatives. Rice hull powder added for stabilization. Capsule shells are made from vegetable cellulose and are 100% vegan.

10. Peak Performance NMN + Resveratrol

peak performance nmn resveratrol

Update: Not available on Amazon

Not all NMN supplements are created equal! Many supplements come with just NMN, which by itself is less effective to produce higher levels of NAD which the body needs to prevent cellular degeneration as we age. Peak Performance combines NMN with Resveratrol. Resveratrol works synergistically with NMN as it acts as an accelerator to produce better results in DNA repair.
- Published in Pharmacology Research and Perspectives (2022), Jiang and colleagues from Macau University of Science and Technology in China demonstrated that combining NMN with resveratrol increases NAD+ levels in heart and skeletal muscle of mice significantly more than NMN alone.
- Anti Aging = NMN + Resveratrol! Our cells use NAD+ to produce energy and to activate proteins that repair damaged DNA. Scientists believe that the decline of NAD+ as we age results in many health-related problems. To sustain healthy levels of NAD+ we can supplement this with its precursor, nicotinamide mononucleotide (NMN) . When combined with Resveratrol this supplement becomes even more powerful. Great for cellular + DNA repair, muscle endurance and strength, vascular health and blood flow.
- What's in your supplement? - Many supplements on the market use standard formulas that may contain cheap fillers and sometimes questionable ingredients. All of our ingredients are carefully chosen and 3rd party tested for purity.
- Vegan & Allergy Free - Free Of Soy, Milk, Egg, Shellfish, Corn, Wheat & Peanuts. Contains NO Gluten or Preservatives. Manufactured Under The Highest Quality GMP Regulations and USA Standards.

64% of NMN Supplements Fail Tests

ChromaDex NMN Report (Oct 2021): Supplement manufacturer ChromaDex alleges that testing has revealed that more than half of NMN anti aging supplements being sold on Amazon contained almost none of the bioactive molecule.

ChromaDex markets TruNiagen, which is based on its branded Niagen ingredient, which is a form of nicotinamide riboside (NR), the form of nicotinamide that actively crosses into the cell to participate in the NAD+ pathway. Boosting this pathway, and thus maintaining cellular function at a lively, youthful level, has become a prominent theme in recent anti aging research.

Credit: ChromaDex

* The same distributor (SerumLab S&C International LLC) was listed on the product packaging from 10 of the 22 product brands.

Recently researchers have argued that a transporter exists for NMN too, which is something that ChromaDex disputes. It claims that NMN must first be converted into NR in the blood before it can be used by the cells.

In the several years since the NMN transporter discovery was asserted, the NAD+ anti aging field has become crowded with NMN based supplements all seeking a piece of the pie created by ChromaDex and its competitor and one time customer Elysium. (The two companies have been locked in various patent infringement and breach of contract suits for several years.)

Last fall, ChromaDex obtained 22 samples of NMN products being sold on Amazon. Of these, 14 claimed to contain 500 mg of NMN. A further two products claimed 300 mg on the label; five claimed 250 mg and one product claimed 125 mg.

Only one of the 500 mg products came close to meeting label claim. It had 456 mg of NMN. All of the other 13 products in the 500 mg group either came in at below reporting limit (BRL, defined as less than 1% of the stated amount) or, in the case of 3 products, no NMN was detected at all.

Almost all of the rest of the products performed better, having at least 88% of the label claim. A lone 250 mg product was identified as BRL.

In summary, ChromaDex said that 64% of the products tested contained less than 1% of the stated amount of the active ingredient, which should give consumers pause, the company said.

"While this is a limited snapshot of the vast NMN finished product landscape, it does provide a glimpse into the high variability of product quality that is available... According to this study, the majority of the products one might purchase online contain such a small amount of NMN that there would be no clinical benefits achieved from the dose. Another concern with these adulterated products is that the actual contents are not known and could pose a risk to the user," the company said in a statement.


Cost Comparison of various NAD supplements

ProHealth Longevity 
  • Cost per bottle: $58
  • Dosage: 500mg 
  • Cost per gram: $2
  • Delivery Method: Capsule
Approved Science 
  • Cost per bottle: $59.95 
  • Dosage: 500mg 
  • Cost per gram: $4.00
  • Delivery Method: Capsule
Nutriop Extreme Potency 
  • Cost per bottle: $49.99
  • Dosage: 500mg 
  • Cost per gram: $3.33
  • Delivery Method: Capsule
TruNiagen
  • Cost per bottle: $47
  • Dosage: 300mg 
  • Cost per gram: $5
  • Delivery Method: Capsule

NAD+ vs NADH

The key question is what ratio of NAD+ does your body need compared to NADH. While the optimal NAD to NADH ratio remains elusive, research suggests that a generally higher NAD to NADH ratio is favorable. 

When it comes to a plain NAD label, it’s not wrong to be identified as a NAD booster. Generating more NAD+ will naturally generate more NADH. However, the specificity of NAD+ is more indicative of what your cells are truly building when using NAD+ boosting supplements.

Read more at NAD+ and NADH: What's the Difference?


How can I increase my NAD+ naturally?

- Exercise
- Reduce sun exposure
- Spend more time in warm places, like hot tubs or saunas
- Consume more food with Vitamin B like avocados, steam fish or milk
- Consume fermented food and drinks which contain NAD+ like sauerkraut and kombucha
- Intermittent fasting : Popular fasting plans often include 16- to 24-hour fasting periods twice a week, followed by healthy meals. This eating pattern triggers body shock, which can boost your natural supply of NAD+.- Ketosis Diets : a low-carb, high-protein, healthy fats food plan.

Do NAD+ Supplements Work?

The answer may not be so simple. NAD+ is a ubiquitous and fundamental molecule, involved in many biological pathways and cellular operations. Its ingestion could lead to a mix of positive and negative outcomes, the balance of which might depend on context. NAD+ precursors, consumed orally, may be taken up by some tissues more than others. And different cell types are known to employ distinct metabolic programs, which could lead to tissue-specific responses to NAD+.

Concerns and Cautions: Be aware that some of these NAD supplements provide amounts of vitamin B-3 above the established daily upper tolerable intake level. There is also a theoretical safety concern that compounds that raise NAD+ levels like, nicotinamide riboside, as well as NAD, NADH, and possibly NMN, may promote the growth of existing cancers.






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