Glucosamine Chondroitin Vs Glucosamine MSM: What's the Difference?

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Glucosamine, chondroitin, and MSM (methylsulfonylmethane) are all popular dietary supplements that are commonly used to support joint health. Let's look at the differences between Glucosamine Chondroitin and Glucosamine MSM:
  • Glucosamine: Glucosamine is a naturally occurring compound found in the body, it is a building block for glycosaminoglycans, which are a type of molecule that makes up a significant part of cartilage. It plays a crucial role in the maintenance and repair of cartilage.
  • Chondroitin: Chondroitin is another natural substance found in the cartilage around joints. It helps give cartilage its elastic properties and is involved in maintaining the structural integrity of the tissue.
  • MSM: MSM, or methylsulfonylmethane, is a naturally occurring organic sulfur compund. MSM is known to have anti-inflammatory effects, and some users have reported pain and inflammation relief.

Glucosamine Chondroitin Combinations

This combination is commonly used to provide a comprehensive approach to joint health. According to a study of the effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis, suggests that oral chondroitin in recommended dosage is more effective than placebo on relieving pain and improving physical function. In addition, glucosamine also showed significant effect on the outcome of stiffness. In the aspect of safety, both compounds are well tolerated.

Oral Glucosamine, Methylsulfonylmethane and their Combination in Osteoarthritis

The study aimed to assess the efficacy and safety of oral glucosamine (Glu), methylsulfonylmethane (MSM), their combination, and a placebo in patients with knee osteoarthritis. 

A total of 118 patients were randomized to receive Glu, MSM, Glu and MSM combination, or placebo for 12 weeks. The results showed that Glu, MSM, and their combination significantly improved osteoarthritis symptoms compared to placebo. 

The combination therapy exhibited a more significant reduction in pain and swelling and improved joint function compared to individual agents. All treatments were well-tolerated, and the combination of MSM with Glu was found to provide better and more rapid improvement in patients with osteoarthritis, suggesting a synergistic effect.


Which One Should I Choose?

Those combinations are commonly used to maintain joint health, however the effectiveness of these supplements combination can vary from person to person. The quality of the supplements, as well as the dosage, can impact their effectiveness. It's essential to choose high-quality supplements and follow recommended dosages.

Therefore, before starting any new supplement regimen, it's advisable to consult with a healthcare professional, especially if you have underlying health conditions or are taking other medications. They can provide personalized advice based on your specific health needs.



Best Glucosamine Chondroitin MSM Supplement

1. Doctor's Best Glucosamine Chondroitin MSM

Doctor's Best Glucosamine Chondroitin MSM


A unique formula of Glucosamine, Chondroitin, and MSM with OptiMSM. Helps support joint mobility, structure, comfort, strength, and flexibility. Also supports overall health for hair, skin, and nails.*

Each daily serving delivers 1000 mg of MSM(OptiMSM), 1500 mg of Glucosamine, 1200 mg of Chondroitin. Combined they work together to help reduce joint discomfort including pain, lack of flexion, joint stiffness and weakness.*

Ingredients
Potassium (from glucosamine sulfate 2KCl) 182 mg; Chloride (from glucosamine sulfate 2KCl) 168 mg; Sodium (from chondroitin sulfate sodium) 56 mg; Glucosamine sulfate 2KCl 1500 mg; Chondroitin sulfate (from chondroitin sulfate sodium) 1200 mg; Methylsulfonylmethane (as OptiMSM) 1000 mg, Gelatin (capsule), microcrystalline cellulose, magnesium stearate (vegetable source).

Ratings: 4.6 out of 5 - more than 16,000 global ratings
Some people claim that most 'health' supplements do nothing, but I can say every time I've run out of a good glucosamine + chondroitin supplement for a week or so my knees start hurting again. I'm not sure if the MSM in this helps as well but as long as i maintain 2 x 2 daily I have zero joint pain ever so this is a keeper.




2. BioSchwartz Glucosamine Chondroitin MSM

BioSchwartz Glucosamine Chondroitin MSM


BioSchwartz Glucosamine Chondroitin and MSM capsules may help support joint mobility, increase joint flexibility, support joint structure and help protect joint tissue and cartilage, making it ideal for men and women looking to ease the occasional discomfort that can come with age, weight, or athletic deterioration of the joints.

All natural, non-GMO, no fillers, no binders: this professional grade glucosamine chondroitin MSM is all natural and has been manufactured exclusively with non-GMO ingredients - these glucosamine chondroitin capsules are also free of gluten, soy, milk, dairy, egg, corn, wheat, and peanuts.

Ingredients
Propietary Blend 2000mg (Glucosamine Sulfate, Methylsulfonylmethane (MSM), Turmeric/Curcumin Root, Boswellia serrata extract, Hydrolyzed Collagen Type II, Chondroitin Sulfate, Bromelain, Ginger Root, Hyaluronic Acid), Fruitex-B calcium fructoborate 110mg. Other ingredients: Vegetable capsule (Plantcaps). No fillers, no binders, no chemicals or preservatives.

Ratings: 4.4 out of 5 - more than 8,450 global ratings

I've had fibromyalgia, arthritis and lots of aches and pains for decades. When I take this regularly it really cuts down on joint pain and inflammation significantly. I got lazy for a few weeks and did not take I daily and sure enough my knuckles and knees started aching again.




3. NOW Supplements, Glucosamine & Chondroitin with MS

NOW Supplements, Glucosamine & Chondroitin with MS


NOW Glucosamine & Chondroitin with MSM combines three of the best known nutrients available for the support of healthy joints in one dietary supplement. It is halal, Non-GMO, Corn Free, Dairy Free, Egg Free, Made without Gluten, Nut Free, Soy Free.

Ingredients
Supplement Facts Serving Size: 3 Capsules Servings Per Container: 60 Description Amount per Serving % Daily Value * Percent Daily Values are based on 2,000 calorie diet.† Daily Value not established. Calories 10 Total Carbohydrate 2 g < 1%* Sodium 150 mg 6% Glucosamine Sulfate (from 1,500 mg Glucosamine Potassium Sulfate Complex) 1.1 g (1,100 mg)† Chondroitin Sodium Sulfate (from Bovine Cartilage) 1.2 g (1,200 mg)† MSM (Methylsulfonylmethane) 300 mg† Other Ingredients: Gelatin (capsule) and Magnesium Stearate (vegetable source). 

Ratings: 4.6 out of 5 - more than 7,000 global ratings

NOW Supplements Glucosamine has been a lifesaver for my joint health. The high-quality formula delivers exceptional support and relief. I've noticed a significant improvement in mobility and reduced discomfort. With easy-to-swallow capsules and trusted brand reputation, I highly recommend NOW Supplements Glucosamine for optimal joint care.



4. Horbäach Glucosamine Chondroitin MSM

Horbäach Glucosamine Chondroitin MSM


This supplement features Glucosamine Chondroitin plus MSM and Turmeric for all day support! Includes Boswellia Serrata, Hyaluronic Acid and Collagen in a synergistic blend. Our supplements use advanced sourcing to ensure purity and potency always. Laboratory Tested, Trusted Ingredients, Superior Quality, 100% Guaranteed!

Ingredients
Vitamin C, Manganese, Potassium, Advanced Support Complex, Boron. Other Ingredients: Cellulose (Plant Origin), Vegetable Stearic Acid, Croscarmellose, Vegetable Magnesium Stearate, Silica, Cellulose Coating.

Ratings: 4.6 out of 5 - more than 2,700 global ratings

I was in so much pain because of the deteriorating cartilage in both knees that I could barely walk up a flight of stairs. It's inherited; my first-cousins have the same problem. After two months of taking these, the pain didn't go away, but it really diminished. Now I can Leg Press 800lbs in the gym, with knee supports, of course.



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