CagriSema and Muscle Loss: What the 2026 Evidence Actually Shows
Updated: October 27, 2026 | Evidence review: REDEFINE 1, Novo Nordisk disclosures, and current obesity-treatment guidance CagriSema has attracted attention for the amount of weight people lost in the phase 3 REDEFINE 1 trial. A more clinically important question is whether that weight loss also preserves muscle, strength and physical function. The evidence supports a measured conclusion: CagriSema produced substantial fat loss, but the published body-composition results do not establish that it eliminates muscle loss or preserves skeletal muscle better than semaglutide or tirzepatide. The distinction matters because fat mass, lean soft tissue, skeletal muscle and muscle function are related but not interchangeable outcomes. What readers should know In REDEFINE 1, mean weight loss at week 68 was 20.4% using the treatment-policy estimand and 22.7% using the trial-product estimand. A small DXA subgroup analysis attributed approximatel...

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