Best Supplements for PMS Mood Swings 2025

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Premenstrual Syndrome (PMS) affects up to 75% of women, with mood swings being one of the most disruptive symptoms. From sudden irritability to overwhelming anxiety and depressive lows, these emotional fluctuations can disrupt daily life—but the right supplements can help.

Are PMS Mood Swings Real? The Science Says Yes

Research confirms that PMS mood disturbances are far more than "just hormones." A study of 328 women (16-35 years old) found:

- 67.4% experienced PMS
- 25.6% met criteria for PMDD (Premenstrual Dysphoric Disorder)
- Mood swings overlapped with anger, irritability, and depression

Contributing Factors of PMS Mood Swings
✔ Hormonal shifts (estrogen & progesterone fluctuations)
✔ Neurotransmitter sensitivity (serotonin & GABA imbalances)
✔ Genetic predisposition (family history of mood disorders)
✔ Lifestyle triggers (stress, poor sleep, diet)

Supplements for PMS Mood Swings

While there is no one-size-fits-all solution, certain supplements have shown promise in alleviating PMS mood swings..

a. Calcium
A double-blind randomized clinical trial involving female students diagnosed with PMS received 500 mg of calcium daily or a placebo for two months. 

Results shows calcium supplements help reduce PMS symptoms, including mood swings, by showing significant improvements in various mood-related symptoms in the calcium group.

b. Magnesium
A study of 32 women with PMS assessed the effects of oral magnesium supplementation. Participants took either 360 mg of magnesium or a placebo daily for two cycles. 

The study found that magnesium significantly reduced mood-related symptoms and increased magnesium levels in certain cells, suggesting it could effectively treat premenstrual mood changes.

c. Vitamin B6
Studies have shown that vitamin B6 can significantly reduce PMS mood symptoms. Maroofi et al. found that 40 mg daily reduced mood symptoms, and Salehi and Salehi found that 200 mg daily decreased depression, anxiety, and other symptoms.

d. Chasteberry
A randomized, double-blind, placebo-controlled study of 170 women found that daily agnus castus (Vitex agnus castus) extract significantly improved PMS symptoms, including mood swings, irritability, and anger, over three menstrual cycles compared to a placebo

1. Advanced PMS Support Supplement for Women


We feature some of the most balancing period vitamins for women in our PMS supplements for women including Vitamin B6 and Vitex berry for long lasting relief.

Unlike many period supplements for women that only target physical effects our formula supports hormone balance for women and period relief from irritability and moodiness.

Ingredients
Vitamin B6 (as Pyridoxine HCI), Vitamin B12, Magnesium, Lemon Balm (Aerial Parts), Black Cohosh Root, Diindolylmethane (DIM),Chasteberry Fruit Extract, Ashwagandha,

Ratings: 4.3 out of 5 - more than 1,000 global ratings

I’ve been delayed on my period for some time now. Last time it took me 2 months until I got my period.
My mood swings were going crazy. My acne kicked in. My period was mad heavy and so we’re the cramps. 

I started taking this a month ago and my period came basically on time! I felt no cramps. No sore breasts. Like they were mildly there but barely anything at all. I’m bloated though. But that’s just me. I still have energy even when I’m on my period. 

And the price is really good compared to so many other ones I’ve bought. I bought the same 30 day supply from another brand I did like, for $30. And this does the same exact as that brand did. 

I’m very impressed. My mood swings are basically gone. I am just a very emotional person as is, but these made me less crazy and my boyfriend agrees lol. Will definitely be buying these again.


2. SMNutrition PMS Relief Gummies

SMNutrition PMS Relief Gummies


CYCLE supports womens hormone balance with a potent blend of Chasteberry, Dong Quai, Cranberry, and Vitamin B6. Our PMS support gummies provide nutrients that can help with cramps, cravings, hormonal acne, mood balance, breast tenderness, energy, and bloating.*

CYCLE is Vegan, Pectin-Based, and formulated Gluten-Free, Non-GMO, and without the top 9 allergens.

Ingredients
Vitamin B6 (pyridoxine hydrochloride) 35 mg, Proprietary Herbal Blend 155 mg (Chasteberry Extract (Vitex Agnus-Castus), Cranberry Extract (Cranberry Anthocyanin) and Dong Quai (Angelica Sinesis)), organic tapioca syrup, sugar, water, pectin, citric acid, sodium citrate, natural flavors, carnauba wax, vegetable juice (color)

I’ve been delayed on my period for some time now. Last time it took me 2 months until I got my period.
I ordered these gummies to help with my mood and bloating and it went great. I’d definitely recommend you buy this if you (like me) are someone who suffers every month with PMS! The gummies are sweet and the taste is just right


3. Atlantis Nutrition Hormonal Balance For Women & PMS Relief Gummies

Atlantis Nutrition Hormonal Balance For Women & PMS Relief Gummies


These PMS vitamins for women contain Vitamin B6 which helps regulate hormones & promotes a regular cycle. It can also help stop unwanted cravings & irritability.
  • Chasteberry is a PMS mood swing & period relief supplement. It helps prevent skin breakouts, reduce breast tenderness & regulates mood swings by actively balancing hormones.
  • Dong Quai is a naturally found pms supplement that relaxes the uterine muscles & helps relieve bloating, helps with cramp relief period symptoms & menopause support.
  • Cranberry is known to avert night sweats & hot flashes caused by perimenopause & menopause. These hot flashes menopause relief gummies flush out unwanted substances.
These hormonal balance for women gummies are naturally formulated with Cranberry, Dong Quai & Chasteberry supplements to relieve your discomfort & support PMS, PMDD, & menopause symptoms*

Ingredients
Canberry Extract, Dong Quai Extract, Chasteberry Extract

The hormone balance gummies have a great taste too! I usually have very painful periods and I’m so glad I got these! I had less cramping, no bloating, I noticed my moods were much better! Very happy with these gummies! Comes as a cute heart design! 

4. Happy Healthy Hippie Hormone Balance for Women



Hormone Balance for Women] Our effective, vegan herbal supplements helps provide relief from uncomfortable symptoms such as acne, hot flashes, stress, restlessness, irritability, mood swings, cramping, bloating, tenderness, & lack of energy.*

Consists of 4 powerful herbs: Chasteberry, Dong Quai, Maca Root, Black Cohosh Root. Each herb included has been widely studied and is well known for their to ability to provide effective menopause and PMS support.

Ingredients
Gelatinized Maca Root, Chasteberry Fruit Extract, Dong Quai Root Extract, Black Cohosh Root Extract, Hyporomellose (Capsule), Microcrystalline Cellulose, L-Leucine (Vegetarian Grade)

Ratings: 4.2 out of 5 - more than 7,950 global ratings

I am allergic to birth control, and most medication. So I had to get the copper IUD. It’s great! But it makes my periods intense and the mood swings brutal! Everyone was saying I was becoming evil (PMDD). 

I found these on amazon and another women said they helped with her IUD symptoms as well. I got these at the first of the month, and my period was the third week. I took two a day as described and I honestly have never felt better. 

To begin with the pills are vegan, and contain nothing I am allergic too! Plus they’re all natural herbs which my body responds too as well. They’ve helped my PMS/ PMDD tremendously and my family and friends even agree. Now I will say it doesn’t “cure” all PMS symptoms. I still have cramps, acne, and back aches. The usual. But my mood? Is beyond better! Thank you for these!!!

FAQ

a. Home Remedies for PMS Mood Swings

Here are some home remedies for PMS Mood Swings:
  • Regular exercise: Engaging in regular physical activity can help reduce stress, improve mood, and alleviate PMS symptoms, including mood swings. Aim for at least 30 minutes of moderate-intensity exercise most days of the week.
  • Mind-body practices: Practices such as yoga, meditation, and deep breathing exercises can help reduce stress and promote relaxation, which may help alleviate PMS mood swings.
  • Dietary changes: Eating a balanced diet rich in fruits, vegetables, whole grains, and lean proteins while limiting caffeine, alcohol, and processed foods may help regulate mood and reduce PMS symptoms.

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