Regenexx and 30,000 Patients: Stem Cell Therapy for Knee, Low Back, Shoulder, Hip, Neck, Ankle/Foot, Hand/Wrist and Elbow

Chris Centeno, MD - As of today, we have almost thirty thousand patients in the Regenexx registry. That makes the registry data that we have collected over the years the world’s largest and oldest. Let’s dig in.

What Is a Registry?

A treatment registry is a formal database where every treated and consented patient is tracked over time with validated questionnaires. That means that at set time points, one or more research-based questionnaires are sent to the patient to measure their progress from a procedure. Any complications are also tracked.

The Start of Our Registry

Way back in 2005, years before we had iPhones, we began tracking patients as part of a two-year research study using cultured mesenchymal stem cells. That evolved into the Regenexx registry. As our network of trained physicians grew, so did the cases in the registry. In fact, the registry is so mature at this point that its data has been transferred into many different software containers. As technology advanced, so did the capabilities of the registry.

We now have the world’s oldest and largest registry focused on orthobiologics. In fact, there isn’t even a close second. What are orthobiologics?

Watch my video below to find out:

What’s In Our Registry?

I pulled the data from our registry this morning and at the top of the page, you can see what’s in there. On the left are the percentage of patients who have been treated in specific body areas. The knee is the most common area for our network to treat, followed by the low back, shoulder, hip, neck, ankle/foot, hand/wrist, and elbow.

On the right, you’ll see the percentage in each category that got platelet based treatments versus “stem cells” (bone marrow concentrate). For example, about half of our platelet based treatments are in the spine. You can also see that in the knee, we tend to use stem cells more often than platelet-rich plasma.

What Else Is in Our Registry?

First, you can access our registry online. We are the only group offering orthopedic stem cell therapies that can say that. Just click here to be taken to that data indexed by body area.

What does that information look like? Below is data on over 8,000 knee and over 1,400 shoulder stem cell patients. This is the patient percent improvement reported by the patient:

Second, we track outcomes and complications and each of our clinics has access to that data. The clinic can also compare their results to how the whole network is doing. The doctor can also see things like the percentage of patients who report that despite the treatment meant to help them avoid surgery, they still need to get the surgery. For example, below is that data for cervical procedures:

Note that despite a high percentage of our patients being neck surgery candidates, only about 3% report getting a neck surgery despite treatment. What else is unique here?

Requiring Physicians to Use a Registry

Everyone interested in controlling the wild west of regenerative medicine has been screaming that everyone should use a registry. At Regenexx, we’ve required this of our physicians from day one. No exceptions.

My Job as Chief Medical Officer

I’m the CMO of Regenexx and one of my jobs is to herd the cats in our physician network. I have a master control panel where I can view everyone’s data to make sure we have no outliers on outcomes. I can also see which clinics are doing what they’re supposed to with entering data or adjudicating reported adverse events (meaning try to ferret out if anything serious has been reported or just routine soreness). I can also see the net promoter score for each clinic (how likely a patient is to recommend that clinic to a friend):
Here you can see that when asked on a scale from 1-10 how good their experience was with all Regenexx clinics, the average answer is 8.4. A total of 76% of patients gave us an 8 or higher score!


It doesn’t matter who you chose to provide a stem cell or PRP treatment, no other network of physicians on earth that offers orthobiologics tracks all of this stuff at this intensity. Nobody has been tracking tens of thousands of patients for 15 years plus. Outside of our network, there is also very little effort placed on controlling the quality of the procedures you can get done.

In addition, tracking the data reported by patients is just the start. Our program to ensure that all of our labs produce the same quality minimally manipulated products is equally or more intense. Our educational requirements for network physicians is also the industry’s most intense.

The upshot? Regenexx has the world’s oldest registry tracking the world’s largest number of patients treated with orthobiologics. There isn’t a close second. All of this is to maximize the chance that when you walk into a Regenexx clinic in Kansas or in California that the experience and procedure you receive has the same quality as our original HQ clinic in Colorado.



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