Chris Centeno, MD - As of today, we have almost thirty thousand patients in the Regenexx registry. That makes the registry data that we have collected over the years the world’s largest and oldest. Let’s dig in.
What Is a Registry?
A treatment registry is a formal database where every treated and consented patient is tracked over time with validated questionnaires. That means that at set time points, one or more research-based questionnaires are sent to the patient to measure their progress from a procedure. Any complications are also tracked.
The Start of Our Registry
Way back in 2005, years before we had iPhones, we began tracking patients as part of a two-year research study using cultured mesenchymal stem cells. That evolved into the Regenexx registry. As our network of trained physicians grew, so did the cases in the registry. In fact, the registry is so mature at this point that its data has been transferred into many different software containers. As technology advanced, so did the capabilities of the registry.
We now have the world’s oldest and largest registry focused on orthobiologics. In fact, there isn’t even a close second. What are orthobiologics?
Watch my video below to find out:
What’s In Our Registry?
I pulled the data from our registry this morning and at the top of the page, you can see what’s in there. On the left are the percentage of patients who have been treated in specific body areas. The knee is the most common area for our network to treat, followed by the low back, shoulder, hip, neck, ankle/foot, hand/wrist, and elbow.
On the right, you’ll see the percentage in each category that got platelet based treatments versus “stem cells” (bone marrow concentrate). For example, about half of our platelet based treatments are in the spine. You can also see that in the knee, we tend to use stem cells more often than platelet-rich plasma.
What does that information look like? Below is data on over 8,000 knee and over 1,400 shoulder stem cell patients. This is the patient percent improvement reported by the patient:
Second, we track outcomes and complications and each of our clinics has access to that data. The clinic can also compare their results to how the whole network is doing. The doctor can also see things like the percentage of patients who report that despite the treatment meant to help them avoid surgery, they still need to get the surgery. For example, below is that data for cervical procedures:
Note that despite a high percentage of our patients being neck surgery candidates, only about 3% report getting a neck surgery despite treatment. What else is unique here?
Requiring Physicians to Use a Registry
Everyone interested in controlling the wild west of regenerative medicine has been screaming that everyone should use a registry. At Regenexx, we’ve required this of our physicians from day one. No exceptions.
My Job as Chief Medical Officer
I’m the CMO of Regenexx and one of my jobs is to herd the cats in our physician network. I have a master control panel where I can view everyone’s data to make sure we have no outliers on outcomes. I can also see which clinics are doing what they’re supposed to with entering data or adjudicating reported adverse events (meaning try to ferret out if anything serious has been reported or just routine soreness). I can also see the net promoter score for each clinic (how likely a patient is to recommend that clinic to a friend):
Here you can see that when asked on a scale from 1-10 how good their experience was with all Regenexx clinics, the average answer is 8.4. A total of 76% of patients gave us an 8 or higher score!
This Is ALL UNIQUE
It doesn’t matter who you chose to provide a stem cell or PRP treatment, no other network of physicians on earth that offers orthobiologics tracks all of this stuff at this intensity. Nobody has been tracking tens of thousands of patients for 15 years plus. Outside of our network, there is also very little effort placed on controlling the quality of the procedures you can get done.
In addition, tracking the data reported by patients is just the start. Our program to ensure that all of our labs produce the same quality minimally manipulated products is equally or more intense. Our educational requirements for network physicians is also the industry’s most intense.
The upshot? Regenexx has the world’s oldest registry tracking the world’s largest number of patients treated with orthobiologics. There isn’t a close second. All of this is to maximize the chance that when you walk into a Regenexx clinic in Kansas or in California that the experience and procedure you receive has the same quality as our original HQ clinic in Colorado.
Zinc picolinate and zinc gluconate are forms of dietary supplements that we use to prevent zinc deficiency. Zinc is an essential mineral that our body can easily absorb. Therefore, if we do not get enough amount of zinc, we may have to take these dietary supplements as directed by the doctor. When choosing a zinc supplement, it’s important to consider the type of zinc, dosage, and supplement form. Types of Zinc Supplements There are several types of zinc supplements. Supplements contain several forms of zinc, including zinc gluconate, zinc citrate and zinc picolinate. The percentage of elemental zinc varies by form. Chelated zinc is a general form of supplementary zinc in which the zinc is chelated — or bound — to a compound to make it easier for the body to absorb. Zinc picolinate or zinc gluconate are formed when zinc is chelated to picolinic acid or gluconic acid, so the main dif
NAC vs NAD vs NR vs Niacin vs NMN. Due to the small alphabetical differences, these supplements are often mixed up and confused by most consumers. We will cover the essentials and explain about each of these supplements below. Contents NAD NAD vs NAD+ NAD+ for Anti Aging NAD+ Helps Restore Age-Related Muscle Deterioration NAD and Resveratrol Naturally Boosting NAD Levels NAD Supplements NAC Niacin (NA) NR NMN NAC vs NMN Gluthatione vs NAC NAC vs Niacin NR vs NMN Can you take NR and NMN together? Niacin vs NR vs NMN Stability and Storage of NMN and NR Related Articles NAD NAD is a type of coenzyme found in all living cells. NAD plays important roles in a variety of metabolic reactions, including energy production and DNA repair. NAD is derived from Nicotinamide Riboside (NR) and various other
The Zelenko COVID-19 Protocols was developed by Dr Vladimir Zelenko. The protocol has as its centerpiece, but not exclusive piece, the combined use of Hydroxychloroquine (HCQ) and Zinc as a means by which a person can both help to prevent or mitigate the contraction of COVID-19 , or can actually treat the disease once it has been diagnosed. A retrospective study analyzing Dr Zelenko's patient data was accepted for publication after a rigorous peer review process. The study finds that early intervention and treatment of high-risk patients with COVID-19 resulted in significantly fewer hospitalizations and deaths. The treatment consisting of zinc, low-dose hydroxychloroquine (HCQ), and azithromycin, is also referred to as "The Zelenko Protocol." Dr Zelenko has since updated his protocols to incorporate new evidence. He has since evolved his protocols to include a quercetin, zinc, vitamin D and C protocol for low-risk patients as w
As of November 2023, there are more than 3,000 early treatment studies that have been published and shared with the whole world. New ones are being added every day. This is a review of the literature, covering multiple observational studies, randomized controlled trials and references related to natural supplements and cytokine storm with more than 300 studies and references. We know that while a large percentage of the population only experiences mild to moderate symptoms of COVID-19 and won’t require hospitalization, others experience severe symptoms and complications, require hospitalization, or may even die. It appears one of the differences between those who have a mild illness and severe illness is related to the body's ability to reduce the hyperimmune response that leads to a cytokine storm and the hyper-coagulability (tendency for blood clots) that often accompanies it. The cytokine storm may be one possible way to explain
Looking for the best or good orthopedic doctors in Malaysia? We've got you covered. Best Orthopedic Doctors in Malaysia Choosing the right orthopedic surgeon in Malaysia is not as simple as choosing a GP to get your next MC. An orthopedic surgeon is a medical specialist and they do sub-specialize in various orthopedic related sub-specialties. Examples of orthopedic sub-specialties include: Hand surgery Shoulder and elbow surgery Total joint reconstruction (arthroplasty), total knee and hip replacement (TKR and THR) Skull reconstruction Pediatric orthopedics Foot and ankle surgery Spine surgery Musculoskeletal oncology Surgical sports medicine Orthopedic trauma To assist you in finding the best orthopedic doctor in Malaysia, we have compiled a list of orthopedic surgery clinics below. Selection Methodology: The selection of the clinics is based on Google Search Results, reviews and information available on blogs and forums . Disclaimer: The list of clinics has been
NMN stands for nicotinamide mononucleotide and is a precursor to NAD+, or nicotinamide adenine dinucleotide. NMN is the direct precursor of the essential molecule nicotinamide adenine dinucleotide (NAD+) and is considered a key component to increase NAD+ levels in cells. NAD+ is a critical molecule found in every cell of your body, but levels of NAD+ naturally fall with age, making it — and NMN, as a result — crucial. NMN is one of the most popular supplements in the anti aging community. The global Nicotinamide Mononucleotide (NMN) market was valued at US$ 98.5 million in 2019 and it is expected to reach US$ 296.5 million ( R ) by the end of 2026, growing at a CAGR (Compound Annual Growth Rate) of 7.3% during 2021-2026. The NAD story took off toward the end of 2013 with a high-profile paper by Harvard's David Sinclair and colleagues. Sinclair, recall, achieved fame in the mid-2000s for research on yeast and mice that suggested the red wine ingredient resvera
In this article, we have covered quercetin with more than 100 studies and references that represent the best of science-backed information for quercetin. Contents 1. What is Quercetin? 2. Benefits of Quercetin 3. Quercetin Dosage 4. Food Sources of Quercetin 5. Quercetin Supplement Types 6. Quercetin Comparison 7. Quercetin and Other Supplements (Zinc, Bromelain, Vitamin C) 8. What Not To Take With Quercetin 9. Quercetin Side Effects 10. Online Shopping Guide 1. What is Quercetin? Quercetin is a pigment that belongs to a group of plant compounds called flavonoids (also known as bioflavonoids). Flavonoids are naturally present in fruits, grains, teas, and wine. Researchers have linked flavonoids to a variety of benefits, including a reduced risk of heart disease, cancer, and degenerative brain disorders. When looking for and using quercetin supplements, it’s important to maintain a nutritious, balanced diet with fiber and healthy fats in it, as research shows that accumulation of querce
Nicotinamide adenine dinucleotide (NAD) is a coenzyme found in all living cells. Most cells in your body use NAD as a coenzyme in the production of energy from glucose. NAD exists in two forms: an oxidized form and a reduced form, which are NAD+ and NADH (H for hydrogen). Nicotinamide Adenine Dinucleotide Market size is anticipated to exceed USD 1.4 billion by 2030, as per research report announced by Global Market Insights Inc. NAD market size was recorded at over USD 488 million in 2021. Driven by changing lifestyle choices, the industry is expected to grow at around 13% CAGR (compound annual growth rate) from 2022 to 2030. Anti-aging and longevity researcher David Sinclair brought nicotinamide adenine dinucleotide (NAD) into the limelight. Here’s what you might not know though: scientists discovered NAD in the early 20th century. Why is it making a comeback? It’s the energetic currency keeping your body functioning at its peak. NAD deficiency dramatically speeds up how fast you
Exploring how your body interacts with insulin is essential for maintaining health, particularly when considering dietary interventions like the ketogenic (keto) diet. Insulin resistance and insulin sensitivity are fundamental concepts that describe your body's ability to process insulin, while the keto diet presents a potential avenue for improving insulin sensitivity and managing conditions such as diabetes. Let's delve into each of these areas to gain a deeper understanding of their significance in health and nutrition. Insulin Resistance Vs Insulin Sensitivity Insulin resistance and insulin sensitivity represent opposite ends of how your body responds to insulin, a hormone produced by the pancreas to regulate blood sugar levels. Insulin Resistance This occurs when your cells don't respond properly to insulin. As a result, your pancreas produces more insulin to help glucose enter cells. Over time, this can lead to high insulin levels in the blood, which is associated wit
If you are confused about all the pico laser treatments in town and are looking for a guide to better understand pico laser and pigmentation treatment, you've come to the right place. “Pico Laser” is a recent buzzword in aesthetic medicine, so it's no surprise that Pico Lasers are one of the most popular treatment nowadays. However, the science is also mixed with hype and you are likely to get overwhelmed and cluttered over this Pico Laser treatment. We have compiled related pico laser questions and answers in one place in order to answer the above question and to de-clutter your mind. All answers are provided by medical doctors and dermatologists. The information below is based on published answers from major sites on the internet. Here is the list: Q: I am looking for a treatment for melasma, pore size reduction and rejuvenation. I came across pico technology but what is the difference between Pico Way and Pico Sure ( apart from a manufacturer). Is one better than the
Comments