Bromelain and Curcumin: Can They Help Against Coronavirus?
Interestingly, a number of natural agents have received attention due to potential anti-inflammatory and anti-oxidant properties. Among these products, collectively named nutraceuticals, curcumin and bromelain comprise two bioactive substances with potent anti-inflammatory and anticoagulant actions [4,5].
A medical review in the December 2020 issue of Metabolism Open is the first report on the potential preventive value of the synergistic effects of bromelain and curcumin against severe COVID-19.
Curcumin - Antiviral Actions
Bromelain - Anti-inflammatory and Anticoagulant EffectsBromelain is an ingredient isolated from the pineapple stem (Ananas comosus) . Traditionally, it has been used for its anti-inflammatory and healing effects in cases of arthritis and injury, while it has been approved in Europe for the debridement of burn wounds. Experimental studies have demonstrated that bromelain presents unique immunomodulatory actions: 1) downregulation of the pro-inflammatory prostaglandin E−2 (PGE-2) through inhibition of NF-kB and cyclooxygenase 2 (COX-2); 2) upregulation of the anti-inflammatory PGE-1; 3) activation of inflammatory mediators (interleukin 1β, interleukin-6, tumor necrosis factor-α and interferon-γ) as an acute response to cellular stress, but also inhibition of inflammatory mediators in states of overt cytokine production; 4) modulation of T cell responses in vitro and in vivo; and 5) enhancement of T-cell dependent antigen-specific B cell antibody responses [,, , , , ].
Importantly, bromelain exerts dose-dependent anticoagulant effects: 1) downregulation of PGE-2 and thromboxane A2 (TXA2), thus leading to relative excess of prostacyclin; 2) promotion of fibrinolysis by stimulating the conversion of plasminogen to plasmin and prevention of platelet aggregation. Bromelain also hydrolyzes bradykinin and reduces kininogen and bradykinin levels in serum and tissues, improving inflammation and edema as shown in animal studies . Notably, the latter action supports a potential role of bromelain in alleviating COVID-19 symptoms such as cough, fever and pain, and the more serious implications of inflammation, thrombosis and edema (Fig. 1). The effect of bromelain on PGE-2 inhibition exceeds that of prednisone and aspirin, presenting very low toxicity and no major side effects [12,16].
Clinical studies have demonstrated multiple beneficial effects of bromelain in trauma, ischemic injury, hypertension, atherosclerosis, inflammatory bowel disease, arthritis, and sinusitis as well as antibacterial and antifungal properties . Interestingly, a recent experimental study demonstrated that bromelain inhibits infection of VeroE6 cells by SARS-CoV-2 through blocking the virus binding and entry into cells via downregulation of ACE-2 and TMPRSS2 expression, and cleavage of the SARS-CoV-2 spike protein, presenting a novel promising therapeutic option that warrants further investigation .
Bromelain and Curcumin Synergistic EffectsDue to its proteolytic action, bromelain is absorbed directly when administered orally, while it substantially promotes the absorption of curcumin enhancing its bioavailability, and making this a perfect combination of immune-boosting nutraceuticals with synergistic anti-inflammatory and anticoagulant actions [12,16].
The hypothesis that the combination of bromelain and curcumin may prove useful for the protection against SARS-Co-V-2 infection warrants clinical investigation. Noteworthy, the favorable safety profile of this nutraceutical combination makes a compelling case for its use in the general population with potentially important implications in preventing severe COVID-19.
- Vaccination based on your local health authority guide.
- Wear protective face mask. This is to protect not only yourself but others.
- Abundant evidence suggests that eating whole in fruits, vegetables and whole grains—all rich in networks of naturally occurring antioxidants and their helper molecules—provides protection against free radicals.
- Getting Enough Sleep
- Avoid Sugar, red meat and processed foods.
- Don't smoke.
- Take steps to avoid infection, such as washing your hands frequently, using hand sanitizer and cooking meats thoroughly.
- Try to minimize stress.
- Drink enough water to keep your body hydrated.
- Avoid excess alcohol.
- Avoid crowded areas.
- Regular physical activity (outdoor activities may not be allowed in countries with 'lock-down').
- Consult your nearest local healthcare provider if you have any doubt.
- Now Foods Quercetin with Bromelain - 400 mg > One capsule daily (Amazon)
- Nature's Bounty Melatonin 5 mg > One tablet before bedtime (Amazon)
- Nature's Bounty Zinc 50 mg/day > One caplet daily (Amazon)
- Nature's Bounty Vitamin D3 - 2,000 IU > One dose daily (Amazon)
- Nature's Bounty Vitamin C - 1,000 mg > One caplet twice daily (Amazon)
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