7 Best Selling Supplements in America 2022

Four out of five Americans use dietary supplements

“Supplement usage among Americans has steadily increased in the more than twenty years CRN has conducted the survey,” said Brian Wommack, CRN’s senior vice president of communications. (Source)

For instance, Vitamin D consumption has increased significantly since 2020 (52 percent vs. 42 percent in 2020). The rise in use of these supplements is particularly notable because has been recognized in the past year as a substance that may help treat COVID-19 and boost overall immunity.

Moreover, 50 percent of supplement users have changed their supplement routine since the COVID-19 pandemic began, and 55 percent of those who have changed their routine have added new supplements to their existing routine.

Most in demand supplements 2022

1. Vitamin D – Immune system booster
2. Magnesium – For better sleep
3. Coenzyme Q10 – Supports heart health
4. Omega 3 (Fish Oil)
5. Curcumin (Turmeric)
6. Probiotic – Supports digestive health
7. Multivitamin

1. Vitamin D

Vitamin D

Surveys show vitamin D use significantly increased during the COVID-19 pandemic. But why Vitamin D?

It’s predicted that up to 40% of Americans don’t get enough vitamin D, and up to 1 billion people globally are vitamin D deficient.

Vitamin D and Covid 19

Early in the pandemic, researchers found a link between groups at high risk of COVID-19-related severe disease and those at risk of vitamin D deficiency, particularly those who are overweight, elderly, or have darker skin.

It sparked a flood of commentary and academic articles questioning whether increasing vitamin D levels could help protect certain vulnerable people from coronavirus infection.

A number of observational studies and large reviews of the available evidence now show that low vitamin D levels are associated with an increased risk of contracting COVID-19 or becoming seriously ill.

Vitamin D and Immune System

A study shown that Vitamin D has important functions beyond those of calcium and bone homeostasis which include modulation of the innate and adaptive immune responses.

Another study suggest that avoidance of severe vitamin D deficiency improves immune health and decreases susceptibility to autoimmune diseases.

How much vitamin D for immune support?

The recommended daily vitamin D intake is 400–800 IU (10–20 micrograms). However, according to some research, a daily intake of 1,000–4,000 IU (25–100 micrograms) is required to maintain healthy blood levels.

Vitamin D Supplements

a. Vitamin D 2000 IU (Softgels) | Nature Made Vitamin D3 2000iu – BUY ON AMAZON
Nature Made provides Vitamin D 2000 IU per softgels. Made from carefully selected ingredients under strict manufacturing practices and guaranteed to meet our high quality standards. No color added. No artificial flavors. Gluten free.

b. Vitamin D 2000 IU (Gummies) | Horbäach Vitamin D3 2000iu Gummies – BUY ON AMAZON
Provides 50 mcg (2,000 IU) of D3 in delicious, natural pineapple flavor gummies. Laboratory Tested, Trusted Ingredients, Superior Quality, 100% Guaranteed. NATURALLY FREE OF: Gluten, Wheat, Yeast, Milk, Artificial Flavor, Artificial Sweetener & Non-GMO.

c. Vitamin D 5000IU (Chewable Tablet) | NOW Foods Chewable Vitamin D3 5000iu – BUY ON AMAZON
NOW Chewable Vitamin D-3 supplies this key vitamin in a tasty chewable form. Quality GMP Assured, Kosher, Soy Free, Made w/o Gluten. NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods

d. Vitamin D 1000 IU/ drop (Liquid) | Sacred Eats Vitali-D Drops Liquid Vitamin D3 – BUY ON AMAZON
Unique needs without the hassle of hard-to-swallow pills. 1,000 IU per Drop (5 Drop Serving Size, 125 mcg). Zero sugar, suitable for Keto, Paleo & low-carb diets. Free of soy, milk, egg, shellfish, corn, wheat & nuts. Contains NO gluten, GMO, preservatives or anything artificial. Manufactured under the highest quality GMP & NSF regulations and standards. Kosher certified.

2. Magnesium


The second-most popular supplement is Magnesium. Magnesium is a mineral that plays a role in a number of vital biological functions. It is involved in muscle and neuron function, blood pressure and blood sugar regulation, and even bone and DNA formation.

Magnesium may help you sleep better. It aids in the activation of mechanisms that quiet and relax you, and it plays a key part in your nervous system. It may also aid in the relief of anxiety and depression, both of which can disrupt sleep. The only research that shows these vitamins help people sleep better has been done on older adults.

Moreover, on January 10, 2022, FDA announced in a letter of enforcement discretion a new qualified health claim for magnesium and reduced risk of high blood pressure. Read more: Magnesium for High Blood Pressure: FDA Gives ‘Qualified’ Nod

How much magnesium should i take?

Healthy adult men should take 400 to 420 milligrams (mg) of magnesium per day, according to the National Institutes of Health’s Office of Dietary Supplements. Healthy adult women should take 310 to 320 mg per day.

Magnesium Supplements

a. Magnesium 100mg (Tablet) | Doctor’s Best Magnesium Glycinate Lysinate 100 mg – BUY ON AMAZON
Made with TRAACS, a patented, form of bioavailable magnesium that is chelated to optimize bioavailability. Doctor’s Best High Absorption Magnesium is “not buffered”, a term meaning that is it not mixed with less expensive and less absorbable magnesium oxide. Vegan, Non-GMO, and Gluten Free

b. Magnesium 250mg (Tablet) | Nature Made Magnesium Oxide 250mg – BUY ON AMAZON
Sourced from high-quality ingredients, these Nature Made Magnesium 250 mg Tablets are gluten free and contain no synthetic dyes and no artificial flavors. In addition to muscle health and muscle relaxation, these Nature Made Magnesium supplements also support healthy bones and teeth, and help convert food into cellular energy.

c. Magnesium 500mg (Caplets) | Sundown Magnesium Supplement 500mg Coated Caplets – BUY ON AMAZON
Sundown products are always third-party tested for safety, quality and purity. Non-GMO(2) and free of artificial flavors; gluten-free, wheat-free, dairy-free, lactose-free.

3. Coenzyme Q10

Coenzyme Q10 for Heart Health

Coenzyme Q10 (CoQ10) is an antioxidant produced naturally by your body. Your cells utilize CoQ10 for both growth and maintenance. CoQ10 is a popular supplement among athletes and those seeking to enhance their physical performance because it is involved in the production of energy.

Coenzyme Q10 and Heart Health

Significant improvement has been observed in patients given adjunctive CoQ10 in doses from 60 to 200 mg daily in the various trials conducted in patients of heart failure, hypertension, ischemic heart disease and other cardiac illnesses. (Source)

Coenzyme Q10 and Immune System

Coenzyme Q10 has a number of important roles in the cell that are required for optimal functioning of the immune system. It plays an important function within the lysosome, an organelle central to the immune response. Furthermore, CoQ10 has also been reported to have an anti-inflammatory role via its ability to repress inflammatory gene expression. (Source)

How much Coenzyme Q10 should i take?

CoQ10 dosages of 90–200 mg per day are usually recommended, while some conditions may require greater doses of 300–600 mg. Best to consult a doctor for determining the best dose for you.

Coenzyme Q10 Supplements

a. Coenzyme Q10 100mg | Jarrow Formulas Co-Q10 100 mg – BUY ON AMAZON
Jarrow Formulas Co-Q10 is a nutrient that supports the function of mitochondria (the “power factories” within our cells). Found in the cells of energy-rich tissues like the heart, our body’s Co-Q10 levels decrease as we age. As an antioxidant, Co-Q10 helps promote vitality by supporting mitochondrial health and efficient energy production, the health benefits of which support cardiovascular function.*

b. Coenzyme Q10 200mg | Solgar Megasorb CoQ-10 200 mg – BUY ON AMAZON
This formulation is offered in an oil-based softgel to promote optimal absorption and assimilation. Gluten, Wheat and Dairy Free; Solgar Megasorb CoQ-10 is free of: gluten, wheat, dairy, yeast, sugar, sodium, artificial flavor, sweetener, and preservatives

4. Omega 3 (Fish Oil)

Omega 3 (Fish Oil)
Fish oil supplements are some of the most useful supplements out there. This is because they provide so many essential nutrients. They’ve been associated with numerous health benefits, such as a reduced risk of heart disease (Eur Rev Med Pharmacol Sci. 2015), reduced inflammation (Biochem Soc Trans. 2017) and improved mood (Front Physiol. 2018).

Omega 3 and Covid 19

That are more than a dozen studies on-going that examine the effect of EPA and/or DHA on the prevention of or lessening of symptoms of COVID-19.

Evidence suggests the omega-3 fats EPA and DHA affect biological pathways that may have direct influence in the outcome of COVID-19. EPA and DHA have a direct influence in the immunological response to viral infections and can modulate immune response and function.

Omega-3 and Heart Health

According to the research published in Mayo Clinic Proceedings in September 2020, EPA and DHA supplementation is associated with a reduced risk of:

Fatal Heart Attack – 35%
Heart Attack (myocardial infarction)- 13%
Risk of death form Coronary Heart Disease – 9%

Your goal should be to take at least 1,000 mg of EPA and DHA per day. Dietary / Food supplements, prescription omega-3s and eating fish regularly will help you meet this goal.

Omega-3 and Knee Pain

EPA and DHA can reduce inflammation, which causes swelling and pain. Research has indicated that both acids might suppress the body’s immune system. However, a 2016 study suggests that DHA might enhance immune function instead. DHA is more effective at reducing inflammation than EPA, but both have a role.

All of these effects makes fish oil potentially beneficial for people with arthritis.

How much omega 3 should i take?

Overall, it is recommended a minimum of 250–500 mg combined EPA and DHA each day for healthy adults.

People who have coronary heart disease and are at risk of having a heart attack are recommended to consume up to 1,000 mg of total EPA and DHA per day.

Omega 3 Supplements

a. Sundown Fish Oil 1000mg – BUY ON AMAZON
100% free of gluten & wheat, dairy & lactose, artificial flavor. Purified to eliminate mercury, PCBs and dioxins

b. Kirkland Signature Natural Fish Oil Concentrate 1000mgBUY ON AMAZON
Kirkland Signature Fish Oil supply comes from deep ocean waters. Our fish oil is not supplied from_farm-raised fish. State-of-the-art purification processes are used to remove PCBS, dioxins and furans. and mercury to ensure purity levels below 0.09 ppm.

c. Arazo Nutrition Omega 3 Fish Oil 4,080mg – BUY ON AMAZON
High dose of 4,080mg Omega 3 fish oil. Ultra pure and refined; purified with molecular distillation at minimal temperatures to remove all heavy metals, mercury and PCB’s. Made in a GMP certified facility in America.

5. Curcumin (Turmeric)

Curcumin (Turmeric)

Curcumin is the active compound of one of the most rigorously studied herbs. It has been used in Asia for its medicinal properties and countless studies have shown its anti-inflammatory, anti-viral, anti-biotic, and anti-fungal benefits. It has been used for joint pain, digestive issues, and many other chronic health conditions.

Curcumin May Help Fight Cancer

One study looked at the effects of curcumin on 44 patients with lesions in the colon that could have become cancerous. After 30 days, 4 grams of curcumin daily reduced the number of lesions present by 40% (Trusted Source).

Curcumin has also been shown to be effective in slowing the growth of lung, breast and prostate cancer cells in other test-tube studies (Trusted Source, Trusted Source, Trusted Source).

For the best results, aim for at least 1/2–3 teaspoons (1–3 grams) of ground turmeric per day. Use it as a ground spice to add flavor to foods, and pair it with black pepper to help boost its absorption.

How much curcumin should i take?

One to three 500 mg capsules daily with or without food.

Curcumin Supplements

a. Best Curcumin with Black Pepper Extract Curcumin | NatureWise Organic Curcumin Turmeric 2250mg, 95 Curcuminoids – BUY ON AMAZON
Curcumin by itself is poorly absorbed by the body. This turmeric with black pepper capsules are enhanced with ginger and Bioperine, a patented black pepper extract proven to dramatically increase bioavailability.

b. Curcumin Elite Turmeric Extract | Life Extension Curcumin Elite Turmeric Extract – BUY ON AMAZON
This supplement combined curcumin from turmeric, a spice steeped in Ayurvedic tradition, with fibers from fenugreek seeds. This formula offers more bioavailable free curcuminoids and better absorption of total curcuminoids than standard curcumin.

6. Probiotic

Probiotic for digestion health

Probiotics are living microorganisms that offer lots of health benefits if consumed in sufficient amounts, such as balancing the “good” bacteria in your digestive system, strengthening immune system, and lowering the risk and severity of diarrhea.

Moreover, probiotics may also improve mental health conditions such as anxiety, depression, and stress, based on many studies.

Probiotic and UTI (Urinary Tract Infection)

By the age of twenty-four, one in every three women will have had a clinically severe urinary tract infection (UTI), and nearly half will have had at least one in their lifetime.

Probiotics have been shown in certain studies to improve vaginal flora and lower the amount of pathogenic bacteria that might cause a UTI. Lactobacillus crispatus, Lactobacillus rhamnosus, and Lactobacillus reuteri in vaginal probiotics may help prevent UTIs from recurring. (Source)

Probiotic Supplements

a. Probiotic for Babies and Kids | UpSpring Probiotic + Colostrum Powder – BUY ON AMAZON
Support Little Tummies with probiotics to help occasional digestive stomach upset like constipation, gas, and diarrhea* . With 6 Probiotic Strains including Lactobacillus Rhamnosus, along with prebiotics as well as colostrum powder.

b. Probiotic for Adults | Wholesome Wellness Organic Probiotics 100 Billion CFU – BUY ON AMAZON
Our probiotic contains a shelf stable 100 Billion Cfu & 34 Strains per serving & 3 Trillion Cfu per bottle. Professional grade Non-Gmo vegan probiotics with No: Binders, Soy, Gluten, Milk, Egg, Wheat, Peanuts, Shellfish, Additives, or Preservatives.

7. Multivitamins

Multivitamins and Multiminerals

A lack of specific nutrients in the diet can cause diseases. For instance scurvy (from a lack of vitamin C), beri-beri (vitamin B1), pellagra (vitamin B3), and rickets (vitamin D). These conditions are uncommon in the United States and other developed countries, where people have easier access to a wider variety of foods, some of which are vitamin-fortified.

However, some people may not manage to eat a healthful diet or have low appetite. This condition may cause lack of nutrient and multivitamins may help them.


a. Multivitamins for Infants and Toddlers | NovaFerrum Multivitamin with Iron for Infants and Toddlers – BUY ON AMAZON
NovaFerrum has been clinically proven to be Safe, Well Tolerated, and Effective at raising iron levels. NovaFerrum Does Not contain Gluten, Sugar, Alcohol, Parabens, Synthetic Colors, or Caffeine.

b. Multivitamins for Kids | Nature Made Kids First Multivitamin with Omega-3 – BUY ON AMAZON
This daily multivitamin gummy for kids contains Vitamin A, Vitamin C, Vitamin D3, Vitamin E, Folic Acid, Niacin, Vitamin B6, Vitamin B12, Zinc, plus heart-healthy Omega-3s. Contains no artificial flavors, no synthetic dyes, no high fructose corn syrup, no artificial sweeteners, and is gluten free

c. Multivitamins for Women | One A Day Women’s Multivitamin Gummies – BUY ON AMAZON

Vitamin A, Vitamin C, Vitamin D, Vitamin E and Zinc for Immune Health Support, Calcium & more, Orange Flavor.

d. Multivitamins for Men | One A Day Men’s Multivitamin – BUY ON AMAZON
One a day Men’s Health Formula Multivitamins are free of gluten, wheat, dairy, artificial colors, and artificial sweeteners. Contains key nutrients like vitamins A, B6, C, D, E, and K, riboflavin, thiamin, and niacin

e. Multivitamins for Woman Above 50 | Centrum Silver Multi-Vitamin/Mineral Supplement for Women 50 Plus – BUY ON AMAZON
65 count bottle of Centrum Silver Multivitamins for Women Over 50, Multimineral Supplement with Vitamin D3, B Vitamins and Calcium. This supplement is non GMO and gluten free

f. Multivitamins for Men Above 50 | Centrum Silver Multivitamin for Men 50 Plus – BUY ON AMAZON
Centrum Silver Multivitamin for Men 50 Plus, Multivitamin/Multimineral Supplement with Vitamin D3, B Vitamins and Zinc. It comes in easy-to-swallow vitamin supplements

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