Best Antihistamine for Histamine Intolerance 2022

Histamine is a significant chemical that is involved in numerous body functions. It stimulates gastric acid secretion, contributes to inflammation, dilates blood vessels, etc. However, too much histamine can be problematic, causing histamine sensitivity or intolerance, digestive issues, allergies, and more.

If you suspect a histamine intolerance, you should avoid alcohol and histamine-rich foods. Moreover, you can take antihistamines for combatting the symptoms for a short period of time.

Histamine Intolerance Symptoms

Common symptoms of histamine intolerance:
headaches or migraines
nasal congestion or sinus issues
digestive problems, such as diarrhea
irregular menstrual cycle

Symptom severity varies from person to person.
People who have both allergies and a histamine intolerance may experience more severe allergic reactions because histamine levels in the body might accumulate. These can include asthma episodes or even anaphylactic shock, a serious, fast reaction that results in breathing difficulties and a drop in blood pressure that poses a life-threatening risk.

High amounts of histamine may be linked to significant chronic diseases like Crohn’s disease and can cause the heart to beat irregularly.

Best Antihistamine for Histamine Intolerance

Antihistamine medications, for example Benadryl (diphenhydramine) may be helpful for blocking histamine activity.

Numerous antihistamine drugs are accessible without a prescription or over-the-counter. Best to discuss with your doctor to choose which antihistamine is best for you.

1. Benadryl Ultratabs Antihistamine (Diphenhydramine)

Benadryl Ultratabs Antihistamine (Diphenhydramine)

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48-count pack of a trusted allergy brand, Benadryl Ultratabs with 25 mg diphenhydramine HCl for powerful allergy & cold relief in 1 pill* *temporarily relieves runny nose & sneezing due to upper respiratory allergies or the common cold.

Can benadryl allergy make you sleepy? Yes. The diphenhydramine in benadryl allergy can cause drowsiness.

4.8 out of 5 more than 13,650 global ratings

Benadryl Diphenhydramine Antihistamine Reviews
I’ve always relied on Benadryl for allergies and sometimes even take it when I have a cold with a runny nose. It dries up your runny nose, but don’t take it and drive — it does make you drowsy. I’m retired, but when I worked, I would take the Benadryl to work with me and then swallow it. The drowsiness usually wears off in about 4 hours. I’ll always rely on Benadryl.

2. Kirkland Signature Antihistamine (Diphenhydramine)

Kirkland Signature Antihistamine (Diphenhydramine)

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Kirkland Signature Antihistamine contains Diphenhydramine HCI 25 MG | Compare to Active Ingredient of Benadryl Allergy

For temporary relief of:
– sneezing & runny nose
– itchy , watery eyes
– hay fever symptoms
– itching of nose or throat

4.8 out of 5 – more than 5,600 global ratings

Kirkland Signature Antihistamine Diphenhydramine HCL Reviews
Great value on Benadryl! Great for allergies insect bites and stings! Works for sinus headaches as well. My Cardiologist prefers Benadryl to other O/C cold medications. I have A-fib and high blood pressure.

3. GeriCare OTC Antihistamine (Diphenhydramine)

GeriCare OTC Antihistamine (Diphenhydramine)

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– 25 mg of diphenhydramine hydrochloride
– compare to active ingredient in benadryl® ultratabs®
– 100 tablets per bottle

GeriCare OTC Antihistamine Diphenhydramine HCL Reviews
Second time ordering from this seller, great price and same quality as the brand name Benadryl.

4. Allegra 24HR Adult Non-Drowsy Antihistamine (Fexofenadine)

Allegra 24HR Adult Non-Drowsy Antihistamine (Fexofenadine)

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– 24 Hour Relief:
One tablet is all you need for round-the-clock relief from your worst allergy symptoms

– Fast Acting:
Allegra Allergy 24-Hour starts working in one hour for fast* relief from sneezing, runny nose, itchy, watery eyes, and itchy nose or throat

– Non Drowsy Antihistamine:
Formulated with active ingredient fexofenadine HCI, a non-drowsy antihistamine

– Indoor & Outdoor Allergies:
Use Allegra tablets for indoor and outdoor allergies, including seasonal allergies and pet allergies

Allegra 24HR Adult Non-Drowsy Antihistamine Reviews
Great over night travel game changers; 24 hour relief is awesome and homely

5. Children’s Claritin® Antihistamine for Kids (Loratadine)

Children’s Claritin® Antihistamine for Kids (Loratadine)

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– children’s claritin® provides 24-hour allergy relief of sneezing, runny nose, itchy, watery eyes, and itching of the nose or throat
– #1 pediatrician recommended non-drowsy oral allergy brand
– for kids ages 2+
– provides non-drowsy relief that lasts all day
– available in grape and bubblegum flavors
– kid-approved great taste

Children’s Claritin® Antihistamine for Kids Reviews
I normally use the liquid but this is easier to travel with. The kids take it with a little water and it works like the liquid. Apparently it tastes pretty good too. No complaints here and it works…

6. Equate Antihistamine (Loratadine)

Equate Antihistamine (Loratadine)
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Compare to Claritin Tablets active ingredient. With non-drowsy allergy relief from Equate Loratadine Tablets 10 mg, you can stop sniffling and enjoy spring without the dreaded symptoms of seasonal allergies. Pet dander, mold or dust? No problem. One dose provides all day, 24-hour relief of sneezing, runny nose, itchy or watery eyes, and itchy throat or nose from indoor or outdoor allergens.

The active ingredient is loratadine 10 mg, a powerful antihistamine in original prescription strength. Get allergy relief without the sleepiness. These tablets will not cause drowsiness when taken as directed. For adults and children 6 years and over. This allergy product is gluten free.

7. Good Sense All Day Allergy Antihistamine (Cetirizine)

Good Sense All Day Allergy Antihistamine (Cetirizine)

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Temporarily relieves these symptoms due to hay fever or other upper respiratory allergies: runny nose; sneezing; itchy, watery eyes; itching of the nose or throat.
– 24-hour relief of both indoor and outdoor allergy symptoms
– original prescription strength
– bottle contains 30 tablets (one-month supply)
– gluten-free

Caution: Do not use if you have ever had an allergic reaction to this product or any of its ingredients or to an antihistamine containing hydroxyzine

8. ValuMeds Antihistamine (Cetirizine)

ValuMeds Antihistamine (Cetirizine)

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ValuMeds Allergy Relief indoor and outdoor allergies 24 hour relief of: runny nose, sneezing, itchy, watery eyes, itching of the nose or throat.

Adults and children 6 years and over one 10 mg tablet once daily; do not take more than one 10 mg tablet in 24 hours. A 5 mg product may be appropriate for less severe symptoms. adults 65 years and over ask a doctor children under 6 years of age ask a doctor consumers with liver or kidney disease ask a doctor


a. What Food Has the Highest Histamine?

Histamine levels are greater in the following foods:

fermented foods (kefir, yogurt, kombucha, kimchi, sauerkraut, tempe, miso, sourdough bread)
alcohol, wine, beer, liquor
processed meat (hot dogs, ham, sausages, canned meat)
aged cheese
wheat germ
citrus fruits
nuts, specifically walnuts, cashews and peanuts
food dyes and other additives

b. What Foods Block DAO Production?

black tea
mate tea
green tea
energy drinks

c. Histamine Intolerance vs Allergies

Some signs of histamine intolerance mimic an allergic reaction. However, because of differences in the body’s cellular response, skin tests and blood allergy tests will come back negative.

Histamine buildup is thought to be the cause of histamine intolerance. As a result, the symptoms might not show up right away.

d. How to Clear Histamine From Body?

i. Start a diet that only involves foods and beverages with low amounts of histamine.

ii. You can take histamine blockers or antihistamines might be used to temporarily ease the symptoms.

iii. Use air purifier. Reduce your exposure to irritable irritants and allergens in your environment by using an air purifier. Pet dander, dust, pollen, and mold spores are just a few examples of the allergens that air purifiers remove from the air in your surroundings.

iv. Natural Histamine Blocker. You might be able to regulate your seasonal allergies with natural antihistamines. Stinging nettle, vitamin C, quercetin, butterbur, bromelain, and probiotics are some examples. Exercise, acupuncture, and other complementary therapies may also help you control your symptoms. However, do not stop using antihistamines or start using herbal or dietary supplements before consult your doctor.

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