Best Pancreatic Enzymes Supplements 2022

Digestive enzymes are proteins that your body naturally produces to help break down food and help digestion. Digestion is the process of turning the food you eat into nutrients to produce energy, support growth, and carry out essential tasks. These enzymes are produced by your pancreas, small intestine, and stomach. And the "powerhouse" of digestion's enzymes is the pancreas.

Three Main Types of Pancreatic Enzymes

a. Lipase. This enzyme works together with bile, which your liver produces, to break down fat in your diet. Your body will have problems absorbing fat and the crucial fat-soluble vitamins (A, D, E, K) if you don't have enough lipase. Poor fat absorption is characterized by diarrhea and fatty bowel movements.

b. Protease. This enzyme is needed to break down the proteins in your diet. Additionally, it aids in defending you against germs like certain bacteria and yeast that may live in your intestines. Lack of protease can cause allergic reactions or toxicity in the intestines.

c. Amylase. This enzyme helps your body break down carbohydrates, which your body can use for energy. Lack of amylase can cause diarrhea from undigested carbohydrates. 

What Causes Pancreatic Enzyme Deficiency?

Some of the conditions that may result in pancreatic insufficiency include surgery (Whipple procedure or total pancreatectomy), cystic fibrosis or pancreatitis, pancreatic or duodenal tumors, blockage or narrowing of the pancreatic or biliary duct.

Pancreatic Enzyme Insufficiency Symptoms

Some of the symptoms associated with pancreatic enzyme insufficiency include:
  • feelings of indigestion 
  • cramping after meals 
  • large amounts of gas 
  • foul-smelling gas or stools 
  • floating or greasy/fatty stools 
  • light-colored, yellow or orange stools 
  • frequent stools 
  • loose stools 
  • weight loss 

Do I Need Digestive Enzyme Supplements?

Overall, taking digestive enzyme supplements is not actually necessary for a healthy person. The finest digestive enzymes are those that our systems naturally produce, and they function best when you consume a diet high in whole foods.

Patients with pancreatic enzyme insufficiency, though, should speak with their doctor to see if taking more pancreatic enzymes could be helpful for them. Even though several digestive enzyme supplements are available over the counter, keep in mind that the FDA does not regulate these over-the-counter digestive enzyme pills. Therefore, it is advised that you speak with your doctor before taking any supplements.

Best Pancreatic Enzymes Supplements

1. Vital Nutrients Pancreatic Enzymes - Digestion Supplement with Protease, Amylase & Lipase

Vital Nutrients Pancreatic Enzymes - Digestion Supplement with Protease, Amylase & Lipase


Pancreatic Enzyme Supplements support healthy digestion by supplying natural enzymes that are secreted by the pancreas. The full-strength Pancreatin powder contained in the capsules provides the protease, amylase and lipase enzymes essential to the breakdown and absorption of food and its nutrients. It supports the normal digestion of proteins, fats and carbohydrates in the gut, for relief of occasional gas and bloating.

This formula is free from gluten, dairy, soy, peanut, tree nut, egg, sugar, artificial colors & more. Some companies skip lot test their products. At Vital Nutrients, we test every batch of raw material and finished product to ensure potency, purity and authenticity.

4.5 out of 5 - more than 1,100 global ratings

I have had digestive issues off and on my whole life. It's finally gotten to the point of affecting my lifestyle. A friend who was given Creon for pancreatic issues told me how expensive that medication is and that his doctor said to try the enzyme which has been very effective, so I gave these a shot. In just 3 days, things are getting back to normal and since I am absorbing nutrients better now, I have more energy. My DIL who has gluten sensitivity has also been using these enzymes with great success.

2. Solaray Pancreatin 1300 with Protease, Amylase, Lipase

Solaray Pancreatin 1300 with Protease, Amylase, Lipase


- Pancreatic Enzymes
Supplies protease, amylase & lipase to help support healthy digestion. It help digest protein, carbohydrates (starch) and fat.

- Essential Role
Healthy digestion helps support the body’s immune system & tissue repair

- Powerful Formula
With Pancreatin 4x, providing the equivalent of 1300 mg in activity level

- Trusted Brand
Made in our own facility & lab verified for potency, purity & identity

4.5 out of 5 - more than 1,150 global ratings

I have chronic pancreatitis. I was prescribed Creon but it’s ridiculously expensive even with insurance. When I saw this product I was suspicious because it’s so cheap. But, it has worked magnificently for me. I highly recommend giving it a try.

3. Pure Encapsulations Pancreatic Enzyme Formula 

Pure Encapsulations Pancreatic Enzyme Formula


- Digestive Support
This formula is designed to aid the body’s natural digestive process and is offered in an acid-resistant capsule.*

- Nutrient Absorption
The formula provides a highly concentrated form of enzymes naturally secreted by the pancreas which are essential to the digestion of food and absorption of nutrients.*

- Enzyme Formula
This formula contains lipase, which digests fat; proteases, which digest protein; and amylases, which digest starch.*

- Pure Quality
Our supplements are made with only premium ingredients sourced from trusted suppliers and guided by our nutritional experts, then carefully manufactured and tested to verify their potency and purity.

- Pure Difference
What makes us different isn't just our process or what goes into our supplements -- what we leave out matters, too. Pure Encapsulations products are free from wheat, eggs, tree nuts & peanuts, gluten, artificial colors, flavors & sweeteners, coatings and shellacs, GMOs, and unnecessary binders, fillers & preservatives.

*these statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Works well! I always take one with food. No more problems digesting food. 😄

4. Designs for Health Digestzymes Pancreatic Enzymes with Betaine HCl

Designs for Health Digestzymes Pancreatic Enzymes with Betaine HCl


- Support Healthy Digestion 
Digestzyme is comprised of a proprietary blend of digestive enzymes along with betaine HCl to support optimal digestion of proteins, fats, and carbohydrates.*

- Take Before Meals 
The use of Digestzyme before meals may be helpful for those experiencing occasional gas and bloating after eating, constipation, or a feeling of fullness after eating only a small quantity of food.*

- Synergistic Enzyme Blend 
Contains protease DPP IV (dipeptidyl peptidase IV), which aids in the breakdown of casomorphin (from casein) and gluteomorphin (from gluten). The enzyme lactase helps break down the dairy sugar lactose.

- Higher Standards, Better Results 
This product is made without GMOs. Eco-conscious, tinted glass bottles offer a moisture barrier against moisture and oxygen, which helps protect nutrient viability.*

- Over 50,000 Doctors Agree 
Designs for Health is the physician's choice for top quality professional strength supplements since 1989. Our "Science First" philosophy ensures our products are based on the most recent research and use the highest quality raw ingredients.

4.6 out of 5 - more than 490 global ratings

I purchased these enzymes based on my doctors suggesting and I am so glad I did. My body more tolerates all the meals and I also have less bloating. Even my boyfriend with ulcerative colitis loves them and is able to tolerate more meals as well.

5. NOW Supplements Pancreatin 2000

NOW Supplements Pancreatin 2000


- Digestive Support*
Pancreatin has naturally occurring protease (protein digesting), amylase (carbohydrate digesting), and lipase (fat digesting) enzymes.

- Assists Protein, Fat, and Carbohydrate Digestion* 
Pancreatin is a preparation of porcine pancreatic enzymes.

- Certifications or Classifications
Keto Friendly, Soy Free, Nut Free, Made without Gluten, Dairy Free, Egg Free

- GMP Quality Assured
NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation).

4.7 out of 5 - more than 450 global ratings

These work. I had bowel problems and was constantly going to the bathroom and now I go once a day by only taking one pill in the morning. I had my gallbladder removed over 10 years ago and eating certain foods would really make my stomach hurt and feel full. These have changed my life. Life is so much better with these pills. I will have them on auto order the next time I order them.

6. Source Naturals Pancreatin 8X

Source Naturals Pancreatin 8X


- Excellent Digestive Enzymes
Pancreatin is a mixture of pancreatic enzymes that support digestion.

- Well Made Supplement
Contains no yeast, dairy, egg, gluten, soy or wheat. Contains no preservatives, or artificial color, flavor or fragrance.

- Trusted for Over 35 Years
Source naturals was created in 1982 by ceo ira goldberg to support each individual's potential to enjoy optimal health. 

Suggested use. For digestive aid: 1 to 2 capsules immediately before a meal. For systemic aid: 1 to 2 capsules an hour before or after a meal.

4.6 out of 5 - more than 300 global ratings

Our functional medicine dr recommended pancreatic enzymes for optimal digestion. We've been through several brands and had several with ingredients we could not take due to allergies. This one was safe, and we both feel it has worked the best so far. It's a good price, too, based on what we've tried far. We are very pleased.


a. Digestive Enzymes Vs Probiotics

Probiotics and digestive enzymes are both required for a healthy digestive tract. Despite their different functions, they both work to promote digestive function and avoid gut imbalance. 

Digestive enzymes help to speed up digestion and enhance chemical processes in the digestive tract. Probiotics are living bacteria that serve to balance the environment of the gut so it can remain healthy and work properly.

b. What Foods Promote Healthy Pancreas?

- turmeric 
- garlic 
- chicken 
- wholegrain
- leafy green vegetables
- purple skin fruits 
- dandelion tea
- olive leaf extract 
- broccoli 
- sweet potato 


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