Which Antihistamine is Best for Histamine Intolerance
Histamine intolerance occurs when the body has difficulties breaking down histamine, resulting in symptoms such as headaches, hives, problems with digestion, and others.
Antihistamines can be used to relieve symptoms of histamine intolerance by blocking the effects of histamine. Common antihistamines include: First-generation Antihistamines (e.g., Diphenhydramine, Cetirizine) and Second-generation Antihistamines (e.g., Loratadine, Cetirizine, Fexofenadine).
Which Antihistamine is Best for Histamine Intolerance?
First Vs Second Generation Antihistamines
First-generation antihistamines block both histaminic and muscarinic receptors as well as passing the blood-brain barrier.- Advantages: Can be effective for treating symptoms, including allergic reactions and insomnia.
- Disadvantages: More likely to cause drowsiness and sedation due to their ability to cross the blood-brain barrier. They may also cause dry mouth and blurred vision. Long-term use may lead to tolerance.
On the other hand, second-generation antihistamines mainly block histaminic receptors and do not pass the blood-brain barrier.
- Advantages: Generally cause less sedation as they have limited penetration of the blood-brain barrier. They are often preferred for daytime use.
- Disadvantages: May still cause some drowsiness, especially in sensitive individuals. They are typically considered safer for long-term use.
Both first-generation and second-generation antihistamines are accessible without a prescription over-the-counter. Their safety profiles, however, might vary, so it's critical to use them as directed and consult with a healthcare professional to decide which one is best to address your symptoms.
Where to Find?
a. First-generation Antihistamines (e.g., Diphenhydramine)
1. Benadryl Ultratabs Allergy Relief, Diphenhydramine HCl 25 mg
This small, oval shaped coated tablets with the antihistamine diphenhydramine HCl provides relief for hay fever or other upper respiratory allergy symptoms & cold symptoms like sneezing & runny nose
Active ingredient (in each tablet)
Diphenhydramine HCl 25 mg (antihistamine) Inactive ingredients: Carnauba wax, croscarmellose sodium, D&C red no. 27 aluminum lake, dibasic calcium phosphate, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, titanium dioxide
Ratings: 4.8 out of 5 - more than 47,200 global ratings
Benedryl is a great drug for allergies and allergic reactions, so it's nice to have a nice quantity around in case of emergencies. The bottle is also much easier than the blister packs.
2. Amazon Allergy Relief, Diphenhydramine HCl 25 mg
These allergy relief tablets contain diphenhydramine HCl 25 mg, an antihistamine, which compares to the active ingredient in Benadryl Allergy Tablets.
One dose provides temporary allergy relief of runny nose, sneezing, itching of the nose or throat and itchy, watery eyes; also temporarily relieves runny nose and sneezing due to the common cold.
- mini-tabs are easy to swallow
- great size for travel
- gluten free
- for adults and children 6 years and over
Active ingredient (in each tablet)
Diphenhydramine HCl 25 mg. Purpose: Antihistamine. Inactive ingredients:carnauba wax, crospovidone, D&C red no. 27 aluminum lake, dibasic calcium phosphate dihydrate, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, pregelatinized starch, stearic acid, titanium dioxide.
Ratings: 4.8 out of 5 - more than 39,070 global ratings
Amazon’s allergy relief contains Diphenhydramine HCL as its active ingredient, the same as Benadryl. It works exactly the same as the name brand while costing a lot less. A household necessity, especially during the late-spring/early-summer when pollen counts are especially high and the cottonwood is falling as if it were snow.
b. Second-generation Antihistamines (e.g., Loratadine, Cetirizine)
3. Amazon Basic Care Allergy Relief Loratadine 10mg
The active ingredient is Loratadine 10 mg, an antihistamine; compare to the active ingredient in Claritin. One dose of Amazon Basic Care Loratadine Tablets 10 mg works for a full 24 hours to relieve your aggravating allergy symptoms
- non drowsy
- 24 hour relief
Active ingredient (in each tablet)
Loratadine 10 mg.
Inactive ingredients: lactose monohydrate, magnesium stearate, povidone, pregelatinized starch.
Ratings: 4.7 out of 5 - more than 20,000 global ratings
This allergy medicine works well for me, and the price on Amazon is better than what I can find locally, even at discount stores. I bought this to last an entire year. I’m thrilled with this purchase!
4. Claritin 24 Hour Allergy Medicine Loratadine 10mg
This Claritin pack contains 100 days of non drowsy allergy relief symptoms including sneezing, runny nose, itchy/watery eyes and itchy throat/nose.
Ingredient
Loratadine 10mg. corn starch, lactose monohydrate, magnesium stearate
Ratings: 4.8 out of 5 - more than 6,400 global ratings
Suffer from anxiety rash and this stops my itching right away..Clears up rash in less than 12hr.
5. Amazon Basic Care 24 Hour Allergy Relief, Cetirizine Hydrochloride Tablets
The active ingredient in Amazon Basic Care All Day Allergy is cetirizine hydrochloride, an antihistamine approved for the treatment of both indoor and outdoor allergy symptoms
Temporarily provides relief of symptoms due to hay fever or other upper respiratory allergies: runny nose, sneezing, itching of the nose or throat and itchy, watery eyes
Active ingredient (in each tablet)
Cetirizine HCl 10 mg. Purpose: Antihistamine. Inactive ingredients: corn starch, FD&C blue no. 1 aluminum lake, hypromellose, lactose monohydrate, magnesium stearate, polydextrose, polyethylene glycol, povidone, titanium dioxide, triacetin.
Ratings: 4.8 out of 5 - more than 56,000 global ratings
These allergy pills have the same concentration of active ingredients as the name brand version, for a fraction of the cost, and at least for me work just as well. Easy switch!
6. Zyrtec 24 Hour Allergy Relief Tablets, 10 mg Cetirizine HCI
Bundle pack containing one 30-count bottle and three 1-count travel packs of Zyrtec 24 Hour Allergy Tablets for powerful relief of your worst indoor & outdoor allergy symptoms, including runny nose, sneezing, itchy, watery eyes, & itchy nose & throat
Active ingredient (in each tablet)
Purpose Cetirizine HCl 10 mg
Antihistamine Inactive ingredients: colloidal silicon dioxide, croscarmellose sodium, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, polyethylene glycol, titanium dioxide
Ratings: 4.8 out of 5 - more than 8,000 global ratings
Great value and works great for my allergies. Fast delivered
FAQ
a. Histamine Intolerance Symptoms
Common symptoms of histamine intolerance:
headaches or migraines
nasal congestion or sinus issues
fatigue
hives
digestive problems, such as diarrhea
irregular menstrual cycle
nausea
vomiting
Symptom severity varies from person to person.
headaches or migraines
nasal congestion or sinus issues
fatigue
hives
digestive problems, such as diarrhea
irregular menstrual cycle
nausea
vomiting
Symptom severity varies from person to person.
People who have both allergies and a histamine intolerance may experience more severe allergic reactions because histamine levels in the body might accumulate. These can include asthma episodes or even anaphylactic shock, a serious, fast reaction that results in breathing difficulties and a drop in blood pressure that poses a life-threatening risk.
High amounts of histamine may be linked to significant chronic diseases like Crohn’s disease and can cause the heart to beat irregularly.
High amounts of histamine may be linked to significant chronic diseases like Crohn’s disease and can cause the heart to beat irregularly.
b. What Food Has the Highest Histamine?
Histamine levels are greater in the following foods:fermented foods (kefir, yogurt, kombucha, kimchi, sauerkraut, tempe, miso, sourdough bread)
alcohol, wine, beer, liquor
processed meat (hot dogs, ham, sausages, canned meat)
avocados
shellfish
aged cheese
bananas
tomatoes
wheat germ
beans
papaya
chocolate
citrus fruits
nuts, specifically walnuts, cashews and peanuts
food dyes and other additives
c. How to Clear Histamine From Body?
i. Start a diet that only involves foods and beverages with low amounts of histamine.ii. You can take histamine blockers or antihistamines might be used to temporarily ease the symptoms.
iii. Use air purifier. Reduce your exposure to irritable irritants and allergens in your environment by using an air purifier. Pet dander, dust, pollen, and mold spores are just a few examples of the allergens that air purifiers remove from the air in your surroundings.
iv. Natural Histamine Blocker. You might be able to regulate your seasonal allergies with natural antihistamines. Stinging nettle, vitamin C, quercetin, butterbur, bromelain, and probiotics are some examples. Exercise, acupuncture, and other complementary therapies may also help you control your symptoms. However, do not stop using antihistamines or start using herbal or dietary supplements before consult your doctor.
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