NAD+, NMN, and Niagen®: The Science-Backed Guide to Cellular Energy and Longevity (2026)

By Dr Frank Yap, MD

Introduction

NAD+ is one of the most important molecules for cellular energy, repair, and longevity. But there’s a lot of confusion about NAD+, NMN, NR, and liposomal supplements. In this guide, we’ll separate myths from science and show what actually works to support cellular health and healthy aging.

NAD+, NMN, and Niagen

Myth 1: You Can Take NAD+ Directly

Many products claim to boost NAD+ by supplying NAD+ itself. 

Reality: NAD+ is not orally bioavailable. Its large molecular size prevents it from entering cells intact. Oral NAD+ supplements are largely ineffective, so look for science-backed precursors like Niagen® (nicotinamide riboside).

Myth 2: NMN is More Effective than NR

NMN (nicotinamide mononucleotide) must first convert into NR (nicotinamide riboside) outside the cell before being absorbed. This extra step makes NMN less efficient. NR, in the patented Niagen® form, enters cells directly and is clinically proven to increase NAD+ levels.

Related: 10 Best NMN Supplements (2025 Review)

Myth 3: Liposomal Delivery Increases Absorption

Dry liposomal powders often degrade during manufacturing or digestion. Liquid liposomal NR or NAD+ supplements are unstable and can break down before ingestion. Research confirms that standard NR (Niagen®) is more reliable at increasing NAD+ than liposomal variants.

What Actually Works: Niagen®

Niagen® is the only patented, clinically studied form of NR. Backed by 35+ human clinical trials and 500+ published research papers, it is trusted by wellness experts, professional athletes, and researchers worldwide.

It is:

  • Science-backed: Clinically shown to increase NAD+ by up to 150%

  • Quality verified: Third-party tested for purity and consistency

  • Trusted: Used by leading researchers and wellness professionals

Cost vs. Effectiveness

Cheaper NAD+ or NMN supplements may degrade before reaching your cells or require extra metabolic steps. With Niagen®, you get direct, efficient, and clinically validated results, saving time, money, and uncertainty.

Related: NAC vs NAD vs NR vs NMN vs Niacin: What Are the Differences?

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