Quercetin Dihydrate vs Quercetin Anhydrous vs Quercetin Phytosome: What are the Differences?

Quercetin is a type of flavonoid present in many fruits, vegetables, and grains. It’s one of the most abundant antioxidants in the diet and plays an important role in helping your body combat free radical damage, which is linked to chronic diseases. In addition, its antioxidant properties may help reduce inflammation, allergy symptoms, and blood pressure.

Some doctors are advocating its use against SARS-CoV-2 (COVID-19), in combination with vitamin C, noting that Quercetin and Vitamin C have synergistic effects.



Quercetin supplements come in different forms. There are many quercetin forms available out there. Which one is better and which one should you buy? 

Quercetin phytosome vs Quercetin dihydrate

On its own, quercetin has a low bioavailability, which means your body absorbs it poorly. 

That’s why the supplements may include other compounds, such as vitamin C or digestive enzymes like bromelain, as they may increase absorption.

Additionally, some research indicates that quercetin has a synergistic effect when combined with other flavonoid supplements, such as resveratrol, genistein, and catechins.

A new food-grade lecithin-based formulation of quercetin, Quercetin Phytosome, was developed and validated in healthy volunteers. Quercetin Phytosome overcomes the low bioavailability hurdle of quercetin and should help to fulfill the great health benefit potential of this flavonoid in the diet and as food supplements.

Most in vitro studies used a form of quercetin called 'quercetin aglycone'. However, this particular form of quercetin is never found in the blood, even after ingested, as it it gets changed in the liver.

According to Examine, the quercetin dihydrate form has the apparent best bioavailability followed by glycosides, aglycone, and finally rutinoside.

Quercetin Anhydrous vs Quercetin Dihydrate

Most of the quercetin ingredients on the market are in the quercetin dihydrate form. Quercetin anhydrous and dihydrate differ in the amount of water they contain. Quercetin anhydrous contains only 1% to 4% moisture and the sugar molecules that are attached to quercetin in its natural form have been extracted. This translates into 13% more quercetin per gram for quercetin anhydrous vs quercetin dihydrate. For formula manufacturers, this means there is substantially less bulk per capsule or tablet.

Quercetin Dihydrate vs Quercetin

The key difference between quercetin and quercetin dihydrate is that quercetin is a plant flavonoid, whereas quercetin dihydrate is a synthetic chemical compound. Moreover, quercetin is a yellow crystalline powder, whereas quercetin dihydrate is a bright yellow colour powder.

Quercetin Dihydrate has the highest bioavailability when it comes to quercetin supplements.

According to Examine.com, this form is preferable to glycosides, aglycone and rutinoside versions.

Best Quercetin Supplements 2021

Check out below the best quercetin supplement available online. Order via the links below and it will be delivered to your designated address by Amazon. 

1. Now Foods Quercetin with Bromelain

$30 - $35 > Check Price 

A two-pack of top notch bromelain-enhanced quercetin from a giant in the health supplement industry. Reliable quality from a trustworthy brand.

Each capsule contains 400 mg of quercetin and 82.5 mg of bromelain. Do take note that their suggested usage is 2 capsules twice daily. Meaning the total daily dosage of quercetin will be 1,600 mg.

Daily value (DV) for quercetin not established.

BestReviews.com: Not suitable for those with pineapple allergies.

Amazon Best Sellers: #1 Best Seller in Bromelain Nutritional Supplements. 4.7 out of 5 overall rating with more than 5,000 customer reviews.

Our Take: If you are looking for best value and are taking it on a long term basis, this would be your choice.

2. Thorne Research Quercenase 

Price: $38 > Check Price on Amazon 

Quercenase is a combination of quercetin phytosome and bromelain. Quercetin phytosome is a new food-grade lecithin-based formulation of quercetin, was developed to overcome the low bioavailability hurdle of quercetin. Phytosome complexes are created by a patented process that binds a botanical extract to a phospholipid (phosphatidylcholine), which are key components of every cell membrane.

Each capsule contains 250 mg of quercetin phytosome and 100 mg of bromelain.

BestReviews.com: Pricier than many similar products on the market

Amazon Best Sellers: #11 Best Seller in Flavonoid Vitamin Supplements. 4.7 out of 5 overall rating with more than 390 customer reviews.

Our Take: If you are looking to buy from a reputable brand, this would be your choice.

3. Pure Encapsulations Quercetin


Our Take: A hypoallergenic, pure quercetin supplement suitable for those with tendency of allergies.

BestReviews.com: Dosage is somewhat low and the pills are relatively expensive.

Amazon Best Sellers: #4 Best Seller in Flavonoid Vitamin Supplements. 4.8 out of 5 overall rating with more than 600 customer reviews.

4. BlueBonnet Super Quercetin and Bromelain

$36 - $40 > Check Price 

A potent blend of antioxidants and natural ingredients to ease allergies and boost immune response. Non-GMO and free of common allergens.

Amazon Best Sellers: #21 Best Seller in Flavonoid Vitamin Supplements. 4.8 out of 5 overall rating with more than 190 customer reviews.

Our Take: If you are looking for a potent antioxidant blend, this would be suitable for you.

5. Natural Factors Bioactive Quercetin

$22 - $25 > Check Price 

Natural Factors Bioactive Quercetin EMIQ claims to have 40 times better absorption than ordinary quercetin. Other quercetin supplements here use bromelain to boost bioavailability, but this supplement uses “EMIQ”, a proprietary formula made from “Enzymatically Modified IsoQuercetin”.

Amazon Best Sellers: #25 Best Seller in Flavonoid Vitamin Supplements. 4.8 out of 5 overall rating with more than 290 customer reviews.

Amazon Review: "This literally took away all of my excessive histamine responses within a couple of hours. the second day got even better. If you suffer from allergies or inflammation and would like a natural option, please consider this." - Sparklebarbie

Our Take: Best Quercetin for Bioavailability

6. Mt. Angel Quercetin Zinc Immune Support Supplement – with Vitamins C & D3, Bromelain

Each capsule contains key ingredients that are similar to Dr Zelenko's Z-Stack Supplement. The cost is around $53 for 300 vegetarian capsules.

> Check Price

Our Take: Best Quercetin in Combination for Immune Support


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