Quercetin Dihydrate vs Quercetin Anhydrous vs Quercetin Phytosome: What are the Differences?

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Quercetin is a type of flavonoid present in many fruits, vegetables, and grains. It’s one of the most abundant antioxidants in the diet and plays an important role in helping your body combat free radical damage, which is linked to chronic diseases. In addition, its antioxidant properties may help reduce inflammation, allergy symptoms, and blood pressure.



Quercetin supplements come in different forms. There are many quercetin forms available out there. Which one is better and which one should you buy? 

Quercetin phytosome vs Quercetin dihydrate

On its own, quercetin has a low bioavailability, which means your body absorbs it poorly. 

That’s why the supplements may include other compounds, such as vitamin C or digestive enzymes like bromelain, as they may increase absorption.

Additionally, some research indicates that quercetin has a synergistic effect when combined with other flavonoid supplements, such as resveratrol, genistein, and catechins.

A new food-grade lecithin-based formulation of quercetin, Quercetin Phytosome, was developed and validated in healthy volunteers. Quercetin Phytosome overcomes the low bioavailability hurdle of quercetin and should help to fulfill the great health benefit potential of this flavonoid in the diet and as food supplements.

Most in vitro studies used a form of quercetin called 'quercetin aglycone'. However, this particular form of quercetin is never found in the blood, even after ingested, as it it gets changed in the liver.

According to Examine, the quercetin dihydrate form has the apparent best bioavailability followed by glycosides, aglycone, and finally rutinoside.

Quercetin Anhydrous vs Quercetin Dihydrate

Most of the quercetin ingredients on the market are in the quercetin dihydrate form. Quercetin anhydrous and dihydrate differ in the amount of water they contain. Quercetin anhydrous contains only 1% to 4% moisture and the sugar molecules that are attached to quercetin in its natural form have been extracted. This translates into 13% more quercetin per gram for quercetin anhydrous vs quercetin dihydrate. For formula manufacturers, this means there is substantially less bulk per capsule or tablet.

Quercetin Dihydrate vs Quercetin

The key difference between quercetin and quercetin dihydrate is that quercetin is a plant flavonoid, whereas quercetin dihydrate is a synthetic chemical compound. Moreover, quercetin is a yellow crystalline powder, whereas quercetin dihydrate is a bright yellow colour powder.

Quercetin Dihydrate has the highest bioavailability when it comes to quercetin supplements.

According to Examine.com, this form is preferable to glycosides, aglycone and rutinoside versions.

Best Quercetin Supplements

Check out below the best quercetin supplement available online. Order via the links below and it will be delivered to your designated address by Amazon. 

1. Thorne Research Quercenase 

Price: $35.90 > Check Price

Quercenase is a combination of quercetin phytosome and bromelain. Quercetin phytosome is a new food-grade lecithin-based formulation of quercetin, was developed to overcome the low bioavailability hurdle of quercetin. Phytosome complexes are created by a patented process that binds a botanical extract to a phospholipid (phosphatidylcholine), which are key components of every cell membrane.

Each capsule contains 250 mg of quercetin phytosome and 100 mg of bromelain.

BestReviews.com: Pricier than many similar products on the market

Amazon Best Sellers: #11 Best Seller in Flavonoid Vitamin Supplements. 4.7 out of 5 overall rating with more than 390 customer reviews.

Our Take: If you are looking to buy from a reputable brand, this would be your choice.

2. BlueBonnet Super Quercetin and Bromelain

$36 - $40 > Check Price 

A potent blend of antioxidants and natural ingredients to ease allergies and boost immune response. Non-GMO and free of common allergens.

Amazon Best Sellers: #21 Best Seller in Flavonoid Vitamin Supplements. 4.8 out of 5 overall rating with more than 190 customer reviews.

Our Take: If you are looking for a potent antioxidant blend, this would be suitable for you.

3. Natural Factors Bioactive Quercetin

$22 - $25 > Check Price 

Natural Factors Bioactive Quercetin EMIQ claims to have 40 times better absorption than ordinary quercetin. Other quercetin supplements here use bromelain to boost bioavailability, but this supplement uses “EMIQ”, a proprietary formula made from “Enzymatically Modified IsoQuercetin”.

Amazon Best Sellers: #25 Best Seller in Flavonoid Vitamin Supplements. 4.8 out of 5 overall rating with more than 290 customer reviews.

Amazon Review: "This literally took away all of my excessive histamine responses within a couple of hours. the second day got even better. If you suffer from allergies or inflammation and would like a natural option, please consider this." - Sparklebarbie

Our Take: Best Quercetin for Bioavailability

4. MoxyVites Quercetin with Bromelain 

$35 > Check Price

Moxyvites quercetin complex is a combination of quercetin phytosome and bromelain. Regular quercetin has poor solubility and low oral absorption. Moxyvites' technology binds quercetin with a glucose bond & incorporation of phospholipids into standardized extracts improving the absorption and bioavailability by 20X. Their complex delivery system utilizes phytosome technology in which phytoconstituents react with phospholipids for better and improved bioavailability.

Amazon Best Sellers: #31 Best Seller in Flavonoid Vitamin Supplements. 4.8 out of 5 overall rating.

Our Take: If you are looking for best value in terms of quercetin phytosome with bromelain and are taking it on a long term basis, this would be your choice. 

5. Amazing Formulas Quercetin 

$12 - $18 > Check Price

Amazon Best Sellers: #1 Best Seller in Flavonoid Vitamin Supplements. 4.7 out of 5 overall rating with more than 12,000 customer reviews.

Amazon Review : "I've been sick twice in the past two months, one a mild cold, the other quite severe, DID NOT GET TESTED so can not attest to Covid 19. Anyway, once I got sick, I took 1000mg of Quercetin, combined with 200mg of Zinc Picolinate - ANECDOTAL EVIDENCE: I was free and clear of symptoms in the range of 6 to 10 hours, save for a lingering itch in my sinuses, which was gone after a good night sleep. Symptoms did not return in either case. This was ONE DOSE."

Our Take: If you are looking for best value in terms of quercetin suitable for vegetarians and vegans; and are taking it on a long term basis, this would be your choice. 


Related Articles

Quercetin vs Curcumin (Turmeric)

Quercetin vs Astaxanthin

Isoquercetin vs Quercetin


Comments

Unknown said…
So is dihydrate or phytosome more bioavalible?
February 10, 2022 at 5:30 AM
Unknown said…
Article states phytosome is most easily absorbed then goes back on that claiming dehydrate is the best without even comparing to phytosome. I'm confused about that section.
February 10, 2022 at 5:31 AM
Jeff State said…
It's now September of 2023 and plenty more research is available about Quercetin Dihydrate vs. Phytosome bioavailability.

Online blog articles do not yet exist that are in-depth about the comparison, citing quantitative research. If you could please parse the latest PubMed articles and summarize the research as a medical doctor, this article would become and remain the top result for Quercetin-related keywords.
September 3, 2023 at 8:30 PM
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