Z Stack and Zelenko Protocols: Review

By
The Zelenko COVID-19 Protocols was developed by Dr Vladimir Zelenko. The protocol has as its centerpiece, but not exclusive piece, the combined use of Hydroxychloroquine (HCQ) and Zinc as a means by which a person can both help to prevent or mitigate the contraction of COVID-19, or can actually treat the disease once it has been diagnosed. 

A retrospective study analyzing Dr Zelenko's patient data was accepted for publication after a rigorous peer review process. The study finds that early intervention and treatment of high-risk patients with COVID-19 resulted in significantly fewer hospitalizations and deaths. The treatment consisting of zinc, low-dose hydroxychloroquine (HCQ), and azithromycin, is also referred to as "The Zelenko Protocol." Dr Zelenko has since updated his protocols to incorporate new evidence.

He has since evolved his protocols to include a quercetin, zinc, vitamin D and C protocol for low-risk patients as well as guidelines for COVID-19 prevention. 
Z STACK Zelenko
In an effort to make it easier for patients, Dr Zelenko has developed an oral supplement that contains all four key ingredients: vitamin C, quercetin, vitamin D3 and zinc. It’s referred to as 'Z-Stack Supplement'.

Z-Stack Vitamin cocktail provides key ingredients needed in order to help your body fight off this deadly invader. 

The cost of the Z-STACK vitamin cocktail is $55 per bottle for a one month supply. 

Where to buy Z-Stack: Z-stack is available on Dr Zelenko's website. Here is the link: Z Stack Supplement 

Note: To get 5% OFF, please use this coupon code: DRFRANCIS

zelenko protocol

Zelenko COVID-19 Prophylaxis Protocol

The Zelenko prophylaxis protocol is sub-divided into:
  1. Prevention Protocol for Low and Moderate Risk Patients
  2. Prevention Protocol for High Risk Patients
Prophylaxis is an action taken to prevent or protect against a specified disease. Greek in origin, from the word "phylax", meaning "to guard" and "watching." 
  
Low Risk Patients 

Young healthy people do not need prophylaxis against COVID-19. In young and healthy people, this infection causes mild cold-like symptoms. It is advantageous for these patients to be exposed to Covid-19, build up their antibodies and have their immune system clear the virus. This will facilitate the development of herd immunity and help prevent future Covid-19 pandemics. However, if these patients desire prophylaxis against Covid-19, then they should take the protocol noted below. 

Moderate Risk Patients 

Patients from this category are healthy but have high potential viral-load exposure. This group includes medical personnel, caregivers of high-risk patients, people who use public transportation, first responders and other essential personnel who are crucial to the continued functioning of society. These patients should be encouraged to take prophylaxis against Covid-19 in accordance with the protocol noted below. 

High Risk Patients 

Patients are considered high risk if they are over the age of 45, or if they are younger than 45 but they have co-morbidities, that is, they have other health conditions that put them at risk. These patients have between a 5 to 10% mortality rate if they are infected with COVID-19. These patients should be strongly encouraged to take prophylaxis against COVID-19 in accordance with the protocol noted below.

Protocol for Low and Moderate Risk Patients: 

If Quercetin is unavailable, then use Epigallocatechin-gallate (EGCG) 400mg 1 time a day  (J. Agric. Food Chem. 2014) 

Protocol for High Risk Patients:
Zelenko vs FLCCC I-MASK+ protocol for prevention

In addition to what is recommended by the zelenko protocol, the FLCCC I-MASK+ prevention protocol includes mouthwash, melatonin and ivermectin as part of the prevention protocol. However, the I-MASK+ prevention protocol does not categorise the patients into low risk or high risk and does not include hydroxychloroquine. For the zelenko protocol, hydroxychloroquine is only recommended for those in high risk category.

Clinical evidence to date has reported promising results for Ivermectin in prevention, early treatment as well as late treatment for COVID-19. While both Ivermectin and Hydroxychloroquine might be useful for early treatment, Ivermectin has a broader potential benefit i.e. prevention, early treatment as well as late treatment / hospital treatment.

Can hydroxychloroquine and ivermectin be used together? The 2 drugs do not seem to have a between-drug interaction. However, no in vitro or in vivo studies have been conducted on the combined effect of HCQ and ivermectin on COVID-19 infection. 

Quercetin is a viable stand-in, if you simply cannot get hydroxychloroquine or ivermectin. Quercetin works best when taken with vitamin C and Bromelain, as vitamin C helps activate it and bromelain helps with the absorption. Do not forget to combine it with zinc.

Although ivermectin and hydroxychloroquine are relatively safe drugs, they are still synthetic chemicals that can have side effects. Quercetin and Vitamin D, C, Zinc are nutrients that your body require for optimal health. Nutrients are safer alternatives especially if your risk is low e.g. age below 50 and no other chronic illness. Discuss with your doctor on the benefit vs risk for each treatment. If you are on multiple medications, be aware of supplement-drug interactions that might enhance the possibilities of adverse effects.

Zelenko Protocol - Treatment Plan for Patients with COVID-19 symptoms

Fundamental Principles (Dr Zelenko Protocol When to Start)

Treat patients based on clinical suspicion as soon as possible, preferably within the first 5 days of symptoms. Perform PCR testing, but do not withhold treatment pending results.

Patient Categories

Low risk patient - Younger than 45, no co-morbidities, and clinically stable
High risk patient - Older than 45, younger than 45 with co-morbidities, or clinically unstable

Treatment Options

Low risk patients - over the counter options:


1. Elemental Zinc 50mg 1 time a day for 7 days (PubMed)

2.1. Quercetin 500mg 2 times a day for 7 days (PubMed) OR

2.2. Epigallocatechin-gallate (EGCG) 400mg 1 time a day for 7 days (J. Agric. Food Chem. 2014)

3. Vitamin C 1000mg 1 time a day for 7 days 
4. Vitamin D3 5000iu 1 time a day for 7 days 


Moderate / High risk patients
  • Elemental Zinc 50-100mg once a day for 7 days 
  • Vitamin C 1000mg 1 time a day for 7 days 
  • Vitamin D3 10000iu once a day for 7 days or 50000iu once a day for 1-2 days 
  • Azithromycin 500mg 1 time a day for 5 days or
  • Doxycycline 100mg 2 times a day for 7 days
  • Hydroxychloroquine (HCQ) 200mg 2 times a day for 5-7 days (ScienceDirect) and/or
  • Ivermectin 0.4-0.5mg/kg/day for 5-7 days (ivmmeta.com). Either or both HCQ and IVM can be used, and if one only, the second agent may be added after about 2 days of treatment if obvious recovery has not yet been observed etc. (Find a Doctor)
If HCQ (hydroxychloroquine) is not available, Quercetin 500mg 3 times a day for 7 days OR EGCG 400mg 2 times a day for 7 days.

Both protocols can be viewed from his website.

Note on Zinc supplements: 
  • How much zinc you should take per day depends on the type and forms of zinc, as each supplement contains a different amount of 'elemental zinc'. The percentage of elemental zinc varies by form. 
  • For example, approximately 23% of zinc sulfate consists of elemental zinc; thus, 220 mg of zinc sulfate contains 50 mg of elemental zinc (Ref). Zinc picolinate (20% of elemental zinc), zinc ascorbate (15%), zinc chloride (48%), zinc carbonate (52%), zinc citrate (31%), zinc bisglycinate (25%) (Ref) and zinc gluconate (14%) and zinc oxide (80%) (Ref).
  • Zinc sulfate​ is an inorganic form of zinc. Inorganic zinc is not as effective or useable by your body as chelated zinc sources. The best form of zinc is one that's chelated to ensure absorbability. 
  • Zinc gluconate​ and zinc glycinate are some of the popular chelated forms of over-the-counter supplements. Zinc acetate is the best zinc supplement to treat the ​common cold​. Findings of a study published in Open Forum Infectious Diseases in 2017 recommended using acetate lozenges within 24 hours of the onset of a cold for a three-fold increase in the rate of recovery.
Zelenko vs FLCCC I-MASK+ protocol for treatment

In addition to what is recommended by the zelenko protocol, the FLCCC I-MASK+ treatment protocol includes mouthwash, melatonin and ivermectin and incorporates repurposed and newer agents like anti-androgens (spironolactone, finasteride and dutasteride), fluvoxamine and monoclonal antibodies as part of the treatment protocol. The I-MASK+ treatment protocol also categorises the treatment agents into first line agents and second line agents for those who do not respond to first line agents and for those high risk patients with co-morbidities.

Many successful studies utilised both ivermectin and hydroxychloroquine in combination. Further, the Zelenko protocol recommends that both hydroxychoroquine and ivermectin can be used together, especially for high risk patients. If you have started with only one, the second agent may be added after about 2 days of treatment if obvious recovery has not yet been observed.

Where to buy Z-Stack: Z-stack is available on Dr Zelenko's website. Here is the link: Z Stack Supplement 

Note: To get 5% OFF, please use this coupon code: drfrancis

 

Comments

Post a Comment

Popular posts from this blog

NAC vs NAD vs NR vs NMN vs Niacin: What Are the Differences?

By
Image
NAC vs NAD vs Niacin vs NR vs NMN . Due to the small alphabetical differences, these supplements are often mixed up and confused by most consumers. We will cover the essentials and explain about each of these supplements below. Contents NAD NAD vs NAD+ NAD+ for Anti Aging NAD+ Helps Restore Age-Related Muscle Deterioration NAD and Resveratrol NAD Supplements NAC Niacin (NA) NR NMN NAC vs NMN Gluthatione vs NAC NAC vs Niacin NR vs NMN Can you take NR and NMN together? Niacin vs NR vs NMN Stability and Storage of NMN and NR Naturally Boosting NAD Levels Related Articles NAD NAD is a type of coenzyme found in all living cells. NAD plays important roles in a variety of metabolic reactions, including energy production and DNA repair. NAD is derived from Nicotinamide Riboside (NR) and various other precu...
Read more

18 Best Supplements to Reduce Cytokine Storm: Advanced Guide

By
Image
As of May 2024, there are more than 4,000 early treatment studies  that have been published and shared with the whole world. New ones are being added every day.  This is a review of the literature, covering multiple observational studies, randomized controlled trials and references related to natural supplements and cytokine storm with more than 300 studies and references. We know that while a large percentage of the population only experiences mild to moderate symptoms of COVID-19 and won’t require hospitalization, others experience severe symptoms and complications, require hospitalization, or may even die.  It appears one of the differences between those who have a mild illness and severe illness is related to the body's ability to reduce the hyperimmune response that leads to a cytokine storm and the hyper-coagulability (tendency for blood clots) that often accompanies it. The cytokine storm may be one possible way to ex...
Read more

12 Best Vitamin D3 Supplements of 2024

By
Image
Vitamin D is a fat-soluble vitamin, meaning that it dissolves in fats and oils and can be stored in your body for a long time. Two main dietary forms exist: Vitamin D3 (cholecalciferol). Found in some animal foods, like fatty fish and egg yolks. Vitamin D2 (ergocalciferol). Found in some plants, mushrooms, and yeasts. The Global Vitamin D Market size was worth US$ 1.1 billion in 2022 ( R ), and it is estimated to reach a valuation of US$ 1.7 billion by the end of 2028, expanding at an annual compound rate of 7.0% between 2023 and 2028. What is Vitamin D Good For? Vitamin D helps keep you bones strong by aiding in the absorption of calcium and phosphorus. It's involved in maintaining a healthy immune system, mood regulation, heart health, and even weight loss .  What is the Best Form of Vitamin D?  Vitamin D is a fat-soluble vitamin, meaning that it does not dissolve in water and is absorbed best in your bloodstre...
Read more

Zinc Gluconate vs Zinc Picolinate: What's the Difference?

By
Image
Zinc picolinate and zinc gluconate are forms of dietary supplements that we use to prevent zinc deficiency.  Zinc  is an essential mineral that our body can easily absorb. Therefore, if we do not get enough amount of zinc, we may have to take these dietary supplements as directed by the doctor. When choosing a zinc supplement, it’s important to consider the type of zinc, dosage, and supplement form. Types of Zinc Supplements   There are several types of zinc supplements. Supplements contain several forms of zinc, including zinc gluconate, zinc citrate and zinc picolinate. The percentage of elemental zinc varies by form.  Chelated zinc is a general form of supplementary zinc in which the zinc is chelated — or bound — to a compound to make it easier for the body to absorb. Zinc picolinate or zinc gluconate are formed when zinc is chelated to picolinic acid or glucon...
Read more

10 Best NMN Supplements (2024 Review)

By
Image
NMN stands for nicotinamide mononucleotide and is a precursor to NAD+, or nicotinamide adenine dinucleotide. NMN is the direct precursor of the essential molecule nicotinamide adenine dinucleotide (NAD+) and is considered a key component to increase NAD+ levels in cells. NAD+ is a critical molecule found in every cell of your body, but levels of NAD+ naturally fall with age, making it — and NMN, as a result — crucial. NMN is one of the most popular supplements in the anti aging community. The global Nicotinamide Mononucleotide (NMN) market was valued at US$ 98.5 million in 2019 and it is expected to reach US$ 296.5 million ( R ) by the end of 2026, growing at a CAGR (Compound Annual Growth Rate) of 7.3% during 2021-2026. The NAD story took off toward the end of 2013 with a  high-profile paper  by Harvard's David Sinclair and colleagues. Sinclair, recall, achieved fame in the mid-2000s for research on yeast and mice that suggested the red wine ing...
Read more

Dr. Zelenko's Z-Stack Vitamin Cocktail: Review 2024

By
Image
The  Zelenko COVID-19 Protocols  was developed by Dr Vladimir Zelenko. The protocol has as its centerpiece, but not exclusive piece, the combined use of Hydroxychloroquine (HCQ) and Zinc as a means by which a person can both help to prevent or mitigate the contraction of  COVID-19 , or can actually treat the disease once it has been diagnosed.  A  retrospective study  analyzing Dr Zelenko's patient data was accepted for publication after a rigorous peer review process. The study finds that early intervention and treatment of high-risk patients with COVID-19 resulted in significantly fewer hospitalizations and deaths. The treatment consisting of zinc, low-dose hydroxychloroquine (HCQ), and azithromycin, is also referred to as "The Zelenko Protocol." Dr Zelenko has since updated his protocols to incorporate new evidence. He has since evolved his protocols to include a quercetin, zinc, vitamin D and C protocol for low-ris...
Read more

I-LONGEVITY Protocol: Anti Aging Guide to Help People Prevent and Reverse Aging (2024)

By
Image
Contents Methodology What is Aging? Biological Age vs Chronological Age Causes of Aging and Hallmarks of Aging What is Cell Senescence? What is Epigenetics? Diet and Lifestyle for Anti Aging Avoiding Sugar and Ultra-processed Foods Mediterranean Diet and Vegetables Avoiding Smoking and Alcohol Stress Management Avoiding Linoleic Acid (Omega-6 Fatty Acids) and Vegetable Oil Exercise, Resistance Training and Walking Sleep Social Support Caloric Restriction, Intermittent fasting (Time Restricted Eating) and Fasting Best Scientifically Proven Anti Aging Supplements Vitamin D3 and K2 Glycine, NAC and Taurine B Vitamins, Nicotinamide mononucleotide (NMN) and NAD Boosting Supplements Omega-3 fatty acids Magnesium and Molecular Hydrogen Curcumin (Turmeric) Vitamin C CoQ10 Zinc EGCG (Green Tea) Lutein and Zeaxanthin Glucosamine and Chondroitin Protein Powder and Collagen Spermidine Crocin (Saffron) Cocoa Creatine Melatonin Other Promising Interventions for Longevity Stem Cell Therapy for Anti-A...
Read more

Private Hospital and Government Hospital Charges in Malaysia

By
Image
Ever wondered How Much Does It Cost to be admitted in a private hospital or a government hospital in Malaysia? Find out and compare hospital charges below. Although the numbers and statistics are everywhere on the internet, we have compiled and organised the information accordingly in one place. The pricing information below is based on the published prices from major centres and pricing information available on blogs and the internet. Here is the list, categorised by Government Hospital Charges and Private Hospital Charges. GOVERNMENT HOSPITAL CHARGES IN MALAYSIA The average cost of popular medical procedures in public hospitals in Malaysia: Angioplasty: RM 200 Cataract: RM 500 / eye Chemotherapy: RM 200/visit Dengue: F.O.C. Heart Bypass: RM 4,000 Hip Replacement: RM 15,000 Kidney Stone: RM 10,000 Spine Surgery: RM 36,000 Stroke: RM 5,000 Additional Medical Costs That You May Need to Pay For Of course, the costs of the medical procedures above aren’t the onl...
Read more

Black Seed Oil and COVID-19: Studies found Nigella Sativa may help in treatment for COVID-19 infection

By
Image
2023 Update: As of August 2023, there are more than 10 published studies of nigella sativa for treatment and prevention of COVID-19 ( c19ns.com ).  Australian Researchers found Nigella Sativa may help in treatment for COVID-19 infection A team from the University of Technology in Sydney found an active ingredient of Nigella sativa or Kalonji can prevent the SARS-CoV-2, the virus leading to COVID-19, from causing a lung infection. Their study is published in the journal Clinical and Experimental Pharmacology and Physiology . Australian researchers have found that seeds of the plant, Nigella sativa , better known as Kalonji, could be utilised in the treatment of COVID-19 infection. Black seed oil is extracted from Nigella sativa seeds and has been used in traditional medicine for over 2,000 years due to its many therapeutic benefits. The flowering plant, native to north Africa and western Asia, has been used for centuries as a traditional remedy for multip...
Read more

Vitamin D 25 Hydroxy and Vitamin D 1 25 Dihydroxy: What's the Difference?

By
Image
Vitamin D is more than just one vitamin. It’s a family of nutrients that shares similarities in chemical structure. Vitamin D helps your body absorb calcium and maintain strong bones throughout your entire life. Your body produces vitamin D when the sun’s UV rays contact your skin. Other good sources of the vitamin include fish, eggs, and fortified dairy products. It’s also available as a dietary supplement. In your diet, the most commonly found members are vitamin D2 and D3. While both types help you meet your vitamin D requirements, they differ in a few important ways. Research even suggests that vitamin D2 is less effective than vitamin D3 at raising blood levels of vitamin D. Dietary vitamin D comes in two main forms: Vitamin D2 (ergocalciferol) Vitamin D3 (cholecalciferol) The two forms of vitamin D differ depending on their food sources. Vitamin D3 is only found in animal-sourced foods, whereas D2 mainly comes from plant sources and fortified foods. Your skin makes vitamin D3 whe...
Read more