5 Best Diamine Oxidase Supplement 2023

Diamine oxidase (DAO) is an important digestive enzyme in your body to break down histamine obtained from foods.

You might have diamine oxidase insufficiency if your body doesn’t make enough DAO. ‌Moreover, you may also develop histamine intolerance, also known as food histaminosis or enteral histaminosis, if you don’t have enough of this enzyme. When you consume histamine-containing meals, this may make you feel sick.

Fortunately, DAO is available as a supplement and has been widely used for treating people with histamine intolerance (HIT). A study suggests oral supplementation of the enzyme DAO before meals could help improve HIT-related symptoms and symptom intensity in HIT.

Best Diamine Oxidase Supplement

1. Bravado Labs Diamine Oxidase Supplement for Food-Derived Histamine Intolerance

Bravado Labs Diamine Oxidase Supplement for Food-Derived Histamine Intolerance

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– Eat Histamine-rich Foods
If wine and cheese parties end with you sniffling, sneezing, or worse, Bravado Labs histamine block can help by increasing your levels of DAO, which in turn helps your body to break down histamines commonly found at high levels in alcohol, cheese, certain vegetables, shellfish, smoked meats, and other fermented foods.

– Reduce Histamines on the Go
With this small, 30-capsule bottle of our DAO supplement, you can add DAO whenever the occasion calls for it. Just take one capsule 15-30 minutes prior to consuming histamine-rich or DAO-blocking food or drink.

– Relief in One Capsule
While other histamine blocking or DAO supplements may require you to take multiple capsules, our Bravado Labs formulation provides the antihistamine power you need with just one capsule.

– Made the Right Way
Each capsule is vegan friendly, gluten free, and contains no major food allergens with entirely non-GMO ingredients.

– Feel the Difference
If high-histamine foods make you miserable, our histamine block may be able to lessen or eliminate your symptoms. If you’re not satisfied with the results, just let us know within 30 days for a full refund. Eat, drink and be merry – order yours today and alleviate your histamine intolerance!

Bravado Labs Diamine Oxidase Supplement Review
I noticed this worked the first time I used it. I take it 15 to 30 minutes before a meal. My stomach does not blow up so much. I always start swelling when eating my first meal. By the time it’s dinner time, my stomach is so bloated it felt like I was pregnant and my clothes even fit tight in the waist. So I wear stretchy pants. I bought the second bottle because it relieved my belly bloat and pain so much I have been very happy with Histamine Block. Thank you!

2. Omne Diem DAO Histamine Neutralizing Enzyme

Omne Diem DAO Histamine Neutralizing Enzyme

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– Digestive Enzymes for Histamine Intolerance
An effective enzyme solution to histamine intolerance and imbalance.
Alcoholic beverages – particularly red wine – present a triple threat to histamine sensitive people, because they contain histamine, they liberate histamine, and they block the action of dao. Diamine oxidase (dao) is your body’s first-line defense against histamine ingested through the diet or released within the gut.

– Natural Ingredients
Omne diem direct histamine neutralizing enzyme is gluten-free, non-GMO, soy-free, non-dairy, food grade diamine oxidase – with no artificial preservatives or sweeteners.

How to Use:
Take omne diem direct histamine neutralizing enzyme about 15-30 minutes prior to consuming high histamine foods and beverages, to help your body break down histamine and reduce the allergy-like reactions of histamine intolerance.

Omne Diem Diamine Oxidase Supplement Review
I developed histamine problems after going on an extreme keto diet for years eating (spinach, avocado, aged cheese, bone broth, aged meats, green tea) every day for about two years. This product gave me my old stomach back, no more histamine issues. Best decision I made. Strongly recommend it.

3. Healthy Habits Living Histamine Manager

Healthy Habits Living Histamine Manager

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Histamine Manager contains 20,000 HDU per serving of the active digestive enzyme Diamine Oxidase (DAO) responsible for neutralizing histamine in your digestive tract.

Supplement with Histamine Manager to increase available DAO during digestion. Eat and drink with ease and confidence. Histamine Manager allows you to enjoy histamine-releasing foods and -more especially- red wine. If you are sensitive to histamine, you know that red wine contains histamine, liberates histamine, and blocks the action of DAO. If you want to avoid a histamine reaction, headache, or allergy-like reaction, take 1-2 capsules up to 15 minutes before you eat a meal, snack or drink alcohol.

Healthy Habits Digestive Enzyme Review
Histamine Manager allows me to eat the foods I enjoy (potatoes, tomatoes, peppers, citrus, spinach, nuts) without getting a stuffy nose. I carry some with me where ever I go.

4. Histazyme from Dr. Amy Myers - DAO Enzyme Supplement

Histazyme from Dr. Amy Myers - DAO Enzyme Supplement

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– Histazyme Works Like a Charm!
If you’ve been told that you have an intolerance to dietary histamine, or have discovered that fact out for yourself, following a low histamine diet can assist you in managing uncomfortable symptoms. Diamine Oxidase can help break down ingested dietary histamine, thereby eliminating the histamine buildup and immune response and uncomfortable symptoms associated with it.

– Supports a Healthy Immune & Inflammatory Response to Ingested Histamine
If you find that certain foods seem to be triggering headaches, dizziness, flushing in the face neuropathy, sinus issues and more, than histamine intolerance may be the culprit. They may also block the activity of DAO, the enzyme which is responsible for breaking down histamine in the gut.

– Clinically Proven to Break Down Food-derived Histamine in the Digestive Tract
Formulated to break down food-derived histamine only. This means that you can take it before meals to help break down histamine in the gut, but it will not exert it’s histamine digesting effects systemically or throughout the body.

Histazyme from Dr. Amy Myers Review
I’ve been histamine intolerant for a few years now (probably most of my life but it only severely affected my diet for 10 years) and discovering DAO has been a godsend. It doesn’t allow me to eat “normally” but I get fewer symptoms when I eat out or otherwise choose to eat moderate histamine foods.

A couple years ago, some evil company either created or bought the patent and forced every company to stop selling it. The main ones actually lied in their online marketing and only changed the ingredient panels of their packaging. I ended up with green tea extract (which is high in histamine!) blends and they didn’t work at all.

So I was really glad to find Histazyme. I don’t know how things have changed such they can get the real thing, but they’ve got it. I’ve used this product on several occasions now and it knocks symptoms down just as well, if not better, than the DAO I used in the past.

5. Seeking Health Histamine Block - DAO Enzyme Supplement

Buy on seekinghealth.com

– comfort and relief after eating foods high in histamine
– patented enzyme formula replenishes DAO in your gut
– great for supporting histamine intolerance protocols

Allergy & Diet Information
– histamine block is not suitable for vegans or vegetarians, as it contains porcine-derived ingredients.
– histamine block is free of milk, egg, fish, shellfish, tree nuts, peanuts, wheat, soy, gluten, GMOs, artificial colors, artificial flavors, and artificial preservatives.
– histamine block meets or exceeds cGMP quality standards.

Seeking Health Histamine Block Review
I have mast cell issues, my body produces too much histamine which creates systemic inflammatory responses. Having one of these capsules with each meal has been massively helpful at normalizing histamine responses from foods. This is now one of my must-have supplements.


a. Histamine Intolerance Symptoms

Common symptoms of histamine intolerance:
  • headaches or migraines
  • nasal congestion or sinus issues
  • fatigue
  • hives
  • digestive problems, such as diarrhea
  • irregular menstrual cycle
  • nausea
  • vomiting
Symptom severity varies from person to person.
People who have both allergies and a histamine intolerance may experience more severe allergic reactions because histamine levels in the body might accumulate. These can include asthma episodes or even anaphylactic shock, a serious, fast reaction that results in breathing difficulties and a drop in blood pressure that poses a life-threatening risk.

High amounts of histamine may be linked to significant chronic diseases like Crohn’s disease and can cause the heart to beat irregularly.

b. Histamine Intolerance vs Allergies

Some signs of histamine intolerance mimic an allergic reaction. However, because of differences in the body’s cellular response, skin tests and blood allergy tests will come back negative.

Histamine buildup is thought to be the cause of histamine intolerance. As a result, the symptoms might not show up right away.

c. What Food Has the Highest Histamine?

Histamine levels are greater in the following foods:
fermented foods (kefir, yogurt, kombucha, kimchi, sauerkraut, tempe, miso, sourdough bread)
alcohol, wine, beer, liquor
processed meat (hot dogs, ham, sausages, canned meat)
aged cheese
wheat germ
citrus fruits
nuts, specifically walnuts, cashews and peanuts
food dyes and other additives

d. What Foods Block DAO Production?

black tea
mate tea
green tea
energy drinks

e. How to Clear Histamine From Body?

i. Start a diet that only involves foods and beverages with low amounts of histamine.

ii. You can take histamine blockers or antihistamines might be used to temporarily ease the symptoms.

iii. Use air purifier. Reduce your exposure to irritable irritants and allergens in your environment by using an air purifier. Pet dander, dust, pollen, and mold spores are just a few examples of the allergens that air purifiers remove from the air in your surroundings.

iv. Natural Histamine Blocker. You might be able to regulate your seasonal allergies with natural antihistamines. Stinging nettle, vitamin C, quercetin, butterbur, bromelain, and probiotics are some examples. Exercise, acupuncture, and other complementary therapies may also help you control your symptoms. However, do not stop using antihistamines or start using herbal or dietary supplements before consult your doctor.

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