8 Best Joint Supplement for Knees 2022

The most frequent causes of knee discomfort include overuse, injuries, and arthritis. Knee pain can occur at any age, but older individuals are more prone to suffer it because of osteoarthritis, a condition characterized by joint degeneration.  

In mild cases, knee pain can be treated at home. Your doctor or physical therapist may advise home care for knee discomfort. You could do things like:
  • Applying heat or ice packs.
  • Modifying activities to avoid causing pain.
  • Performing light stretches or workouts.
  • Using over-the-counter pain relievers like ibuprofen or acetaminophen. 
  • Use topical treatments like muscle creams or rubs.
  • Using a knee brace to provide support. 
However, more severe situations (such as acute accidents that harm tendons and ligaments or significant joint degeneration) require medical care and sometimes surgery.

Do Joint Supplements Really Work?

Some supplements have demonstrated potential in reducing pain, stiffness, and other symptoms of arthritis. Below are some supplements that have been studied for osteoarthritis (OA) and rheumatoid arthritis (RA):

a. Glucosamine and Chondroitin 

A study comparing glucosamine and chondroitin with placebo for treating knee and/or hip osteoarthritis found that oral chondroitin in recommended dosage is more effective than placebo on relieving pain and improving physical function. And compared with placebo, glucosamine showed significant effect on the outcome of stiffness. In the aspect of safety, both compounds are well tolerated.

b. Fish Oil

A study showed that supplementation of fish oil 1,000-2,000 mg daily had significant efficacy to improve knee performance and also are safe in mild to moderate stages of knee osteoarthritics patients. However higher dose 2,000 mg of fish oil had not significant higher efficacy than 1,000 mg of fish oil.

c. S-Adenosyl Methionine (SAMe)

SAMe is an important physiologic compound that is distributed throughout the body tissues and fluids. A study indicates a possible role for SAMe in the management of osteoarthritis. SAMe may be helpful management of pain in osteoarthritis, and demonstrates similar effectiveness as a currently accepted COX-2 inhibitor celecoxib.

d. Curcumin

Turmeric, a spice long known for its therapeutic benefits, has caught the interest of medical world because it is the primary source of the polyphenol curcumin.

A study found that curcumin has similar efficacy to diclofenac but demonstrated better tolerance among patients with knee OA. Curcumin can be an alternative treatment option in the patients with knee OA who are intolerant to the side effects of non-steroidal anti-inflammatory drugs.

e. Vitamins

Several studies have shown that vitamin D, calcium, and recently vitamin K play an important role in the maintenance of optimal bone health, especially among older adults.

Studies showed that a combination of calcium and vitamin D supplementation was effective in the preventive treatment of osteoporosis in people aged 50 years or older. The treatment was associated with a reduced rate of bone loss, and fracture risk reduction.

In addition to those vitamins, some evidence also showed that other vitamins are also necessary for maintaining bone health. For instance, lack of vitamin B, along with the consequent elevated homocysteine level, are linked to bone loss, poor bone strength, and increased risk of fracture. Moreover, lack of vitamin C can lead to conditions such as scurvy, which can cause bone pain, impaired bone growth, and many more.

Is It Safe to Take Joint Supplements?

In general, supplements are safe as long as you take them as prescribed and under your doctor's supervision. A few supplements, meanwhile, can cause side effects or interact with the medications you take. For instance, excessive doses of fish oil supplements can cause blood thinning and may interact with anticoagulant medicines such as warfarin (Coumadin).

Best Joint Supplement for Knees

1. Vimerson Health Glucosamine with Chondroitin Turmeric & MSM

Vimerson Health Glucosamine with Chondroitin Turmeric & MSM


- Supplement for Occasional Joint Discomfort
Whether you’re looking to support your joints through intense exercise, or simply want to relieve occasional joint discomfort, our Glucosamine, Chondroitin, Turmeric & MSM supplement can help keep you active and complement a healthy lifestyle.* This supplement is designed to ease discomfort that may come with age, weight, or athletic deterioration of the joints. It promotes joint health and comfort, supports cartilage and joint flexibility, and helps increase joint mobility.*

- With Turmeric
Turmeric is renowned for its joint-supporting properties, so we’ve added a 4:1 Turmeric extract. By using an extract, we’ve ensured a high curcuminoid content, which promotes joint function and enhances joint mobility.*

- Quality Checked
Made in the USA from global ingredients in a GMP-certified facility. It is non-GMO, shellfish-free, dairy-free, gluten-free, nut-free, soy-free, and pork-free.

Per serving (3 capsules): Glucosamine Sulfate Sodium (Shellfish-Free) 1500 mg, Boswellia Extract 65% Boswellia Acid (Boswellia serrata; Bark) 200 mg, Chondroitin Sulfate 150 mg, Turmeric 4:1 Extract (Curcuma longa, Root) 150 mg, Quercetin (Sophora japonica, Buds) 25 mg, L-Methionine 25 mg, Methylsulfonylmethane (MSM) 25 mg, Bromelain (Ananas comosus, Stem) 25 mg. Other ingredients: Gelatin Capsule, Rice Extract Blend.

4.5 out of 5 - more than 29,400 global ratings

Absolutely the best thing for joint pain!! I play basketball once a week . And at 42 years old 6 feet 2 and 336 lbs by knees have been killing me . After only 1 1/2 weeks of this I played the last two weeks with no brace and no pain at all. You have lifetime believer here !!!

2. Arazo Nutrition Glucosamine Chondroitin Turmeric MSM

Arazo Nutrition Glucosamine Chondroitin Turmeric MSM


- Powerful Joint Relief
A complete dietary supplement for joints; it helps repair cartilage, boost joint mobility, increase joint flexibility, support joint structure and protect joint tissue; suitable for anyone with joint pain, joint inflammation or stiff joints; for men, women and seniors

- Extra Strength Ingredients
Glucosamine 1500mg, Chondroitin 1200mg, Msm 1000mg with Turmeric, Boswellia, Hyaluronic Acid for better joint health, range of motion and comfort; helps rebuild and maintain joint flexibility and ease discomforts that comes with age, weight, or sports related stress

- Safety Checked
Made in a GMP certified facility in America and third party safety tested for purity

Glucosamine Sulfate 1500mg, Chondroitin Sulfate 1200mg, MSM 1000mg, Boswellia Serrata extract 100mg, Turmeric 100mg, Hyaluronic acid 25mg, Flavorless coating (Yellow 5, Red 40, blue 1).

4.4 out of 5 - more than 28,000 global ratings

First, I have never taken supplements before and rarely take any medications. I appreciate the product for the relief it has brought my knee and to some extent hand. I have had stiff and sore right knee and hand for over a year. 

Exercise helps, but after sitting I would need to walk 20- 30 steps just to get going and reduce soreness. After a week of being on Joint Support Supplement, there was a noticeable improvement. I am on my second bottle and find anywhere from 40 - 75% less soreness and increased range of motion. After sitting at my desk for prolonged periods, it now takes about 3-5 steps to get going! 

I have recommended this product to a friend that has had knee surgery. She and her husband now take it and claim the same results.

3. Move Free Joint Health Glucosamine Chondroitin MSM

Move Free Joint Health Glucosamine Chondroitin MSM

- Advanced Joint Support for Men & Women
This joint support supplement contains glucosamine, chondroitin, hyaluronic acid, uniflex and msm to help support the 5 signs of joint health!*

- Joint Comfort
Move free advanced contains uniflex which is a clinically tested mineral complex that supports joint comfort in as little as 2 weeks.*

- Extra Cartilage Support
Methylsulfonylmethane (msm) is a source of sulfur found in the body that is important in the formation of collagen in joints. Collagen is a vital part of your joints because it supports the structure of cartilage.*

- Supports 5 Signs of Joint Health
Move free advanced supports g3, plus it provides extra cartilage support.*

- Developed by Scientists
The move free product family with clinically tested ingredients, offers a range of solutions to help you move better. Because when you move freely, you live freely.

Glucosamine Hydrochloride, Chondroitin Sulfate, Hyaluronic Acid, Calcium Fructoborate, MSM (Methylsulfonylmethane), Other Ingredients (microcrystalline cellulose, coating {hydroxypropyl methylcellulose, modified corn starch, titanium dioxide, polyethylene glycol, magnesium silicate}, magnesium stearate)

4.5 out of 5 - more than 15,200 global ratings

Move Free is a fantastic product! I exercise daily, and I do have knee problems. Lots of popping and just basic stiffness. Dosage recommendation is 2-3 a day, but actually I take one at night. Never took in the morning, so I'm not sure how well this would work on an empty stomach etc but I can tell a huge difference in the mobility of my joints. No stiffness, a very lubricated feeling. If I miss a few days, I can tell. The price on Amazon is far cheaper than retail. I highly recommend this product

4. Nordic Naturals Omega Joint Xtra

Nordic Naturals Omega Joint Xtra


- Why Omega Joint Xtra 
Omega joint xtra is a synergistic blend of high-intensity omega-3 and shellfish-free glucosamine sulfate to support healthy joint function and recovery.

- Undenatured Type Ii Collagen 
This formulation offers Uc-ii standardized cartilage with undenatured type ii collagen to accelerate overall benefits and effectiveness. It is undenatured to preserve its native form and thus ensure efficacy.

- Better Absorption, Better Taste, No Fishy Burps 
All of our omega-3 fish oil products are in the triglyceride molecular form (the form naturally found in fish) for optimal absorption.

- Purity Guaranteed 
Every batch of nordic naturals fish oil is non-gmo and third-party tested, surpassing the strictest international standards for purity and freshness. This product is gluten & dairy free with no artificial colors or flavors.

- Ethical Innovation 
Nordic naturals has always been at the forefront of sustainable & ethical practices in the natural products industry. Through science & innovation, we are committed to delivering safe, effective nutrients for optimal wellness.

Purified deep sea fish oil (from anchovies and sardines), soft gel capsule (gelatin, glycerin, purified water, carob color, natural lemon flavor), glucosamine sulfate, beeswax, UC-II(R) standardized chicken cartilage, d-alpha tocopherol (antioxidant), rosemary extract (a natural preservative), potassium chloride (stabilizer).

4.7 out of 5 - more than 200 global ratings

It is an excellent supplement for pain relief of knee problems. It is expensive but it does a great job in reducing the stiffness in my joints. Additionally, it is made by a reputable company, which has been endorsed by several medical doctors.

5. Zenwise Joint Support Supplement

Zenwise Joint Support Supplement


- Extra Strength Joint Care Supplement
This advanced supplement supports the health of knees, hips, and other joints while helping to relieve joint aches. Designed for men and women who wish to maintain their active and healthy lifestyle.

- Move Easily and Comfortably Again
Each daily serving delivers 1500 mg of glucosamine, 1200 mg of chondroitin, 1000 mg of msm plus boswellia, turmeric and hyaluronic acid to support the health of knees, hips, joints and cartilage.

- Support Joint Health
Glucosamine, chondroitin and MSM to support joint structure, protect joint tissue, ease aches and promote joint mobility and flexibility. Boswellia, curcumin and hyaluronic acid to help maintain healthy cartilage, promote joint comfort and support a healthy inflammation response.

Glucosamine Sulfate KCL, Chondroitin Sulfate, MSM (Methylsulfonylmethane), Bosweillia (Serrata), Curcumin (Curcuma Longa), Hyaluronic Acid, Microcrystalline Cellulose, Dicalcium Phosphate, Stearic Acid, Magnesium Stearate, Silicon Dioxide

4.4 out of 5 - more than 5,850 global ratings

I have ordered my second bottle of Zenwise Joint Support. This is a wonderful supplement. It is much better than just the two ingredients that are usually in joint support, Glucosamine, and Chondroitin, I had used in the past. I have taken joint supports for decades and this is the best ever. I love the Curcumin and Hyaluronic Acid that is also added that I have taken separately. I am approaching 80 yrs. and have good joints. Protect your joints with this excellent supplement. You will be pleased you did.

6. Solgar Glucosamine Hyaluronic Acid Chondroitin MSM

Solgar Solgar Glucosamine Hyaluronic Acid Chondroitin MSM

- Supports Comfortable Movement
Glucosamine supports mobility, range of motion and flexibility; It helps ease occasional joint stress due to exercise or physical activity

- Cartilage & Joint Function
Chondroitin supports cartilage and joint function; This formulation also provides Hyaluronic Acid

- Joint Comfort
MSM (Methylsulfonylmethane) provides a natural, bioavailable source of sulfur and promotes joint comfort; MSM works synergistically to support the benefits of glucosamine and chondroitin. Health Concern: Joint Health & Support Bone

- Gluten, Wheat & Dairy Free
Non-GMO and free of gluten, wheat, dairy, soy, yeast, sugar, artificial flavor, sweetener, preservatives, and color

- The Gold Standard
For over 70 years, Solgar has been committed to quality, health, and well-being. Our mission is to create the finest nutritional supplements in small batches, through tireless research, using only the finest raw materials

4.6 out of 5 - more than 1,900 global ratings

I'm over 60 and had been having some joint pain especially in my elbows and knees.. My brother told me about this product, so I tried it, and honestly it really does work. Within a month the pain was gone, and as long as I keep taking even 1 or 2 tablets per day, I don't have the joint pain any longer.

7. Animal Flex All-in-one Complete Joint Supplement

Animal Flex – All-in-one Complete Joint Supplement

Animal Flex is formulated for the bodybuilder and elite athlete that puts their body to the test in the gym and on the field. Joint health is part of the foundation of a healthy athlete, that can push their body to the limit.; Flex is a combination of many stand-alone supplements in one convenient and complete dose. Turmeric Curcumin, Glucosamine, MSM and much more. 

Flex works not only to repair and restore joints, but also protects your ligaments.; Flex is available in a 44 pack container, or in a 30 serving powder. Whichever your delivery method of choice, Animal Flex has you covered.; Take one dose of Animal Flex with any meal during the day. Simple as that. So effective that you only need a single dose every day, unlike most joint products. 

4.7 out of 5 - more than 4,050 global ratings

I have used Animal Flex off and on for over a decade. Combines the usual Glucosamine/Chondroitin with MSM and then adds Flax, Turmeric, Ginger Root and more in one easy to use daily pack. This is the only joint supplement that I have found that not only provides support but actually relieves joint pain. If you put in a lot of running miles as well as deep squats, crawling, jumping, etc. try it out. You won't be sorry.

8. Nature's Nutrition Joint Support Gummies Extra Strength 

Nature's Nutrition Joint Support Gummies Extra Strength


- Joint Support Gummies with Glucosamine Sulfate
Great value, our advanced formulation glucosamine sulfate supplement provides effective support for joints, bones, and cartilage

- Includes Vitamin E
A powerful antioxidant that helps defend against free radicals and oxidation; Formulated to support mobility and specifically for joint support; For women and men

- Supports Joint Health
Each 2 gummy serving includes a potent dose of 160mg; Adult joint gummy vitamins provide effective and delicious benefits to joint health support including mobility, movement, strength and flexibility

- Delicious & Convenient
Delicious chewable raspberry gummies are the easy swallow and are made with pectin for better texture; A natural way to support your daily routine

- Trusted Formula
We care; All of Nature’s Gummies products are manufactured in a cGMP facility and are reviewed by an independent 3rd party lab to ensure quality and purity

4.5 out of 5 - more than 600 global ratings

I am always skeptical about this kind of product but really they are working for my husband and me. Movement is easier and less to no pain in joints.


a. How to Reduce Knee Pain Naturally

i. Stay at a healthy weight. Extra pounds put pressure on weight-bearing joints like hips and knees. Each pound you gain adds nearly four pounds of stress on your knees and puts six times the pressure on your hips.

ii. Control your blood sugar. High blood sugar can stiffen the tissue that supports your joints and make them more sensitive to stress.

iii. Exercise. Just 30 minutes of exercise five times a week helps joints stay limber and strengthens the muscles that support your knees and hips. Focus on low-impact exercises like walking, cycling or swimming.

iv. Stretch. Gentle stretching can improve your range of motion and keep your joints limber. Try to work in simple stretches into every day.

v. Avoid injury. An injured joint is more likely to develop arthritis than one that was never injured. Wear protective gear when playing sports and always lift with your knees and hips, not your back. 

vi. Quit smoking. Smoking puts stress on tissues that protect your joints and can lead to arthritis pain. Learn how Blue Cross can help you quit.

vii. Eat fish twice a week. Eat fish high in Omega-3s, like salmon, trout and mackerel. Omega-3s have many health benefits and may reduce inflammation.

viii. Get routine preventive care. Your doctor may be able to suggest lifestyle changes that can help reduce your risk or slow the progress of arthritis.


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