CoQ10, commonly referred to as coenzyme Q10, is one of the most well-liked dietary supplements for cardiovascular health. It has also been linked in studies to regulating blood sugar, boosting fertility, preventing cancer, and even reducing migraines.
CoQ10 Supplement Market size was valued at $548.69 Million in 2020 and is projected to reach $1.15 Billion in 2028, growing at a CAGR of 9.73% from 2021 to 2028. (R)
As you age, your body produces less CoQ10. In addition, it has been discovered that statin users and patients with specific diseases, such type 2 diabetes mellitus (T2DM), have lower amounts of CoQ10. Restoring CoQ10 levels in T2DM patients may reduce oxidative stress, protect mitochondrial function, and ultimately result in better glycemic control.
CoQ10 supplements may also help atrial fibrillation (a-fib), nonalcoholic fatty liver disease (NAFLD), insulin resistance, heart failure, cancer and migraines (R).
Ubiquinol May Be More Bioavailable Than Ubiquinone
Both ubiquinol and ubiquinone are forms of CoQ10 (coenzyme Q10). Some studies showed that ubiquinol may be more bioavailable than ubiquinone. However, the study is still inconsistent.
aimed to compare the effectiveness between ubiquinone and ubiquinol to enhance the CoQ10 status in older men suggests that ubiquinol supplement are more effective than ubiquinone supplement.
found no significant differences between ubiquinone capsules and ubiquinol capsules in the redox status of the absorbed CoQ10.
Best CoQ10 Supplements
1. Qunol Ultra CoQ10 100mg
Ratings: 4.7 out of 5 - more than 48,000 global ratings
#1 Amazon Best Seller in CoQ10 Nutritional Supplement Category
- 3X BETTER ABSORPTION THAN REGULAR  CoQ10. Clinical trials have proven that no other CoQ10 supplement absorbs better than Qunol. In fact, Qunol Ultra absorbs 3X better than regular  CoQ10
- Product Note: Exposure to heat or sunlight may lead to melting/damage of product. Hence customers are expected to be available during the product delivery
- #1 CARDIOLOGIST RECOMMENDED FORM OF COQ10. With superior absorption compared to regular  CoQ10, Qunol 100mg CoQ10 softgel capsules can help you reach optimal levels of Coenzyme Q10 sooner, so you can experience the potential benefits faster
- 100% WATER AND FAT-SOLUBLE, Qunol CoQ10's patented formulation is 100% water and fat-soluble, unlike regular  CoQ10 that does not dissolve in water and dissolves very poorly in fat.
- ESSENTIAL FOR ENERGY PRODUCTION. CoQ10 plays a vital role in the production of energy in the body. Taking a CoQ10 supplement helps increase natural CoQ10 levels that can be depleted by age and medications.
2. Qunol Mega Ubiquinol CoQ10 100mg
Ratings: 4.7 out of 5 - more than 16,000 global ratings
#7 Amazon Best Seller in CoQ10 Nutritional Supplement Category
- Superior Absorption Vs. Regular CoQ10
With superior absorption compared to regular1 CoQ10, Qunol Mega CoQ10 can help you reach optimal levels of CoQ10 quicker, so you can experience the potential benefits faster
- Cardiologist Recommended Form of CoQ10
With superior absorption compared to regular CoQ10, Qunol 100mg Ubiquinol capsules can help you reach optimal levels of Coenzyme Q10 sooner, so you can experience the potential benefits faster
- 100% Water and Fat Soluble
Qunol CoQ10's patented formulation is 100% water and fat-soluble, unlike regular CoQ10 that does not dissolve in water and dissolves very poorly in fat. Gluten free
- Beneficial to Statin Drug Users
Both cholesterol and CoQ10 are produced in the same pathway. Because statins work by blocking this pathway, they also block the production of CoQ10. Statin medications have been shown to lower CoQ10 levels and the addition of a CoQ10 supplement to statin drug therapy can help replenish lost CoQ10
Over the years,I have tried several CO-Q10 products.This is the best out there,and I have used it now for the past 2 years.It has made a difference in my heart health and overall health.In addition,Qunol is gluten,nut and dairy free.It works very well for me and I recommend it.
3. NOW Supplements Ubiquinol 200 mg, High Bioavailability
- Double Strength for Cardiovascular Health
NOW Extra Strength Ubiquinol has twice the Ubiquinol (200 mg per softgel) as in our regular strength product (100 mg per softgel). Ubiquinol is the reduced and active free radical quencher form of coenzyme Q10 (CoQ10).*
- Active Form of CoQ10
Ubiquinol has been shown to be highly bioavailable and the addition of MCT Oil (medium chain triglycerides) to this product naturally improves its solubility and enhances intestinal absorption, thereby creating a product with superior biological value.*
Dairy Free, Egg Free, Low Sodium, Made without Gluten, Sugar Free, Soy Free, GMP Quality Assured
Ratings: 4.7 out of 5 - more than 400 global ratings
I compare and compare and compare and I always come back to this brand. recently I decided to go to the 200 mg. I take this because I'm a woman who takes a statin drug, so I need the protection that this product provides. I recently learned that I was not taking enough. I used to take 100 mg, now I take 200mg.
Related: NOW Tests CoQ10 & Quercetin Sold on Amazon
4. Solgar Ubiquinol Supplement 200 mg
- Advanced Antioxidant Support
Coenzyme Q-10 (as ubiquinone) performs several important health supporting roles in the body; Ubiquinol (the reduced form of CoQ-10) provides advanced antioxidant support- Ready-To-Use
By supplementing with Ubiquinol, you are providing your body with a form of CoQ-10 that is in a ready-to-use state to help fight free radicals; Free radicals can cause oxidative stress which may damage cells- Oil-Based For Optimal Absorption
Solgar Ubiquinol 200 mg is offered in oil-based softgels to ensure optimal absorption and assimilation- Gluten and Dairy Free
Solgar Ubiqunol Reduced CoQ-10 Softgels are free of: gluten, wheat, dairy, yeast, sugar, sodium, artificial flavor and sweetener- The Gold Standard
For over 70 years Solgar has been committed to quality, health, and well-being. Our mission is to create the finest nutritional supplements in small batches, through tireless research, using only the finest raw materials
4.6 out of 5 - more than 450 global ratings
I like Solgar brand, I like the glass jars and I like taking Q10 so this is an all around plus. Ubiquinol is something I've been taking for several years after developing a constant state of tachycardia for no apparent reason. The medications prescribed by the cardiologist had horrid side effects yet the racing heart rate was interfering with my daily life...so, I opted to try a few supplements instead. Heart rate went back into range - not immediately but absolutely back into range with an average of about 70 versus well over 100. Works well for me and will continue to take.
5. Nordic Naturals Nordic CoQ10 Ubiquinol 100 mg
BUY ON AMAZON
- Why Ubiquinol
Ubiquinol is the active antioxidant form of Coenzyme Q10 (CoQ10) required for energy production in the cell, and has been shown to support cardiovascular and brain health.- Turn Food Into Energy
Ubiquinol helps transform food into energy. It's found in nearly every cell, tissue, and organ in the body, however, as you get older, CoQ10 levels may go down. To make up for these losses, try Nordic Naturals CoQ10 Ubiquinol.- Easy to Swallow
Each mini soft gel provides 100 mg of ubiquinol and is ideal for individuals aged 40+ looking for extra antioxidant support.- Purity Guaranteed
Everything we make is third-party tested, surpassing the strictest international standards for purity & freshness. This product is non-GMO, gluten & dairy free, and contains no artificial flavors.- Ethical Innovation
Nordic Naturals has always been at the forefront of sustainable & ethical practices in the natural products industry. Through science & innovation, we are committed to delivering safe, effective nutrients for optimal wellness.
Ratings: 4.8 out of 5 - more than 250 global ratings
This is the first COQ10 supplement that I have actually noticed an increase in energy. Food for your heart. I have tried lots of different manufacturers but this is the first that I have noticed a difference.
6. Q10.1 CoQ10 Ubiquinol 100mg
- 100mg Next Gen CoQ10
This unique formulation of ubiquinol and geranylgeraniol (GG) works synergistically to support your body’s natural CoQ10 production with enhanced cellular absorption.*
- The Breakthrough Ingredient
Geranylgeraniol or GG is now commercially available for the first time as a groundbreaking nutritional ingredient. GG is the critically important nutrient in your body that helps naturally make CoQ10*.
- Statin Companion
As cholesterol and CoQ10 are produced in the same pathway, taking statins can reduce your CoQ10 levels. If you're taking statin medications to reduce cholesterol, also talk to your doctor about supplementing with ubiquinol.
- Superior Absorption
This Statin Companion naturally stimulates the production of CoQ10 in the body, suggesting it may have greater bioavailability than ubiquinol alone.*. Small softgel capsule: One big advantage of this product is the small size. Support cardiovascular and cellular health while making your supplement routine easier to swallow.*
4.5 out of 5 - more than 300 global ratings
I've been using this product for two weeks now and have noticed improvements in daily energy levels and mental clarity! I came to drop this review when coming back to buy my second bottle!
7. Health Thru Nutrition Kaneka Ubiquinol CoQ10 Softgels 100mg
- Featuring Kaneka Ubiquinol
Kaneka Ubiquinol is derived from the world’s most recognized and researched CoQ10 ingredient for 30 years. Kaneka Ubiquinol is more absorbable than conventional CoQ10, which means that optimal levels of CoQ10 can be restored quickly and efficiently, especially in those who are over 40 or are affected by certain age-related conditions.
- Researched Benefits
Ubiquinol & CoQ10 have been found in countless studies to improve specific blood markers associated with Heart Health and Energy Production!
- Quality, Safety, Integrity
TN's core beliefs guide us to empower people to live healthier lives by providing superior-quality nutrition products and serving as a trusted source of nutrition information.
Ratings: 4.7 out of 5 - more than 1,100 global ratings
Great quality. A part of my healthy heart supplement regimen. Anyone taking a prescription or natural OTC statin to lower their bad cholesterol should also take a quality CoQ10 (in the form of Ubiquinol, not Ubiquinone if you're over age 30) because statins eliminate the CoQ10 produced by the body. Some doctors recommend this to their statin taking patients but most don't.
a. Who Should Avoid Taking CoQ10?
CoQ10 has possible interaction with anticoagulants. CoQ10 may reduce the effectiveness of blood-thinning medications like warfarin (Jantoven). This could increase the risk of a blood clot.
b. What Happens if Your Coq10 Levels Are Low?
A slight CoQ10 deficiency can result in muscle weakness and fatigue. Although CoQ10 deficiency is unlikely to occur in the general population, there is a higher risk in people with particular medical problems including cancer, diabetes, or genetic abnormalities.
Studies have also shown that a lack of coenzyme Q10 can make cells more vulnerable to harm from free radicals.
The main differences between ubiquinol and ubiquinone is that ubiquinol is the reduced form of CoQ10, whereas ubiquinone is the oxidized form. Therefore, ubiquinone has more electrons than the ubiquinol.
Ubiquinone = oxidized CoQ10 = yellow
Ubiquinol = reduced CoQ10 = white
In contrast to ubiquinone, which has a characteristic yellowish color, ubiquinol is essentially white. As soon as ubiquinol is exposed to oxygen, it transforms back into ubiquinone, which is its oxidized (and yellow) form.
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