9 Best CoQ10 Supplements of 2025
CoQ10, commonly referred to as coenzyme Q10, is one of the most well-liked dietary supplements for cardiovascular health. It has also been linked in studies to regulating blood sugar, boosting fertility, preventing cancer, and even reducing migraines.
Coq10 Supplement Market size was valued at USD 614.3 Million in 2023 and is projected to reach USD 852.53 Million by 2030, growing at a CAGR (compound annual growth rate) of 5.1% during the forecast period 2024-2030. (R)
As you age, your body produces less CoQ10. In addition, it has been discovered that statin users and patients with specific diseases, such type 2 diabetes mellitus (T2DM), have lower amounts of CoQ10. Restoring CoQ10 levels in T2DM patients may reduce oxidative stress, protect mitochondrial function, and ultimately result in better glycemic control.
CoQ10 supplements may also help atrial fibrillation (a-fib), nonalcoholic fatty liver disease (NAFLD), insulin resistance, heart failure, cancer and migraines (R).Best CoQ10 Supplements
1. Qunol Ultra CoQ10 100mg
Ratings: 4.7 out of 5 - more than 50,000 global
ratings
#1 Amazon Best Seller in CoQ10 Nutritional Supplement Category
- Product Note: Exposure to heat or sunlight may lead to melting/damage of product. Hence customers are expected to be available during the product delivery
- #1 CARDIOLOGIST RECOMMENDED FORM OF CoQ10. With superior absorption compared to regular [2] CoQ10, Qunol 100mg CoQ10 softgel capsules can help you reach optimal levels of Coenzyme Q10 sooner, so you can experience the potential benefits faster
- 100% WATER AND FAT-SOLUBLE, Qunol CoQ10's patented formulation is 100% water and fat-soluble, unlike regular [2] CoQ10 that does not dissolve in water and dissolves very poorly in fat.
- ESSENTIAL FOR ENERGY PRODUCTION. CoQ10 plays a vital role in the production of energy in the body. Taking a CoQ10 supplement helps increase natural CoQ10 levels that can be depleted by age and medications.
2. The Wellness Company's Elevated Energy Formula
Elevated Energy is the revolutionary mitochondrial supplement designed to rejuvenate your cellular energy production and unlock your true mental and physical potential.
With Elevated Energy, approach every day with a sharp mind full of energy to overcome challenges - without having the jitters.
- CoQ10 and pyrroloquinoline quinone (PQQ) - To increase your daily overall cellular energy levels
- Citicoline - Which may aid in supporting your memory functionality
- L Carnitine L-tartrate - Which can support cognition and mitochondrial efficiency
- D-Ribose - Which may facilitate energy production within your cells
Where to buy the Elevated Energy Formula: Available on The Wellness Company's website. Here is the link: Elevated Energy Formula
Note: To get 10% OFF, please use this coupon code: ONEDAYMD
3. The Wellness Company Healthy Heart Formula
The Wellness Company's (TWC) Signature Series Healthy Heart Formula is packed with the following ingredients:- Coenzyme Q10 and Selenium Citrate may work together to help reduce the risk of cardiac disease.
- Together with a Vitamin B Complex which may help fortify muscles, L-Carnitine may also provide energy for your heart, muscle, and brain.
- D-Ribose, which may improve heart function after damage to cardiac tissue.
- Taurine is being researched extensively and may support combating heart failure.
Healthy Heart Formula has been vetted by the TWC Chief Medical Board.
One bottle contains a 1-month supply.
Mito Support Formula has been vetted by the TWC Chief Medical Board.
Where to buy Healthy Heart Formula: Healthy Heart Formula is available on The Wellness Company's website. Here is the link: Health Heart Formula.
The Wellness Company's (TWC) Signature Series Healthy Heart Formula is packed with the following ingredients:
- Coenzyme Q10 and Selenium Citrate may work together to help reduce the risk of cardiac disease.
- Together with a Vitamin B Complex which may help fortify muscles, L-Carnitine may also provide energy for your heart, muscle, and brain.
- D-Ribose, which may improve heart function after damage to cardiac tissue.
- Taurine is being researched extensively and may support combating heart failure.
One bottle contains a 1-month supply.
Mito Support Formula has been vetted by the TWC Chief Medical Board.
Where to buy Healthy Heart Formula: Healthy Heart Formula is available on The Wellness Company's website. Here is the link: Health Heart Formula.
4. Qunol Mega Ubiquinol CoQ10 100mg
Ratings: 4.7 out of 5 - more than 16,000 global ratings
#7 Amazon Best Seller in CoQ10 Nutritional Supplement Category
- Superior Absorption Vs. Regular CoQ10
With superior absorption compared to regular1 CoQ10, Qunol Mega CoQ10 can help you reach optimal levels of CoQ10 quicker, so you can experience the potential benefits faster
- Cardiologist Recommended Form of CoQ10
With superior absorption compared to regular CoQ10, Qunol 100mg Ubiquinol capsules can help you reach optimal levels of Coenzyme Q10 sooner, so you can experience the potential benefits faster
- 100% Water and Fat Soluble
Qunol CoQ10's patented formulation is 100% water and fat-soluble, unlike regular CoQ10 that does not dissolve in water and dissolves very poorly in fat. Gluten free
- Beneficial to Statin Drug Users
Both cholesterol and CoQ10 are produced in the same pathway. Because statins work by blocking this pathway, they also block the production of CoQ10. Statin medications have been shown to lower CoQ10 levels and the addition of a CoQ10 supplement to statin drug therapy can help replenish lost CoQ10
Over the years,I have tried several CO-Q10 products.This is the best out there,and I have used it now for the past 2 years.It has made a difference in my heart health and overall health.In addition,Qunol is gluten,nut and dairy free.It works very well for me and I recommend it.
5. Life Extension COQ10 Super Ubiquinol with Enhanced Mitochondrial Support
Ratings: 4.6 out of 5 - more than 2,900 global ratings.
Life Extension offers its CoQ10 supplements in three different dose strengths.
- Life Extension Super Ubiquinol CoQ10 with Enhanced Mitochondrial Support, 50 mg, 30 softgels
- Life Extension Super Ubiquinol CoQ10 with Enhanced Mitochondrial Support, 100 mg, 30 softgels
- Life Extension Super Ubiquinol CoQ10 with Enhanced Mitochondrial Support, 200 mg, 30 Softgels
- CoQ10 for Heart Health and Cellular Energy
Co Q10 (or coenzyme Q10) is an essential nutrient your body requires for healthy mitochondrial function, a process that produces body energy at the cellular level.
- Improved Bioavailability: Ubiquinol and Shilajit
The traditional form of CoQ10, ubiquinone, is difficult for the body to absorb. But another form, ubiquinol, has been shown to absorb up to 8 times greater than ubiquinone. That’s why LE offers a highly bioavailable form of ubiquinol CoQ 10 in a patented delivery system with superior absorption levels.
- Shilajit Enhances Coq10 Effectiveness
When combined with ubiquinol CoQ10, it has been clinically shown to double levels of CoQ10 in the mitochondria. Shilajit prolongs CoQ10’s efficacy at the cellular level by stabilizing it in its ubiquinol form and facilitates greater cellular energy output by improving delivery of CoQ10 into the mitochondria.
- Breakthrough Longevity and Cellular Energy Formula
Research supports the value of this unique combination of ubiquinol CoQ10 and shilajit. That’s why we’ve created Super Ubiquinol CoQ10 with Enhanced Mitochondrial Support, to create a powerful synergy that supports heart health and youthful cellular energy production better than CoQ10 alone.
Life Extension CoQ10 100 mg Ingredients: Ubiquinol (as Kaneka Ubiquinol™) 100 mg, PrimaVie® Shilajit fulvic acid complex 100 mg, Other ingredients: sunflower oil, gelatin, glycerin, purified water, beeswax, sunflower lecithin, annatto color.
6. NOW Supplements Ubiquinol 200 mg, High Bioavailability
Ratings: 4.7 out of 5 - more than 500 global ratings
- Double Strength for Cardiovascular Health
NOW Extra Strength Ubiquinol has twice the Ubiquinol (200 mg per
softgel) as in our regular strength product (100 mg per softgel).
Ubiquinol is the reduced and active free radical quencher form of
coenzyme Q10 (CoQ10).*
- Active Form of CoQ10
Ubiquinol has been shown to be highly bioavailable and the addition
of MCT Oil (medium chain triglycerides) to this product naturally
improves its solubility and enhances intestinal absorption, thereby
creating a product with superior biological value.*
- Certifications/Classifications
Dairy Free, Egg Free, Low Sodium, Made without Gluten, Sugar Free,
Soy Free, GMP Quality Assured
I compare and compare and compare and I always come back to this
brand. recently I decided to go to the 200 mg. I take this because
I'm a woman who takes a statin drug, so I need the protection that
this product provides. I recently learned that I was not taking
enough. I used to take 100 mg, now I take 200mg.
7. MitoQ Advanced CoQ10 Ubiquinol Supplement
Ratings: 4.2 out of 5 - more than 900 global ratings.
- Over $60 million has been invested in independent studies exploring the
advanced benefits of MitoQ.
- Leading institutions around the world have studies MitoQ in over 600
peer-reviewed scientific papers and 12 clinical trials.
- Shown in studies to be 847 times more effective than regular CoQ10.
- Most CoQ10 are too big in size and "oily" to penetrate the mitochondrial
bilayer - so they work only externally.
-
American Heart Association Journal
(2018) showed MitoQ reversed aging of blood vessels by the equivalent of
15 to 20 years within 6 weeks of treatment duration.
- TARGETED ANTIOXIDANT SUPPORT TO THE MITOCHONDRIA: The mitochondria is
where your energy is made; MitoQ delivers targeted CoQ10 antioxidants
directly into the mitochondria to help your organs perform at their best
and beyond. The level of CoQ10 produced inside our mitochondria naturally
declines with age. Positively charged ions in MitoQ easily pass through
the mitochondria membrane, which makes CoQ10 available to perform vital
functions for your health, unlike any other cellular supplement.
- NEXT-GEN ANTIOXIDANT FOR VITALITY: MitoQ is better absorbed by your cell powerhouses than regular antioxidants. MitoQ is able to pass easily through the cell wall to distribute CoQ10 directly to the sources allowing MitoQ to deliver targeted support directly to your mitochondria cells. Our innovative and proven effective method of reducing free radical damage increases the intensity of our health benefits and allows you to see proven results, sooner.
- BOOST ORGAN PERFORMANCE AND DAILY ENERGY LEVELS: 90% of your body's energy comes from the mitochondria, yet every year mitochondria produce less energy due to natural aging. This is a result of free radicals present in the body during the energy process damaging the walls of the mitochondria, which causes the cell to operate less effectively. MitoQ helps to limit free radical damage at the source, supporting your cells and building resilience by reducing the risk of oxidative stress.
- UNPARALLELED BREAKTHROUGH CELLULAR SCIENCE: MitoQ relies on advanced, patented CoQ10 technology based on two decades of research and $60 million of investments. Our ingredients have been selected and formulated to provide the highest level of bioavailability and absorption on the market. Not only does MitoQ build up the mitochondria’s free radical defence, but it also works to prevent future damage of the cell membrane which significantly increases the cell’s resilience and health.
- TRUSTED BY PROFESSIONALS FOR ENDURANCE AND RECOVERY: MitoQ is a mitochondria supplement expertly trusted by professional athletes and medical specialists to deliver high quality cell support. Support your mental focus, healthy aging, and boosted energy levels with the supplements that are shown to deliver optimized organ support. MitoQ ingredients and products are manufactured to Good Manufacturing Practice (GMP) standards so you can have confidence in the supplements that you take.
- NEXT-GEN ANTIOXIDANT FOR VITALITY: MitoQ is better absorbed by your cell powerhouses than regular antioxidants. MitoQ is able to pass easily through the cell wall to distribute CoQ10 directly to the sources allowing MitoQ to deliver targeted support directly to your mitochondria cells. Our innovative and proven effective method of reducing free radical damage increases the intensity of our health benefits and allows you to see proven results, sooner.
- BOOST ORGAN PERFORMANCE AND DAILY ENERGY LEVELS: 90% of your body's energy comes from the mitochondria, yet every year mitochondria produce less energy due to natural aging. This is a result of free radicals present in the body during the energy process damaging the walls of the mitochondria, which causes the cell to operate less effectively. MitoQ helps to limit free radical damage at the source, supporting your cells and building resilience by reducing the risk of oxidative stress.
- UNPARALLELED BREAKTHROUGH CELLULAR SCIENCE: MitoQ relies on advanced, patented CoQ10 technology based on two decades of research and $60 million of investments. Our ingredients have been selected and formulated to provide the highest level of bioavailability and absorption on the market. Not only does MitoQ build up the mitochondria’s free radical defence, but it also works to prevent future damage of the cell membrane which significantly increases the cell’s resilience and health.
- TRUSTED BY PROFESSIONALS FOR ENDURANCE AND RECOVERY: MitoQ is a mitochondria supplement expertly trusted by professional athletes and medical specialists to deliver high quality cell support. Support your mental focus, healthy aging, and boosted energy levels with the supplements that are shown to deliver optimized organ support. MitoQ ingredients and products are manufactured to Good Manufacturing Practice (GMP) standards so you can have confidence in the supplements that you take.
8. Health Thru Nutrition Kaneka Ubiquinol CoQ10 Softgels 100mg
Ratings: 4.7 out of 5 - more than 1,200 global ratings
- Featuring Kaneka Ubiquinol
Kaneka Ubiquinol is derived from the world’s most recognized and
researched CoQ10 ingredient for 30 years. Kaneka Ubiquinol is more
absorbable than conventional CoQ10, which means that optimal levels of
CoQ10 can be restored quickly and efficiently, especially in those who
are over 40 or are affected by certain age-related conditions.
- Researched Benefits
Ubiquinol & CoQ10 have been found in countless studies to improve
specific blood markers associated with Heart Health and Energy
Production!
- Quality, Safety, Integrity
TN's core beliefs guide us to empower people to live healthier lives
by providing superior-quality nutrition products and serving as a
trusted source of nutrition information.
Great quality. A part of my healthy heart supplement regimen. Anyone
taking a prescription or natural OTC statin to lower their bad
cholesterol should also take a quality CoQ10 (in the form of
Ubiquinol, not Ubiquinone if you're over age 30) because statins
eliminate the CoQ10 produced by the body. Some doctors recommend this
to their statin taking patients but most don't.
9. Nordic Naturals Nordic CoQ10 Ubiquinol 100 mg
Ratings: 4.8 out of 5 - more than 250 global ratings
- Why Ubiquinol
Ubiquinol is the active antioxidant form of Coenzyme Q10 (CoQ10) required for energy production in the cell, and has been shown to support cardiovascular and brain health.
- Turn Food Into Energy
Ubiquinol helps transform food into energy. It's found in nearly every cell, tissue, and organ in the body, however, as you get older, CoQ10 levels may go down. To make up for these losses, try Nordic Naturals CoQ10 Ubiquinol.
- Easy to Swallow
Each mini soft gel provides 100 mg of ubiquinol and is ideal for individuals aged 40+ looking for extra antioxidant support.
- Purity Guaranteed
Everything we make is third-party tested, surpassing the strictest international standards for purity & freshness. This product is non-GMO, gluten & dairy free, and contains no artificial flavors.
- Ethical Innovation
Nordic Naturals has always been at the forefront of sustainable & ethical practices in the natural products industry. Through science & innovation, we are committed to delivering safe, effective nutrients for optimal wellness.
- Why Ubiquinol
Ubiquinol is the active antioxidant form of Coenzyme Q10 (CoQ10) required for energy production in the cell, and has been shown to support cardiovascular and brain health.
- Turn Food Into Energy
Ubiquinol helps transform food into energy. It's found in nearly every cell, tissue, and organ in the body, however, as you get older, CoQ10 levels may go down. To make up for these losses, try Nordic Naturals CoQ10 Ubiquinol.
- Easy to Swallow
Each mini soft gel provides 100 mg of ubiquinol and is ideal for individuals aged 40+ looking for extra antioxidant support.
- Purity Guaranteed
Everything we make is third-party tested, surpassing the strictest international standards for purity & freshness. This product is non-GMO, gluten & dairy free, and contains no artificial flavors.
- Ethical Innovation
Nordic Naturals has always been at the forefront of sustainable & ethical practices in the natural products industry. Through science & innovation, we are committed to delivering safe, effective nutrients for optimal wellness.
This is the first COQ10 supplement that I have actually noticed an increase in energy. Food for your heart. I have tried lots of different manufacturers but this is the first that I have noticed a difference.
CoQ10 Deficiency and Statins
Your body can naturally make CoQ10, but genetic alterations in
metabolism, poor diet, oxidative stress, chronic conditions, aging and
statins can all interfere with CoQ10 production and lead to CoQ10
deficiency. Statins can induce coenzyme Q10 deficiency, which can lead
to muscle symptoms such as myopathy, rhabdomyolysis, myoglobinuria,
impaired mitochondrial energy and metabolism. As the CoQ10 levels
drop, the side effects of statins increase (Healthline).
To maintain good health, an adult body should contain 0.5 to 1.5 g of CoQ10 and sometimes it takes a supplement to keep you there. Dosing
requirements will vary depending on your individual situation and
needs.
How much CoQ10 is recommended daily? As a general rule, the sicker you are, the more you need. The suggested dose is usually between 30 mg to 100 mg per day if you're healthy, or 60 to 1,200 mg daily if you're sick or have underlying health conditions.
If you have an active lifestyle, exercise a lot or are under a lot of stress, you may want to increase your dose to 200 to 300 mg per day. Importantly, if you're on a statin drug, you need at least 100 mg to 200 mg of ubiquinol or CoQ10 per day, or more. Ideally, you'll want to work with your physician to determine your ideal dose.
How much CoQ10 is recommended daily? As a general rule, the sicker you are, the more you need. The suggested dose is usually between 30 mg to 100 mg per day if you're healthy, or 60 to 1,200 mg daily if you're sick or have underlying health conditions.
If you have an active lifestyle, exercise a lot or are under a lot of stress, you may want to increase your dose to 200 to 300 mg per day. Importantly, if you're on a statin drug, you need at least 100 mg to 200 mg of ubiquinol or CoQ10 per day, or more. Ideally, you'll want to work with your physician to determine your ideal dose.
Other Effective Choices to Improve Heart Health
To effectively manage your cardiovascular risk, it is critical to reduce
chronic inflammation. Magnesium plays a vital role in biological function
and mitochondrial health, and is a culprit in the development of
inflammation when your levels are low. It may also play a role in
inhibiting the deposit of lipids on arterial walls and plaque formation
(R).
There are multiple factors affecting the inflammatory process in your
body. Some of the more significant over which you have control,
include:
Hyperinsulinemia — An excess of insulin in your blood triggered by a diet
high in net carbohydrates. What you eat tends to be the deal-breaker in
how much insulin your body secretes. However, there are other factors
contributing to your insulin levels, such as smoking, sleep quality,
exercise and vitamin D level.
Unbalanced fatty acids — Your body needs a balance of omega-3 and omega-6
fats. Unfortunately, most diets have an overabundance of omega-6 fats
leading to greater levels of inflammation. Strive for a 1-to-1 ratio of
omega-3 to omega-6 fats to reduce inflammation and your risk of heart
disease.
High iron stores — Ensure your ferritin blood levels are below 80 ng/ml.
If elevated, the simplest and most efficient way to lower your iron level
is to donate blood. If you can't donate, then therapeutic phlebotomy will
effectively eliminate the excess iron.
Leaky gut — Food particles and bacteria leaking from your intestines
increase your level of inflammation and your risk of heart disease. By
eliminating grains, sugars and lectin-rich legumes, while adding fermented
foods, you may heal your gut and reduce your level of inflammation.
Inadequate levels of magnesium — A century ago your diet provided nearly
500 milligrams (mg) of magnesium per day. Today, courtesy of
nutrient-depleted soil, you may be getting only 150 mg per day. Your body
flushes excess magnesium through your stool, so using magnesium citrate
and monitoring stool consistency, consider starting with 200 mg of oral
magnesium citrate and gradually increasing until you develop slightly
loose stools. Magnesium threonate is preferred, as it appears to more
efficiently penetrate cell membranes, including your mitochondria. It
penetrates your blood-brain barrier and may help improve memory. It also
may be a good alternative to reduce migraine headaches. In one double-blind, placebo-controlled trial (2014), patients who received intravenous magnesium within 24 hours
of their heart attack experienced 24% fewer deaths within the following
five years. Researchers concluded the benefits of magnesium intake on
chronic disease may be explained by the effect it has on inhibiting
inflammation.
Best CoQ10 Supplements FAQs
a. Who Should Avoid Taking CoQ10?
CoQ10 has possible interaction with anticoagulants. CoQ10 may
reduce the effectiveness of blood-thinning medications like warfarin
(Jantoven). This could increase the risk of a blood clot.
b. What Happens if Your Coq10 Levels Are Low?
A slight CoQ10 deficiency can result in muscle weakness and
fatigue. Although CoQ10 deficiency is unlikely to occur in the
general population, there is a higher risk in people with
particular medical problems including cancer, diabetes, or genetic
abnormalities.
Studies have also shown that a lack of coenzyme Q10 can make cells
more vulnerable to harm from free radicals.
c. Ubiquinone Vs Ubiquinol
The main differences between ubiquinol and ubiquinone is that
ubiquinol is the reduced form of CoQ10, whereas ubiquinone is the
oxidized form. Therefore, ubiquinone has more electrons than
ubiquinol.
Ubiquinone = oxidized CoQ10 = yellow
Ubiquinol = reduced CoQ10 = white
Ubiquinol = reduced CoQ10 = white
In contrast to ubiquinone, which has a characteristic yellowish color, ubiquinol is essentially white. As soon as ubiquinol is exposed to oxygen, it transforms back into ubiquinone, which is its oxidized (and yellow) form.
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