8 Best CoQ10 Supplements in 2024
CoQ10, commonly referred to as coenzyme Q10, is one of the most well-liked dietary supplements for cardiovascular health. It has also been linked in studies to regulating blood sugar, boosting fertility, preventing cancer, and even reducing migraines.
CoQ10 Supplement Market size was valued at $548.69 Million in 2020 and is projected to reach $1.15 Billion in 2028, growing at a CAGR of 9.73% from 2021 to 2028. (R)
As you age, your body produces less CoQ10. In addition, it has been discovered that statin users and patients with specific diseases, such type 2 diabetes mellitus (T2DM), have lower amounts of CoQ10. Restoring CoQ10 levels in T2DM patients may reduce oxidative stress, protect mitochondrial function, and ultimately result in better glycemic control.
CoQ10 supplements may also help atrial fibrillation (a-fib), nonalcoholic fatty liver disease (NAFLD), insulin resistance, heart failure, cancer and migraines (R).
Related: Best CoQ10 Supplement Consumer ReportsUbiquinol May Be More Bioavailable Than Ubiquinone
Both ubiquinol and ubiquinone are forms of CoQ10 (coenzyme Q10). Some studies showed that ubiquinol may be more bioavailable than ubiquinone. However, the study is still inconsistent.
A study aimed to compare the effectiveness between ubiquinone and ubiquinol to enhance the CoQ10 status in older men suggests that ubiquinol supplement are more effective than ubiquinone supplement.
Another study found no significant differences between ubiquinone capsules and ubiquinol capsules in the redox status of the absorbed CoQ10.
Best CoQ10 Supplements
1. Qunol Ultra CoQ10 100mg
Ratings: 4.7 out of 5 - more than 48,000 global ratings
#1 Amazon Best Seller in CoQ10 Nutritional Supplement Category
- Product Note: Exposure to heat or sunlight may lead to melting/damage of product. Hence customers are expected to be available during the product delivery
- #1 CARDIOLOGIST RECOMMENDED FORM OF COQ10. With superior absorption compared to regular [2] CoQ10, Qunol 100mg CoQ10 softgel capsules can help you reach optimal levels of Coenzyme Q10 sooner, so you can experience the potential benefits faster
- 100% WATER AND FAT-SOLUBLE, Qunol CoQ10's patented formulation is 100% water and fat-soluble, unlike regular [2] CoQ10 that does not dissolve in water and dissolves very poorly in fat.
- ESSENTIAL FOR ENERGY PRODUCTION. CoQ10 plays a vital role in the production of energy in the body. Taking a CoQ10 supplement helps increase natural CoQ10 levels that can be depleted by age and medications.
2. Qunol Mega Ubiquinol CoQ10 100mg
Ratings: 4.7 out of 5 - more than 16,000 global ratings
#7 Amazon Best Seller in CoQ10 Nutritional Supplement Category
- Superior Absorption Vs. Regular CoQ10
With superior absorption compared to regular1 CoQ10, Qunol Mega CoQ10 can help you reach optimal levels of CoQ10 quicker, so you can experience the potential benefits faster
- Cardiologist Recommended Form of CoQ10
With superior absorption compared to regular CoQ10, Qunol 100mg Ubiquinol capsules can help you reach optimal levels of Coenzyme Q10 sooner, so you can experience the potential benefits faster
- 100% Water and Fat Soluble
Qunol CoQ10's patented formulation is 100% water and fat-soluble, unlike regular CoQ10 that does not dissolve in water and dissolves very poorly in fat. Gluten free
- Beneficial to Statin Drug Users
Both cholesterol and CoQ10 are produced in the same pathway. Because statins work by blocking this pathway, they also block the production of CoQ10. Statin medications have been shown to lower CoQ10 levels and the addition of a CoQ10 supplement to statin drug therapy can help replenish lost CoQ10
Over the years,I have tried several CO-Q10 products.This is the best out there,and I have used it now for the past 2 years.It has made a difference in my heart health and overall health.In addition,Qunol is gluten,nut and dairy free.It works very well for me and I recommend it.
3. The Wellness Company Mito Support Formula
The Wellness Company's (TWC) Signature Series Mito Support Formula restores balance in your cells, nerves, and neurons to assist with focus and boost daily energy levels.
TWC's Mito Support Formula includes citicoline, which may aid in supporting your memory functionality, along with CoQ10 and pyrroloquinoline quinone (PQQ) to boost additional focus while increasing your daily overall energy levels.
Mito Support Formula has been vetted by the TWC Chief Medical Board.
Mito Support Formula has been vetted by the TWC Chief Medical Board.
The science behind Mito Support Formula:
Where to buy Mito Support Formula: Mito Support Formula is available on The Wellness Company's website. Here is the link: Mito Support Formula.
Note: To get 10% OFF, please use this coupon code: ONEDAYMD
4. NOW Supplements Ubiquinol 200 mg, High Bioavailability
Ratings: 4.7 out of 5 - more than 400 global ratings
- Double Strength for Cardiovascular Health
NOW Extra Strength Ubiquinol has twice the Ubiquinol (200 mg per softgel) as in our regular strength product (100 mg per softgel). Ubiquinol is the reduced and active free radical quencher form of coenzyme Q10 (CoQ10).*
- Active Form of CoQ10
Ubiquinol has been shown to be highly bioavailable and the addition of MCT Oil (medium chain triglycerides) to this product naturally improves its solubility and enhances intestinal absorption, thereby creating a product with superior biological value.*
- Certifications/Classifications
Dairy Free, Egg Free, Low Sodium, Made without Gluten, Sugar Free, Soy Free, GMP Quality Assured
I compare and compare and compare and I always come back to this brand. recently I decided to go to the 200 mg. I take this because I'm a woman who takes a statin drug, so I need the protection that this product provides. I recently learned that I was not taking enough. I used to take 100 mg, now I take 200mg.
5. Solgar Ubiquinol Supplement 200 mg
Ratings: 4.6 out of 5 - more than 450 global ratings
Coenzyme Q-10 (as ubiquinone) performs several important health supporting roles in the body; Ubiquinol (the reduced form of CoQ-10) provides advanced antioxidant support
- Ready-To-Use
By supplementing with Ubiquinol, you are providing your body with a form of CoQ-10 that is in a ready-to-use state to help fight free radicals; Free radicals can cause oxidative stress which may damage cells
- Oil-Based For Optimal Absorption
Solgar Ubiquinol 200 mg is offered in oil-based softgels to ensure optimal absorption and assimilation
- Gluten and Dairy Free
Solgar Ubiqunol Reduced CoQ-10 Softgels are free of: gluten, wheat, dairy, yeast, sugar, sodium, artificial flavor and sweetener
- The Gold Standard
For over 70 years Solgar has been committed to quality, health, and well-being. Our mission is to create the finest nutritional supplements in small batches, through tireless research, using only the finest raw materials
6. Nordic Naturals Nordic CoQ10 Ubiquinol 100 mg
Ratings: 4.8 out of 5 - more than 250 global ratings
- Why Ubiquinol
Ubiquinol is the active antioxidant form of Coenzyme Q10 (CoQ10) required for energy production in the cell, and has been shown to support cardiovascular and brain health.
- Turn Food Into Energy
Ubiquinol helps transform food into energy. It's found in nearly every cell, tissue, and organ in the body, however, as you get older, CoQ10 levels may go down. To make up for these losses, try Nordic Naturals CoQ10 Ubiquinol.
- Easy to Swallow
Each mini soft gel provides 100 mg of ubiquinol and is ideal for individuals aged 40+ looking for extra antioxidant support.
- Purity Guaranteed
Everything we make is third-party tested, surpassing the strictest international standards for purity & freshness. This product is non-GMO, gluten & dairy free, and contains no artificial flavors.
- Ethical Innovation
Nordic Naturals has always been at the forefront of sustainable & ethical practices in the natural products industry. Through science & innovation, we are committed to delivering safe, effective nutrients for optimal wellness.
- Why Ubiquinol
Ubiquinol is the active antioxidant form of Coenzyme Q10 (CoQ10) required for energy production in the cell, and has been shown to support cardiovascular and brain health.
- Turn Food Into Energy
Ubiquinol helps transform food into energy. It's found in nearly every cell, tissue, and organ in the body, however, as you get older, CoQ10 levels may go down. To make up for these losses, try Nordic Naturals CoQ10 Ubiquinol.
- Easy to Swallow
Each mini soft gel provides 100 mg of ubiquinol and is ideal for individuals aged 40+ looking for extra antioxidant support.
- Purity Guaranteed
Everything we make is third-party tested, surpassing the strictest international standards for purity & freshness. This product is non-GMO, gluten & dairy free, and contains no artificial flavors.
- Ethical Innovation
Nordic Naturals has always been at the forefront of sustainable & ethical practices in the natural products industry. Through science & innovation, we are committed to delivering safe, effective nutrients for optimal wellness.
This is the first COQ10 supplement that I have actually noticed an increase in energy. Food for your heart. I have tried lots of different manufacturers but this is the first that I have noticed a difference.
7. MitoQ Advanced CoQ10 Ubiquinol Supplement
- Over $60 million has been invested in independent studies exploring the advanced benefits of MitoQ.
- Leading institutions around the world have studies MitoQ in over 600 peer-reviewed scientific papers and 12 clinical trials.
- Shown in studies to be 847 times more effective than regular CoQ10.
- Most CoQ10 are too big in size and "oily" to penetrate the mitochondrial bilayer - so they work only externally.
- American Heart Association Journal (2018) showed MitoQ reversed aging of blood vessels by the equivalent of 15 to 20 years within 6 weeks of treatment duration.
- TARGETED ANTIOXIDANT SUPPORT TO THE MITOCHONDRIA: The mitochondria is where your energy is made; MitoQ delivers targeted CoQ10 antioxidants directly into the mitochondria to help your organs perform at their best and beyond. The level of CoQ10 produced inside our mitochondria naturally declines with age. Positively charged ions in MitoQ easily pass through the mitochondria membrane, which makes CoQ10 available to perform vital functions for your health, unlike any other cellular supplement.
- NEXT-GEN ANTIOXIDANT FOR VITALITY: MitoQ is better absorbed by your cell powerhouses than regular antioxidants. MitoQ is able to pass easily through the cell wall to distribute CoQ10 directly to the sources allowing MitoQ to deliver targeted support directly to your mitochondria cells. Our innovative and proven effective method of reducing free radical damage increases the intensity of our health benefits and allows you to see proven results, sooner.
- BOOST ORGAN PERFORMANCE AND DAILY ENERGY LEVELS: 90% of your body's energy comes from the mitochondria, yet every year mitochondria produce less energy due to natural aging. This is a result of free radicals present in the body during the energy process damaging the walls of the mitochondria, which causes the cell to operate less effectively. MitoQ helps to limit free radical damage at the source, supporting your cells and building resilience by reducing the risk of oxidative stress.
- UNPARALLELED BREAKTHROUGH CELLULAR SCIENCE: MitoQ relies on advanced, patented CoQ10 technology based on two decades of research and $60 million of investments. Our ingredients have been selected and formulated to provide the highest level of bioavailability and absorption on the market. Not only does MitoQ build up the mitochondria’s free radical defence, but it also works to prevent future damage of the cell membrane which significantly increases the cell’s resilience and health.
- TRUSTED BY PROFESSIONALS FOR ENDURANCE AND RECOVERY: MitoQ is a mitochondria supplement expertly trusted by professional athletes and medical specialists to deliver high quality cell support. Support your mental focus, healthy aging, and boosted energy levels with the supplements that are shown to deliver optimized organ support. MitoQ ingredients and products are manufactured to Good Manufacturing Practice (GMP) standards so you can have confidence in the supplements that you take.
- NEXT-GEN ANTIOXIDANT FOR VITALITY: MitoQ is better absorbed by your cell powerhouses than regular antioxidants. MitoQ is able to pass easily through the cell wall to distribute CoQ10 directly to the sources allowing MitoQ to deliver targeted support directly to your mitochondria cells. Our innovative and proven effective method of reducing free radical damage increases the intensity of our health benefits and allows you to see proven results, sooner.
- BOOST ORGAN PERFORMANCE AND DAILY ENERGY LEVELS: 90% of your body's energy comes from the mitochondria, yet every year mitochondria produce less energy due to natural aging. This is a result of free radicals present in the body during the energy process damaging the walls of the mitochondria, which causes the cell to operate less effectively. MitoQ helps to limit free radical damage at the source, supporting your cells and building resilience by reducing the risk of oxidative stress.
- UNPARALLELED BREAKTHROUGH CELLULAR SCIENCE: MitoQ relies on advanced, patented CoQ10 technology based on two decades of research and $60 million of investments. Our ingredients have been selected and formulated to provide the highest level of bioavailability and absorption on the market. Not only does MitoQ build up the mitochondria’s free radical defence, but it also works to prevent future damage of the cell membrane which significantly increases the cell’s resilience and health.
- TRUSTED BY PROFESSIONALS FOR ENDURANCE AND RECOVERY: MitoQ is a mitochondria supplement expertly trusted by professional athletes and medical specialists to deliver high quality cell support. Support your mental focus, healthy aging, and boosted energy levels with the supplements that are shown to deliver optimized organ support. MitoQ ingredients and products are manufactured to Good Manufacturing Practice (GMP) standards so you can have confidence in the supplements that you take.
8. Health Thru Nutrition Kaneka Ubiquinol CoQ10 Softgels 100mg
Ratings: 4.7 out of 5 - more than 1,100 global ratings
- Featuring Kaneka Ubiquinol
Kaneka Ubiquinol is derived from the world’s most recognized and researched CoQ10 ingredient for 30 years. Kaneka Ubiquinol is more absorbable than conventional CoQ10, which means that optimal levels of CoQ10 can be restored quickly and efficiently, especially in those who are over 40 or are affected by certain age-related conditions.
- Researched Benefits
Ubiquinol & CoQ10 have been found in countless studies to improve specific blood markers associated with Heart Health and Energy Production!
- Quality, Safety, Integrity
TN's core beliefs guide us to empower people to live healthier lives by providing superior-quality nutrition products and serving as a trusted source of nutrition information.
Great quality. A part of my healthy heart supplement regimen. Anyone taking a prescription or natural OTC statin to lower their bad cholesterol should also take a quality CoQ10 (in the form of Ubiquinol, not Ubiquinone if you're over age 30) because statins eliminate the CoQ10 produced by the body. Some doctors recommend this to their statin taking patients but most don't.
CoQ10 Deficiency and Statins
Your body can naturally make CoQ10, but genetic alterations in metabolism, poor diet, oxidative stress, chronic conditions, aging and statins can all interfere with CoQ10 production and lead to CoQ10 deficiency. Statins can induce coenzyme Q10 deficiency, which can lead to muscle symptoms such as myopathy, rhabdomyolysis, myoglobinuria, impaired mitochondrial energy and metabolism. As the CoQ10 levels drop, the side effects of statins increase (Healthline).
To maintain good health, an adult body should contain 0.5 to 1.5 g of CoQ10 and sometimes it takes a supplement to keep you there. Dosing requirements will vary depending on your individual situation and needs.
As a general rule, the sicker you are, the more you need. The suggested dose is usually between 30 mg to 100 mg per day if you're healthy, or 60 to 1,200 mg daily if you're sick or have underlying health conditions.
If you have an active lifestyle, exercise a lot or are under a lot of stress, you may want to increase your dose to 200 to 300 mg per day. Importantly, if you're on a statin drug, you need at least 100 mg to 200 mg of ubiquinol or CoQ10 per day, or more. Ideally, you'll want to work with your physician to determine your ideal dose.
As a general rule, the sicker you are, the more you need. The suggested dose is usually between 30 mg to 100 mg per day if you're healthy, or 60 to 1,200 mg daily if you're sick or have underlying health conditions.
If you have an active lifestyle, exercise a lot or are under a lot of stress, you may want to increase your dose to 200 to 300 mg per day. Importantly, if you're on a statin drug, you need at least 100 mg to 200 mg of ubiquinol or CoQ10 per day, or more. Ideally, you'll want to work with your physician to determine your ideal dose.
Other Effective Choices to Improve Heart Health
To effectively manage your cardiovascular risk, it is critical to reduce chronic
inflammation. Magnesium plays a vital role in biological function and mitochondrial
health, and is a culprit in the development of inflammation when your levels are low. It
may also play a role in inhibiting the deposit of lipids on arterial walls and plaque
formation (R).
There are multiple factors affecting the inflammatory process in your body. Some of the
more significant over which you have control, include:
Hyperinsulinemia — An excess of insulin in your blood triggered by a diet high in net
carbohydrates. What you eat tends to be the deal-breaker in how much insulin your
body secretes. However, there are other factors contributing to your insulin levels,
such as smoking, sleep quality, exercise and vitamin D level.
Unbalanced fatty acids — Your body needs a balance of omega-3 and omega-6 fats.
Unfortunately, most diets have an overabundance of omega-6 fats leading to
greater levels of inflammation. Strive for a 1-to-1 ratio of omega-3 to omega-6 fats
to reduce inflammation and your risk of heart disease.
High iron stores — Ensure your ferritin blood levels are below 80 ng/ml. If elevated,
the simplest and most efficient way to lower your iron level is to donate blood. If
you can't donate, then therapeutic phlebotomy will effectively eliminate the excess
iron.
Leaky gut — Food particles and bacteria leaking from your intestines increase your
level of inflammation and your risk of heart disease. By eliminating grains, sugars
and lectin-rich legumes, while adding fermented foods, you may heal your gut and
reduce your level of inflammation.
Inadequate levels of magnesium — A century ago your diet provided nearly 500
milligrams (mg) of magnesium per day. Today, courtesy of nutrient-depleted soil,
you may be getting only 150 mg per day. Your body flushes excess magnesium
through your stool, so using magnesium citrate and monitoring stool consistency,
consider starting with 200 mg of oral magnesium citrate and gradually increasing
until you develop slightly loose stools. Magnesium threonate is preferred, as it
appears to more efficiently penetrate cell membranes, including your mitochondria. It
penetrates your blood-brain barrier and may help improve memory. It also may be a
good alternative to reduce migraine headaches. In one double-blind, placebo-controlled trial (2014), patients who received intravenous magnesium within 24 hours of their heart attack experienced 24% fewer deaths within the following five years. Researchers concluded the benefits of magnesium intake on chronic disease may be explained by the effect it has on inhibiting inflammation.
FAQs
a. Who Should Avoid Taking CoQ10?
CoQ10 has possible interaction with anticoagulants. CoQ10 may reduce the effectiveness of blood-thinning medications like warfarin (Jantoven). This could increase the risk of a blood clot.
b. What Happens if Your Coq10 Levels Are Low?
A slight CoQ10 deficiency can result in muscle weakness and fatigue. Although CoQ10 deficiency is unlikely to occur in the general population, there is a higher risk in people with particular medical problems including cancer, diabetes, or genetic abnormalities.
Studies have also shown that a lack of coenzyme Q10 can make cells more vulnerable to harm from free radicals.
c. Ubiquinone Vs Ubiquinol
The main differences between ubiquinol and ubiquinone is that ubiquinol is the reduced form of CoQ10, whereas ubiquinone is the oxidized form. Therefore, ubiquinone has more electrons than ubiquinol.
Ubiquinone = oxidized CoQ10 = yellow
Ubiquinol = reduced CoQ10 = white
Ubiquinol = reduced CoQ10 = white
In contrast to ubiquinone, which has a characteristic yellowish color, ubiquinol is essentially white. As soon as ubiquinol is exposed to oxygen, it transforms back into ubiquinone, which is its oxidized (and yellow) form.
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