8 Best Mitochondria Boosting Supplements in 2024

Mitochondria play a critical role in the production of necessary energy for the cell's survival and functioning. They are responsible for most of the useful energy obtained from the breakdown of carbohydrates and fatty acids, which is transformed to ATP via the oxidative phosphorylation process.

Mitochondrial Dysfunction and Aging

Many studies found that age-related processes are associated with mitochondrial dysfunction.

A study observing mitochondrial dysfunction in the elderly supports the hypothesis that an age-associated decline in mitochondrial function contributes to insulin resistance in the elderly. Furthermore, it is also known that mitochondrial mutations increase in frequency with age in both animal models and in humans.

Best Supplements for Mitochondrial Health

A. CoQ10

CoQ10, also known as coenzyme Q10, is one of the most popular dietary supplements for heart health and overall wellness. 

A study showed that ubiquinol-10 may enhance mitochondrial activity by increasing levels of SIRT1, PGC-1α, and SIRT3 that slow the rate of age-related hearing loss and protect against the progression of aging and symptoms of age-related diseases

CoQ10 Recommended Dosage

CoQ10 dosages of 90 to 200 mg per day are often advised, while larger doses of 300 to 600 mg may be necessary for specific illnesses. CoQ10 is a supplement is generally well-tolerated and safe.

1. Life Extension COQ10 Super Ubiquinol 100mg with Enhanced Mitochondrial Support

Life Extension COQ10 Super Ubiquinol 100mg with Enhanced Mitochondrial Support

- CoQ10 for Heart Health and Cellular Energy
Co Q10 (or coenzyme Q10) is an essential nutrient your body requires for healthy mitochondrial function, a process that produces body energy at the cellular level.

Improved Bioavailability: Ubiquinol and Shilajit
The traditional form of CoQ10, ubiquinone, is difficult for the body to absorb. But another form, ubiquinol, has been shown to absorb up to 8 times greater than ubiquinone. That’s why LE offers a highly bioavailable form of ubiquinol CoQ 10 in a patented delivery system with superior absorption levels.

Shilajit Enhances Coq10 Effectiveness
When combined with ubiquinol CoQ10, it has been clinically shown to double levels of CoQ10 in the mitochondria. Shilajit prolongs CoQ10’s efficacy at the cellular level by stabilizing it in its ubiquinol form and facilitates greater cellular energy output by improving delivery of CoQ10 into the mitochondria. 

Breakthrough Longevity and Cellular Energy Formula
Research supports the value of this unique combination of ubiquinol CoQ10 and shilajit. That’s why we’ve created Super Ubiquinol CoQ10 with Enhanced Mitochondrial Support, to create a powerful synergy that supports heart health and youthful cellular energy production better than CoQ10 alone.

Ubiquinol (as Kaneka Ubiquinol™) 100 mg PrimaVie® Shilajit fulvic acid complex 100 mg Other ingredients: sunflower oil, gelatin, glycerin, purified water, beeswax, sunflower lecithin, annatto color.

4.6 out of 5 - more than 2,250 global ratings

Taken twice a day with meals this noticeably improves my blood sugar but this was just a bonus I discovered and not the reason I purchased this.

I purchased this for it's positive effect on heart health and have since discovered it helps boost the immune system, increases energy levels by improving mitochondria function, reduces cholesterol, prevents migraines, and helps with gum disease. I trust Life Extension more than other brands although I am suspect of all of them.

2. Jarrow Formulas Co-Q10 100 mg

- Support the Power Factories 
Co-Q10 is a nutrient that supports the function of mitochondria (the “power factories'' within our cells).* Found in the cells of energy-rich tissues like the heart, our body’s Co-Q10 levels decrease as we age.

- Co-Q10 Benefits 
As an antioxidant, Co-Q10 helps promote vitality by supporting mitochondrial health and efficient energy production, the health benefits of which support cardiovascular function.*

- Superior Nutrition and Formulation
The goal of Jarrow Formulas is to promote optimal health with high-quality, effective, affordable, and superior formulation of dietary supplements; Our customers can be assured of purity, value, and potency

- Convenient Capsules 
Take one capsule up to three times per day with a fat-containing meal or as directed by your qualified healthcare professional.

- Superior Nutrition & Formulation 
The goal of Jarrow Formulas is to promote optimal health with high-quality, effective, affordable, and superior formulation of dietary supplements. Our customers can be assured of purity, value, and potency.

Coenzyme Q10 100mg (ubiquinone), cellulose, magnesium stearate (vegetable source) and silicon dioxide. Capsule consists of hydroxypropyl methylcellulose.

4.7 out of 5 - more than 700 global ratings

Co-Q10 is an excellent supplement that should be part of anyone's regimen..I take it as part of my natural approach to high blood pressure. But it also has the added benefits of helping cholesterol levels, helps protect the lungs, reduces headaches, and even has properties of a cancer prevention. It's one of the oldest supplements in my regimen.

3. Actif Super Ubiquinol CoQ10 with Enhanced Mitochondrial Support

Actif Super Ubiquinol CoQ10 with Enhanced Mitochondrial Support

Actif Super Ubiquinol CoQ10 with Enhanced Mitochondrial Support provides 200mg ubiquinol, a highly bioavailable form of coenzyme Q10 nutrient, augmented with unique herbal blend. Actif product has been clinically shown to further increase CoQ10 absorption, promote cardiovascular health, and help restore youthful cellular energy. Brought to you by ACTIF — the leader in high quality health products.

- promotes cellular energy production in heart, brain and muscle tissue
- unique blend that enhances mitochondrial coq10 absorption
- certified non-GMO, gluten-free, BPA-free
- free shipping, made in USA, 100% customer satisfaction

4.6 out of 5 - more than 500 global ratings

Not only do you get Ubiquinol but you also get supplements that increase your metabolism and energy. What is so surprising it that the cost for the extras is minimal. Easy to verify this.... compare this to products that contain only Ubiquinol. Also, I like that it is very small and easy to swallow.

4. MaryRuth Organics CoQ10 Liquid Vitamin

- Megadose CoQ10 Liposomal
Coenzyme Q10, a notoriously difficult compound for the body to absorb, is more bioavailable here in a liposomal format. Our liposomal contains CoQ10 as Ubiquinone, which is the oxidized form and essential for CoQ10’s role in cellular energy metabolism.

- Multiple Benefits
Support your heart, cells, & immune system! CoQ10 is an integral component of the mitochondrial electron transport chain and energy production. Critical for heart health, CoQ10 is also important for organs and tissues, and a deficiency may result in a number of health complications.

- Easy-to-Take Liposomal
With CoQ10 in easy-to-take liposomal form, you can simply take it by mouth, add it into your favorite blended beverage, or as a topping on a variety of foods! Shake gently before using. Take 5 mL (1 Teaspoon) daily. Each bottle comes with 45 servings.

- Free of Most Common Allergens
MaryRuth's CoQ10 Liquid Liposomal is Non-GMO, Vegan, and made in a GMP (Good Manufacturing Practice) Facility. Dairy Free, Gluten & Wheat Free, Soy Free, Corn Free, Nightshade Free, No Added Sugar, No Artificial Colors. *This product CONTAINS nut allergens: Coconut-derived glycerin.

Vitamin E (D-Alpha Tocopherol), Liposomal Proprietary Blend (Organic Sunflower Seed Oil, Phosphatidylcholine), Coenzyme Q10 (Ubiquinone), Organic Vegetable Glycerin, Purified Water, Citric Acid, Natural Citrus Peach Flavor Potassium Bicarbonate, Oleic Acid, Phosphoric Acid, Gum Acacia. CONTAINS COCONUT.

4.6 out of 5 - more than 340 global ratings

MaryRuth Organics CoQ10 Liquid Reviews
We all need Coq10 regularly, for the mitochondria of our cells. In addition if you are on prescriptions like me, you need Coq10 even more to protect your body. I am using this liposomal type for the first time, the second liquid type I've tried. I think I will stick with this one because liposomal is known for absorbability and the price is moderate compared to other liquids. I want a liquid because of a swallowing disorder.

B. Pyrroloquinoline Quinone (PQQ)

PQQ, also called methoxatin can be found in fruits and vegetables such as kiwi fruit and green peppers. 

PQQ may promote tumor cell apoptosis (death) and lower reactive oxygen species (ROS) levels. Furthermore, PQQ may safeguard the general tissue function of the liver, neurons, and other significant tissues by enhancing their mitochondrial function.

An animal study provide direct evidence that PQQ reduces oxidative stress, mitochondrial dysfunction, and cell death in isolated adult rat cardiomyocytes.

5. Double Wood Supplements PQQ Supplement 20mg

- Mitochondrial Support
PQQ helps promote Mitochondria Energy Cofactor levels and efficiency

- Promote Energy Levels
By helping Mitochondria work more efficiently, PQQ helps promote overall energy levels

- Supports Healthy Sleep Quality
An 8 week study revealed PQQ may help support sleep quality by supporting healthy cortisol levels

- Vegan, Non Gmo, Gluten Free 
Double Wood's PQQ is Vegan, Non Gmo, and Gluten Free

- Manufactured and Tested in the USA
Double Wood's PQQ capsules are manufactured and tested for microbes and heavy metals right here in the USA

PQQ 20mg, Other Ingredients: microcrystalline cellulose and Hypromellose (veggie) capsules

4.6 out of 5 - more than 1,300 global ratings

Double Wood Supplements PQQ Supplement Reviews
I am on my 3rd bottle of your PQQ, I find i do notice a difference when I don’t take it; less energy. I purchased this product to help improve my mitochondrial health. I have noticed an increase in my energy since taking it. I have recommended this to others.

6. Mitochondria Maximizer with CoQ10 and Active PQQ

- Don’t Be Fooled By Cheap Imitations 
Most energy supplements use weak formulas with synthetic vitamins as fillers with unwanted side effects. With Peak Performance you can rest assured knowing that you’re getting the ingredients designed to give you the highest absorption and bioavailability.

- Enhanced with PQQ and CoQ10 
Works at a cellular level by pairing two natural ingredients: PQQ and CoQ10, giving this supplement the remarkable ability to support the healthy functioning of mitochondria. Both CoQ10 and PQQ occur naturally in the body, and are integral to good mitochondrial function and cellular energy production.*

- Vegetarian Formulated 
Manufactured Without Gluten, GMOs, Additives, Preservatives, Artificial Colors, Soy, and Dairy. Made Under The Highest Quality GMP Regulations and USA Standards.

Medium chain triglycerides, coenzyme Q10, pyrroloquinoline quinone. other ingredients: hydroxypropyl, methylcellulose, rice fiber, silicon dioxide

According to my dr. it is very good for my cellular mitochondria and helps them function as well as they can even though they are damaged. It is easy to swallow.

7. Life Extension PQQ Supplement 20mg

- PQQ Benefits 
PQQ (Pyrroloquinoline quinone) is a novel nutrient that actually encourages your body to grow NEW mitochondria – the cellular structures responsible for producing the energy your body needs to function.

- Why You Need New Mitochondria
Mitochondria create a compound called ATP out of the foods you eat. Your body then uses ATP to power your cells. But over time, you lose these tiny little powerplants. PQQ helps “flip the switch” that encourages your body to grow new ones.

- Fighting Oxidative Stress
Your cellular mitochondria are also vulnerable to oxidative stress caused by free radical compounds. PQQ helps protect these vital cellular structures, so they can keep creating the vital energy your body needs.

- Ingredients Matter 
Sourced using only the finest raw ingredients with the purity and potency your body deserves. The majority of our products are non-GMO, gluten-free, and Manufactured in the USA—and a Certificate of Analysis is available for every product we produce.

PQQ (Pyrroloquinoline quinone) disodium salt 20mg, Other ingredients: rice bran, rice flour, vegetable cellulose (capsule), silica.

4.6 out of 5 - more than 400 global ratings

I'm sleeping well for the first time in a long time. I take PQQ with CO Q10 and the results have been wonderful. I can't recommend this enough for people who are having trouble sleeping. PQQ has many other cognitive benefits because it crosses the BBB and supports mitochondria but the sleep benefit was a gift. Wonderful supplement.

C. Other Supplements

i. Magnesium for Mitochondrial Health

ii. Acetyl-L-Carnitine for Mitochondrial Health

8. Doctor's Best Coq10, L-Carnitine, Magnesium

Doctor's Best Coq10, L-Carnitine, Magnesium

- Unique Blend Combination
CoQ10, L-Carnitine and Magnesium unique blend of nutrients that supports energy, muscle mass and muscle recovery.* This synergistic combination is designed to help support your high intensity workouts and optimize physical performance.

- CoQ10 
Antioxidant has been shown to help support, protect heart health and cellular energy. Also helps support the body’s ATP production, helping to increase energy levels. Helps reduce muscular fatigue

- L-Carnitine 
Helps support the production of energy by transporting long-chain fatty acids into your mitochondria oxidizing it and producing energy. Also helps remove compounds from mitochondria to prevent their accumulation, which helps promote muscle recovery.

- Magnesium 
Helps provide energy and prevent loss of muscle mass. Magnesium could play a role in prevention of age-related loss of skeletal muscle mass, power and strength.

CoQ10 is one of the most important supplements as one gets older. It boosts energy, and it seems to slightly lower blood pressure and slow Alzheimer's.

Magnesium is the neglected mineral, but it is critical for good sleep and bone strength. Many take a calcium supplement, but neglect magnesium.

How Can I Improve My Mitochondrial Function Naturally?

a. Eating a Healthy Diet

Cut Excess Calories From Your Diet
Obesity and heightened inflammatory processes are caused by an excess of calories, which increases reactive oxygen species (ROS) generation during the Krebs cycle in mitochondria. 

Increased amounts of ROS cause cellular damage known as oxidative stress which has been associated to many diseased (i.e., Parkinson's disease, Alzheimer's disease (AD), and many more)

According to some datas, caloric restriction attenuates age-related cellular oxidative damage, decreases mitochondrial oxidant emission, and increases the activity of endogenous antioxidants

Eating an Anti-inflammatory Diet

According to research, inflammatory foods stress and overwork the mitochondria, therefore avoiding them may help your body stay healthy and powerful.

b. Get at Least 30 Minutes of Physical Activity Daily

Physical activity is the most effective strategy to boost your oxygen intake, which is essential for the Krebs cycle in mitochondria. As your body expends more energy, it will be forced to manufacture more mitochondria to meet the need. Your body and mitochondria will become complacent if you are not expending energy or using up oxygen.

c. Get Enough Sleep

Sleep can affect mitochondrial function and thus our health and longevity. There's a connection between having a shorter lifespan and having fewer copies of mitochondrial DNA in the blood. A study found that people who did not sleep enough, and had a restless sleep, also had the lowest copies of mitochondrial DNA. (Source)

d. Yoga

A randomized controlled trial observing the impact of yoga in rheumatoid arthritis patients suggest that yoga enhance mitochondrial health, improve circadian rhythm markers, OS marker regulation, upregulation of transcripts that maintain mitochondrial integrity, reduce disease activity and its associated consequences on health outcome and hence can be beneficial as an adjunct therapy.


a. What Happens if Mitochondria Stopped Working?

When the mitochondria fail, the cells do not receive enough energy. Unused oxygen and fuel molecules accumulate in cells and cause harm.

Different mitochondrial diseases have different symptoms. It relies on the number of damaged mitochondria and their location in the body. Sometimes only one type of cell, tissue, or organ is impacted. However, the issue frequently impacts a lot of them. Due to the high energy requirements of muscle and nerve cells, neurological and muscular issues are frequently happened.


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