7 Best Natural Supplements for Chronic Fatigue Syndrome 2023

Chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis is a complex disease characterized by extreme fatigue that lasts for at least six months and it can't be explained by an underlying condition. The fatigue gets worse with physical or mental activity, but it doesn't get better with rest.

What is the Most Common Reason for Chronic Fatigue?

Although the cause of chronic fatigue syndrome is still unknown, some experts believe that multiple factors contribute to CFS, ranging from viral infections to psychological stress.

Certain factors include age and gender are also contribute to CFS. Even though CFS can affect anyone at any age, it frequently affects people in their mid-20s and mid-40s. Women are affected up to four times more often than men. 

What Are the Symptoms of Chronic Fatigue Syndrome?

Symptoms of CFS often mimic the flu. The following are the most common symptoms of CFS. However, each person may experience symptoms differently. Symptoms may include:
  • Sensitivity to light
  • Headache
  • Tender lymph nodes
  • Fatigue and weakness
  • Muscle and joint pain
  • Inability to concentrate
  • Insomnia
  • Forgetfulness
  • Mood swings
  • Confusion
  • Low-grade fever
  • Depression
The symptoms of CFS may look like other medical conditions. Always talk with your healthcare provider for a diagnosis.

Best Supplements for Chronic Fatigue Syndrome

CoQ10 and NADH

Studies have suggested that the common antioxidant dietary supplements coenzyme Q10 (CoQ10) and nicotinamide adenine dinucleotide (NADH), which are known to have cardioprotective effects, may ease the symptoms of chronic fatigue syndrome (CFS).

Both supplements have been shown to significantly reduce fatigue levels and other symptoms associated with chronic diseases, such as fibromyalgia. Studies of their utility in treating CFS, however, have been very small with inconsistent conclusions, according to researchers. (Source)

Can Nutrient Deficiencies Cause Chronic Fatigue Syndrome?

Numerous studies suggested that certain nutritional deficits could play a role in the etiology of CFS. These include deficiencies of vitamin C, vitamin B complex, sodium, magnesium, zinc, folic acid, l-carnitine, l-tryptophan, essential fatty acids, and coenzyme Q10.

For example, a dose-response association and long-lasting effects of B12/folic acid provide a proper positive reaction in the examined CFS patients. 

The low content of serum vitamin E during the remission and exacerbation phase of CFS patients revealed that high oxidative stress could be contributing to the CFS pathogenesis, and may be directly related to the severity of the symptoms of CFS patients, indicating that antioxidant supplementation could alleviate muscle symptoms in this syndrome. (Source)

A. CoQ10 and NADH Supplement

1. MAAC10 Formulas NADH + CoQ10 Supplement 

MAAC10 NADH + CoQ10 Supplement | Supports Fatigue, Energy and NAD+ | Active Vitamin B3 | 50mg PANMOL® NADH + 100mg CoQ10 (60 Count 2 per Serving).

NADH is the reduced form of Nicotinamide Adenine Dinucleotide (NAD+ the longevity molecule). NADH + CoQ10 is a versatile super-nutrient combination that uniquely promotes cellular energy by donating high-energy electrons to the body that creates ATP Energy. Time Tested and Proven Formula Since 2015.

- NADH + CoQ10 is powerful antioxidant 
- supports healthy mitochondrial energy production, NAD+, and CoQ10 levels.
- GMP certified product 
- non-GMO, Gluten Free, NO egg, peanut, milk, tree nuts, fish or crustacean.

4.3 out of 5 - more than 700 global ratings 

My 13 year old daughter has arthritis and recently diagnosed with fibromyalgia and has not been able to go to school due to pain and low energy levels. None of the regular medications her doctor had prescribed were helping. I was researching this and read some of the other reviews and bought a bottle and within a week her energy level is at a 7-8 out of 10. She is even talking about trying to go back to school next year. 

I also struggle with chronic fatigue and started taking this at the same time and notice a huge difference in my afternoon energy level. I used to have to take naps in the afternoon as well as not want to get out of bed in the morning. I now wake up and feel I can get out of bed and do things I need to get done without lethargy and feel I can go without napping in the afternoon. I have ordered a second bottle. I have not left many positive product reviews on here but I can say this definitely worked for us!

2. Corllia NADH 50mg + CoQ10 200mg + D-Ribose 150mg Supplement

Corllia NADH 50mg + CoQ10 200mg + D-Ribose 150mg Supplement

- Push Your ATP to New Levels
This vegan friendly alternative to NMN includes the effective dosage of 50mg Reduced NADH, 200mg Ubiquinol and 150mg D-Ribose. NADH and CoQ10 are natural coenzymes for NAD+ and ATP. D-ribose is an essential compound in energy metabolism that serves for ATP.

- Proven 3X More Effective Than Regular NADH
Curdisol-QR is our patented Ubiquinol and this form of CoQ10 has 3-4 times better absorption rate in the body compared to Ubiquinone. Curdisol-QR taps into the power of this supplement to deliver up to 5x the bioactive benefits of ordinary NADH! 

- 2 Month Supply 
Take 1 veggie capsule each day. That’s it! Each package comes with 60 servings (60 caps) to last you two month.

- Trusted Brand 
Corllia provides scientifically-formulated supplements to support each individual's potential to enjoy optimal life. We offer trust & transparency in our brand.

I am very pleased with this product and can report no adverse effects. I am a 40 year CFS/ME sufferer which is hugely fatiguing!! With this, I feel like I have more to fight with, more pleasant mood and an ability to keep going more hours of the day. Give it a try!! I hope you have similar results....

3. Seeking Health NADH + CoQ10 Metabolic Support

Seeking Health NADH + CoQ10 Metabolic Support


NADH + CoQ10 by Seeking Health provides 50 mg coenzyme Q10 and 25 mg PANMOL NADHmicro in an easy-to-deliver lozenge. NADH + CoQ10 contains patented PANMOL-NADH. Nicotinamide adenine dinucleotide (NADH) is the biologically active form of niacin (vitamin B3) and function as a biological spark plug in the cellular energy metabolism. 

- may help support healthy cellular energy production and healthy mitochondria
- may help support cognitive and cardiovascular health
- does not contain: milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, soy, gmo, or preservatives

I love taking products that will increase my long-term health and wellness, so am always looking for new supplements. I had been experiencing some fatigue and so I did some research and discovered NADH. I decided I wanted to take it and ran across this product. I have taken CoQ10 for a long time but when I found this product I was so pleased to get NADH, as well without having to take an extra pill. I love the orange flavor and take one every night before bed. My energy is great, yet I don't experience hyper-ness or greater stress, so this is the perfect product for me.

4. ASquared Nutrition Nicotinamide with CoQ10

Nicotinamide with CoQ10 (120 Capsules) - Vitamin B3 500mg (Niacinamide Flush Free) - Coenzyme Q10 Powder - VIT B-3 & Coq 10 Supplement Pills to Support Energy, NAD, & Skin Cell Health


- Promotes Longevity
Our maximum strength Nicotinamide supplement contains 500mg of Non-Flush vitamin B3 per vegetable capsule, and is enhanced with 100mg of CoQ10 powder to promote cellular health & repair, brain health, and longevity. Our potent complex contains powerful antioxidants and anti-inflammatory properties*

- Amazing Proprietary Formula
Our natural Nicotinamide + Coenzyme Q-10 formula supports energy levels, and helps boost immunity, brain health, & cognition. Nicotinamide + CoQ10 may help combat age related decline in energy levels, and promotes cellular & DNA health. A prominent element of the metabolic pathway, Nicotinamide is vital for the production of Nicotinamide Adenine Dinucleotide (NAD)*

- Promotes Energy Production
As we age our energy levels naturally decline. Our unique formula helps your cells metabolize & synthesize nutrients more effectively to boost energy. Our natural formula contains 120 capsules per bottle, is vegan friendly, Non-GMO, and Gluten Free. Don’t settle for products that only offer 60, 90 or 100 pills per bottle*

- Supports NAD Levels
Nicotinamide is flush free, and should not be confused with Niacin or nicotinic acid. Our proprietary complex contains 500mg of Nicotinamide & 100mg of CoQ10 powder to help support normal NAD / NAD+ levels (Nicotinamide adenine dinucleotide), and to support cellular health & longevity. Try also our Resveratrol 1000mg, Methyl B12, Quercetin Dihydrate with Zinc, and Liposomal Vitamin C*

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

i like that its pretty good quality NMN and also affordable! Ive noticed that a lot o NMN products are super expensive on Amazon. This one is a little more affordable but still has a good quality capsule, made with no cheap harmful stearates. i like that NMN gives me a boost of energy and stamina. I actually got pregnant recently, accidently, and it was right after i started taking this supplement. After looking it up, i see that Dr.Google says that it actually increases fertility... go figure!!

5. ProHealth NADH + CoQ10 Supplements

ProHealth NADH + CoQ10 Supplements

This supplement helps increase energy levels by supporting ATP production. Every cell in the body requires ATP to function properly and a continual supply of this crucial element is essential to the proper function of the heart, brain, nerves and muscles. ATP is produced in the human body through the process of cellular respiration. NADH and CoQ10 are important co-enzymes in the cell respiration pathway and are needed for the body to maintain adequate levels of ATP.

- supports greater mental focus and improved mood
- patented delayed release capsules protect the delicate co-enzymes from stomach acid. 
- these innovative capsules are designed to release their contents in the small intestine, where it can be most readily absorbed by the body.

Buy these. Do it now. NAD has been life changing in my energy levels. I have Lyme disease which comes with debilitating chronic fatigue and this is the first thing that has caused a noticeable difference in my energy levels. I’m a functioning human being with NAD.  

I felt results the first time I took it. Make sure to take it on an empty stomach. I usually take it right when I wake up and then wait a half hour to ingest anything.  

I would also strongly recommend this to anyone struggling with PAWS after drug addiction/recovery.  

I have done NAD intravenous infusion during drug recovery, which was life changing. Afterwards I used transdermal NAD patches. These pills are immensely more effective than patches, and I would say that under a doctors supervision you could get similar results to having an infusion with a high enough dose.

B. Multivitamins Multiminerals with CoenzymeQ10

6. Pure Encapsulations O.N.E. Multivitamin

Pure Encapsulations O.N.E. Multivitamin

- Multivitamin for Men & Women
Once-daily nutrient essentials provides vitamins A, B, C, D and E in highly bioavailable forms, and sustained-release CoQ10, Metafolin L-5-methyltetrahydrofolate (L-5-MTHF), and alpha lipoic acid for antioxidant support.*

- Cognitive Support
O.N.E Multivitamin provides choline, inositol, lycopene, vitamin D, lutein, and zeaxanthin for healthy cognitive function, cellular health, and eye health.*

- Natural Color Variation
O.N.E. Multivitamin is a light yellow powder with dark speckles, and does have a distinct odor/taste. The odor/taste is due to the selenium and choline. Methylcobalamin, which is naturally darker in color, can cause a light pink to dark red speckled look to the product. The smallest amount of moisture will accelerate blooming of the B12, which can cause more of a spotted appearance. These observations are characteristic for this product, and it is safe to use.*

- Pure Quality
Our supplements are made with only premium ingredients sourced from trusted suppliers and guided by our nutritional experts, then carefully manufactured and tested to verify their potency and purity.

4.7 out of 5 - more than 6,400 global ratings

Been taking these for almost two months and I can totally feel the difference. I'm more energized, happier, feel way less fatigue and muscle aches, and even my fingernails are looking better. I've even had friends comment on my improved attitude and vibrancy! I'm so pleased with this multivitamin!

7. Inessa Bioactive Advanced Multivitamin

Inessa BIOACTIVE Advanced Multivitamin | Potent, Proven Most Absorbable Form & Optimal Dose CoQ10 100mg, Vitamin D3 2000 IU, B Spectrum, K2 100mcg, VIT A, 5-MTHF 400mcg Folic Acid, Zinc 20 mcg Lutein


- Superior Absorption
Just one a day, 2 month supply – fast acting, bioavailable, nutrient rich womens and mens multivitamin delivers full spectrum nutrition in the precise form cells need to support more energy, happiness, wellness & total body health, without wasting money on individual vitamins for women and men.

- Richest Nutrient Base 
Naturopath & nutritionist formulated multi vitamin pack contains 2000iu vitamin d3, 100mcg mk-7 vitamin k2 (w/ absorption maximizing macular carotenoid lutein), vitamin a, vitamin c, vitamin e, vitamin b1, vitamin b2, riboflavin, vitamin b3, vitamin b5, vitamin b6, pyridoxal, folate, vitamin b12, biotin, iodine, zinc, selenium, manganese, chromium, molybdenum, boron, inositol, lutein, and coq10.

- Only the Good Stuff 
All natural, allergen free, vegan multivitamin contains zero yuck, fillers, or chemicals like most vitamins for men and women, plus it’s gluten free, dairy free, and artificial flavor and color free – just pure, potent, powerful vitamins your body really needs. (made in gmp facility)

4.5 out of 5 - more than 1,300 global ratings

I did a lot of research into vitamins and supplements before purchasing these. The vitamins that comprise these pills are such great quality and sourced from the best origins. They don’t irritate my stomach, which is such a common problem with supplements for me and I already have seen an improvement in my lab work for the depleted vitamins I had.


a. Who Should Avoid Taking CoQ10?

CoQ10 has possible interaction with anticoagulants. CoQ10 may reduce the effectiveness of blood-thinning medications like warfarin (Jantoven). This could increase the risk of a blood clot.

b. What Happens if Your CoQ10 Levels Are Low?

A slight CoQ10 deficiency can result in muscle weakness and fatigue. Although CoQ10 deficiency is unlikely to occur in the general population, there is a higher risk in people with particular medical problems including cancer, diabetes, or genetic abnormalities.

Studies have also shown that a lack of coenzyme Q10 can make cells more vulnerable to harm from free radicals.

You May Be Interested In...

Best Vitamins Made In The USA

Best Strategies to Prevent Cancer

Best Antioxidant Supplements

Best Vitamins for Women Over 60


Popular posts from this blog

NAC vs NAD vs NR vs NMN vs Niacin: What Are the Differences?

18 Best Supplements to Reduce Cytokine Storm: Advanced Guide

Zinc Gluconate vs Zinc Picolinate: What's the Difference?

Dr. Zelenko's Z-Stack Vitamin Cocktail: Review 2024

10 Best NMN Supplements (2024 Review)

12 rules for healthy eating - Dr William Davis

How Your Microbiome Influences Your Dietary Recommendations - Georgi Dinkov

Rapamycin: Benefits, Side Effects and Research 2024

Salt Deficiency Could Be Life-Threatening. Here Are the Lesser-Known Dangers

Rapamycin: A Compound Discovered on Easter Island May Extend Life, Combat Age-Related Diseases