Ubiquinone Vs Ubiquinol | Which Form of CoQ10 is Superior?

Both ubiquinol and ubiquinone are forms of CoQ10(coenzyme Q10), act as an antioxidant, substances that may shield your cells from free radicals, which have been linked to heart disease, cancer, and other diseases. 

Ubiquinone Vs Ubiquinol

The main differences between ubiquinol and ubiquinone is that ubiquinol is the reduced form of CoQ10, whereas ubiquinone is the oxidized form. Therefore, ubiquinone has more electrons than the ubiquinol. 

Ubiquinol May Be More Bioavailable Than Ubiquinone

The ability of a medicine or other substance to be absorbed and used by the body is referred to as bioavailability. According to some researches, ubiquinol is more bioavailable. However, the study is still inconsistent.

A study aimed to compare the effectiveness between ubiquinone and ubiquinol to enhance the CoQ10 status in older men suggests that ubiquinol supplement are more effective than ubiquinone supplement.

However, another study found no significant differences between ubiquinone capsules and ubiquinol capsules in the redox status of the absorbed CoQ10, which indicates that CoQ10 appears in blood almost exclusively as ubiquinol, even if consumed as ubiquinone.

Ubiquinol is More Expensive and Less Stable Than Ubiquinone

Ubiquinol cost more to manufacture than ubiquinone, therefore, they are more expensive for consumers and researchers. Moreover, ubiquinol is less stable than ubiquinone, biochemically speaking.

Other Differences

Ubiquinone = oxidized CoQ10 = yellow
Ubiquinol = reduced CoQ10 = white

In contrast to ubiquinone, which has a characteristic yellowish color, ubiquinol is essentially white. As soon as ubiquinol is exposed to oxygen, it transforms back into ubiquinone, which is its oxidized (and yellow) form.

CoQ10 Benefits

a. CoQ10 for Cardiovascular Health
Clinical evidence shows that CoQ10 supplementation with doses of 200 mg/day or higher for prolonged periods is safe, well-tolerated, significantly increases the concentration of CoQ10 in plasma, and reduces oxidative stress and mortality from cardiovascular causes.

b. CoQ10 for Type 2 Diabetes Mellitus (T2DM) 
Patients with T2DM frequently have CoQ10 deficiency. Restoring CoQ10 levels in T2DM patients may reduce oxidative stress, protect mitochondrial function, and ultimately result in better glycemic control. 

c. CoQ10 for Fertility 
CoQ10 is a powerful antioxidant and can lead to a higher rate of fertilization and more high-quality embryos. Moreover, CoQ10 can improve ovulation and increase the number of ovarian follicles. For men, CoQ10 with vitamin C and E can effectively improve semen parameters in infertile men.  

d. CoQ10 for Cancer Prevention 
Coenzyme may lower your risk of developing some cancers and strengthen your immune system. In addition, it can shield your heart from the negative effects of some chemotherapy. 

e. CoQ10 for Migraine Control 
According to a study  CoQ10 appears to have beneficial effects in reducing duration and frequency of migraine attack.

Best Ubiquinol Supplements

1. Ubiquinol Softgels 100mg | Qunol Mega Ubiquinol CoQ10 100mg

- Superior Absorption Vs. Regular CoQ10
With superior absorption compared to regular1 CoQ10, Qunol Mega CoQ10 can help you reach optimal levels of CoQ10 quicker, so you can experience the potential benefits faster

- Cardiologist Recommended Form of CoQ10
With superior absorption compared to regular CoQ10, Qunol 100mg Ubiquinol capsules can help you reach optimal levels of Coenzyme Q10 sooner, so you can experience the potential benefits faster

- 100% Water and Fat Soluble
Qunol CoQ10's patented formulation is 100% water and fat-soluble, unlike regular CoQ10 that does not dissolve in water and dissolves very poorly in fat. Gluten free

- Beneficial to Statin Drug Users
Both cholesterol and CoQ10 are produced in the same pathway. Because statins work by blocking this pathway, they also block the production of CoQ10. Statin medications have been shown to lower CoQ10 levels and the addition of a CoQ10 supplement to statin drug therapy can help replenish lost CoQ10

2. Ubiquinol Softgels 100mg | Nordic Naturals Nordic CoQ10 Ubiquinol 100 mg 

Nordic Naturals Nordic CoQ10 Ubiquinol 100 mg

- Why Ubiquinol
Ubiquinol is the active antioxidant form of Coenzyme Q10 (CoQ10) required for energy production in the cell, and has been shown to support cardiovascular and brain health.

- Turn Food Into Energy
Ubiquinol helps transform food into energy. It's found in nearly every cell, tissue, and organ in the body, however, as you get older, CoQ10 levels may go down. To make up for these losses, try Nordic Naturals CoQ10 Ubiquinol.

- Easy to Swallow
Each mini soft gel provides 100 mg of ubiquinol and is ideal for individuals aged 40+ looking for extra antioxidant support.

- Purity Guaranteed
Everything we make is third-party tested, surpassing the strictest international standards for purity & freshness. This product is non-GMO, gluten & dairy free, and contains no artificial flavors.

- Ethical Innovation
Nordic Naturals has always been at the forefront of sustainable & ethical practices in the natural products industry. Through science & innovation, we are committed to delivering safe, effective nutrients for optimal wellness.

3. Ubiquinol Softgels 200mg | Solgar Ubiquinol 200 mg

Solgar Ubiquinol Supplement 200 mg

- Advanced Antioxidant Support
Coenzyme Q-10 (as ubiquinone) performs several important health supporting roles in the body; Ubiquinol (the reduced form of CoQ-10) provides advanced antioxidant support

- Ready-To-Use
By supplementing with Ubiquinol, you are providing your body with a form of CoQ-10 that is in a ready-to-use state to help fight free radicals; Free radicals can cause oxidative stress which may damage cells

- Oil-Based For Optimal Absorption
Solgar Ubiquinol 200 mg is offered in oil-based softgels to ensure optimal absorption and assimilation

- Gluten and Dairy Free
Solgar Ubiqunol Reduced CoQ-10 Softgels are free of: gluten, wheat, dairy, yeast, sugar, sodium, artificial flavor and sweetener

- The Gold Standard
For over 70 years Solgar has been committed to quality, health, and well-being. Our mission is to create the finest nutritional supplements in small batches, through tireless research, using only the finest raw materials

4. Ubiquinol Softgels 200mg | NOW Supplements, Ubiquinol 200 mg

NOW Supplements Ubiquinol 200 mg, High Bioavailability

- Double Strength for Cardiovascular Health
NOW Extra Strength Ubiquinol has twice the Ubiquinol (200 mg per softgel) as in our regular strength product (100 mg per softgel). Ubiquinol is the reduced and active free radical quencher form of coenzyme Q10 (CoQ10).*

- Active Form of CoQ10
Ubiquinol has been shown to be highly bioavailable and the addition of MCT Oil (medium chain triglycerides) to this product naturally improves its solubility and enhances intestinal absorption, thereby creating a product with superior biological value.*

- Certifications/Classifications
Dairy Free, Egg Free, Low Sodium, Made without Gluten, Sugar Free, Soy Free, GMP Quality Assured

Best Ubiquinone Supplements

1. Ubiquinone Softgels 100mg | Nutrigenomic Naturals Coenzyme Q10 Ubiquinone 100mg

Nutrigenomic Naturals CoQ10, Highest Absorption With Organic Olive Oil, 100mg

- Natural, Organic, Highest Absorption
Our CoQ10 100mg is pure, free of allergens, non-gmo, gluten free, GMP certified and lab tested to ensure purity, potency and effectivness. Our High Absorption COQ10 is formulated in Organic Olive oil, which is full of beneficial fatty acids such as Omega 3, Omega 6 and monounsaturated fats that increase absorption and can improve heart health and overall health.

- Supports Heart Health
Our CoQ10 Ubiquinone converts to Ubiquinol in the body and works to better the functioning of your heart and improving cardiovascular health, your blood pressure and immune function!

- Increases Energy Production
CoQ10 supplement fuels your mitochodria to function better and increase your cellular energy production.

- Anti Aging and Cell Protection
Our CoQ10 100mg is a powerful antioxidant, it protects your mitochondria & cells from oxidative and other cellular damage and age related decay, which is helpful for many health conditions!

2. Ubiquinone Softgels 200mg | Arazo Nutrition CoQ10 Ubiquinone 200mg

- high potency antioxidant that helps maintain heart health
- replenish coq 10 and antioxidant levels that may be depleted
- 200mg per capsule for one month’s supply (30 day supply)
- made in a gmp certified facility in america and third party safety tested for purity
- high standard; trusted for ingredient safety, nutritional value and label accuracy

3. Ubiquinone Softgels 200mg |  Zebora CoQ10-200mg-Softgels with PQQ, BioPerine & Omega-3

- Enhance CoQ10 and PQQ
Our CoQ10-200mg provides a 120 day supply and helps you to increase your natural CoQ10 levels. Coenzyme Q10 (Ubiquinone) helps maintain a healthy heart. In addition, PQQ helps promote Mitochondria Energy Co-Factor levels and efficiency. Both of which are important for energy production and heart health.

- Advantage Black Pepper and Sunflower Lecithin
ZEBORA Coenzyme Q10 is blended with Black Pepper Extract and Sunflower Lecithin to enhance the absorption and bioavailability of Ubiquinone in the body. Black Pepper is not only a bioavailability enhancer; it also has potent antioxidant and anti-inflammatory properties. In addition, sunflower lecithin is safer than other sources of lecithin as it has been shown to help with skin health and improving liver function.

- Optimal Combined Omega-3s
Every soft gel of ZEBORA CoQ10 contains 60 mg of omega-3s, which are imperative to promoting heart health. Omega-3s can improve sleep quality, plus it supports the eyes, skin, and brain health. Better absorption, better taste, and no fishy burps!

- Benefits for Statin Drug Users
CoQ10 plays a vital role in producing 95% of the energy used by our organs. However, natural CoQ10 levels drop with age or when taking statin medications. Therefore, it is better to have the addition of a CoQ10 supplement when on statin drug therapy as it can help replenish lost CoQ10.

4. Ubiquinone Capsules 400mg | ASquared Nutrition CoQ10 400mg Max Strength

- Maximum Strength 400mg/capsule
Our top rated supplement delivers 400 mg of coenzyme Q10 (CoQ10) powder per daily intake (yielding 6% ubiquinone-10). Our high absorption CoQ 10 formula is naturally sourced and packs in 400mg per serving. *

- Heart Health
Coenzyme Q10 has been clinically shown to support heart health, improving blood pressure, and boost overall cardiovascular health. CoQ10 helps maintain healthy cholesterol levels. Co enzyme Q-10 is required for a variety of metabolic pathways including promoting "good" HDL cholesterol. *

- Energy Levels
CoQ10 has shown to increase your pure energy and stamina levels, support your nervous and immune system, and act as a powerful antioxidant to help fight free radicals which damage your cells. 


a. How Much CoQ10 Should I Take?

CoQ10 dosages of 90 to 200 mg per day are often advised, while larger doses of 300 to 600 mg may be necessary for specific illnesses. CoQ10 is a supplement is generally well-tolerated and safe.

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