Best Urolithin A Supplements Review 2023

Urolithin A is the most active and effective gut metabolite and acts as a powerful anti-inflammatory and antioxidant properties. Urolithin A is produced endogenously by human gut bacteria exposed to dietary polyphenolic compounds that include ellagic acid (EA) and ellagitannins (ET), such as punicalagin. 

Exotic and delicious pomegranate on white background
Numerous fruits (including pomegranate and some berries) and nuts (walnuts and pecans) contain these polyphenolic precursors.

Urolithin A Supplement Benefits

One study showed that long-term urolithin A supplementation was beneficial for muscle endurance and plasma biomarkers, suggesting that urolithin A may counteract age-associated muscle decline; however, future work is needed to confirm this finding. 

Another study also found therapeutic potential of urolithin A for cancer treatment and prevention. Urolithin A attenuated the pro-inflammatory factors production in vitro studies. Moreover, oral urolithin A treatment caused prominent anti-cancer and anti-inflammatory action in various in vivo studies.

The main molecular mechanisms of these effects might be the modulation of aryl hydrocarbon receptors, which antagonism may lead to decreasing of chronic inflammation. This might be of vital importance for preventing immune suppression associated with chronic inflammation in cancer.

Best Urolithin A Supplements

1. Puritan's Pride Pomegranate Extract, 250 Mg

Puritan's Pride Pomegranate Extract, 250 Mg

Pomegranate contains important nutrients that help promote good health and help fight free radicals. This pomegranate extract is standardized 40% for ellagic acid, so you receive all of the goodness the pomegranate is famous for! Use as part of your health program.

- highest quality
- scientifically formulated
- one to 4 month supply

4.5 out of 5 - more than 1,900 global ratings

It helps me to sleep deeper and see more dreams when I take one capsule at night. Taking more starts to cause constipation. This is one of the supplements I am trying for healthy aging. Some did not work but this seems good.

2. Navitas Organics Pomegranate Powder, 8oz

Navitas Organics Pomegranate Powder, 8oz. Bag, 45 Servings — Organic, Non-GMO, Freeze-Dried, Gluten-Free


Enjoy the sweet taste and powerful antioxidant benefits of pomegranate year round with Navitas Organics Pomegranate Powder! Navitas Organics Pomegranate Powder has a bright, sweet taste that is fantastic in smoothies, yogurt, marinades, desserts, salad dressings and baked goods.

100% freeze-dried powder of cold-pressed pomegranate juice. Provides 2.15mg of ellagic acid, a potent antioxidant, per serving. USDA Organic, Non-GMO, Kosher, vegan, gluten-free. Committed to accuracy and transparency, we third party test all products to verify quality and nutritional values.

4.5 out of 5 - more than 2,800 global ratings

Pomegranates are an incredibly healthy food, but I can't digest the raw fruit very well, so this powder is an easy way to get some tasty nutrition. I just add a spoonful to applesauce. It's also quite affordable; a half-pound lasts for months.

3. Source Naturals Pomegranate Extract 500mg

Source Naturals Pomegranate Extract 500mg

Pomegranate benefits: they are a rich red fruit loaded with antioxidants, vitamins, potassium, folic acid and iron. Suitable for vegetarians. Contains no yeast, dairy, egg, gluten, soy or wheat. Contains no sugar, starch, salt, preservatives, or artificial color, flavor or fragrance.

- suggested use: the suggested use is to take 2 tablets twice daily.
- manufactured in the USA. Our facility is located in scotts valley california.

4.5 out of 5 - more than 900 global ratings

I take this for the health benefits and this works very well. I have a hard time with certain juices and this is a wonderful alternative to it. Good product and with Healthy ingredients.

4. Pure Original Ingredients Pomegranate Extract

Pomegranate extract capsules are filled with a single ingredient, providing a pure undiluted supplement. Pomegranate extract is a natural source of anthocyanin

- always pure: no additives, stearates, or rice fillers
- 180 day supply: more than 5 months of peak health support
- packaged in utah, usa

4.6 out of 5 - more than 400 global ratings

Pure Original Ingredients Pomegranate Extract Reviews
I have serious osteoarthritis almost everywhere. For its anti inflammatory properties, research led me to tart cherry juice (expensive). Further research indicated that pomegranate juice was the highest in antioxidants, so I switched (also expensive and awful tasting, but it did provide even more relief). It finally occurred to me to look for pomegranate juice extract capsules, and these are great! 

I take the recommended dosage (4 capsules, twice daily - a 3-month supply). They are only a third of the cost of the juice, and offer even better relief! I could probably drop my every-other-day Celebrex if I wanted to, but haven't taken that step yet. If you have arthritis and don't want to take expensive prescription drugs to manage the inflammation and resulting pain, give these a try. I think you'll be pleased. My doctor is happy with my results, as well.

5. Life Extension Pomegranate Complete Supplement

Life Extension Pomegranate Complete - Superfood Health Pomegranate Extract Supplement Pills for Antioxidant Protection - Rich in Polyphenols, Fruit, Flower, Seed Extracts - Gluten-Free - 30 Softgels


- Stay Heart Heart with Pomegrante
Pomegranate is a potent source of polyphenols. These compounds help maintain already-healthy blood pressure, promote healthy endothelial function (the delicate inner lining of your blood vessels), protect against oxidative stress, and promotes a healthy inflammatory response.

- Why Use the Entire Pomegranate Plant
Our Pomegranate Complete formula features standardized pomegranate fruit extracts sourced from pomegranate’s fruit, flower, and seed oil. Why? By using the entire pomegranate plant, our formula offers a broad range of health benefits. It includes the equivalent polyphenol content of about 12 oz of juice.

- Benefits of Pomegranate Juice, Hold the Sugar
Pomegranate juice is healthy and delicious. But like all fruit juices, it’s high in calories. So, don’t drink your pomegranate. Choose a comprehensive pomegranate extract supplement like Pomegranate Complete instead. Since it includes extracts from the entire pomegranate plant, you’ll get more out of this formula than you from a glass of juice—and less, too, because there’s no sugar!

- Ingredients Matter 
Sourced using only the finest raw ingredients with the purity and potency your body deserves. This product is certified non-GMO and gluten-free. Manufactured in the USA and a Certificate of Analysis is available for every product we produce.

I heard about it from Dr Nirala Jacobi in a podcast and decided to give it a try. I'm shocked that it actually seems to have a noticeable, beneficial impact on my severe methane-dominant SIBO.

6. Fresh Healthcare Premium Pomegranate Juice Powder Supplement

- Premium Pomegranate Supplement
Pomegranate has been used for its nutritional benefits for thousands of years. The hundreds of seeds enclosed called arils contain the prized “juice” providing a natural source of Vitamins C, K, B that help support healthy circulation, joints, skin, and anti-aging. Unlike other Pomegranate Supplements, we offer 1200mg of Pomegranate Juice Powder per serving. Our max strength capsules contain black pepper and punicic acid delivering max benefits to the body.*

- Highly Potent Supplement
Our potent pomegranate supplement packs a powerful punch containing 1200mg of pure potent pomegranate juice powder. We took these pomegranate capsules to the next level by adding bioperine black pepper so you can feel the maximum benefits such as support of your immune system, cardiovascular health, joint health, and vibrant skin by taking just 2 capsules a day! It has also been used by athletes to help support increased endurance.*

- We Take Purity Seriously
Our pure & potent pomegranate supplement was professionally formulated and tested in the USA to bring you the purest form of potent pomegranate juice powder and black pepper fruit extract. Our supplement is non-GMO and is suitable for vegetarians and vegans. Let us help you support healthy circulation, joints, and anti-aging when you choose to put your mind, body, and spirit first.*

4.4 out of 5 - more than 600 global ratings

Looking for more energy ~ perfect way to get healthy and quick energy. Recommend to everyone that doesn’t want chemicals in your energy supplements. Great price too.

7. 21st Century Pomegranate Veg Capsules

21st Century Pomegranate Veg Capsules, 500 mg 120 Vegetarian Capsules

21st Century's Pomegranate 500 mg (Punica granatum) features pomegranate fruit extract standardized to 40% ellagic acid. This important polyphenol helps promote antioxidant health and supports the body's fight to suppress free radicals that can lead to pre-mature aging of cells.

 21st Century's standardized herbal extracts are thoroughly tested to assure specific levels of the important ingredients are present for maximum benefit.

4.5 out of 5 - more than 500 global ratings

21st Century Pomegranate Veg Capsules Reviews
Dr Ephraim Lansky , a brilliant researcher in Israel, has researched the positive effects of pomegranate extract for helping improve our health. When you are not near a live fruit, these capsules are a great backup.


a. Does Pomegranate Extract Contain Urolithin A?

The most abundant type of polyphenols in pomegranate juice are ellagitannins that are hydrolyzable tannins releasing ellagic acid on hydrolysis () and form urolithins such as urolithin A following metabolism by gut flora (FIGURE 10.1).

b. Importance of Urolithin A


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