Best AMPK Activator Supplements 2023

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AMP-activated protein kinase (AMPK) is a crucial regulator of energy in the body. It is also referred to as a "metabolic master switch" because in low energy condition, AMPK will help to maintain cellular energy homeostasis by promoting energy production (catabolic processes) and inhibiting energy-consuming processes (anabolic processes). 


What Compounds Activate AMPK?

Here are some common ingredients that have been studied for their potential to activate AMPK..

a. Hesperidin
Hesperidin is a bioflavonoid occurring in high concentration in citrus fruits, particularly in the peel and inner white pith of oranges and lemons. A study indicates a significant increase in SIRT1 protein level and activity as well as an induction of AMPK phosphorylation by hesperetin. 

b. Actiponin
Actiponin is often marketed as a dietary supplement that may have beneficial effects on health and metabolism, particularly by influencing AMP-activated protein kinase (AMPK).

According to an animal study, oral administration of actiponin to ob/ob ("obese") mice for 8 weeks decreased body weight gain, liver weight, and blood cholesterol levels with AMPK activation in the soleus muscle. However, further studies are still needed to confirm this.

c. Berberin
Berberine: Berberine is a chemical found in some plants like European barberry, goldenseal, goldthread, Oregon grape, phellodendron, and tree turmeric. 

Berberine is also an AMPK agonist, and it increases energy production and reduces energy storage by activating AMPK. (R) Moreover, Berberine's activation of AMPK is associated with a range of metabolic effects. It can help improve insulin sensitivity, which is crucial for regulating blood sugar levels and preventing insulin resistance.

d. Quercetin
Quercetin is a flavonoid, a type of plant compound found in a variety of fruits, vegetables, and is available as supplement. It has gained attention for its potential health benefits, including its role in activating AMP-activated protein kinase (AMPK). However, the effectiveness in each person may be vary and further studies are needed to confirm.


What Are the Benefits of Activating AMPK?

Activating AMPK can also have other health benefits, including:

a. Insulin Sensitivity
AMPK and insulin sensitivity are interconnected in the regulation of glucose metabolism. Because activated AMPK increases the uptake and utilization of glucose by cells, it can improve insulin sensitivity. Insulin sensitivity can be increased through a variety of lifestyle changes, including regular exercise, eating a balanced diet, and occasionally taking supplements or medications that may increase AMPK activity.

b. Increased Fat Oxidation
When there is an increase in energy demand or when exercising, AMPK is activated to promote the breakdown of stored fat in order to enhance the utilization of fatty acids for energy. Our body can therefore keep the balance of energy. Dietary choices and regular exercise are examples of lifestyle factors that can affect AMPK activity and, consequently, fat oxidation.

c. Protection Against Metabolic Diseases
AMPK can be activated by diverse phytochemical substances such as EGCG, chicoric acid, tomatidine, and others, all of which have been found to contribute to preventing or ameliorating chronic disorders. On the other hand, recent studies have found that metabolic disruptions induced by pesticides such as 1,3-Dichloro-2-propanol, imidacloprid, permethrin, are attributed to the inactivation of AMPK. (R)


Best AMPK Activator Supplements

1. Life Extension AMPK Metabolic Activator - Calcium, Hesperidin and Actiponin®

1. Life Extension AMPK Metabolic Activator - Calcium, Hesperidin and Actiponin®

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Our AMPK Metabolic Activator combines the citrus flavonoid hesperidin with G. pentaphyllum (Jiaogulan) extract, two botanical ingredients that trigger AMPK and help promote abdominal fat reduction. Healthy cellular AMPK activity is an essential part of any weight management program. 

But please note: AMPK activation will be more effective when combined with a healthy diet and regular exercise.

Ingredients 
Calcium (as calcium carbonate) 130 mg Hesperidin [from orange extract (fruit)] 500 mg ActivAMP® gynostemma extract (leaf) 450 mg Other ingredients: microcrystalline cellulose, stearic acid, croscarmellose sodium, hydroxypropyl cellulose, aqueous film coating (hypromellose, glycerin, purified water), silica, vegetable stearate.

Ratings: 4.2 out of 5 - more than 2,120 global ratings
AMPK Metabolic Activator reduces bloat. As regards losing weight, I still have to push away from the table. There is no magic bullet that guarantees weight loss for me.



2. GENEX Berberine AMPK Activator*

GENEX Berberine AMPK Activator*

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Genex Formulas Berberine capsules contain 500mg of Berberine HCL each. Our capsules are easy to swallow and contain no additives or fillers. Genex Berberine Supplement features Berberine Hydrochloride, a form widely studied and may be absorbed more easily by the body.

It is tested at a GMP and NSF-certified facility in Georgia, USA. We believe in your health so our Berberine 500mg capsules are Non-GMO, Gluten Free, and Vegetarian.
Had blood work done, glucose was 101. That's a little high. Bought this and half a bottle later had blood drawn again glucose was 91. I'd say it worked well.



3. Horbäach AMPK Metabolic Activator

Horbäach AMPK Metabolic Activator

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Horbaach AMPK activator features 450 mg Actiponin per serving in quick-release capsules for maximum support. Our supplements use advanced sourcing to ensure purity and potency always

- Laboratory Tested, Trusted Ingredients, Superior Quality, 100% Guaranteed!
- Naturally free of: Gluten, Wheat, Yeast, Milk, Lactose, Soy, Artificial Color & Flavor 
- Non-GMO

Ingredients 
Actiponin® Gynostemma pentaphyllum Extract (leaf). Other Ingredients: Gelatin Capsule, Rice Powder, Vegetable Magnesium Stearate, Silica.

Ratings: 4.2 out of 5 - more than 460 global ratings
This gives me that lift I need when I feel tired,I work nights and if you have ever done that you know there is a feeling no amount of sleep can fix from being up all night. This AMPK is the remedy to so many issues I have. It curbs my appetite by taking away that "I want something but not sure what it is" feeling. It makes me feel at ease in a way I can not put into words. I hope they never stop making it.



4. Vitablosom AMPK Activator Supplement

Vitablosom AMPK Activator Supplement

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Vitablossom AMPK Activator Supplement, 5 in 1 Herbal Complex Advanced Metabolic Activator, for Immune Support, Energy Support and Weight Management, 60 Capsules, Premium Grade Jiaogulan Gynostemma, Vegan, Non-GMO

Ingredients
Gynostemma Pentaphyllum Leaf Extract 600mg, Berberis Aristata Root Extract 150mg, Quercetin (as Quercetin Dihydrate) 100mg, Tans- Resveratrol 100mg, Ceylon Cinnamon (Cinnamomum verum) (bark) 50mg, Other Ingredients: (Veggie Capsule) Cellulose.

I lost six pounds in a week when I first started taking this! However, everyone's metabolism is different and this may or may not work as well for you. Decades of work in the supplement industry has taught me that no supplement works the same for everyone. Give it a try for a month before making a final decision!


FAQ

a. How to Activate AMPK?




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